Blocking TGF-β-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

Nature Medicine

Volumn 14, Issue 6, 2008, Pages 681-687

  Town, Terrence ^a,b   Laouar, Yasmina ^a,f   Pittenger, Christopher ^a   Mori, Takashi ^c   Szekely, Christine A ^b,d   Tan, Jun ^e   Duman, Ronald S ^a   Flavell, Richard A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c SAITAMA MEDICAL UNIVERSITY   (Japan)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^e UNIVERSITY OF SOUTH FLORIDA   (United States)

^f UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN LIKE KINASE 5; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BONE MORPHOGENETIC PROTEIN; CD11B ANTIGEN; CD45 ANTIGEN; CYTOKINE; GLYCOPROTEIN P 15095; MUTANT PROTEIN; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD VESSEL; CELL INFILTRATION; CONTROLLED STUDY; FEMALE; IMMUNOCOMPETENT CELL; IMMUNOSTIMULATION; IN VITRO STUDY; INFLAMMATION; INNATE IMMUNITY; MACROPHAGE; MALE; MICROGLIA; MOUSE; NERVE CELL LESION; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; SENILE PLAQUE; SPATIAL MEMORY; TRANSGENIC MOUSE; WORKING MEMORY;

ALZHEIMER DISEASE; ANIMALS; CROSSES, GENETIC; DISEASE MODELS, ANIMAL; FEMALE; HETEROZYGOTE; HUMANS; IMMUNITY, NATURAL; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

MUS; MUS MUSCULUS;

EID: 44949173099     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1781     Document Type: Article

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