Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction

Journal of Neuroscience

Volumn 26, Issue 35, 2006, Pages 9057-9068

  Devi, Latha ^a   Prabhu, Badanavalu M ^a   Galati, Domenico F ^a   Avadhani, Narayan G ^a   Anandatheerthavarada, Hindupur K ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Amyloid ; Mitochondria; Protein import; Translocational arrest

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; CYTOCHROME C OXIDASE;

ALZHEIMER DISEASE; AMYGDALOID NUCLEUS; ARTICLE; BRAIN MITOCHONDRION; BRAIN REGION; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOPAMINERGIC NERVE CELL; ENZYME ACTIVITY; FEMALE; FRONTAL CORTEX; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MEMBRANE CHANNEL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NEUROPATHOLOGY; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; BIOLOGICAL TRANSPORT; BRAIN; CADAVER; CASE-CONTROL STUDIES; ELECTRON TRANSPORT COMPLEX IV; GLYCOSYLATION; HUMANS; HYDROGEN PEROXIDE; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL MEMBRANES; MITOCHONDRIAL PROTEINS; NEURONS; TISSUE DISTRIBUTION;

EID: 33748283747     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1469-06.2006     Document Type: Article

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