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Volumn 24, Issue SUPPL. 2, 2011, Pages 199-209

Targeting the kynurenine pathway-related alterations in alzheimer's disease: A future therapeutic strategy

Author keywords

Alzheimer's disease; animal models; kynurenine pathway; therapy

Indexed keywords

4 CHLOROKYNURENINE; CHOLINESTERASE INHIBITOR; DONEPEZIL; GALANTAMINE; GLUTAMIC ACID; KYNURENIC ACID DERIVATIVE; KYNURENINE; MEMANTINE; RIVASTIGMINE; UNCLASSIFIED DRUG;

EID: 79955643831     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2011-110131     Document Type: Review
Times cited : (23)

References (113)
  • 1
    • 0037058753 scopus 로고    scopus 로고
    • The incremental direct costs associated with behavioral symptoms in AD
    • Murman DL, Chen MS, Powell MC, Kuo SB, Bradley CJ, Colenda CC (2002) The incremental direct costs associated with behavioralsymptoms in AD. Neurology 59, 1721-1729. (Pubitemid 35424453)
    • (2002) Neurology , vol.59 , Issue.11 , pp. 1721-1729
    • Murman, D.L.1    Chen, Q.2    Powell, M.C.3    Kuo, S.B.4    Bradley, C.J.5    Colenda, C.C.6
  • 2
    • 44249126470 scopus 로고    scopus 로고
    • Improvement in behavioural symptoms in patients with moderate to severe AD by memantine: A pooled data analysis
    • Gauthier S, Loft H, Cummings J (2007) Improvement in behavioural symptoms in patients with moderate to severe AD by memantine: a pooled data analysis. Int J Geriatr Psychiatry 23, 537-545.
    • (2007) Int J Geriatr Psychiatry , vol.23 , pp. 537-545
    • Gauthier, S.1    Loft, H.2    Cummings, J.3
  • 3
    • 0018675642 scopus 로고
    • Neurotransmitter-related enzymes in senile dementia of the Alzheimer type
    • DOI 10.1016/0006-8993(79)90336-6
    • Davies P (1979) Neurotransmitter-related enzymes in senile dementia of the Alzheimer type. Brain Res 171, 319-327. (Pubitemid 10246672)
    • (1979) Brain Research , vol.171 , Issue.2 , pp. 319-327
    • Davies, P.1
  • 4
    • 0022496162 scopus 로고
    • Neurotransmitter deficits in Alzheimer's disease and in other dementing disorders
    • Mann DMA, Yates PO (1986) Neurotransmitter deficits in Alzheimer's disease and in other dementing disorders. Hum Neurobiol5, 147-158.
    • (1986) Hum Neurobiol , vol.5 , pp. 147-158
    • Mann, D.M.A.1    Yates, P.O.2
  • 5
    • 0023095310 scopus 로고
    • Reinnervation of the hippocampal perforant pathway zone in Alzheimer's disease
    • DOI 10.1002/ana.410210307
    • Hyman BT, Kromer LJ, Van Hoesen GW (1987) Rein-nervation of the hippocampal perforant pathway zone in Alzheimer's disease. Ann Neurol 21, 259-267. (Pubitemid 17035282)
    • (1987) Annals of Neurology , vol.21 , Issue.3 , pp. 259-267
    • Hyman, B.T.1    Kromer, L.J.2    Van Hoesen, G.W.3
  • 7
    • 0032051614 scopus 로고    scopus 로고
    • Temporal cortex synaptophysin mRNA is reduced in Alzheimer's disease and is negatively correlated with the severity of dementia
    • DOI 10.1006/exnr.1997.6772
    • Heffernan JM, Eastwood SL, Nagy S, Sanders MW, McDonald B, Harrison PJ (1998) Temporal cortex synaptophysin mRNA is reduced in Alzheimer's disease and is negatively correlated with the severity of dementia. Exp Neurol 150, 235-239. (Pubitemid 28231954)
    • (1998) Experimental Neurology , vol.150 , Issue.2 , pp. 235-239
    • Heffernan, J.M.1    Eastwood, S.L.2    Nagy, Z.3    Sanders, M.W.4    McDonald, B.5    Harrison, P.J.6
  • 9
    • 0032513938 scopus 로고    scopus 로고
    • Association at LRP gene locus with sporadic late-onset Alzheimer's disease
    • DOI 10.1016/S0140-6736(05)78749-3
    • Lambert JC, Wavrant-De Vrieze F, Amouyel P, Chartier-Harlin MC (1998) Association at LRP gene locus with sporadic late-onset Alzheimer's disease. Lancet 351, 1787-1788. (Pubitemid 28269197)
    • (1998) Lancet , vol.351 , Issue.9118 , pp. 1787-1788
    • Lambert, J.-C.1    Wavrant-De Vrieze, F.2    Amouyel, P.3    Chartier-Harlin, M.-C.4
  • 10
    • 78649486194 scopus 로고    scopus 로고
    • Swedish mutation within amyloid precursor protein modulates global gene expression towards the pathogenesis of Alzheimer's disease
    • Shin J, Yu SB, Yu UY, Jo SA, Ahn JH (2010) Swedish mutation within amyloid precursor protein modulates global gene expression towards the pathogenesis of Alzheimer's disease. BMB Rep 43, 704-709.
    • (2010) BMB Rep , vol.43 , pp. 704-709
    • Shin, J.1    Yu, S.B.2    Yu, U.Y.3    Jo, S.A.4    Ahn, J.H.5
  • 11
    • 5644239087 scopus 로고    scopus 로고
    • Alzheimer disease: Mechanis-tic understanding predicts novel therapies
    • American College of Physicians, American Physiological Society
    • Selkoe DJ, American College of Physicians, American Physiological Society (2004) Alzheimer disease: mechanis-tic understanding predicts novel therapies. Ann Intern Med 140, 627-638.
    • (2004) Ann Intern Med , vol.140 , pp. 627-638
    • Selkoe, D.J.1
  • 12
    • 33748792821 scopus 로고    scopus 로고
    • Opposing activities protect against age-onset proteotoxicity
    • DOI 10.1126/science.1124646
    • Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A (2006) Opposing activities protect against age-onset pro-teotoxicity. Science 313, 1604-1610. (Pubitemid 44414028)
    • (2006) Science , vol.313 , Issue.5793 , pp. 1604-1610
    • Cohen, E.1    Bieschke, J.2    Perciavalle, R.M.3    Kelly, J.W.4    Dillin, A.5
  • 13
    • 0035968117 scopus 로고    scopus 로고
    • Presenilin mutations line up along transmembrane α-helices
    • DOI 10.1016/S0304-3940(01)01910-3, PII S0304394001019103
    • Hardy J, Crook R (2001) Presenilin mutations line up along transmembrane alpha-helices. Neurosci Lett 306, 203-205. (Pubitemid 32530834)
    • (2001) Neuroscience Letters , vol.306 , Issue.3 , pp. 203-205
    • Hardy, J.1    Crook, R.2
  • 14
    • 2942525794 scopus 로고    scopus 로고
    • A new presenilin Alzheimer's disease case confirms the helical alignment of pathogenic mutations in transmembrane domain 5
    • DOI 10.1016/j.neulet.2004.04.030, PII S0304394004004239
    • Coleman P, Kurlan R, Crook R, Werner J, Hardy J (2004) A new presenilin Alzheimer's disease case confirms the heli-cal alignment of pathogenic mutations in transmembrane domain 5. Neurosci Lett 364, 139-140. (Pubitemid 38757919)
    • (2004) Neuroscience Letters , vol.364 , Issue.3 , pp. 139-140
    • Coleman, P.1    Kurlan, R.2    Crook, R.3    Werner, J.4    Hardy, J.5
  • 15
    • 37049048544 scopus 로고
    • Paired helical filaments in electron microscopy of Alzheimer's disease
    • Kidd M (1963) Paired helical filaments in electron microscopy of Alzheimer's disease. Nature 197, 192-193.
