메뉴 건너뛰기




Volumn 73, Issue 1, 2016, Pages 201-215

Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-β or hyperphosphorylated tau protein

Author keywords

Amyloid peptide; Bioenergetics; Mitochondria; Neurosteroids; Tau protein

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANDROGEN RECEPTOR; ANDROSTANEDIOL; ESTRADIOL; ESTROGEN RECEPTOR; ESTRONE; NEUROSTEROID; PROGESTERONE; PROGESTERONE RECEPTOR; TAU PROTEIN; TESTOSTERONE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; APP PROTEIN, HUMAN; SEX HORMONE;

EID: 84952982461     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-015-1988-x     Document Type: Article
Times cited : (82)

References (74)
  • 1
    • 84872109456 scopus 로고    scopus 로고
    • The global prevalence of dementia: A systematic review and metaanalysis
    • 10.1016/j.jalz.2012.11.007 e62
    • Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP (2013) The global prevalence of dementia: a systematic review and metaanalysis. Alzheimer's Dement 9(1):63-75. doi: 10.1016/j.jalz.2012.11.007 e62
    • (2013) Alzheimer's Dement , vol.9 , Issue.1 , pp. 63-75
    • Prince, M.1    Bryce, R.2    Albanese, E.3    Wimo, A.4    Ribeiro, W.5    Ferri, C.P.6
  • 2
    • 33750503415 scopus 로고    scopus 로고
    • Drug discovery in dementia: The role of rodent models
    • 10.1038/nrd2075 17080031
    • Van Dam D, De Deyn PP (2006) Drug discovery in dementia: the role of rodent models. Nat Rev Drug Discovery 5(11):956-970. doi: 10.1038/nrd2075
    • (2006) Nat Rev Drug Discovery , vol.5 , Issue.11 , pp. 956-970
    • Van Dam, D.1    De Deyn, P.P.2
  • 3
    • 11144258263 scopus 로고    scopus 로고
    • Mutations causing neurodegenerative tauopathies
    • 10.1016/j.bbadis.2004.08.007 15615642
    • Goedert M, Jakes R (2005) Mutations causing neurodegenerative tauopathies. Biochim Biophys Acta 1739(2-3):240-250. doi: 10.1016/j.bbadis.2004.08.007
    • (2005) Biochim Biophys Acta , vol.1739 , Issue.2-3 , pp. 240-250
    • Goedert, M.1    Jakes, R.2
  • 4
    • 34250819839 scopus 로고    scopus 로고
    • Intracellular amyloid-beta in Alzheimer's disease
    • 10.1038/nrn2168 17551515
    • LaFerla FM, Green KN, Oddo S (2007) Intracellular amyloid-beta in Alzheimer's disease. Nat Rev Neurosci 8(7):499-509. doi: 10.1038/nrn2168
    • (2007) Nat Rev Neurosci , vol.8 , Issue.7 , pp. 499-509
    • LaFerla, F.M.1    Green, K.N.2    Oddo, S.3
  • 5
    • 3943092621 scopus 로고    scopus 로고
    • Pathways towards and away from Alzheimer's disease
    • 10.1038/nature02621 15295589 3091392
    • Mattson MP (2004) Pathways towards and away from Alzheimer's disease. Nature 430(7000):631-639. doi: 10.1038/nature02621
    • (2004) Nature , vol.430 , Issue.7000 , pp. 631-639
    • Mattson, M.P.1
  • 6
    • 84873184976 scopus 로고    scopus 로고
    • In vivo functional brain mapping in a conditional mouse model of human tauopathy (tauP301L) reveals reduced neural activity in memory formation structures
    • 10.1186/1750-1326-8-9 23379588 3579718
    • Perez PD, Hall G, Kimura T, Ren Y, Bailey RM, Lewis J, Febo M, Sahara N (2013) In vivo functional brain mapping in a conditional mouse model of human tauopathy (tauP301L) reveals reduced neural activity in memory formation structures. Mol Neurodegener 8:9. doi: 10.1186/1750-1326-8-9
    • (2013) Mol Neurodegener , vol.8 , pp. 9
    • Perez, P.D.1    Hall, G.2    Kimura, T.3    Ren, Y.4    Bailey, R.M.5    Lewis, J.6    Febo, M.7    Sahara, N.8
  • 7
    • 34249697099 scopus 로고    scopus 로고
    • Forecasting the global burden of Alzheimer's disease
    • 10.1016/j.jalz.2007.04.381
    • Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi HM (2007) Forecasting the global burden of Alzheimer's disease. Alzheimer's Dement 3(3):186-191. doi: 10.1016/j.jalz.2007.04.381
    • (2007) Alzheimer's Dement , vol.3 , Issue.3 , pp. 186-191
    • Brookmeyer, R.1    Johnson, E.2    Ziegler-Graham, K.3    Arrighi, H.M.4
  • 8
    • 81455157378 scopus 로고    scopus 로고
