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Volumn 166, Issue 4, 2016, Pages 802-821

Metabolic Control of Longevity

Author keywords

[No Author keywords available]

Indexed keywords

METFORMIN;

EID: 84981312038     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.07.031     Document Type: Review
Times cited : (575)

References (196)
  • 1
    • 84925581335 scopus 로고    scopus 로고
    • Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity
    • Arruda, A.P., Pers, B.M., Parlakgül, G., Güney, E., Inouye, K., Hotamisligil, G.S., Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity. Nat. Med. 20 (2014), 1427–1435.
    • (2014) Nat. Med. , vol.20 , pp. 1427-1435
    • Arruda, A.P.1    Pers, B.M.2    Parlakgül, G.3    Güney, E.4    Inouye, K.5    Hotamisligil, G.S.6
  • 2
    • 84925844053 scopus 로고    scopus 로고
    • Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock
    • Asher, G., Sassone-Corsi, P., Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock. Cell 161 (2015), 84–92.
    • (2015) Cell , vol.161 , pp. 84-92
    • Asher, G.1    Sassone-Corsi, P.2
  • 7
    • 84942294112 scopus 로고    scopus 로고
    • Epigenetic regulation of ageing: linking environmental inputs to genomic stability
    • Benayoun, B.A., Pollina, E.A., Brunet, A., Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nat. Rev. Mol. Cell Biol. 16 (2015), 593–610.
    • (2015) Nat. Rev. Mol. Cell Biol. , vol.16 , pp. 593-610
    • Benayoun, B.A.1    Pollina, E.A.2    Brunet, A.3
  • 10
    • 84925873107 scopus 로고    scopus 로고
    • Immune regulation of metabolic homeostasis in health and disease
    • Brestoff, J.R., Artis, D., Immune regulation of metabolic homeostasis in health and disease. Cell 161 (2015), 146–160.
    • (2015) Cell , vol.161 , pp. 146-160
    • Brestoff, J.R.1    Artis, D.2
  • 11
    • 84929497730 scopus 로고    scopus 로고
    • GWAS and meta-analysis in aging/longevity
    • Broer, L., van Duijn, C.M., GWAS and meta-analysis in aging/longevity. Adv. Exp. Med. Biol. 847 (2015), 107–125.
    • (2015) Adv. Exp. Med. Biol. , vol.847 , pp. 107-125
    • Broer, L.1    van Duijn, C.M.2
  • 12
    • 77955610464 scopus 로고    scopus 로고
    • Could exercise metabolomics pave the way for gymnomimetics?
    • Burke, M.F., Dunbar, R.L., Rader, D.J., Could exercise metabolomics pave the way for gymnomimetics?. Sci. Transl. Med., 2, 2010, 41ps35.
    • (2010) Sci. Transl. Med. , vol.2 , pp. 41ps35
    • Burke, M.F.1    Dunbar, R.L.2    Rader, D.J.3
  • 15
    • 84941879755 scopus 로고    scopus 로고
    • Short-chain fatty acids in control of body weight and insulin sensitivity
    • Canfora, E.E., Jocken, J.W., Blaak, E.E., Short-chain fatty acids in control of body weight and insulin sensitivity. Nat. Rev. Endocrinol. 11 (2015), 577–591.
    • (2015) Nat. Rev. Endocrinol. , vol.11 , pp. 577-591
    • Canfora, E.E.1    Jocken, J.W.2    Blaak, E.E.3
  • 17
    • 84860614281 scopus 로고    scopus 로고
    • Short-term calorie restriction enhances skeletal muscle stem cell function
    • Cerletti, M., Jang, Y.C., Finley, L.W., Haigis, M.C., Wagers, A.J., Short-term calorie restriction enhances skeletal muscle stem cell function. Cell Stem Cell 10 (2012), 515–519.