    • (1963) Nature , vol.197 , pp. 192-193
    • Kidd, M.1
  • 16
    • 0033055359 scopus 로고    scopus 로고
    • Stable expression in Chinese hamster ovary cells of mutated tau genes causing frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)
    • Matsumura N, Yamazaki T, Ihara Y (1999) Stable expres-sion in Chinese hamster ovary cells of mutated tau genes causing frontotemporal dementia and parkinsonism linked to chromosome-17 (FTDP-17). Am J Pathol 154, 1649-1656. (Pubitemid 29262846)
    • (1999) American Journal of Pathology , vol.154 , Issue.6 , pp. 1649-1656
    • Matsumura, N.1    Yamazaki, T.2    Ihara, Y.3
  • 17
    • 0342368837 scopus 로고    scopus 로고
    • The FTDP-17-linked mutation R406W abolishes the interaction of phosphorylated tau with microtubules
    • DOI 10.1046/j.1471-4159.2000.0742583.x
    • Perez M, Lim F, Arrasate M, Avila J (2000) The FTDP-17-linked mutation R406W abolishes the interaction of phosphorylated tau with microtubules. J Neurochem 74, 2583-2589. (Pubitemid 30314236)
    • (2000) Journal of Neurochemistry , vol.74 , Issue.6 , pp. 2583-2589
    • Perez, M.1    Lim, F.2    Arrasate, M.3    Avila, J.4
  • 18
    • 0034193290 scopus 로고    scopus 로고
    • Missense point mutations of tau to segregate with FTDP-17 exhibit site- specific effects on microtubule structure in COS cells: A novel action of R406W mutation
    • DOI 10.1002/(SICI)1097-4547(20000501)60:3<380::AID-JNR13>3.0.CO;2-5
    • Sahara N, Tomiyama T, Mori H (2000) Missense point muta-tions oftau to segregate with FTDP-17 exhibit site-specific effects on microtubule structure in COS cells: a novel action ofR406W mutation. J Neurosci Res 60, 380-387. (Pubitemid 30253602)
    • (2000) Journal of Neuroscience Research , vol.60 , Issue.3 , pp. 380-387
    • Sahara, N.1    Tomiyama, T.2    Mori, H.3
  • 19
    • 0035937481 scopus 로고    scopus 로고
    • Effects of FTDP-17 mutations on the in vitro phosphorylation of tau by glycogen synthase kinase 3β identified by mass spectrometry demonstrate certain mutations exert long-range conformational changes
    • DOI 10.1016/S0014-5793(01)02267-0, PII S0014579301022670
    • Connell JW, Gibb GM, Betts JC, Blackstock WP, Gallo JM, Lovestone S, Hutton M, Anderton BH (2001) Effects of FTDP-17 mutations on the in vitro phosphorylation of tau by glycogen synthase kinase 3β identified by mass spec-trometry demonstrate certain mutations exert long-range conformational changes. FEBS Lett 493, 40-44. (Pubitemid 32241173)
    • (2001) FEBS Letters , vol.493 , Issue.1 , pp. 40-44
    • Connell, J.W.1    Gibb, G.M.2    Betts, J.C.3    Blackstock, W.P.4    Gallo, J.-M.5    Lovestone, S.6    Hutton, M.7    Anderton, B.H.8
  • 21
    • 0042697305 scopus 로고    scopus 로고
    • Triple-transgenic model of Alzheimer's Disease with plaques and tangles: Intracellular Aβ and synaptic dysfunction
    • DOI 10.1016/S0896-6273(03)00434-3
    • Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, La erla FM (2003) Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39, 409-421. (Pubitemid 36937044)
    • (2003) Neuron , vol.39 , Issue.3 , pp. 409-421
    • Oddo, S.1    Caccamo, A.2    Shepherd, J.D.3    Murphy, M.P.4    Golde, T.E.5    Kayed, R.6    Metherate, R.7    Mattson, M.P.8    Akbari, Y.9    LaFerla, F.M.10
  • 22
    • 0344845132 scopus 로고    scopus 로고
    • Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
    • DOI 10.1016/j.neurobiolaging.2003.08.012
    • Oddo S, Caccamo A, Kitazawa M, Tseng BP, LaFerla FM, (2003) Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol Aging24, 1063-1070. (Pubitemid 37487883)
    • (2003) Neurobiology of Aging , vol.24 , Issue.8 , pp. 1063-1070
    • Oddo, S.1    Caccamo, A.2    Kitazawa, M.3    Tseng, B.P.4    LaFerla, F.M.5
  • 23
    • 0031108103 scopus 로고    scopus 로고
    • Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing
    • Baumeister R, Leimer U, Zweckbronner I, Jakubek C, Grunberg J, Haass C (1997) Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing. Genes Funct 1, 149-159.