    • Mitochondrial dysfunction - The beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-beta toxicity
    • 10.1186/alzrt74 21545753 3226305
    • Eckert A, Schmitt K, Götz J (2011) Mitochondrial dysfunction - the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-beta toxicity. Alzheimers Res Ther 3(2):15. doi: 10.1186/alzrt74
    • (2011) Alzheimers Res Ther , vol.3 , Issue.2 , pp. 15
    • Eckert, A.1    Schmitt, K.2    Götz, J.3
  • 9
    • 84897954407 scopus 로고    scopus 로고
    • Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers
    • 10.1016/j.bcp.2013.12.024 24398425 3992261
    • Reitz C, Mayeux R (2014) Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers. Biochem Pharmacol 88(4):640-651. doi: 10.1016/j.bcp.2013.12.024
    • (2014) Biochem Pharmacol , vol.88 , Issue.4 , pp. 640-651
    • Reitz, C.1    Mayeux, R.2
  • 10
    • 84860213834 scopus 로고    scopus 로고
    • Insights into mitochondrial dysfunction: Aging, amyloid-beta, and tau-A deleterious trio
    • 10.1089/ars.2011.4400 22117646
    • Schmitt K, Grimm A, Kazmierczak A, Strosznajder JB, Götz J, Eckert A (2012) Insights into mitochondrial dysfunction: aging, amyloid-beta, and tau-A deleterious trio. Antioxid Redox Signal 16(12):1456-1466. doi: 10.1089/ars.2011.4400
    • (2012) Antioxid Redox Signal , vol.16 , Issue.12 , pp. 1456-1466
    • Schmitt, K.1    Grimm, A.2    Kazmierczak, A.3    Strosznajder, J.B.4    Götz, J.5    Eckert, A.6
  • 11
    • 57049143140 scopus 로고    scopus 로고
    • Mitochondria in neuroplasticity and neurological disorders
    • 10.1016/j.neuron.2008.10.010 19081372 2692277
    • Mattson MP, Gleichmann M, Cheng A (2008) Mitochondria in neuroplasticity and neurological disorders. Neuron 60(5):748-766. doi: 10.1016/j.neuron.2008.10.010
    • (2008) Neuron , vol.60 , Issue.5 , pp. 748-766
    • Mattson, M.P.1    Gleichmann, M.2    Cheng, A.3
  • 13
    • 0031737226 scopus 로고    scopus 로고
    • Abnormalities of mitochondrial enzymes in Alzheimer disease
    • 9869323
    • Gibson GE, Sheu KF, Blass JP (1998) Abnormalities of mitochondrial enzymes in Alzheimer disease. J Neural Transm 105(8-9):855-870
    • (1998) J Neural Transm , vol.105 , Issue.8-9 , pp. 855-870
    • Gibson, G.E.1    Sheu, K.F.2    Blass, J.P.3
  • 14
    • 2342628596 scopus 로고    scopus 로고
    • Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: Implications for early mitochondrial dysfunction and oxidative damage
    • 10.1385/NMM:5:2:147 15075441
    • Manczak M, Park BS, Jung Y, Reddy PH (2004) Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: implications for early mitochondrial dysfunction and oxidative damage. Neuromolecular Med 5(2):147-162. doi: 10.1385/NMM:5:2:147
    • (2004) Neuromolecular Med , vol.5 , Issue.2 , pp. 147-162
    • Manczak, M.1    Park, B.S.2    Jung, Y.3    Reddy, P.H.4
  • 15
    • 84903304968 scopus 로고    scopus 로고
    • The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives
    • 10.1016/j.bbadis.2013.09.010 24071439 3962811
    • Swerdlow RH, Burns JM, Khan SM (2014) The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives. Biochim Biophys Acta 1842(8):1219-1231. doi: 10.1016/j.bbadis.2013.09.010
    • (2014) Biochim Biophys Acta , vol.1842 , Issue.8 , pp. 1219-1231
    • Swerdlow, R.H.1    Burns, J.M.2    Khan, S.M.3
  • 16
    • 57649187117 scopus 로고    scopus 로고
    • Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease
    • 10.1196/annals.1427.007 19076441 2661241
    • Mosconi L, Pupi A, De Leon MJ (2008) Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease. Ann N Y Acad Sci 1147:180-195. doi: 10.1196/annals.1427.007
    • (2008) Ann N y Acad Sci , vol.1147 , pp. 180-195
    • Mosconi, L.1    Pupi, A.2    De Leon, M.J.3
  • 17
    • 80052279560 scopus 로고    scopus 로고
    • Allopregnanolone promotes regeneration and reduces beta-amyloid burden in a preclinical model of Alzheimer's disease
    • 10.1371/journal.pone.0024293 21918687 3168882