    • (2012) Cell Stem Cell , vol.10 , pp. 515-519
    • Cerletti, M.1    Jang, Y.C.2    Finley, L.W.3    Haigis, M.C.4    Wagers, A.J.5
  • 19
    • 38349087249 scopus 로고    scopus 로고
    • Mitochondrial function and apoptotic susceptibility in aging skeletal muscle
    • Chabi, B., Ljubicic, V., Menzies, K.J., Huang, J.H., Saleem, A., Hood, D.A., Mitochondrial function and apoptotic susceptibility in aging skeletal muscle. Aging Cell 7 (2008), 2–12.
    • (2008) Aging Cell , vol.7 , pp. 2-12
    • Chabi, B.1    Ljubicic, V.2    Menzies, K.J.3    Huang, J.H.4    Saleem, A.5    Hood, D.A.6
  • 20
    • 84919649838 scopus 로고    scopus 로고
    • Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges
    • Chaix, A., Zarrinpar, A., Miu, P., Panda, S., Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. Cell Metab. 20 (2014), 991–1005.
    • (2014) Cell Metab. , vol.20 , pp. 991-1005
    • Chaix, A.1    Zarrinpar, A.2    Miu, P.3    Panda, S.4
  • 21
    • 84879391795 scopus 로고    scopus 로고
    • SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging
    • Chang, H.C., Guarente, L., SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell 153 (2013), 1448–1460.
    • (2013) Cell , vol.153 , pp. 1448-1460
    • Chang, H.C.1    Guarente, L.2
  • 22
    • 84924301510 scopus 로고    scopus 로고
    • Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
    • Chassaing, B., Koren, O., Goodrich, J.K., Poole, A.C., Srinivasan, S., Ley, R.E., Gewirtz, A.T., Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature 519 (2015), 92–96.
    • (2015) Nature , vol.519 , pp. 92-96
    • Chassaing, B.1    Koren, O.2    Goodrich, J.K.3    Poole, A.C.4    Srinivasan, S.5    Ley, R.E.6    Gewirtz, A.T.7
  • 23
    • 84962128814 scopus 로고    scopus 로고
    • Type 2 diabetes as a risk factor for dementia in women compared with men: a pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia
    • Chatterjee, S., Peters, S.A., Woodward, M., Mejia Arango, S., Batty, G.D., Beckett, N., Beiser, A., Borenstein, A.R., Crane, P.K., Haan, M., et al. Type 2 diabetes as a risk factor for dementia in women compared with men: a pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia. Diabetes Care 39 (2016), 300–307.
    • (2016) Diabetes Care , vol.39 , pp. 300-307
    • Chatterjee, S.1    Peters, S.A.2    Woodward, M.3    Mejia Arango, S.4    Batty, G.D.5    Beckett, N.6    Beiser, A.7    Borenstein, A.R.8    Crane, P.K.9    Haan, M.10
  • 24
    • 75549090275 scopus 로고    scopus 로고
    • mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
    • Chen, C., Liu, Y., Liu, Y., Zheng, P., mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci. Signal., 2, 2009, ra75.
    • (2009) Sci. Signal. , vol.2 , pp. ra75
    • Chen, C.1    Liu, Y.2    Liu, Y.3    Zheng, P.4
  • 29
    • 77957661352 scopus 로고    scopus 로고
    • Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice
    • D'Antona, G., Ragni, M., Cardile, A., Tedesco, L., Dossena, M., Bruttini, F., Caliaro, F., Corsetti, G., Bottinelli, R., Carruba, M.O., et al. Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice. Cell Metab. 12 (2010), 362–372.
    • (2010) Cell Metab. , vol.12 , pp. 362-372
    • D'Antona, G.1    Ragni, M.2    Cardile, A.3    Tedesco, L.4    Dossena, M.5    Bruttini, F.6    Caliaro, F.7    Corsetti, G.8    Bottinelli, R.9    Carruba, M.O.10
  • 31
    • 84955563080 scopus 로고    scopus 로고
    • Programmed hyperphagia in offspring of obese dams: Altered expression of hypothalamic nutrient sensors, neurogenic factors and epigenetic modulators
    • Desai, M., Han, G., Ross, M.G., Programmed hyperphagia in offspring of obese dams: Altered expression of hypothalamic nutrient sensors, neurogenic factors and epigenetic modulators. Appetite 99 (2016), 193–199.
