Neurotoxic Aβ peptides increase oxidative stress in vivo through NMDA-receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro

Journal of Neurochemistry

Volumn 76, Issue 4, 2001, Pages 1050-1056

  Parks, Janice K ^a   Smith, Trisha S ^a   Trimmer, Patricia A ^a   Bennett Jr , James P ^a   Davis Parker, W Jr ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Alzheimer's disease; Beta amyloid; Complex IV; Mitochondrial permeability transition; Neurotoxicity; Oxidative stress

Indexed keywords

AMYLOID BETA PROTEIN; CHLORPROMAZINE; CYCLOSPORIN A; CYTOCHROME C OXIDASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OXYGEN RADICAL; RUTHENIUM RED; AMYLOID BETA PROTEIN (1 28); AMYLOID BETA PROTEIN (25 35); AMYLOID BETA PROTEIN (35 25); AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA-PROTEIN (1-28); AMYLOID BETA-PROTEIN (25-35); AMYLOID BETA-PROTEIN (35-25); CYCLOSPORIN; NITRIC OXIDE SYNTHASE; PEPTIDE FRAGMENT; REACTIVE OXYGEN METABOLITE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME ACTIVITY; IN VIVO STUDY; MICRODIALYSIS; MITOCHONDRION; MOUSE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; ANIMAL; CORPUS STRIATUM; DRUG ANTAGONISM; DRUG EFFECT; IN VITRO STUDY; INTRACELLULAR MEMBRANE; LIVER MITOCHONDRION; MALE; METABOLISM; PERMEABILITY; RAT; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE; WAKEFULNESS;

ANIMALIA;

AMYLOID BETA-PROTEIN; ANIMALS; CORPUS STRIATUM; CYCLOSPORINE; ELECTRON TRANSPORT COMPLEX IV; INTRACELLULAR MEMBRANES; MALE; MICRODIALYSIS; MITOCHONDRIA, LIVER; NITRIC OXIDE SYNTHASE; PEPTIDE FRAGMENTS; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECEPTORS, N-METHYL-D-ASPARTATE; RUTHENIUM RED; WAKEFULNESS;

EID: 0034745636     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00112.x     Document Type: Article

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