    • Chen S, Wang JM, Irwin RW, Yao J, Liu L, Brinton RD (2011) Allopregnanolone promotes regeneration and reduces beta-amyloid burden in a preclinical model of Alzheimer's disease. PLoS One 6(8):e24293. doi: 10.1371/journal.pone.0024293
    • (2011) PLoS One , vol.6 , Issue.8 , pp. e24293
    • Chen, S.1    Wang, J.M.2    Irwin, R.W.3    Yao, J.4    Liu, L.5    Brinton, R.D.6
  • 18
    • 84868115047 scopus 로고    scopus 로고
    • Alzheimer's disease, oestrogen and mitochondria: An ambiguous relationship
    • 10.1007/s12035-012-8281-x 22678467 3443477
    • Grimm A, Lim YA, Mensah-Nyagan AG, Götz J, Eckert A (2012) Alzheimer's disease, oestrogen and mitochondria: an ambiguous relationship. Mol Neurobiol 46(1):151-160. doi: 10.1007/s12035-012-8281-x
    • (2012) Mol Neurobiol , vol.46 , Issue.1 , pp. 151-160
    • Grimm, A.1    Lim, Y.A.2    Mensah-Nyagan, A.G.3    Götz, J.4    Eckert, A.5
  • 19
    • 84910044705 scopus 로고    scopus 로고
    • Improvement of neuronal bioenergetics by neurosteroids: Implications for age-related neurodegenerative disorders
    • 10.1016/j.bbadis.2014.09.013 4388199
    • Grimm A, Schmitt K, Lang UE, Mensah-Nyagan AG, Eckert A (2014) Improvement of neuronal bioenergetics by neurosteroids: Implications for age-related neurodegenerative disorders. Biochim Biophys Acta. doi: 10.1016/j.bbadis.2014.09.013
    • (2014) Biochim Biophys Acta
    • Grimm, A.1    Schmitt, K.2    Lang, U.E.3    Mensah-Nyagan, A.G.4    Eckert, A.5
  • 20
    • 0343671487 scopus 로고
    • Characterization and measurement of dehydroepiandrosterone sulfate in rat brain
    • 6458035 320231
    • Corpechot C, Robel P, Axelson M, Sjovall J, Baulieu EE (1981) Characterization and measurement of dehydroepiandrosterone sulfate in rat brain. Proc Natl Acad Sci U S A 78(8):4704-4707
    • (1981) Proc Natl Acad Sci U S A , vol.78 , Issue.8 , pp. 4704-4707
    • Corpechot, C.1    Robel, P.2    Axelson, M.3    Sjovall, J.4    Baulieu, E.E.5
  • 21
    • 0032956181 scopus 로고    scopus 로고
    • Neurosteroids: Expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system
    • 10049998
    • Mensah-Nyagan AG, Do-Rego JL, Beaujean D, Luu-The V, Pelletier G, Vaudry H (1999) Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system. Pharmacol Rev 51(1):63-81
    • (1999) Pharmacol Rev , vol.51 , Issue.1 , pp. 63-81
    • Mensah-Nyagan, A.G.1    Do-Rego, J.L.2    Beaujean, D.3    Luu-The, V.4    Pelletier, G.5    Vaudry, H.6
  • 25
    • 40449088635 scopus 로고    scopus 로고
    • Neuroactive steroids: State of the art and new perspectives
    • 10.1007/s00018-007-7403-5
    • Melcangi RC, Garcia-Segura LM, Mensah-Nyagan AG (2008) Neuroactive steroids: state of the art and new perspectives. Cellular Mol Life Sci 65(5):777-797. doi: 10.1007/s00018-007-7403-5
    • (2008) Cellular Mol Life Sci , vol.65 , Issue.5 , pp. 777-797
    • Melcangi, R.C.1    Garcia-Segura, L.M.2    Mensah-Nyagan, A.G.3
  • 26
    • 68149148549 scopus 로고    scopus 로고
    • Amyloid-beta leads to impaired cellular respiration, energy production and mitochondrial electron chain complex activities in human neuroblastoma cells
    • 10.1007/s10571-009-9398-y 19350381
    • Rhein V, Baysang G, Rao S, Meier F, Bonert A, Muller-Spahn F, Eckert A (2009) Amyloid-beta leads to impaired cellular respiration, energy production and mitochondrial electron chain complex activities in human neuroblastoma cells. Cell Mol Neurobiol 29(6-7):1063-1071. doi: 10.1007/s10571-009-9398-y
    • (2009) Cell Mol Neurobiol , vol.29 , Issue.6-7 , pp. 1063-1071
    • Rhein, V.1    Baysang, G.2    Rao, S.3    Meier, F.4    Bonert, A.5    Muller-Spahn, F.6    Eckert, A.7
  • 28
    • 84878443230 scopus 로고    scopus 로고
    • Estradiol and testosterone regulate arginine-vasopressin expression in SH-SY5Y human female neuroblastoma cells through estrogen receptors-alpha and -beta
    • 10.1210/en.2012-2137 23584859
    • Grassi D, Bellini MJ, Acaz-Fonseca E, Panzica G, Garcia-Segura LM (2013) Estradiol and testosterone regulate arginine-vasopressin expression in SH-SY5Y human female neuroblastoma cells through estrogen receptors-alpha and -beta. Endocrinology 154(6):2092-2100. doi: 10.1210/en.2012-2137
