Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein

Science

Volumn 284, Issue 5421, 1999, Pages 1845-1848

  Sattler, Rita ^a   Xiong, Zhigang ^b   Lu, Wei Yang ^b   Hafner, Mathias ^c   MacDonald, John F ^b   Tymianski, Michael ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MANNHEIM UNIVERSITY OF APPLIED SCIENCES   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; CALCIUM CHANNEL; CALCIUM ION; DIZOCILPINE; GLUTAMIC ACID; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; POSTSYNAPTIC DENSITY PROTEIN 95; POTASSIUM ION; STRUCTURAL PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ARTICLE; CALCIUM CURRENT; CONCENTRATION RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; MOLECULAR DYNAMICS; NERVE CELL CULTURE; NEUROTOXICITY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL CELL; MOUSE; NERVE CELL DEGENERATION; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NONHUMAN; SYNAPTIC TRANSMISSION;

ANIMALS; CALCIUM; CALCIUM CHANNELS; CELL SURVIVAL; CELLS, CULTURED; ENZYME ACTIVATION; GUANYLATE KINASE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; N-METHYLASPARTATE; NERVE TISSUE PROTEINS; NEURONS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NUCLEOSIDE-PHOSPHATE KINASE; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PATCH-CLAMP TECHNIQUES; RECEPTORS, N-METHYL-D-ASPARTATE; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION;

EID: 0033546347     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.284.5421.1845     Document Type: Article

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36. Supported by NIH grant NS 39060 (M.T.) and MRC (J.F.M.). We thank O. T. Jones and K. Iihara for technical assistance, and D. W. Choi, M. W. Salter, and Y. T. Wang for critical comments on the manuscript. R.S. is a student, and W.Y.L. a fellow, of the Ontario Heart and Stroke Foundation. Z.X. is an MRC Centennial Fellow. M.T. is an MRC Clinician-Scientist.