Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1

Journal of Neuroscience

Volumn 27, Issue 26, 2007, Pages 7011-7020

  Lazarov, Orly ^a   Morfini, Gerardo A ^a   Pigino, Gustavo ^a   Gadadhar, Archana ^a   Chen, Xiangjun ^b   Robinson, John ^b   Ho, Hanson ^b   Brady, Scott T ^a   Sisodia, Sangram S ^b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Alzheimer's disease; Axonal transport; GSK 3; Kinase; Kinesin; Motor neurons; Neurofilament; Presenilin; Protein trafficking; Tau

Indexed keywords

CYTOSKELETON PROTEIN; NEUROTROPHIN; PRESENILIN 1;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HUMAN; MAMMAL CELL; MOTOR NEURON DISEASE; MOUSE; MUTANT; NERVE DEGENERATION; NERVE FIBER TRANSPORT; NEUROFILAMENT; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; SCIATIC NERVE; SPINAL CORD; STATISTICAL SIGNIFICANCE; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; ANIMALS; AXONAL TRANSPORT; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR NEURON DISEASE; MOTOR NEURONS; MUTATION; NERVE DEGENERATION; PERIPHERAL NERVOUS SYSTEM DISEASES; PRESENILIN-1; SCIATIC NEUROPATHY; SPINAL CORD DISEASES;

EID: 34347353311     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4272-06.2007     Document Type: Article

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