    • (2013) Endocrinology , vol.154 , Issue.6 , pp. 2092-2100
    • Grassi, D.1    Bellini, M.J.2    Acaz-Fonseca, E.3    Panzica, G.4    Garcia-Segura, L.M.5
  • 30
    • 0035823495 scopus 로고    scopus 로고
    • Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease
    • 10.1074/jbc.M105410200 11438549
    • Scheuermann S, Hambsch B, Hesse L, Stumm J, Schmidt C, Beher D, Bayer TA, Beyreuther K, Multhaup G (2001) Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease. J Biol Chem 276(36):33923-33929. doi: 10.1074/jbc.M105410200
    • (2001) J Biol Chem , vol.276 , Issue.36 , pp. 33923-33929
    • Scheuermann, S.1    Hambsch, B.2    Hesse, L.3    Stumm, J.4    Schmidt, C.5    Beher, D.6    Bayer, T.A.7    Beyreuther, K.8    Multhaup, G.9
  • 31
    • 77957885219 scopus 로고    scopus 로고
    • Ginkgo biloba extract ameliorates oxidative phosphorylation performance and rescues abeta-induced failure
    • 10.1371/journal.pone.0012359 20808761 2927422
    • Rhein V, Giese M, Baysang G, Meier F, Rao S, Schulz KL, Hamburger M, Eckert A (2010) Ginkgo biloba extract ameliorates oxidative phosphorylation performance and rescues abeta-induced failure. PLoS One 5(8):e12359. doi: 10.1371/journal.pone.0012359
    • (2010) PLoS One , vol.5 , Issue.8 , pp. e12359
    • Rhein, V.1    Giese, M.2    Baysang, G.3    Meier, F.4    Rao, S.5    Schulz, K.L.6    Hamburger, M.7    Eckert, A.8
  • 32
    • 0141960033 scopus 로고    scopus 로고
    • Beta-Amyloid induces paired helical filament-like tau filaments in tissue culture
    • 10.1074/jbc.M308243200 12893817
    • Ferrari A, Hoerndli F, Baechi T, Nitsch RM, Götz J (2003) beta-Amyloid induces paired helical filament-like tau filaments in tissue culture. J Biol Chem 278(41):40162-40168. doi: 10.1074/jbc.M308243200
    • (2003) J Biol Chem , vol.278 , Issue.41 , pp. 40162-40168
    • Ferrari, A.1    Hoerndli, F.2    Baechi, T.3    Nitsch, R.M.4    Götz, J.5
  • 34
    • 80054761710 scopus 로고    scopus 로고
    • Modes of Abeta toxicity in Alzheimer's disease
    • 10.1007/s00018-011-0750-2
    • Götz J, Eckert A, Matamales M, Ittner LM, Liu X (2011) Modes of Abeta toxicity in Alzheimer's disease. Cellular Mol Life Sci 68(20):3359-3375. doi: 10.1007/s00018-011-0750-2
    • (2011) Cellular Mol Life Sci , vol.68 , Issue.20 , pp. 3359-3375
    • Götz, J.1    Eckert, A.2    Matamales, M.3    Ittner, L.M.4    Liu, X.5
  • 37
    • 79955454688 scopus 로고    scopus 로고
    • Amyloid-Beta interaction with mitochondria
    • 10.4061/2011/925050 21461357 3065051
    • Pagani L, Eckert A (2011) Amyloid-Beta interaction with mitochondria. Int J Alzheimers Dis 2011:925050. doi: 10.4061/2011/925050
    • (2011) Int J Alzheimers Dis , vol.2011 , pp. 925050
    • Pagani, L.1    Eckert, A.2
  • 38
    • 80053892506 scopus 로고    scopus 로고
    • Brain aging, Alzheimer's disease, and mitochondria
    • 10.1016/j.bbadis.2011.08.012 21920438 3210037
    • Swerdlow RH (2011) Brain aging, Alzheimer's disease, and mitochondria. Biochim Biophys Acta 1812(12):1630-1639. doi: 10.1016/j.bbadis.2011.08.012
    • (2011) Biochim Biophys Acta , vol.1812 , Issue.12 , pp. 1630-1639
    • Swerdlow, R.H.1
  • 40
    • 84884954360 scopus 로고    scopus 로고
    • Actions of 17beta-estradiol and testosterone in the mitochondria and their implications in aging
    • 10.1016/j.arr.2013.09.001 24041489
    • Vasconsuelo A, Milanesi L, Boland R (2013) Actions of 17beta-estradiol and testosterone in the mitochondria and their implications in aging. Ageing Res Rev 12(4):907-917. doi: 10.1016/j.arr.2013.09.001
    • (2013) Ageing Res Rev , vol.12 , Issue.4 , pp. 907-917
    • Vasconsuelo, A.1    Milanesi, L.2    Boland, R.3
  • 41
    • 44249087833 scopus 로고    scopus 로고
    • Progesterone and estrogen regulate oxidative metabolism in brain mitochondria
    • 10.1210/en.2007-1227 18292191 2408802
