The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits

Neurochemistry International

Volumn 28, Issue 4, 1996, Pages 445-452

  Prado De Carvalho, Lia ^a   Bochet, Pascal ^a   Rossier, Jean ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; QUINOLINIC ACID; QUINOLINIC ACID DERIVATIVE; RECEPTOR SUBTYPE; RECEPTOR SUBUNIT;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SPECIFICITY; DRUG STRUCTURE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RECEPTOR AFFINITY; XENOPUS;

EID: 0342468278     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/0197-0186(95)00091-7     Document Type: Article

References (39)

1. Audinat E., Lambolez B., Rossier J. and Crépel F. (1994) Activity-dependant regulation of N-methyl-D-aspartate receptor subunits in cerebellar granule cells. Eur. J. Neurosci. 69, 1792-1800.
2. Beal M. F., Kowall N. W., Ellison D. W., Maurek M. F., Swartz K. J. and Martin J. B. (1986) Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid. Nature 321, 168-171.
3. +-induced depolarization and NMDA treatment. Neuron 12, 87-95.
4. Buller A., Larson H., Schneider B. E., Beaton J. A., Morrisett R. A. and Monaghan D. (1994) The molecular basis of NMDA receptor diversity is predicted by subunit composition. J. Neurosci. 14, 5471-5484.
5. Flanagan E. M., Erickson J. B., Humberto Viveros O., Chang S. Y. and Reinhard Jr J. F. (1995) Neurotoxin quinolinic acid is selectively elevated in spinal cords of rats with experimental allergic encephalomyelitis. J. Neurochem. 64, 1192-1196.
6. Garthwaite G. and Garthewaite J. (1987) Quinolinate mimics neurotoxic actions of N-methyl-D-aspartate in rat cerebellar slices. Neurosci. Lett. 79, 35-39.
7. Heyes M. P. and Lackner A. (1990) Increased cerebrospinal fluid quinolinic acid, kynurenic acid, and L-kynurenine in acute septicemia. J. Neurochem. 55, 338-341.
8. Heyes M. P., Rubinow D., Lane C. and Markey S. (1989) Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome. Ann. Neurol. 26, 275-277.
9. Heyes M. P., Swartz K. J., Markey S. P. and Beal M. F. (1991a) Regional brain cerebrospinal fluid quinolinic acid concentrations in Huntington's disease. Neurosci. Lett. 122, 265-269.
10. Heyes M. P., Brew B. J., Martin A., Price R. W., Salazar A. M., Sidtis J. J., Yergey J. A., Mouradian M. M., Sadler A. E., Keilp J., Rubinow D. and Markey S. (1991b) Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical status. Ann. Neurol. 29, 202-209.
11. Ishii T., Moriyoshi K., Sugihara H., Sakurada K., Kadotani H., Yokoi M., Akazawa C., Shigemoto R., Mizuno N., Masu M. and Nakanishi S. (1993) Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J. biol. Chem. 268, 2836-2843.
12. Kushner L., Lerma J., Zukin S. and Bennett M. (1988) Coexpression of N-methyl-D-aspartate and phencyclidine receptors in Xenopus oocytes injected with rat brain mRNA. Proc. natn. Acad. Sci. U.S.A. 85, 3250-3254.
13. Kutsuwada T., Kashiwabuchi N., Mori H., Sakimura K., Kushiya E., Araki K., Meguro H., Masaki H., Kumanishi T., Arakawa M. and Mishina M. (1992) Molecular diversity of the NMDA receptor channel. Nature 358, 36-41.
14. Lambolez B., Curutchet P., Stinnakre J., Bregestovski P., Rossier J. and Prado de Carvalho L. (1991) Electrophysiological and pharmacological properties of GluR1, a subunit of a glutamate receptor channel expressed in Xenopus oocytes. Neurosc. Lett. 123, 69-72.
15. Leonard J. P. and Kelso S. R. (1990) Apparent desensitization of NMDA responses in Xenopus oocytes involves calcium-dependent chloride current. Neuron 2, 53-60.
16. Lipton S. (1992) Models of neuronal injury in AIDS: another role for the NMDA receptor? Trends Neurosci. 15, 75-79.