    • (1997) Genes Funct , vol.1 , pp. 149-159
    • Baumeister, R.1    Leimer, U.2    Zweckbronner, I.3    Jakubek, C.4    Grunberg, J.5    Haass, C.6
  • 24
    • 0028981288 scopus 로고
    • Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans
    • Link CD (1995) Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. Proc Natl Acad Sci USA 92, 9368-9372.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9368-9372
    • Link, C.D.1
  • 25
    • 15044339964 scopus 로고    scopus 로고
    • Intraneuronal Aβ, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease
    • DOI 10.1016/j.neuroscience.2004.12.025
    • Crowther DC, Kinghorn KJ, Miranda E, Page R, Curry JA, Duthie FA, Gubb DC, Lomas DA (2005) Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease. Neuroscience 132, 123-135. (Pubitemid 40380720)
    • (2005) Neuroscience , vol.132 , Issue.1 , pp. 123-135
    • Crowther, D.C.1    Kinghorn, K.J.2    Miranda, E.3    Page, R.4    Curry, J.A.5    Duthie, F.A.I.6    Gubb, D.C.7    Lomas, D.A.8
  • 26
    • 44849144494 scopus 로고    scopus 로고
    • A new method to measure cellular toxicity of non-fibrillar and fibrillar Alzheimer's Aβ using yeast
    • Bharadwaj P, Waddington L, Varghese J, Macreadie IG (2008) A new method to measure cellular toxicity of non-fibrillar and fibrillar Alzheimer's Abeta using yeast. J Alzheimers Dis 13, 147-150. (Pubitemid 352038519)
    • (2008) Journal of Alzheimer's Disease , vol.13 , Issue.2 , pp. 147-150
    • Bharadwaj, P.1    Waddington, L.2    Varghese, J.3    Macreadie, I.G.4
  • 27
    • 18144406846 scopus 로고    scopus 로고
    • A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease
    • DOI 10.1038/ng1542
    • Giorgini F, Guidetti P, Nguyen QV, Bennett SC, Muchowski PJ (2005) A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington's disease. Nat Genet 37, 526-531. (Pubitemid 40617282)
    • (2005) Nature Genetics , vol.37 , Issue.5 , pp. 526-531
    • Giorgini, F.1    Guidetti, P.2    Nguyen, Q.3    Bennett, S.C.4    Muchowski, P.J.5
  • 31
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid β-peptide
    • DOI 10.1038/nrm2101, PII NRM2101
    • Haass C, Selkoe DJ (2007) Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 8, 101-112. (Pubitemid 46432529)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.2 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 33
    • 44949213717 scopus 로고    scopus 로고
    • Mito-chondrial DNA damage and repair in neurodegenerative disorders
    • Yang JL, Weissman L, Bohr VA, Mattson MP (2008) Mito-chondrial DNA damage and repair in neurodegenerative disorders. DNA Repair 7, 1110-1120.
    • (2008) DNA Repair , vol.7 , pp. 1110-1120
    • Yang, J.L.1    Weissman, L.2    Bohr, V.A.3    Mattson, M.P.4
  • 35
    • 64349099993 scopus 로고    scopus 로고
    • The role of abnormal mitochondrial dynamics in the patho-genesis of Alzheimer's disease
    • Wang X, Su B, Zheng L, Perry G, Smith MA, Zhu X (2009) The role of abnormal mitochondrial dynamics in the patho-genesis of Alzheimer's disease. JNeurochem 109, 153-159.
    • (2009) JNeurochem , vol.109 , pp. 153-159
    • Wang, X.1    Su, B.2    Zheng, L.3    Perry, G.4    Smith, M.A.5    Zhu, X.6
  • 36
    • 72149118206 scopus 로고    scopus 로고
    • Mitochondrial permeability transition porein Alzheimer's disease: Cyclophilin D and amyloidbeta
    • Du H, Yan SS (2010) Mitochondrial permeability transition porein Alzheimer's disease: cyclophilin D and amyloidbeta. Biochim Biophys Acta 1802, 2-10.
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 2-10
    • Du, H.1    Yan, S.S.2
  • 37
    • 36248988467 scopus 로고    scopus 로고
    • Insights into amyloid-β-induced mitochondrial dysfunction in Alzheimer disease
    • DOI 10.1016/j.freeradbiomed.2007.09.007, PII S0891584907006235
    • Wang X, Su B, Perry G, Smith MA, Zhu X (2007) Insights into amyloid-beta-induced mitochondrial dysfunction in Alzheimer's disease. Free Radic Biol Med 43, 1569-1573. (Pubitemid 350122990)
    • (2007) Free Radical Biology and Medicine , vol.43 , Issue.12 , pp. 1569-1573
    • Wang, X.1    Su, B.2    Perry, G.3    Smith, M.A.4    Zhu, X.5
  • 39
    • 0345055313 scopus 로고    scopus 로고
    • Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production
    • Keller JN, Guo Q, Holtsberg FW, Bruce-Keller AJ, Mattson MP (1998) Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production. JNeurosci 18, 4439-4450. (Pubitemid 28280155)
    • (1998) Journal of Neuroscience , vol.18 , Issue.12 , pp. 4439-4450
    • Keller, J.N.1    Quo, Q.2    Holtsberg, F.W.3    Bruce-Keller, A.J.4    Mattson, M.P.5
  • 40
    • 70350304571 scopus 로고    scopus 로고
    • Calcium dysregulation in Alzheimer's disease: From mechanisms to therapeutic opportunities
    • Yu JT, Chang RC, Tan L (2009) Calcium dysregulation in Alzheimer's disease: from mechanisms to therapeutic opportunities. Prog Neurobiol 89, 240-255.
    • (2009) Prog Neurobiol , vol.89 , pp. 240-255
    • Yu, J.T.1    Chang, R.C.2    Tan, L.3
  • 41
    • 0014668762 scopus 로고
    • Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate
    • Olney JW (1969) Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science 164, 719-721.
    • (1969) Science , vol.164 , pp. 719-721
    • Olney, J.W.1
  • 42
    • 0032967382 scopus 로고    scopus 로고
    • The role of excitotoxicity in neurodegenerative disease: Implications for therapy
    • DOI 10.1016/S0163-7258(98)00042-4, PII S0163725898000424
    • Doble A (1999) The role of excitotoxicity in neurodegenerative disease: implications oftherapy. Pharmacol Ther 81, 163-221. (Pubitemid 29094735)
    • (1999) Pharmacology and Therapeutics , vol.81 , Issue.3 , pp. 163-221
    • Doble, A.1
  • 43
    • 33645899316 scopus 로고    scopus 로고
    • Role of astrocytes in glutamate homeostasis: Implications for excitotoxicity
    • Schousboe A, Waagepetersen HS (2005) Role of astrocytes in glutamate homeostasis: implications for excitotoxicity. Neurotox Res 8, 221-225.
    • (2005) Neurotox Res , vol.8 , pp. 221-225
    • Schousboe, A.1    Waagepetersen, H.S.2
  • 44
    • 0029996740 scopus 로고    scopus 로고
    • ROLE DU GLUTAMATE ET DE L'EXCITOTOXICITE DANS LES MALADIES NEUROLOGIQUES
    • Hugon J, Vallat JM, Dumas M (1996) Role of glutamate and excitotoxicity in neurologic diseases. Rev Neurol (Paris) 152, 239-248. (Pubitemid 26189439)
    • (1996) Revue Neurologique , vol.152 , Issue.4 , pp. 239-248
    • Hugon, J.1    Vallat, J.M.2    Dumas, M.3
  • 45
    • 0036796276 scopus 로고    scopus 로고
    • Role of oxidative stress and antioxidants in neurodegenerative diseases
    • DOI 10.1080/1028415021000033767
    • Rao AV, Balachandran B (2002) Role of oxidative stress and antioxidants in neurodegenerative diseases. Nutr Neurosci 5, 291-309. (Pubitemid 35174629)
    • (2002) Nutritional Neuroscience , vol.5 , Issue.5 , pp. 291-309
    • Rao, A.V.1    Balachandran, B.2
  • 46
    • 0025265926 scopus 로고
    • The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death
    • Choi DW, Rothman SM (1990) The role of glutamate neurotoxicity in hypoxic-ischaemic neuronal death. Annu Rev Neurosci13, 171-182. (Pubitemid 20100647)
    • (1990) Annual Review of Neuroscience , vol.13 , pp. 171-182
    • Choi, D.W.1    Rothman, S.M.2
  • 47
    • 33746281456 scopus 로고    scopus 로고
    • Inflammation and excitotoxicity: Role in migraine pathogenesis
    • Longoni M, Ferrarese C (2006) Inflammation and excitotoxicity: role in migraine pathogenesis. Neurol Sci 27, 107-110.