    • Irwin RW, Yao J, Hamilton RT, Cadenas E, Brinton RD, Nilsen J (2008) Progesterone and estrogen regulate oxidative metabolism in brain mitochondria. Endocrinology 149(6):3167-3175. doi: 10.1210/en.2007-1227
    • (2008) Endocrinology , vol.149 , Issue.6 , pp. 3167-3175
    • Irwin, R.W.1    Yao, J.2    Hamilton, R.T.3    Cadenas, E.4    Brinton, R.D.5    Nilsen, J.6
  • 42
    • 84872841524 scopus 로고    scopus 로고
    • Gender, sex steroid hormones, and Alzheimer's disease
    • 10.1016/j.yhbeh.2012.04.006 22554955 3413783
    • Vest RS, Pike CJ (2013) Gender, sex steroid hormones, and Alzheimer's disease. Horm Behav 63(2):301-307. doi: 10.1016/j.yhbeh.2012.04.006
    • (2013) Horm Behav , vol.63 , Issue.2 , pp. 301-307
    • Vest, R.S.1    Pike, C.J.2
  • 43
    • 77954092125 scopus 로고    scopus 로고
    • Women live longer than men: Understanding molecular mechanisms offers opportunities to intervene by using estrogenic compounds
    • 10.1089/ars.2009.2952 20059401
    • Vina J, Borras C (2010) Women live longer than men: understanding molecular mechanisms offers opportunities to intervene by using estrogenic compounds. Antioxid Redox Signal 13(3):269-278. doi: 10.1089/ars.2009.2952
    • (2010) Antioxid Redox Signal , vol.13 , Issue.3 , pp. 269-278
    • Vina, J.1    Borras, C.2
  • 44
    • 20344371487 scopus 로고    scopus 로고
    • Sex differences in the clinical manifestations of Alzheimer disease pathology
    • 10.1001/archpsyc.62.6.685 15939846
    • Barnes LL, Wilson RS, Bienias JL, Schneider JA, Evans DA, Bennett DA (2005) Sex differences in the clinical manifestations of Alzheimer disease pathology. Arch Gen Psychiatry 62(6):685-691. doi: 10.1001/archpsyc.62.6.685
    • (2005) Arch Gen Psychiatry , vol.62 , Issue.6 , pp. 685-691
    • Barnes, L.L.1    Wilson, R.S.2    Bienias, J.L.3    Schneider, J.A.4    Evans, D.A.5    Bennett, D.A.6
  • 45
    • 3242682466 scopus 로고    scopus 로고
    • The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: Modification by age, sex, and APOE polymorphism
    • 10.1196/annals.1297.005 15246987
    • Corder EH, Ghebremedhin E, Taylor MG, Thal DR, Ohm TG, Braak H (2004) The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: modification by age, sex, and APOE polymorphism. Ann N Y Acad Sci 1019:24-28. doi: 10.1196/annals.1297.005
    • (2004) Ann N y Acad Sci , vol.1019 , pp. 24-28
    • Corder, E.H.1    Ghebremedhin, E.2    Taylor, M.G.3    Thal, D.R.4    Ohm, T.G.5    Braak, H.6
  • 46
    • 4544354817 scopus 로고    scopus 로고
    • Impact of gender on upregulation of antioxidant defence mechanisms in Alzheimer's disease brain
    • 10.1007/s00702-004-0156-5 15338332
    • Schuessel K, Leutner S, Cairns NJ, Muller WE, Eckert A (2004) Impact of gender on upregulation of antioxidant defence mechanisms in Alzheimer's disease brain. J Neural Transm 111(9):1167-1182. doi: 10.1007/s00702-004-0156-5
    • (2004) J Neural Transm , vol.111 , Issue.9 , pp. 1167-1182
    • Schuessel, K.1    Leutner, S.2    Cairns, N.J.3    Muller, W.E.4    Eckert, A.5
  • 47
    • 0035102386 scopus 로고    scopus 로고
    • Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice
    • 11238065 1850367
    • Callahan MJ, Lipinski WJ, Bian F, Durham RA, Pack A, Walker LC (2001) Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice. Am J Pathol 158(3):1173-1177
    • (2001) Am J Pathol , vol.158 , Issue.3 , pp. 1173-1177
    • Callahan, M.J.1    Lipinski, W.J.2    Bian, F.3    Durham, R.A.4    Pack, A.5    Walker, L.C.6
  • 48
    • 0346848902 scopus 로고    scopus 로고
    • Gender differences in the amount and deposition of amyloidbeta in APPswe and PS1 double transgenic mice
    • 14678749
    • Wang J, Tanila H, Puolivali J, Kadish I, van Groen T (2003) Gender differences in the amount and deposition of amyloidbeta in APPswe and PS1 double transgenic mice. Neurobiol Dis 14(3):318-327
    • (2003) Neurobiol Dis , vol.14 , Issue.3 , pp. 318-327
    • Wang, J.1    Tanila, H.2    Puolivali, J.3    Kadish, I.4    Van Groen, T.5
  • 49