17. Macaya A., Munell F., Gubits R. and Burke R. E. (1994) Apoptosis in substancia nigra following developmental striatal excitotoxic injury. Proc. natn. Acad. Sci. U.S.A. 91, 8117-8121.
18. Meguro H., Mori H., Araki K., Kushiya E., Kutsuwada T., Yamasaki M., Kumanishi T., Arakawa M., Sakimura K. and Mishina M. (1992) Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature 357, 70-74.
19. Monyer H., Burnashev N, Laurie D., Sakman B. and Seeburg P. (1994) Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12, 1-20.
20. Moriyoshi K., Masu M., Ishii T., Shigemoto R., Mizuno N. and Nakanishi S. (1991) Molecular cloning and characterization of the rat NMDA receptor. Nature 354, 31-37.
21. 3H]D-2-Amino-5-phosphonopentanoic acid binding in rat brain membranes. Neuroscience 26, 17-31.
22. Patneau D. and Mayer M. (1990) Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors. J. Neurosci. 10, 2285-2399.
23. Perkins M. N. and Stone T. W. (1983) Pharmacology and regional variations of quinolinic acid-evoked excitations in the rat central nervous system. J. Pharmac. exp. Ther. 226, 551-557.
24. Saito K., Nowak Jr T. S., Markey S. P. and Heyes M. P. (1993) Mechanism of delayed increases in kynurenine metabolism in damaged brain regions following transient cerebral ischemia. J. Neurochem. 60, 180-192.
25. Schwarcz R., Whetsell Jr W. O. and Mangano R. M. (1983) Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain. Science 219, 316-318.
26. Seeburg P. (1993) The molecular biology of mammalian glutamate receptor channels. Trends Neurosci. 16, 355-364.
27. Stone T. W. (1984) Excitant activity of methyl derivatives of quinolinic acid on rat cortical neurones. Br. J. Pharmac. 81, 175-181.
28. Stone T. W. (1993) Neuropharmacology of quinolinic and kynurenic acids. Pharmac. Rev. 45, 309-379.
29. Stone T. W. and Perkins M. N. (1981) Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS. Eur. J. Pharmac. 72, 411-412.
30. Sugihara H., Moriyoshi K., Ishii T., Masu M. and Nakanishi S. (1992) Structure and properties of seven isoforms of the NMDA receptor generated by alternative splicing. Biochem. biophys. Res. Commun. 185, 826-831.
31. Tsuzuki K., Iino M. and Osawa S. (1989) Ion channels activated by quinolinic acid in cultured rat hippocampal neurons. Brain Res. 481, 258-264.
32. Verdoorn T., Kleckner N. and Dingledine R. (1987) Rat brain N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Science 238, 1114-1116.
33. Watanabe M., Mishina M. and Inoue Y. (1994) Distinct spatiotemporal expressions of five NMDA receptor channel subunit mRNAs in the cerebellum. J. comp. Neurol. 343, 513-519.
34. Whetsell Jr W. O. and Schwarcz R. (1989) Prolonged exposure to submicromolar concentrations of quinolinic acid causes excitotoxic damage in organotypic cultures of rat corticostriatal system. Neurosci. Lett. 97, 271-275.
35. Williams K. (1994) Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Molec. Pharmac. 44, 851-859.
36. Williams K., Russel S., Shen Y. M. and Molinoff P. (1993) Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro. Neuron 10, 267-278.
37. Yamakura T., Mori H., Masaki H., Shimoji K. and Mishina M. (1993) Different sensitivities of NMDA channel subtypes to non-competitive antagonists. NeuroReport 4, 687-690.
38. Yamasaki M., Mori H., Araki K., Mori K. J. and Mishina M. (1992) Cloning, expression and modulation of a mouse NMDA receptor subunit. FEBS Lett. 300, 39-45.
39. Zhong J., Russel S. L., Pritchett D. B., Molinoff P. B. and Williams K. (1994) Expression of mRNAs encoding subunits of the N-methyl-D-aspartate receptor in cultured cortical neurons. Molec. Pharmac. 45, 846-853.