    • (2006) Neurol Sci , vol.27 , pp. 107-110
    • Longoni, M.1    Ferrarese, C.2
  • 48
    • 38949126940 scopus 로고    scopus 로고
    • Excitotoxicity and new antiglutamatergic strategies in PD and AD
    • Koutsilieri E, Riederer P (2007) Excitotoxicity and new antiglutamatergic strategies in PD and AD. Parkinsonism Relat Disord 13, 329-331.
    • (2007) Parkinsonism Relat Disord , vol.13 , pp. 329-331
    • Koutsilieri, E.1    Riederer, P.2
  • 49
    • 0027686249 scopus 로고
    • Oxidative stress, glutamate, and neurodegenerative disorders
    • Coyle JT, Puttfarcken P (1993) Oxidative stress, glutamate and neurodegenerative disorders. Science 262, 689-695. (Pubitemid 23350687)
    • (1993) Science , vol.262 , Issue.5134 , pp. 689-695
    • Coyle, J.T.1    Puttfarcken, P.2
  • 50
    • 39149117756 scopus 로고    scopus 로고
    • Amyloid beta peptides and glutamatergic synaptic dysregulation
    • DOI 10.1016/j.expneurol.2007.10.008, PII S0014488607003913
    • Parameshwaran K, Dhanasekaran M, Suppiramaniam V (2008) Amyloid beta peptides and glutamatergic synaptic dysregulation. Exp Neurol 210, 7-13. (Pubitemid 351258072)
    • (2008) Experimental Neurology , vol.210 , Issue.1 , pp. 7-13
    • Parameshwaran, K.1    Dhanasekaran, M.2    Suppiramaniam, V.3
  • 51
    • 0024363934 scopus 로고
    • Excitatory amino acids and Alzheimer's disease
    • DOI 10.1016/0197-4580(89)90143-7
    • Greenamyre JT, Young AB (1989) Excitatory amino acids and Alzheimer's disease. Neurobiol Aging 10, 593-602. (Pubitemid 19245482)
    • (1989) Neurobiology of Aging , vol.10 , Issue.5 , pp. 593-602
    • Greenamyre, J.T.1    Young, A.B.2
  • 53
    • 30844439634 scopus 로고    scopus 로고
    • Glutamate-based therapeutic approaches: Clinical trials with NMDA antagonists
    • DOI 10.1016/j.coph.2005.12.002, PII S1471489205001785
    • Muir KW (2006) Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists. Curr Opin Pharmacol 6, 53-60. (Pubitemid 43103819)
    • (2006) Current Opinion in Pharmacology , vol.6 , Issue.SPEC. ISS. , pp. 53-60
    • Muir, K.W.1
  • 54
    • 0742323784 scopus 로고    scopus 로고
    • The kynurenine pathway of tryptophan degradation as a drug target
    • DOI 10.1016/j.coph.2003.10.006, PII S1471489203002029
    • Schwarcz R (2004) The kynurenine pathway of tryptophan degradationas adrug target. Curr Opin Pharmacol 4, 12-17. (Pubitemid 38145832)
    • (2004) Current Opinion in Pharmacology , vol.4 , Issue.1 , pp. 12-17
    • Schwarcz, R.1
  • 55
    • 71949108894 scopus 로고    scopus 로고
    • Syn thesis transformations and pharmaceutical applications of kynurenic acid derivatives
    • Fülöp F, Szatmári I, Vámos E, Zádori D, Toldi J, Vécsei L (2009) Synthesis, transformations and pharmaceutical applications of kynurenic acid derivatives. Curr Med Chem 16, 4828-4842.
    • (2009) Curr Med Chem , vol.16 , pp. 4828-4842
    • Fülöp, F.1    Szatmári, I.2    Vámos, E.3    Zádori, D.4    Toldi, J.5    Vécsei, L.6
  • 57
    • 47849119964 scopus 로고    scopus 로고
    • Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer's disease: A systematic review and meta-analysis
    • Hansen RA, Gartlehner G, Webb AP, Morgan LC, Moore CG, Jonas DE (2008) Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer's disease: a systematic review and metaanalysis. Clin Interv Aging 3, 211-225. (Pubitemid 352037861)
    • (2008) Clinical Interventions in Aging , vol.3 , Issue.2 , pp. 211-225
    • Hansen, R.A.1    Gartlehner, G.2    Webb, A.P.3    Morgan, L.C.4    Moore, C.G.5    Jonas, D.E.6
  • 59
    • 50649117539 scopus 로고    scopus 로고
    • Study of neuroprotection of donepezil, a therapy for Alzheimer's disease
    • Akasofu S, Kimura M, Kosasa T, Sawada K, Ogura H (2008) Study of neuroprotection of donepezil, a therapy for Alzheimer's disease. Chem Biol Interact 175, 222-226.
    • (2008) Chem Biol Interact , vol.175 , pp. 222-226
    • Akasofu, S.1    Kimura, M.2    Kosasa, T.3    Sawada, K.4    Ogura, H.5
  • 60
    • 34249090813 scopus 로고    scopus 로고
    • 25-35 I.c.v.-injected mice: Involvement of dopaminergic systems
    • DOI 10.1038/sj.npp.1301256, PII 1301256
    • Wang D, Noda Y, Zhou Y, Mouri A, Mizoguchi H, Nitta A, Chen W, Nabeshima T (2007) The allosteric potentiation of nicotinic acetylcholinereceptors by galantamine ameliorates the cognitive dysfunction in beta amyloid25-35 i.c.v.-injected mice: involvement of dopaminergic systems. Neuropsychopharmacology 32, 1261-1271. (Pubitemid 46788859)
    • (2007) Neuropsychopharmacology , vol.32 , Issue.6 , pp. 1261-1271
    • Wang, D.1    Noda, Y.2    Zhou, Y.3    Mouri, A.4    Mizoguchi, H.5    Nitta, A.6    Chen, W.7    Nabeshima, T.8
  • 61
    • 33645510613 scopus 로고    scopus 로고
    • Galantamine for Alzheimer's disease and mild cognitive impairment
    • Loy C, Schneider L (2006) Galantamine for Alzheimer's disease and mild cognitive impairment. Cochrane Database Syst Rev 1, CD001747.