    • (2016) Appetite , vol.99 , pp. 193-199
    • Desai, M.1    Han, G.2    Ross, M.G.3
  • 32
    • 84931573456 scopus 로고    scopus 로고
    • Management of obesity: improvement of health-care training and systems for prevention and care
    • Dietz, W.H., Baur, L.A., Hall, K., Puhl, R.M., Taveras, E.M., Uauy, R., Kopelman, P., Management of obesity: improvement of health-care training and systems for prevention and care. Lancet 385 (2015), 2521–2533.
    • (2015) Lancet , vol.385 , pp. 2521-2533
    • Dietz, W.H.1    Baur, L.A.2    Hall, K.3    Puhl, R.M.4    Taveras, E.M.5    Uauy, R.6    Kopelman, P.7
  • 36
    • 84922789990 scopus 로고    scopus 로고
    • Nutrient-sensing mechanisms and pathways
    • Efeyan, A., Comb, W.C., Sabatini, D.M., Nutrient-sensing mechanisms and pathways. Nature 517 (2015), 302–310.
    • (2015) Nature , vol.517 , pp. 302-310
    • Efeyan, A.1    Comb, W.C.2    Sabatini, D.M.3
  • 41
    • 84949550661 scopus 로고    scopus 로고
    • The metabolic regulation of aging
    • Finkel, T., The metabolic regulation of aging. Nat. Med. 21 (2015), 1416–1423.
    • (2015) Nat. Med. , vol.21 , pp. 1416-1423
    • Finkel, T.1
  • 43
    • 84925852614 scopus 로고    scopus 로고
    • Promoting health and longevity through diet: from model organisms to humans
    • Fontana, L., Partridge, L., Promoting health and longevity through diet: from model organisms to humans. Cell 161 (2015), 106–118.
    • (2015) Cell , vol.161 , pp. 106-118
    • Fontana, L.1    Partridge, L.2
  • 44
    • 84955178200 scopus 로고    scopus 로고
    • Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: a randomized clinical trial
    • Fontana, L., Villareal, D.T., Das, S.K., Smith, S.R., Meydani, S.N., Pittas, A.G., Klein, S., Bhapkar, M., Rochon, J., Ravussin, E., Holloszy, J.O., CALERIE Study Group. Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: a randomized clinical trial. Aging Cell 15 (2016), 22–27.
    • (2016) Aging Cell , vol.15 , pp. 22-27
    • Fontana, L.1    Villareal, D.T.2    Das, S.K.3    Smith, S.R.4    Meydani, S.N.5    Pittas, A.G.6    Klein, S.7    Bhapkar, M.8    Rochon, J.9    Ravussin, E.10    Holloszy, J.O.11
  • 46
    • 84962160948 scopus 로고    scopus 로고
    • Obesity impairs skeletal muscle regeneration through inhibition of AMPK
    • Fu, X., Zhu, M., Zhang, S., Foretz, M., Viollet, B., Du, M., Obesity impairs skeletal muscle regeneration through inhibition of AMPK. Diabetes 65 (2016), 188–200.
    • (2016) Diabetes , vol.65 , pp. 188-200
    • Fu, X.1    Zhu, M.2    Zhang, S.3    Foretz, M.4    Viollet, B.5    Du, M.6
  • 47
    • 84954391956 scopus 로고    scopus 로고
    • The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?
    • Fuku, N., Pareja-Galeano, H., Zempo, H., Alis, R., Arai, Y., Lucia, A., Hirose, N., The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?. Aging Cell 14 (2015), 921–923.