    • 79251611368 scopus 로고    scopus 로고
    • Sex differences in beta-amyloid accumulation in 3xTg-AD mice: Role of neonatal sex steroid hormone exposure
    • 10.1016/j.brainres.2010.10.009 20934413 2993873
    • Carroll JC, Rosario ER, Kreimer S, Villamagna A, Gentzschein E, Stanczyk FZ, Pike CJ (2010) Sex differences in beta-amyloid accumulation in 3xTg-AD mice: role of neonatal sex steroid hormone exposure. Brain Res 1366:233-245. doi: 10.1016/j.brainres.2010.10.009
    • (2010) Brain Res , vol.1366 , pp. 233-245
    • Carroll, J.C.1    Rosario, E.R.2    Kreimer, S.3    Villamagna, A.4    Gentzschein, E.5    Stanczyk, F.Z.6    Pike, C.J.7
  • 50
    • 84861895505 scopus 로고    scopus 로고
    • Ovarian hormone loss induces bioenergetic deficits and mitochondrial beta-amyloid
    • 10.1016/j.neurobiolaging.2011.03.001 21514693 3181273
    • Yao J, Irwin R, Chen S, Hamilton R, Cadenas E, Brinton RD (2012) Ovarian hormone loss induces bioenergetic deficits and mitochondrial beta-amyloid. Neurobiol Aging 33(8):1507-1521. doi: 10.1016/j.neurobiolaging.2011.03.001
    • (2012) Neurobiol Aging , vol.33 , Issue.8 , pp. 1507-1521
    • Yao, J.1    Irwin, R.2    Chen, S.3    Hamilton, R.4    Cadenas, E.5    Brinton, R.D.6
  • 51
    • 70149093436 scopus 로고    scopus 로고
    • Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
    • 10.1073/pnas.0903563106 19667196 2732886
    • Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, Brinton RD (2009) Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 106(34):14670-14675. doi: 10.1073/pnas.0903563106
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.34 , pp. 14670-14675
    • Yao, J.1    Irwin, R.W.2    Zhao, L.3    Nilsen, J.4    Hamilton, R.T.5    Brinton, R.D.6
  • 52
    • 36849045250 scopus 로고    scopus 로고
    • Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice
    • 10.1523/JNEUROSCI.2718-07.2007 18045930
    • Carroll JC, Rosario ER, Chang L, Stanczyk FZ, Oddo S, LaFerla FM, Pike CJ (2007) Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice. J Neurosci 27(48):13357-13365. doi: 10.1523/JNEUROSCI.2718-07.2007
    • (2007) J Neurosci , vol.27 , Issue.48 , pp. 13357-13365
    • Carroll, J.C.1    Rosario, E.R.2    Chang, L.3    Stanczyk, F.Z.4    Oddo, S.5    LaFerla, F.M.6    Pike, C.J.7
  • 53
    • 0036170745 scopus 로고    scopus 로고
    • Age trends in the level of serum testosterone and other hormones in middle-aged men: Longitudinal results from the Massachusetts male aging study
    • 10.1210/jcem.87.2.8201 11836290
    • Feldman HA, Longcope C, Derby CA, Johannes CB, Araujo AB, Coviello AD, Bremner WJ, McKinlay JB (2002) Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. J Clin Endocrinol Metab 87(2):589-598. doi: 10.1210/jcem.87.2.8201
    • (2002) J Clin Endocrinol Metab , vol.87 , Issue.2 , pp. 589-598
    • Feldman, H.A.1    Longcope, C.2    Derby, C.A.3    Johannes, C.B.4    Araujo, A.B.5    Coviello, A.D.6    Bremner, W.J.7    McKinlay, J.B.8
  • 54
    • 67449141652 scopus 로고    scopus 로고
    • Protective actions of sex steroid hormones in Alzheimer's disease
    • 10.1016/j.yfrne.2009.04.015 19427328 2728624
    • Pike CJ, Carroll JC, Rosario ER, Barron AM (2009) Protective actions of sex steroid hormones in Alzheimer's disease. Front Neuroendocrinol 30(2):239-258. doi: 10.1016/j.yfrne.2009.04.015
    • (2009) Front Neuroendocrinol , vol.30 , Issue.2 , pp. 239-258
    • Pike, C.J.1    Carroll, J.C.2    Rosario, E.R.3    Barron, A.M.4
  • 55
    • 79953116520 scopus 로고    scopus 로고
    • Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease
    • 10.1016/j.neurobiolaging.2009.04.008 19428144 2930132
    • Rosario ER, Chang L, Head EH, Stanczyk FZ, Pike CJ (2011) Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease. Neurobiol Aging 32(4):604-613. doi: 10.1016/j.neurobiolaging.2009.04.008
    • (2011) Neurobiol Aging , vol.32 , Issue.4 , pp. 604-613
    • Rosario, E.R.1    Chang, L.2    Head, E.H.3    Stanczyk, F.Z.4    Pike, C.J.5
  • 56
    • 77957982982 scopus 로고    scopus 로고
    • Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways
    • 10.1016/j.brainres.2010.08.068 20807511 2965035
    • Rosario ER, Carroll J, Pike CJ (2010) Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways. Brain Res 1359:281-290. doi: 10.1016/j.brainres.2010.08.068
    • (2010) Brain Res , vol.1359 , pp. 281-290
    • Rosario, E.R.1    Carroll, J.2    Pike, C.J.3
  • 57
    • 33845789124 scopus 로고    scopus 로고
    • Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease
    • 10.1523/JNEUROSCI.2514-06.2006 17182789
    • Rosario ER, Carroll JC, Oddo S, LaFerla FM, Pike CJ (2006) Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease. J Neurosci 26(51):13384-13389. doi: 10.1523/JNEUROSCI.2514-06.2006
    • (2006) J Neurosci , vol.26 , Issue.51 , pp. 13384-13389
    • Rosario, E.R.1    Carroll, J.C.2    Oddo, S.3    LaFerla, F.M.4    Pike, C.J.5
  • 58
    • 0030990102 scopus 로고    scopus 로고
    • The heat shock-induced hyperphosphorylation of tau is estrogen-independent and prevented by androgens: Implications for Alzheimer disease
    • 9192613 21206
    • Papasozomenos SC (1997) The heat shock-induced hyperphosphorylation of tau is estrogen-independent and prevented by androgens: implications for Alzheimer disease. Proc Natl Acad Sci USA 94(13):6612-6617
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.13 , pp. 6612-6617
    • Papasozomenos, S.C.1
  • 59
    • 42249085980 scopus 로고    scopus 로고
    • Refining frontotemporal dementia with parkinsonism linked to chromosome 17: Introducing FTDP-17 (MAPT) and FTDP-17 (PGRN)
    • 10.1001/archneur.65.4.460 18413467 2746630
    • Boeve BF, Hutton M (2008) Refining frontotemporal dementia with parkinsonism linked to chromosome 17: introducing FTDP-17 (MAPT) and FTDP-17 (PGRN). Arch Neurol 65(4):460-464. doi: 10.1001/archneur.65.4.460
    • (2008) Arch Neurol , vol.65 , Issue.4 , pp. 460-464
    • Boeve, B.F.1    Hutton, M.2
  • 60
    • 84906314231 scopus 로고    scopus 로고
    • Parkinsonian syndrome in familial frontotemporal dementia
    • 10.1016/j.parkreldis.2014.06.004 24998994 4160731
    • Siuda J, Fujioka S, Wszolek ZK (2014) Parkinsonian syndrome in familial frontotemporal dementia. Parkinsonism Relat Disord 20(9):957-964. doi: 10.1016/j.parkreldis.2014.06.004
    • (2014) Parkinsonism Relat Disord , vol.20 , Issue.9 , pp. 957-964
    • Siuda, J.1    Fujioka, S.2    Wszolek, Z.K.3
  • 61
    • 80355148410 scopus 로고    scopus 로고
    • Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice
    • 10.1096/fj.11-186650 21825035 3205832
    • Dumont M, Stack C, Elipenahli C, Jainuddin S, Gerges M, Starkova NN, Yang L, Starkov AA, Beal F (2011) Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice. FASEB J 25(11):4063-4072. doi: 10.1096/fj.11-186650
    • (2011) FASEB J , vol.25 , Issue.11 , pp. 4063-4072
    • Dumont, M.1    Stack, C.2    Elipenahli, C.3    Jainuddin, S.4    Gerges, M.5    Starkova, N.N.6    Yang, L.7    Starkov, A.A.8    Beal, F.9
  • 62
    • 48349124965 scopus 로고    scopus 로고
    • Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A
    • 10.1007/s11064-008-9638-4 18338250
    • Liu XA, Zhu LQ, Zhang Q, Shi HR, Wang SH, Wang Q, Wang JZ (2008) Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A. Neurochem Res 33(9):1811-1820. doi: 10.1007/s11064-008-9638-4
    • (2008) Neurochem Res , vol.33 , Issue.9 , pp. 1811-1820
    • Liu, X.A.1    Zhu, L.Q.2    Zhang, Q.3    Shi, H.R.4    Wang, S.H.5    Wang, Q.6    Wang, J.Z.7
  • 64
    • 77954623481 scopus 로고    scopus 로고
    • Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease
    • 10.1016/j.neuroscience.2010.05.031 20493928
    • Amtul Z, Wang L, Westaway D, Rozmahel RF (2010) Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease. Neuroscience 169(2):781-786. doi: 10.1016/j.neuroscience.2010.05.031
    • (2010) Neuroscience , vol.169 , Issue.2 , pp. 781-786
    • Amtul, Z.1    Wang, L.2    Westaway, D.3    Rozmahel, R.F.4
  • 65
    • 34250220693 scopus 로고    scopus 로고