    • (2006) Cochrane Database Syst Rev , vol.1
    • Loy, C.1    Schneider, L.2
  • 62
    • 13844251864 scopus 로고    scopus 로고
    • Empirical evidence of neuroprotection by dual cholinesterase inhibition in Alzheimer's disease
    • DOI 10.1097/00001756-200502080-00006
    • Venneri A, McGeown WJ, Shanks MF (2005) Empirical evidence of neuroprotection by dual cholinesterase inhibition in Alzheimer's disease. Neuroreport 16, 107-110. (Pubitemid 40250379)
    • (2005) NeuroReport , vol.16 , Issue.2 , pp. 107-110
    • Venneri, A.1    McGeown, W.J.2    Shanks, M.F.3
  • 63
    • 16344378591 scopus 로고    scopus 로고
    • Cognitive performance in Alzheimer's disease patients receiving rivastigmine for up to 5 years
    • DOI 10.1111/j.1368-5031.2005.00524.x
    • Small GW, Kaufer D, Mendiondo MS, Quarg P, Spiegel R (2005) Cognitive performance in Alzheimer's disease patients receiving rivastigmine for up to 5 years. Int J Clin Pract 59, 473-477. (Pubitemid 40467894)
    • (2005) International Journal of Clinical Practice , vol.59 , Issue.4 , pp. 473-477
    • Small, G.W.1    Kaufer, D.2    Mendiondo, M.S.3    Quarg, P.4    Spiegel, R.5
  • 64
    • 0032892343 scopus 로고    scopus 로고
    • Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist - A review of preclinical data
    • DOI 10.1016/S0028-3908(99)00019-2, PII S0028390899000192
    • Parsons CG, Danysz W, Quack G (1999) Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist: a review ofpreclinical data. Neuropharmacology 38, 735-767. (Pubitemid 29187336)
    • (1999) Neuropharmacology , vol.38 , Issue.6 , pp. 735-767
    • Parsons, C.G.1    Danysz, W.2    Quack, G.3
  • 66
    • 33745370049 scopus 로고    scopus 로고
    • PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine
    • DOI 10.1016/j.febslet.2006.06.021, PII S0014579306007241
    • Chohan MO, Khatoon S, Iqbal I-G, Iqbal K (2006) Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by memantine. FEBS Lett 580, 3973-3979. (Pubitemid 43946883)
    • (2006) FEBS Letters , vol.580 , Issue.16 , pp. 3973-3979
    • Chohan, M.O.1    Khatoon, S.2    Iqbal, I.-G.3    Iqbal, K.4
  • 67
    • 34548063499 scopus 로고    scopus 로고
    • O3-05-07: Reduction of hyperphosphorylatedtau during memantine treatment of Alzheimer's disease
    • Gunnarsson MD, Kilander L, Sudelöf J, Basun H, Lannfelt L (2006) O3-05-07: Reduction of hyperphosphorylatedtau during memantine treatment of Alzheimer's disease. Alzheimers Dement 2(3 Suppl), S63-S64.
    • (2006) Alzheimers Dement , vol.2 , Issue.3 SUPPL.
    • Gunnarsson, M.D.1    Kilander, L.2    Sudelöf, J.3    Basun, H.4    Lannfelt, L.5
  • 68
    • 77649106680 scopus 로고    scopus 로고
    • Memantine versus donepezil in mild to moderate Alzheimer's disease: A randomized trial with magnetic resonance spectroscopy
    • Modrego PJ, Fayed N, Errea JM, Rios C, Pina MA, Sarasa M (2010) Memantine versus donepezil in mild to moderate Alzheimer's disease: a randomized trial with magnetic resonance spectroscopy. Eur J Neurol 17, 405-412.
    • (2010) Eur J Neurol , vol.17 , pp. 405-412
    • Modrego, P.J.1    Fayed, N.2    Errea, J.M.3    Rios, C.4    Pina, M.A.5    Sarasa, M.6
  • 69
    • 33947308625 scopus 로고    scopus 로고
    • ed. From Experiments to Clinics, Nova, New York
    • Vécsei L (ed.) (2005) Kynurenines in the Brain. From Experiments to Clinics, Nova, New York.
    • (2005) Kynurenines in the Brain
    • Vécsei, L.1
  • 70
    • 40749131240 scopus 로고    scopus 로고
    • L-kynurenine: Metabolism and mechanism of neuroprotection
    • DOI 10.2217/14796708.3.2.169
    • Robotka H, Toldi J, Vécsei L (2008a) L-Kynurenine: metabolism and mechanism of neuroprotection. Future Neurol 3, 169-188. (Pubitemid 351385961)
    • (2008) Future Neurology , vol.3 , Issue.2 , pp. 169-188
    • Robotka, H.1    Toldi, J.2    Vecsei, L.3
  • 71
    • 33750347713 scopus 로고    scopus 로고
    • Kynurenines, Parkinson's disease and other neurodegenerative disorders: Preclinical and clinical studies
    • Németh H, Toldi J, Vécsei L (2006) Kynurenines, PD and other neurodegenerative disorders: preclinical and clinical studies. J Neural Transm 70, 285-304. (Pubitemid 44622214)
    • (2006) Journal of Neural Transmission, Supplement , Issue.70 , pp. 285-304
    • Nemeth, H.1    Toldi, J.2    Vecsei, L.3
  • 72
    • 0026076136 scopus 로고
    • Blood-brain barrier transport of kynurenines: Implications for brain synthesis and metabolism
    • Fukui S, Schwarcz R, Rapoport SI, Takada Y, Smith OR (1991) Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism. J Neurochem 56, 2007-2017.