    • (2015) Aging Cell , vol.14 , pp. 921-923
    • Fuku, N.1    Pareja-Galeano, H.2    Zempo, H.3    Alis, R.4    Arai, Y.5    Lucia, A.6    Hirose, N.7
  • 52
    • 84950327004 scopus 로고    scopus 로고
    • Eliciting the mitochondrial unfolded protein response via NAD repletion reverses fatty liver disease
    • Published online December 16, 2015
    • Gariani, K., Menzies, K.J., Ryu, D., Wegner, C.J., Wang, X., Ropelle, E.R., Moullan, N., Zhang, H., Perino, A., Lemos, V., et al. Eliciting the mitochondrial unfolded protein response via NAD repletion reverses fatty liver disease. Hepatology 63 (2016), 1190–1204, 10.1002/hep.28245 Published online December 16, 2015.
    • (2016) Hepatology , vol.63 , pp. 1190-1204
    • Gariani, K.1    Menzies, K.J.2    Ryu, D.3    Wegner, C.J.4    Wang, X.5    Ropelle, E.R.6    Moullan, N.7    Zhang, H.8    Perino, A.9    Lemos, V.10
  • 54
    • 84948747653 scopus 로고    scopus 로고
    • Vaccenic acid and trans fatty acid isomers from partially hydrogenated oil both adversely affect LDL cholesterol: a double-blind, randomized controlled trial
    • Gebauer, S.K., Destaillats, F., Dionisi, F., Krauss, R.M., Baer, D.J., Vaccenic acid and trans fatty acid isomers from partially hydrogenated oil both adversely affect LDL cholesterol: a double-blind, randomized controlled trial. Am. J. Clin. Nutr. 102 (2015), 1339–1346.
    • (2015) Am. J. Clin. Nutr. , vol.102 , pp. 1339-1346
    • Gebauer, S.K.1    Destaillats, F.2    Dionisi, F.3    Krauss, R.M.4    Baer, D.J.5
  • 55
    • 84927748959 scopus 로고    scopus 로고
    • Drivers of age-related inflammation and strategies for healthspan extension
    • Goldberg, E.L., Dixit, V.D., Drivers of age-related inflammation and strategies for healthspan extension. Immunol. Rev. 265 (2015), 63–74.
    • (2015) Immunol. Rev. , vol.265 , pp. 63-74
    • Goldberg, E.L.1    Dixit, V.D.2
  • 58
    • 84949036093 scopus 로고    scopus 로고
    • Stem cells and healthy aging
    • Goodell, M.A., Rando, T.A., Stem cells and healthy aging. Science 350 (2015), 1199–1204.
    • (2015) Science , vol.350 , pp. 1199-1204
    • Goodell, M.A.1    Rando, T.A.2
  • 69
    • 84947492879 scopus 로고    scopus 로고
    • Roux-en-Y gastric bypass acutely decreases protein carbonylation and increases expression of mitochondrial biogenesis genes in subcutaneous adipose tissue
    • Jahansouz, C., Serrot, F.J., Frohnert, B.I., Foncea, R.E., Dorman, R.B., Slusarek, B., Leslie, D.B., Bernlohr, D.A., Ikramuddin, S., Roux-en-Y gastric bypass acutely decreases protein carbonylation and increases expression of mitochondrial biogenesis genes in subcutaneous adipose tissue. Obes. Surg. 25 (2015), 2376–2385.
    • (2015) Obes. Surg. , vol.25 , pp. 2376-2385
    • Jahansouz, C.1    Serrot, F.J.2    Frohnert, B.I.3    Foncea, R.E.4    Dorman, R.B.5    Slusarek, B.6    Leslie, D.B.7    Bernlohr, D.A.8    Ikramuddin, S.9
  • 70
    • 84951088776 scopus 로고    scopus 로고
    • Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: Possible role of oxidative stress, neuroinflammation, and neurotransmitters
    • Jamwal, S., Kumar, P., Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: Possible role of oxidative stress, neuroinflammation, and neurotransmitters. Physiol. Behav. 155 (2016), 180–187.