    • Estrogen has anti-amyloidogenic effects on Alzheimer's beta-amyloid fibrils in vitro
    • 10.1016/j.bbrc.2007.05.158 17559807
    • Morinaga A, Hirohata M, Ono K, Yamada M (2007) Estrogen has anti-amyloidogenic effects on Alzheimer's beta-amyloid fibrils in vitro. Biochem Biophys Res Commun 359(3):697-702. doi: 10.1016/j.bbrc.2007.05.158
    • (2007) Biochem Biophys Res Commun , vol.359 , Issue.3 , pp. 697-702
    • Morinaga, A.1    Hirohata, M.2    Ono, K.3    Yamada, M.4
  • 67
    • 30044438885 scopus 로고    scopus 로고
    • Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model
    • 10.1073/pnas.0505203102 16365303 1323154
    • Yue X, Lu M, Lancaster T, Cao P, Honda S, Staufenbiel M, Harada N, Zhong Z, Shen Y, Li R (2005) Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model. Proc Natl Acad Sci U S A 102(52):19198-19203. doi: 10.1073/pnas.0505203102
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.52 , pp. 19198-19203
    • Yue, X.1    Lu, M.2    Lancaster, T.3    Cao, P.4    Honda, S.5    Staufenbiel, M.6    Harada, N.7    Zhong, Z.8    Shen, Y.9    Li, R.10
  • 68
    • 84867776138 scopus 로고    scopus 로고
    • 17beta-estradiol and progesterone regulate expression of beta-amyloid clearance factors in primary neuron cultures and female rat brain
    • 10.1210/en.2012-1464 22962256 3473201
    • Jayaraman A, Carroll JC, Morgan TE, Lin S, Zhao L, Arimoto JM, Murphy MP, Beckett TL, Finch CE, Brinton RD, Pike CJ (2012) 17beta-estradiol and progesterone regulate expression of beta-amyloid clearance factors in primary neuron cultures and female rat brain. Endocrinology 153(11):5467-5479. doi: 10.1210/en.2012-1464
    • (2012) Endocrinology , vol.153 , Issue.11 , pp. 5467-5479
    • Jayaraman, A.1    Carroll, J.C.2    Morgan, T.E.3    Lin, S.4    Zhao, L.5    Arimoto, J.M.6    Murphy, M.P.7    Beckett, T.L.8    Finch, C.E.9    Brinton, R.D.10    Pike, C.J.11
  • 69
    • 84873054927 scopus 로고    scopus 로고
    • Sex steroid levels and AD-like pathology in 3xTgAD mice
    • 10.1111/j.1365-2826.2012.02374.x 22889357 4065422
    • Overk CR, Perez SE, Ma C, Taves MD, Soma KK, Mufson EJ (2013) Sex steroid levels and AD-like pathology in 3xTgAD mice. J Neuroendocrinol 25(2):131-144. doi: 10.1111/j.1365-2826.2012.02374.x
    • (2013) J Neuroendocrinol , vol.25 , Issue.2 , pp. 131-144
    • Overk, C.R.1    Perez, S.E.2    Ma, C.3    Taves, M.D.4    Soma, K.K.5    Mufson, E.J.6
  • 71
    • 84877753769 scopus 로고    scopus 로고
    • Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease
    • 10.1523/JNEUROSCI.1350-13.2013 23678130 3733563
    • Barron AM, Garcia-Segura LM, Caruso D, Jayaraman A, Lee JW, Melcangi RC, Pike CJ (2013) Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease. J Neurosci 33(20):8891-8897. doi: 10.1523/JNEUROSCI.1350-13.2013
    • (2013) J Neurosci , vol.33 , Issue.20 , pp. 8891-8897
    • Barron, A.M.1    Garcia-Segura, L.M.2    Caruso, D.3    Jayaraman, A.4    Lee, J.W.5    Melcangi, R.C.6    Pike, C.J.7
  • 72
    • 0029584349 scopus 로고
    • Estradiol and testosterone in specific regions of the human female brain in different endocrine states
    • 8541226
    • Bixo M, Backstrom T, Winblad B, Andersson A (1995) Estradiol and testosterone in specific regions of the human female brain in different endocrine states. J Steroid Biochem Mol Biol 55(3-4):297-303
    • (1995) J Steroid Biochem Mol Biol , vol.55 , Issue.3-4 , pp. 297-303
    • Bixo, M.1    Backstrom, T.2    Winblad, B.3    Andersson, A.4
  • 74
    • 84901483236 scopus 로고    scopus 로고
    • Oophorectomy, estrogen, and dementia: A 2014 update
    • 10.1016/j.mce.2014.01.020 24508665 4040304
    • Rocca WA, Grossardt BR, Shuster LT (2014) Oophorectomy, estrogen, and dementia: a 2014 update. Mol Cell Endocrinol 389(1-2):7-12. doi: 10.1016/j.mce.2014.01.020
    • (2014) Mol Cell Endocrinol , vol.389 , Issue.1-2 , pp. 7-12
    • Rocca, W.A.1    Grossardt, B.R.2    Shuster, L.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.