Microglia lacking E prostanoid receptor subtype 2 have enhanced Aβ phagocytosis yet lack Aβ-activated neurotoxicity

American Journal of Pathology

Volumn 166, Issue 4, 2005, Pages 1163-1172

  Shie, Feng Shiun ^a,c   Breyer, Richard M ^b   Montine, Thomas J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CHEMOATTRACTANT; CHEMOKINE; E PROSTANOID RECEPTOR TYPE 2; MACROPHAGE CHEMOATTRACTANT PROTEIN 1; MACROPHAGE CHEMOTACTIC FACTOR; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; PROSTANOID RECEPTOR; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BYSTANDER EFFECT; CELL CULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; EX VIVO STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNITY; MICROGLIA; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PARACRINE SIGNALING; PHAGOCYTOSIS; PRIORITY JOURNAL; SENILE PLAQUE; STATISTICAL SIGNIFICANCE; TISSUE SECTION;

EID: 17144380506     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)62336-X     Document Type: Article

References (37)

1. Cooper NR, Kalaria RN, McGeer PL, Rogers J: Key issues in Alzheimer's disease inflammation. Neurobiol Aging 2000, 21:451-453
2. El Khoury J, Hickman SE, Thomas CA, Cao L, Silverstein SC, Loike JD: Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils. Nature 1996, 382:716-719
3. Husemann J, Loike JD, Kodama T, Silverstein SC: Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar β-amyloid. J Neuroimmunol 2001, 114:142-150
4. Lue LF, Rydel R, Brigham EF, Yang LB, Hampel H, Murphy Jr GM, Brachova L, Van SD, Walker DG, Shen Y, Rogers J: Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro. Glia 2001, 35:72-79
5. D'Andrea MR, Cole GM, Ard MD: The microglial phagocytic role with specific plaque types in the Alzheimer disease brain. Neurobiol Aging 2004, 25:675-683
6. McGeer PL, McGeer EG: Inflammation, autotoxicity and Alzheimer disease. Neurobiol Aging 2001, 22:799-809
7. Szekely CA, Thorne JE, Zandi PP, Ek M, Messias E, Breitner JC, Goodman SN: Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review. Neuroepidemiology 2004, 23:159-169
8. McGeer PL, Schulzer M, McGeer EG: Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology 1996, 47:425-432
9. 42 independently of cyclooxygenase activity. Nature 2001, 414:212-216
10. Wyss-Coray T, Mucke L: Inflammation in neurodegenerative disease - a double-edged sword. Neuron 2002, 35:419-432
11. Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, Landreth G, Lue L, Mrak R, Mackenzie IR, McGeer PL, O'Banion MK, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I, Van Muiswinkel FL, Veerhuis R, Walker D, Webster S, Wegrzyniak B, Wenk G, Wyss-Coray T: Inflammation and Alzheimer's disease. Neurobiol Aging 2000, 21:383-421
12. Narumiya S, Sugimoto Y, Ushikubi F: Prostanoid receptors: structures, properties, and functions. Physiol Rev 1999, 79:1193-1226
13. Caggiano AO, Kraig RP: Prostaglandin E receptor subtypes in cultured rat microglia and their role in reducing lipopolysaccharide-induced interleukin-1β production. J Neurochem 1999, 72:565-575
14. 2 inhibits alveolar macrophage phagocytosis through an E-prostanoid 2 receptor-mediated increase in intracellular cyclic AMP. J Immunol 2004, 173:559-565
15. 2 in the central nervous system in response to brain injury and circulating lipopolysaccharide. J Neurochem 2001, 76:855-864
16. Petrova TV, Akama KT, Van Eldik LJ: Selective modulation of BV-2 microglial activation by prostaglandin E(2). Differential effects on endotoxin-stimulated cytokine induction. J Biol Chem 1999, 274:28823-28827