    • (2016) Physiol. Behav. , vol.155 , pp. 180-187
    • Jamwal, S.1    Kumar, P.2
  • 72
    • 84872527628 scopus 로고    scopus 로고
    • mTOR is a key modulator of ageing and age-related disease
    • Johnson, S.C., Rabinovitch, P.S., Kaeberlein, M., mTOR is a key modulator of ageing and age-related disease. Nature 493 (2013), 338–345.
    • (2013) Nature , vol.493 , pp. 338-345
    • Johnson, S.C.1    Rabinovitch, P.S.2    Kaeberlein, M.3
  • 74
    • 84949035121 scopus 로고    scopus 로고
    • Healthy aging: The ultimate preventative medicine
    • Kaeberlein, M., Rabinovitch, P.S., Martin, G.M., Healthy aging: The ultimate preventative medicine. Science 350 (2015), 1191–1193.
    • (2015) Science , vol.350 , pp. 1191-1193
    • Kaeberlein, M.1    Rabinovitch, P.S.2    Martin, G.M.3
  • 78
    • 84955335015 scopus 로고    scopus 로고
    • Peripheral circadian clocks mediate dietary restriction-dependent changes in lifespan and fat metabolism in Drosophila
    • Katewa, S.D., Akagi, K., Bose, N., Rakshit, K., Camarella, T., Zheng, X., Hall, D., Davis, S., Nelson, C.S., Brem, R.B., et al. Peripheral circadian clocks mediate dietary restriction-dependent changes in lifespan and fat metabolism in Drosophila. Cell Metab. 23 (2016), 143–154.
    • (2016) Cell Metab. , vol.23 , pp. 143-154
    • Katewa, S.D.1    Akagi, K.2    Bose, N.3    Rakshit, K.4    Camarella, T.5    Zheng, X.6    Hall, D.7    Davis, S.8    Nelson, C.S.9    Brem, R.B.10
  • 80
    • 84901346313 scopus 로고    scopus 로고
    • Autophagy—a key player in cellular and body metabolism
    • Kim, K.H., Lee, M.S., Autophagy—a key player in cellular and body metabolism. Nat. Rev. Endocrinol. 10 (2014), 322–337.
    • (2014) Nat. Rev. Endocrinol. , vol.10 , pp. 322-337
    • Kim, K.H.1    Lee, M.S.2
  • 81
    • 77955789211 scopus 로고    scopus 로고
    • Altered lipid content inhibits autophagic vesicular fusion
    • Koga, H., Kaushik, S., Cuervo, A.M., Altered lipid content inhibits autophagic vesicular fusion. FASEB J. 24 (2010), 3052–3065.
    • (2010) FASEB J. , vol.24 , pp. 3052-3065
    • Koga, H.1    Kaushik, S.2    Cuervo, A.M.3
  • 83
    • 79961083402 scopus 로고    scopus 로고
    • Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice
    • Krishnan, V., Chow, M.Z., Wang, Z., Zhang, L., Liu, B., Liu, X., Zhou, Z., Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice. Proc. Natl. Acad. Sci. USA 108 (2011), 12325–12330.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 12325-12330
    • Krishnan, V.1    Chow, M.Z.2    Wang, Z.3    Zhang, L.4    Liu, B.5    Liu, X.6    Zhou, Z.7
  • 85
    • 84930746830 scopus 로고    scopus 로고
    • The biology of proteostasis in aging and disease
    • Labbadia, J., Morimoto, R.I., The biology of proteostasis in aging and disease. Annu. Rev. Biochem. 84 (2015), 435–464.