    • (1991) J Neurochem , vol.56 , pp. 2007-2017
    • Fukui, S.1    Schwarcz, R.2    Rapoport, S.I.3    Takada, Y.4    Smith, O.R.5
  • 73
    • 0017883532 scopus 로고
    • Synthesis and metabolism of L-kynurenine in rat brain
    • Gal EM, Sherman AD (1978) Synthesis and metabolism of L-kynurenine in rat brain. J Neurochem 30, 607-613. (Pubitemid 8291438)
    • (1978) Journal of Neurochemistry , vol.30 , Issue.3 , pp. 607-613
    • Gal, E.M.1    Sherman, A.D.2
  • 74
    • 0022416845 scopus 로고
    • Quinolinic acid and other kynurenines in the central nervous system
    • DOI 10.1016/0306-4522(85)90063-6
    • Stone TW, Connick JH (1985) Quinolinic acid and other kynurenines in the central nervous system. Neuroscience 15, 597-617. (Pubitemid 15236335)
    • (1985) Neuroscience , vol.15 , Issue.3 , pp. 597-617
    • Stone, T.W.1    Connick, J.H.2
  • 75
    • 0024564076 scopus 로고
    • A glycine site associated with N-methyl-D-aspartic acid receptors: Characterization and identification of a new class of antagonists
    • DOI 10.1111/j.1471-4159.1989.tb01881.x
    • Kessler M, Terramani T, Lynch G, Baudry M (1989) A glycine site associated with N-methyl-D-aspartic acid receptors: characterization and identification of a new class of antagonists. J Neurochem 52, 1319-1328. (Pubitemid 19085960)
    • (1989) Journal of Neurochemistry , vol.52 , Issue.4 , pp. 1319-1328
    • Kessler, M.1    Terramani, T.2    Lynch, G.3    Baudry, M.4
  • 76
    • 0021799575 scopus 로고
    • Actions of kynurenic acid and quinolinic acid in the rat hippocampus in vivo
    • DOI 10.1016/0014-4886(85)90072-X
    • Perkins MN, Stone TW (1985) Actions of kynurenic acid and quinolinic acid in the rat hippocampus in vivo. Exp Neurol 88, 570-579. (Pubitemid 15027225)
    • (1985) Experimental Neurology , vol.88 , Issue.3 , pp. 570-579
    • Perkins, M.N.1    Stone, T.W.2
  • 77
    • 33646780229 scopus 로고    scopus 로고
    • Kynurenic acid has a dual action on AMPA receptor responses
    • DOI 10.1016/j.neulet.2006.03.051, PII S0304394006003247
    • Prescott C, Weeks AM, Staley KJ, Partin KM (2006) Kynurenic acid has a dual action on AMPA receptor re-sponses. Neurosci Lett 402, 108-112. (Pubitemid 43766458)
    • (2006) Neuroscience Letters , vol.402 , Issue.1-2 , pp. 108-112
    • Prescott, C.1    Weeks, A.M.2    Staley, K.J.3    Partin, K.M.4
  • 79
    • 0035478066 scopus 로고    scopus 로고
    • The brain metabolite kynurenic acid inhibits α7 nicotinic receptor activity and increases non-α7 nicotinic receptor expression: Physiopathological implications
    • Hilmas C, Pereira EF, Alkondon M, Rassoulpour A, Schwarcz R, Albuquerque EX (2001) The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: phys-iopathological implications. J Neurosci 21, 7463-7473. (Pubitemid 32904945)
    • (2001) Journal of Neuroscience , vol.21 , Issue.19 , pp. 7463-7473
    • Hilmas, C.1    Pereira, E.F.R.2    Alkondon, M.3    Rassoulpour, A.4    Schwarcz, R.5    Albuquerque, E.X.6
  • 81
    • 2442714056 scopus 로고    scopus 로고
    • Targeted deletion of the kynurenine aminotransferase II gene reveals a critical role of endogenous kynurenic acid in the regulation of synaptic transmission via α7 nicotinic receptors in the hippocampus
    • DOI 10.1523/JNEUROSCI.5631-03.2004
    • Alkondon M, Pereira EF, Yu P, Arruda EZ, Almeida LE, Guidetti P, Fawcett WP, Sapko MT, Randall WR, Schwarcz R, Tagle DA, Albuquerque EX (2004) Targeted deletion of the kynurenine aminotransferase ii gene reveals a crit-ical role of endogenous kynurenic acid in the regulation of synaptic transmission via alpha 7 nicotinic receptors in the hippocampus. J Neurosci 24, 4635-4648. (Pubitemid 38656619)
    • (2004) Journal of Neuroscience , vol.24 , Issue.19 , pp. 4635-4648
    • Alkondon, M.1    Pereira, E.F.R.2    Yu, P.3    Arruda, E.Z.4    Almeida, L.E.F.5    Guidetti, P.6    Fawcett, W.P.7    Sapko, M.T.8    Randall, W.R.9    Schwarcz, R.10    Tagle, D.A.11    Albuquerque, E.X.12
  • 82
    • 0025201208 scopus 로고
    • Intracerebroventricular injec-tion of kynurenic acid, but not kynurenine, induces ataxia and stereotyped behaviour in rats
    • Vécsei L, Beal MF (1990) Intracerebroventricular injec-tion of kynurenic acid, but not kynurenine, induces ataxia and stereotyped behaviour in rats. Brain Res Bull 25, 623-627.
    • (1990) Brain Res Bull , vol.25 , pp. 623-627
    • Vécsei, L.1    Beal, M.F.2
  • 83
    • 34248335693 scopus 로고    scopus 로고
    • Elevations of endogenous kynurenic acid produce spatial working memory deficits
    • DOI 10.1093/schbul/sbl033
    • Chess AC, Simoni MK, Alling TE, Bucci DJ (2007) Eleva-tions of endogenous kynurenic acid produce spatial working memory deficits. Schizophr Bull 33, 797-804. (Pubitemid 47343705)
    • (2007) Schizophrenia Bulletin , vol.33 , Issue.3 , pp. 797-804
    • Chess, A.C.1    Simoni, M.K.2    Alling, T.E.3    Bucci, D.J.4
  • 84
    • 77953617514 scopus 로고    scopus 로고
    • Reduction of endogenous kynurenic acid formation enhances extra-cellular glutamate, hippocampal plasticity, and cognitive behaviour
    • Potter MC, Elmer GI, Bergeron R, Albuquerque EX, Guidetti P, Wu HQ, Schwarcz R (2010) Reduction of endogenous kynurenic acid formation enhances extra-cellular glutamate, hippocampal plasticity, and cognitive behaviour. Neuropsychopharmacology 35, 1734-1742.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 1734-1742
    • Potter, M.C.1    Elmer, G.I.2    Bergeron, R.3    Albuquerque, E.X.4    Guidetti, P.5    Wu, H.Q.6    Schwarcz, R.7
  • 85
    • 0019440926 scopus 로고
    • Quinolinic acid: A potent endogenous excitant at amino acid receptors in CNS
    • DOI 10.1016/0014-2999(81)90587-2
    • Stone TW, Perkins MN (1981) Quinolic acid: a potent endogenous excitant at amino acid receptors in CNS. Eur J Pharmacol72, 411-412. (Pubitemid 11081065)
    • (1981) European Journal of Pharmacology , vol.72 , Issue.4 , pp. 411-412
    • Stone, T.W.1    Perkins, M.N.2
  • 86
    • 0342468278 scopus 로고    scopus 로고
    • The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits
    • DOI 10.1016/0197-0186(95)00091-7
    • de Carvalho LP, Bochet P, Rossier J (1996) The endoge-nous agonist quinolinic acid and the non endogenous homo-quinolinic acid discriminate between NMDAR2 receptor subunits. Neurochem Int 28, 445-452. (Pubitemid 26120215)
    • (1996) Neurochemistry International , vol.28 , Issue.4 , pp. 445-452
    • Prado De Carvalho, L.1    Bochet, P.2    Rossier, J.3
  • 88
    • 0025936872 scopus 로고
    • Quinolinic acid is a potent lipid peroxidant in rat brain homogenates
    • Rios C, Santamaria A (1991) Quinolinic acid is a potent lipid peroxidant in rat brain homogenates. Neurochem Res 16, 1139-1143.
