Differential Expression of Oxidative Phosphorylation Genes in Patients with Alzheimer's Disease: Implications for Early Mitochondrial Dysfunction and Oxidative Damage

NeuroMolecular Medicine

Volumn 5, Issue 2, 2004, Pages 147-162

  Manczak, Maria ^a   Park, Byung S ^a   Jung, Youngsin ^a   Reddy, P Hemachandra ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

8 OHG; Alzheimer's disease; GAPDH; Mitochondrial abnormalities; Mitochondrial genes; Oxidative damage; Oxidative phosphorylation; Postmortem brains

Indexed keywords

8 HYDROXYGUANINE; ADENOSINE TRIPHOSPHATASE; CYTOCHROME C OXIDASE; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE;

AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; MALE; MITOCHONDRION; NERVE CELL; NEUROPATHOLOGY; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN CHEMISTRY; DNA MUTATIONAL ANALYSIS; DNA, MITOCHONDRIAL; DOWN-REGULATION; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX IV; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; HUMANS; MALE; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; MUTATION; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PROTON-TRANSLOCATING ATPASES; RNA, MESSENGER;

EID: 2342628596     PISSN: 15351084     EISSN: None     Source Type: Journal    
DOI: 10.1385/NMM:5:2:147     Document Type: Article

References (40)

