PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation

Journal of Neuroscience

Volumn 23, Issue 26, 2003, Pages 8989-9003

  Richards, J Grayson ^a,b   Higgins, Guy A ^a,c   Ouagazzal, Abdel Mouttalib ^a,d   Ozmen, Laurence ^a   Kew, James N C ^a,e   Bohrmann, Bernd ^a   Malherbe, Pari ^a   Brockhaus, Manfred ^a   Loetscher, Hansruedi ^a   Czech, Christian ^a   Huber, Gerda ^a,f   Bluethmann, Horst ^a   Jacobsen, Helmut ^a   Kemp, John A ^a,g  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b Schering Plough Research Institute ^*  (Switzerland)

^c MERCK RESEARCH LABORATORIES   (United States)

^d INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^e GLAXOSMITHKLINE   (United Kingdom)

^f Fachhochsch Solothurn NW Schweiz   (Switzerland)

^g Evotec Neurosciences GmbH   (Germany)

Author keywords

Alzheimer; Amyloid precursor protein; Amyloid protein; Cognition; Inflammation; LTP; Plaque; Presenilin 2; PS2APP; Transgenic

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN;

AGING; ALZHEIMER DISEASE; AMYLOIDOSIS; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN REGION; COGNITIVE DEFECT; CONTROLLED STUDY; DENTATE GYRUS; DISEASE ASSOCIATION; DISEASE SEVERITY; ELECTRON MICROSCOPY; ELECTROPHYSIOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOELECTRON MICROSCOPY; IMMUNOGOLD LABELING; INFLAMMATION; LIMBIC CORTEX; MOTOR CORTEX; MOUSE; NEOCORTEX; NONHUMAN; ORBITAL CORTEX; PATHOPHYSIOLOGY; PONS; PRIORITY JOURNAL; SUBICULUM; SYNAPSE; THALAMUS NUCLEUS;

EID: 0141707862     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-26-08989.2003     Document Type: Article

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