17. 2 levels in patients with probable Alzheimer's disease. Neurology 1999, 53:1495-1498
18. Walker DG, Lue LF, Beach TG: Gene expression profiling of amyloid β peptide-stimulated human post-mortem brain microglia. Neurobiol Aging 2001, 22:957-966
19. Rogers J, Strohmeyer R, Kovelowski CJ, Li R: Microglia and inflammatory mechanisms in the clearance of amyloid β peptide. Glia 2002, 40:260-269
20. -/- knock-out mice. J Neurosci 2003, 23:8532-8538
21. Mitrasinovic OM, Murphy Jr GM: Microglial overexpression of the M-CSF receptor augments phagocytosis of opsonized Aβ. Neurobiol Aging 2003, 24:807-815
22. Qin L, Liu Y, Cooper C, Liu B, Wilson B, Hong JS: Microglia enhance β-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species. J Neurochem 2002, 83:973-983
23. Minagar A, Shapshak P, Fujimura R, Ownby R, Heyes M, Eisdorfer C: The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis. J Neurol Sci 2002, 202:13-23
24. Novarino G, Fabrizi C, Tonini R, Denti MA, Malchiodi-Albedi F, Lauro GM, Sacchetti B, Paradisi S, Ferroni A, Curmi PM, Breit SN, Mazzanti M: Involvement of the intracellular ion channel CLIC1 in microglia-mediated β-amyloid-induced neurotoxicity. J Neurosci 2004, 24:5322-5330
25. Manabe Y, Anrather J, Kawano T, Niwa K, Zhou P, Ross ME, Iadecola C: Prostanoids, not reactive oxygen species, mediate COX-2-dependent neurotoxicity. Ann Neurol 2004, 55:668-675
26. Andreasson KI, Savonenko A, Vidensky S, Goellner JJ, Zhang Y, Shaffer A, Kaufmann WE, Worley PF, Isakson P, Markowska AL: Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice. J Neurosci 2001, 21:8198-8209
27. Dawson VL, Dawson TM: Nitric oxide in neurodegeneration. Prog Brain Res 1998, 118:215-229
28. Solomon B, Koppel R, Frankel D, Hanan-Aharon E: Disaggregation of Alzheimer β-amyloid by site-directed mAb. Proc Natl Acad Sci USA 1997, 94:4109-4112
29. Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Liao Z, Lieberburg I, Motter R, Mutter L, Soriano F, Shopp G, Vasquez N, Vandevert C, Walker S, Wogulis M, Yednock T, Games D, Seubert P: Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999, 400:173-177
30. Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Lieberburg I, Motter R, Nguyen M, Soriano F, Vasquez N, Weiss K, Welch B, Seubert P, Schenk D, Yednock T: Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 2000, 6:916-919
31. Bacskai BJ, Kajdasz ST, McLellan ME, Games D, Seubert P, Schenk D, Hyman BT: Non-Fc-mediated mechanisms are involved in clearance of amyloid-β in vivo by immunotherapy. J Neurosci 2002, 22:7873-7878
32. 2+-independent protein kinase Cs mediate heterologous desensitization of leukocyte chemokine receptors by opioid receptors. J Biol Chem 2003, 278:12729-12736
33. Carnevale KA, Cathcart MK: Protein kinase C β is required for human monocyte chemotaxis to MCP-1. J Biol Chem 2003, 278:25317-25322
34. Montine TJ, Milatovic D, Gupta RC, Valyi-Nagy T, Morrow JD, Breyer RM: Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent. J Neurochem 2002, 83:463-470
35. Combs CK, Johnson DE, Karlo JC, Cannady SB, Landreth GE: Inflammatory mechanisms in Alzheimer's disease: inhibition of β-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARγ agonists. J Neurosci 2000, 20:558-567
36. Han S, Roman J: Suppression of prostaglandin E2 receptor subtype EP2 by PPARγ ligands inhibits human lung carcinoma cell growth. Biochem Biophys Res Commun 2004, 314:1093-1099
37. McGeer PL, McGeer E: Is there a future for vaccination as a treatment for Alzheimer's disease? Neurobiol Aging 2003, 24:391-395