1. Aarskog N. K. and Vedeler C. A. (2000) A new method that detects both the peripheral myelin protein 22 duplication in Charcot-Marie-Tooth type 1A disease and the peripheral myelin protein 22 deletion in hereditary neuropathy with liability to pressure palsies. Hum. Genet. 107, 494-498.
2. Aksenov M. Y., Tucker H. M., Nair P., et al. (1999) The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, NADH dehydrogenase in different brain regions inAlzheimer's disease. Neurochem. Res. 24, 767-774.
3. Aldea C., Alvarez C. P., Folgueira L., Delgado R., and Otero J. R. (2002) Rapid detection of herpes simplex virus DNA in genital ulcers by real-time PCR suing SYBR green I dye as the detection signal. J. Clin. Microbiol. 40, 1060-1062.
4. Beal M. F. (1998) Mitochondrial dysfunction in neurodegenerative diseases. Biochim. Biophys. Acta 1366, 211-213.
5. Blass J. P. (1997) Cerebral metabolic impairments. In: Alzheimer's disease: cause(s), diagnosis, treatment, and care. Khachuaturian Z. S. and Radebaugh T. S. (eds.). CRC Press NY, 1997;187-206.
6. Blass J. P. (2000) The mitochondrial spiral. An adequate cause of dementia in Alzheimer's disease. Ann. New Acad. Sci. 924, 170-183.
7. Blass J. P. (2001) Brain metabolism and brain disease: is metabolic deficiency the proximate cause of Alzheimer dementia? J. Neurosci. Res. 66, 851-856.
8. Bonilla E., Tanji K., Hirano M., Vu T. H., DiMauro S., and Schon E. A. (1999) Mitochondrial involvement inAlzheimer's disease. Biochim. Biophys. Acta 1410, 171-182.
9. Bonilla E., Tanji K., Hirano M., Vu T. H., DiMauuro S., and Schon E. A. (2001) Mitochondrial involvement in Alzheimer's disease. Biochim. Biophys. Acta: Bioenertics 1410, 171-182.
10. Braak H. and Braak E. (1991) Neuropathological staging of Alzheimer-related changes. Acta Neuropathol. 82, 239-259.
11. Bustin S. A. (2000) Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J. Mol. Endocrinol. 25, 169-193.
12. Castellano R., Hirai K., Aliev G., et al. (2002) Role of mitochondrial dysfunction in Alzheimer's disease. J. Neurosci. Res. 70, 357-360.
13. Cavelier L., Erikson I., Tammi M., et al. (2001) Mt DNA mutations in maternally inherited diabetes: presence of the 3397NDI mutation previously associated with Alzheimer's and Parkinson's disease. Hereditas 135, 65-70.
14. Chandrasekaran K., Giordano T., Brady D. R., et al. (1994) Impairment in gene expression ox oxidative metabolism in vulnerable brain regions in Alzheimer's disease. Neurobiol. Aging 14, 343-532.
15. Chandrasekaran K., Hatanpää K., Brady D. R., and Rapoport S. I. (1996) Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimer's disease. Exp. Neurol. 142, 80-88.
16. Chandrasekaran K., Hatanpää K., Rapoport S. I., and Brady D. R. (1997) Decreased expression of nuclear and mitochdnrial DNA-encoded genes of oxidative phosphorylation in association neocortex in Alzheimer disease. Mol. Brain Res. 44, 99-104.
17. De la Monte S. M., Luong T. L., Neely T. R., Robinson D., and Wands J. R. (2000) Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease. Lab. Invest. 80, 1323-1335.
18. Egensperger R., Kosel S., Schnopp N. M., Mehraein P., and Graeber M. B. (1997) Association of the mitochondrial tRNA(A4336G) mutation with Alzheimer's and Parkinson's diseases. Neuropathol. Appl. Neurobiol. 23, 315-321.
19. Fukuyama R., Hatanpaa K., Rapoport S. I., and Chandrasekaran K. (1996) Gene expression of ND4, a subunit of complex I of oxidative phosphorylation in mitochondria, is deceased in temporal cortex of brains of Alzheimer's disease patients. Brain Res. 25, 290-293.
20. Gutala R. V. and Reddy P. H. (2004) The use of real-time PCR analysis in a gene expression study of Alzheimer's disease postmortem brain. J. Neurosci. Methods 131, 101-107.
21. Hatanpaa K., Chandrasekaran K., Brady D. R., and Rapoprt S. I. (1998) No association between Alzheimer's plaques and decreased levels of cytochrome oxidase subunit mRNA, a marker of neuronal energy metabolism. Mol. Brain Res. 59, 13-21.
22. Hirai K., Aliev G., Nunomura A., et al. (2001) Mitochondrial abnormalities in Alzheimer's disease. J. Neurosci. 21, 3017-3023.
23. Hutchin T. P., Heath P. R., Pearson R. C., and Sinclair A. J. (1997) Mitochondrial DNA mutations in Alzheimer's disease. Biochem. Biophys. Res. Commun. 241, 221-225.
24. Lin M. T., Simon D. K., Ahn C. H., Kim L. M., and Beal F. M. (2002) High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain. Hum. Mol. Genet. 11, 133-145.
25. Lin F. H., Lin R., Wisniewski H. M., Hwang Y. W., Grundke-Iqbal I., Healy-Louie G., and Iqbal K. (1992) Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's brains. Biochem. Biophys. Res. Commun. 182, 238-246.
26. Mattson M. P., Pederson W. A., Duan W., Culmsee C., and Camandola S. (1999) Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases. Ann NY Acad. Sci. 893, 154-175.
27. Ojaimi J. and Byrne E. (2001) Mitochondrial function and Alzheimer's disease. Bio Signals Recept. 10, 254-262.
28. Olney R. C., Mougey E. B., Wang J., Shulman D. I., and Sylvester J. E. (2002) Using real-time, quantitative PCR for rapid genotyping of the steroid 21-hydroxylase gene in a north Florida population. J. Clin. Endocrinol. Metab. 87, 735-741.
29. Orth A. and Schpira A. H. V. (2001) Mitochondria and degenerative diseases. Am. J. Med. Genet. 106, 27-36.
30. Schapira A. H. (2002) Primary and secondary defects in the mitochondrial respiratory chain. J. Inherit. Meta-Dis. 25, 207-214.
31. Schapira A. H. V. and Cock H. R. (1999) Mitochondrial myopathies and encepahlomyopathies. Eur. J. Clin. Invest. 29, 886-898.
32. Shoffner J. M. (1997) Oxidative phosphorylation defects and Alzheimer's disease. Neurogenetics 1, 13-19.
33. Schoffner J. M. (2000) Mitochondrial myopathy diagnosis. Neurol. Clin. 18, 105-123.
34. Shoffner J. M., Brown M. D., Torroni A., et al. (1993) Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients. Genomics 17, 171-184.
35. Sieber O. M., Lamlum H., Crabtree M. D., et al. (2002) Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas. Proc. Natl. Acad. Sci. USA 99, 2954-2958.
36. Simonian N. A. and Hyman B. T. (1994) Functional alterations in Alzheimer's disease: selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation. J. Neuropathol. Exp. Neurol. 53, 508-512.
37. Strazielle C., Sturchler-Pierrat C., Staufenbiel M., and Lalonde R. (2003) Regional brain cytochrome oxidase activity in beta-amyloid precursor protein transgenic mice with the Swedish mutation. Neuroscience 118, 1151-1163.
38. User Bulletin no. 2 (1997) ABI Prism 7700 Sequence Detection System.
39. Wallace D. C. (1999) Mitochondrial diseases in man and mouse. Science 283, 1482-1488.
40. Wallace D. C., Lott M. T., and Brown M. D. (1997) Mitochondrial defects in neurodegenerative diseases and aging. In Mitochondria and Free Radicals in Neurodegenerative Diseases. Beal F., Howell N., and Bodis-Wollner I., eds.). Wiley-Liss: NY, pp. 283-308.