    • (1991) Neurochem Res , vol.16 , pp. 1139-1143
    • Rios, C.1    Santamaria, A.2
  • 90
    • 0037337196 scopus 로고    scopus 로고
    • Quinolinic acid upregulates chemokine production and chemokine receptor expression in astrocytes
    • DOI 10.1002/glia.10175
    • Guillemin GJ, Croitoru-Lamoury J, Dormont D, Armati PJ, Brew BJ (2003) Quinolinic acid upregulates chemokine pro-duction and chemokine receptor expression in astrocytes. Glia 41, 371-381. (Pubitemid 36314150)
    • (2003) GLIA , vol.41 , Issue.4 , pp. 371-381
    • Guillemin, G.J.1    Croitoru-Lamoury, J.2    Dormont, D.3    Armati, P.J.4    Brew, B.J.5
  • 91
    • 70349754448 scopus 로고    scopus 로고
    • Mechanism for quinolinic acid cytotoxicity in human astro-cytes and neurons
    • Braidy N, Grant R, Adams S, Brew BJ, Guillemin GJ (2009) Mechanism for quinolinic acid cytotoxicity in human astro-cytes and neurons. Neurotox Res 16, 77-86.
    • (2009) Neurotox Res , vol.16 , pp. 77-86
    • Braidy, N.1    Grant, R.2    Adams, S.3    Brew, B.J.4    Guillemin, G.J.5
  • 92
    • 73249145672 scopus 로고    scopus 로고
    • Effect of quino-linic acid on human astrocytes morphology and functions: Implications in Alzheimer's disease
    • Ting KK, Brew BJ, Guillemin GJ (2009) Effect of quino-linic acid on human astrocytes morphology and functions: implications in Alzheimer's disease. J Neuroinflammation 10, 6-36.
    • (2009) J Neuroinflammation , vol.10 , pp. 6-36
    • Ting, K.K.1    Brew, B.J.2    Guillemin, G.J.3
  • 93
    • 23044462498 scopus 로고    scopus 로고
    • Indoleamine 2,3 dioxygenase and quinolinic acid Immunoreactivity in Alzheimer's disease hippocampus
    • DOI 10.1111/j.1365-2990.2005.00655.x
    • Guillemin GJ, Brew BJ, Noonan CE, Takikawa O, Cullen KM (2005) Indoleamine 2, 3-dioxygenase and quinolinic acid immunoreactivity in Alzheimer' disease hippocampus. Neuropathol Appl Neurobiol 31, 395-404. (Pubitemid 41059860)
    • (2005) Neuropathology and Applied Neurobiology , vol.31 , Issue.4 , pp. 395-404
    • Guillemin, G.J.1    Brew, B.J.2    Noonan, C.E.3    Takikawa, O.4    Cullen, K.M.5
  • 95
    • 2342507918 scopus 로고    scopus 로고
    • A beta 1-42 induces production of quinolinic acid by human macrophages and microglia
    • Guillemin GJ, Smythe GA, Veas LA, Takikawa O, Brew BJ (2003b) A beta 1-42 induces production of quinolinic acid by human macrophages and microglia. Neuroreport 14, 2311-2315.
    • (2003) Neuroreport , vol.14 , pp. 2311-2315
    • Guillemin, G.J.1    Smythe, G.A.2    Veas, L.A.3    Takikawa, O.4    Brew, B.J.5
  • 96
    • 0034843077 scopus 로고    scopus 로고
    • The role of kynurenines in the production of neuronal death, and the neuroprotective effect of purines
    • Stone TW, Behan WM, Jones PA, Darlington LG, Smith RA (2001) The role of kynurenines in the production of neuronal death, and the neuroprotective effect of purines. J Alzheimers Dis 3, 355-366. (Pubitemid 32843052)
    • (2001) Journal of Alzheimer's Disease , vol.3 , Issue.4 , pp. 355-366
    • Stone, T.W.1    Behan, W.M.H.2    Jones, P.A.3    Darlington, L.G.4    Smith, R.A.5
  • 100
    • 0036784518 scopus 로고    scopus 로고
    • Manipulation of brain kynurenines: Glial targets, neuronal effects, and clinical opportunities
    • Schwarcz R, Pellicciari R (2002) Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities. J Pharmacol Exp Ther303, 1-10.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 1-10
    • Schwarcz, R.1    Pellicciari, R.2
  • 101
    • 0027132491 scopus 로고
    • Effects of the excitatory amino acid receptor antagonists kynurenate and indole-2-carboxylic acid on behavioral and neurochemical outcome following experimental brain injury
    • Smith DH, Okiyama K, Thomas MJ, Mcintosh TK (1993) Effects of excitatory amino acid receptor antagonists kynurenate and indole-2-carboxylic acid on behavioural and neurochemical outcome following experimental brain injury. JNeurosci 13, 5383-5392. (Pubitemid 24001020)
    • (1993) Journal of Neuroscience , vol.13 , Issue.12 , pp. 5383-5392
    • Smith, D.H.1    Okiyama, K.2    Thomas, M.J.3    McIntosh, T.K.4
  • 102
    • 0041529913 scopus 로고    scopus 로고
    • Endogenous level of kynurenic acid and activities of kynurenine aminotransferases following transient global ischemia in the gerbil hippocampus
    • Luchowska E, Luchowski P, Sarnowska A, Wielosz M, Turski WA, Urbanska EM (2003) Endogenous level of kynurenic acid and activities of kynurenine aminotrans-ferases following transient global ischaemia in the gerbil hippocampus. Pol J Pharmacol 55, 443-447. (Pubitemid 36975212)
    • (2003) Polish Journal of Pharmacology , vol.55 , Issue.3 , pp. 443-447
    • Luchowska, E.1    Luchowski, P.2    Sarnowska, A.3    Wielosz, M.4    Turski, W.A.5    Urbanska, E.M.6
  • 103
    • 34250625265 scopus 로고    scopus 로고
    • Neuroprotective effect of L-kynurenine sulfate administered before focal cerebral ischemia in mice and global cerebral ischemia in gerbils
    • DOI 10.1016/j.ejphar.2007.02.029, PII S0014299907002403
    • Gigler G, Szénási G, Simó A, Lévay G, Hársing LG Jr, Sas K, Vécsei L, Toldi J (2007) Neuroprotective effect of L-kynurenine sulfate administered before focal cerebral ischaemia in mice and global cerebral ischaemia in gerbils. Eur JPharmacol 564, 116-122. (Pubitemid 46946855)
    • (2007) European Journal of Pharmacology , vol.564 , Issue.1-3 , pp. 116-122
    • Gigler, G.1    Szenasi, G.2    Simo, A.3    Levay, G.4    Harsing Jr., L.G.5    Sas, K.6    Vecsei, L.7    Toldi, J.8
  • 104
