Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease

Journal of Neurochemistry

Volumn 120, Issue 3, 2012, Pages 419-429

  Sheng, Baiyang ^a   Wang, Xinglong ^a,b   Su, Bo ^a   Lee, Hyoung Gon ^a,b   Casadesus, Gemma ^a   Perry, George ^c   Zhu, Xiongwei ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c University of San Antonio   (United States)

Author keywords

Alzheimer's disease; mitochondrial biogenesis; mitochondrial transcription factor A; nuclear respiratory factors; proliferator activated receptor gamma coactivator 1

Indexed keywords

ADENOSINE TRIPHOSPHATE; CELL NUCLEUS DNA; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR NRF2;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BIOGENESIS; BRAIN MITOCHONDRION; CLINICAL ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; BIOGENESIS; CELL LINE, TUMOR; CREB-BINDING PROTEIN; DNA, MITOCHONDRIAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT COMPLEX IV; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION; HEAT-SHOCK PROTEINS; HIPPOCAMPUS; HUMANS; MALE; MIDDLE AGED; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NEUROBLASTOMA; NUCLEAR RESPIRATORY FACTORS; RNA INTERFERENCE; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 84855687153     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07581.x     Document Type: Article

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