    • 0030895630 scopus 로고    scopus 로고
    • Facilitated brain uptake of 4-chlorokynurenine and conversion to 7-chlorokynurenic acid
    • Hokari M, Wu HQ, Schwarcz R, Smith QR (1996) Facili-tated brain uptake of 4-chlorokynurenine and conversion to 7-chlorokynurenic acid. Neuroreport 8, 15-18. (Pubitemid 126785523)
    • (1996) NeuroReport , vol.8 , Issue.1 , pp. 15-18
    • Hokari, M.1    Wu, H.-Q.2    Schwarcz, R.3    Smith, Q.R.4
  • 105
    • 2442465965 scopus 로고    scopus 로고
    • Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration
    • DOI 10.1016/j.febslet.2004.04.047, PII S0014579304004727
    • Li L, Sengupta A, Haque N, Grundke-Iqbal I, Iqbal K (2004) Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neu-rodegeneration. FEBS Lett 566, 261-269. (Pubitemid 38625969)
    • (2004) FEBS Letters , vol.566 , Issue.1-3 , pp. 261-269
    • Li, L.1    Sengupta, A.2    Haque, N.3    Grundke-Iqbal, I.4    Iqbal, K.5
  • 106
    • 0035947210 scopus 로고    scopus 로고
    • Excitotoxic injury stimulates pro-drug-induced 7-chlorokynurenate formation in the rat striatum in vivo
    • DOI 10.1016/S0304-3940(01)01791-8, PII S0304394001017918
    • Lee SC, Schwarcz R (2001) Excitotoxic injury stimulates pro-drug-induced 7-chlorokynurenate formation in the rat striatum in vivo. Neurosci Lett 304, 185-188. (Pubitemid 32436407)
    • (2001) Neuroscience Letters , vol.304 , Issue.3 , pp. 185-188
    • Lee, S.-C.1    Schwarcz, R.2
  • 107
    • 0034598966 scopus 로고    scopus 로고
    • Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus
    • DOI 10.1016/S0014-2999(00)00024-8, PII S0014299900000248
    • Wu HQ, Lee SC, Schwarcz R (2000) Systemic administra-tion of 4-chlorokynurenine prevents quinolinate neurotoxi-city in the rat hippocampus. Eur J Pharmacol 390, 267-274. (Pubitemid 30119941)
    • (2000) European Journal of Pharmacology , vol.390 , Issue.3 , pp. 267-274
    • Wu, H.-Q.1    Lee, S.-C.2    Schwarcz, R.3
  • 108
    • 0019294951 scopus 로고
    • Metabolism of 6-chlorotryptophan to 4-chloro-3-hydroxyanthranilic acid: A potent inhibitor of 3-hydroxyanthranilic acid oxidase
    • DOI 10.1016/0003-9861(80)90164-2
    • Parli CJ, Krieter P, Schmidt B (1980) Metabolism of 6-chlorotryptophan to 4-chloro-3-hydroxyanthranilic acid: a potent inhibitor of 3-hydroxyanthranilic acid oxidase. Arch Biochem Biophys 203, 161-166. (Pubitemid 11147994)
    • (1980) Archives of Biochemistry and Biophysics , vol.203 , Issue.1 , pp. 161-166
    • Parli, C.J.1    Krieter, P.2    Schmidt, B.3
  • 109
    • 79955655710 scopus 로고    scopus 로고
    • Kynurenines in the brain: Pre-clinical and clinical studies, therapeutic considerations
    • Brain and Spinal Cord Trauma, Springer-Verlag, Berlin, Heidelberg
    • Kiss C, Vécsei L (2009) Kynurenines in the brain: pre-clinical and clinical studies, therapeutic considerations. In Handbook ofNeurochemistry and Molecular Neurobiology, Lajtha A, ed. 3rd edn. Brain and Spinal Cord Trauma, Springer-Verlag, Berlin, Heidelberg, pp. 91-105.
    • (2009) Handbook OfNeurochemistry and Molecular Neurobiology, Lajtha A, Ed. 3rd Edn , pp. 91-105
    • Kiss, C.1    Vécsei, L.2
  • 110
    • 0031434549 scopus 로고    scopus 로고
    • Synthesis and biochemical evaluation of N-(4-phenylthiazol-2- yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3- hydroxylase
    • DOI 10.1021/jm970467t
    • Röver S, Cesura AM, Huguenin P, Kettler R, Szente A (1997) Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl) benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. J Med Chem 40, 4378-4385. (Pubitemid 28042317)
    • (1997) Journal of Medicinal Chemistry , vol.40 , Issue.26 , pp. 4378-4385
    • Rover, S.1    Cesura, A.M.2    Huguenin, P.3    Kettler, R.4    Szente, A.5
  • 111
    • 0035025738 scopus 로고    scopus 로고
    • A comparative study on the inhibition of human and bacterial kynureninase by novel bicyclic kynurenine analogues
    • DOI 10.1016/S0968-0896(00)00318-7, PII S0968089600003187
    • Fitzgerald DH, Muirhead KM, Botting NP (2001) A comparative study on the inhibition of human and bacte-rial kynureninase by novel bicyclic kynurenine analogues. Bioorg Med Chem 9, 983-989. (Pubitemid 32448118)
    • (2001) Bioorganic and Medicinal Chemistry , vol.9 , Issue.4 , pp. 983-989
    • Fitzgerald, D.H.1    Muirhead, K.M.2    Botting, N.P.3
  • 112
    • 0037059896 scopus 로고    scopus 로고
    • 2-Amino-4-[3′-hydroxyphenyl]-4-hydroxybutanoic acid; A potent inhibitor of rat and recombinant human kynureninase
    • DOI 10.1016/S0960-894X(01)00758-2, PII S0960894X01007582
    • Walsh HA, Leslie PL, O'Shea KC, Botting NP (2002) 2-Amino-4-[3- hydroxyphenyl]-4-hydroxybutanoic acid; a potent inhibitor ofrat and recombinant human kynureninase. Bioorg Med Chem Lett 12, 361-363. (Pubitemid 34113903)
    • (2002) Bioorganic and Medicinal Chemistry Letters , vol.12 , Issue.3 , pp. 361-363
    • Walsh, H.A.1    Leslie, P.L.2    O'Shea, K.C.3    Botting, N.P.4
  • 113
    • 79955675748 scopus 로고    scopus 로고
    • Endogenous neuroprotection in chronic neurodegenerative disorders: With particular regard to the kynurenines
    • (in press). doi:10.1111/j.1582-4934.2010.01237.x
    • Zádori D, Klivényi P, Plangár I, Toldi J, Vécsei L (2010) Endogenous neuroprotection in chronic neurodegenerative disorders: with particular regard to the kynurenines. J Cell Mol, (inpress). doi:10.1111/j.1582-4934.2010.01237.x
    • (2010) J Cell Mol
    • Zádori, D.1    Klivényi, P.2    Plangár, I.3    Toldi, J.4    Vécsei, L.5


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