    • (2015) Annu. Rev. Biochem. , vol.84 , pp. 435-464
    • Labbadia, J.1    Morimoto, R.I.2
  • 87
    • 84869488061 scopus 로고    scopus 로고
    • Lessons from C. elegans: signaling pathways for longevity
    • Lapierre, L.R., Hansen, M., Lessons from C. elegans: signaling pathways for longevity. Trends Endocrinol. Metab. 23 (2012), 637–644.
    • (2012) Trends Endocrinol. Metab. , vol.23 , pp. 637-644
    • Lapierre, L.R.1    Hansen, M.2
  • 90
    • 84889681863 scopus 로고    scopus 로고
    • Sestrins orchestrate cellular metabolism to attenuate aging
    • Lee, J.H., Budanov, A.V., Karin, M., Sestrins orchestrate cellular metabolism to attenuate aging. Cell Metab. 18 (2013), 792–801.
    • (2013) Cell Metab. , vol.18 , pp. 792-801
    • Lee, J.H.1    Budanov, A.V.2    Karin, M.3
  • 93
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine, B., Kroemer, G., Autophagy in the pathogenesis of disease. Cell 132 (2008), 27–42.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 96
    • 84867051812 scopus 로고    scopus 로고
    • IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes
    • Li, J., Tang, Y., Cai, D., IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes. Nat. Cell Biol. 14 (2012), 999–1012.
    • (2012) Nat. Cell Biol. , vol.14 , pp. 999-1012
    • Li, J.1    Tang, Y.2    Cai, D.3
  • 97
    • 84896692038 scopus 로고    scopus 로고
    • Rapamycin: one drug, many effects
    • Li, J., Kim, S.G., Blenis, J., Rapamycin: one drug, many effects. Cell Metab. 19 (2014), 373–379.
    • (2014) Cell Metab. , vol.19 , pp. 373-379
    • Li, J.1    Kim, S.G.2    Blenis, J.3
  • 98
    • 84923331724 scopus 로고    scopus 로고
    • Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes
    • Lim, Y.M., Lim, H., Hur, K.Y., Quan, W., Lee, H.Y., Cheon, H., Ryu, D., Koo, S.H., Kim, H.L., Kim, J., et al. Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes. Nat. Commun., 5, 2014, 4934.
    • (2014) Nat. Commun. , vol.5 , pp. 4934
    • Lim, Y.M.1    Lim, H.2    Hur, K.Y.3    Quan, W.4    Lee, H.Y.5    Cheon, H.6    Ryu, D.7    Koo, S.H.8    Kim, H.L.9    Kim, J.10
  • 99
    • 85006512188 scopus 로고    scopus 로고
    • Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer's disease
    • Lin, A.L., Jahrling, J.B., Zhang, W., DeRosa, N., Bakshi, V., Romero, P., Galvan, V., Richardson, A., Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer's disease. J. Cereb. Blood Flow Metab., 2015, 10.1177/0271678X15621575.
    • (2015) J. Cereb. Blood Flow Metab.
    • Lin, A.L.1    Jahrling, J.B.2    Zhang, W.3    DeRosa, N.4    Bakshi, V.5    Romero, P.6    Galvan, V.7    Richardson, A.8
  • 100
    • 84870506099 scopus 로고    scopus 로고
    • Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria
    • Liu, B., Ghosh, S., Yang, X., Zheng, H., Liu, X., Wang, Z., Jin, G., Zheng, B., Kennedy, B.K., Suh, Y., et al. Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria. Cell Metab. 16 (2012), 738–750.
    • (2012) Cell Metab. , vol.16 , pp. 738-750
    • Liu, B.1    Ghosh, S.2    Yang, X.3    Zheng, H.4    Liu, X.5    Wang, Z.6    Jin, G.7    Zheng, B.8    Kennedy, B.K.9    Suh, Y.10
  • 101
    • 84927641793 scopus 로고    scopus 로고
    • Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization
    • Liu, K., Zhao, E., Ilyas, G., Lalazar, G., Lin, Y., Haseeb, M., Tanaka, K.E., Czaja, M.J., Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization. Autophagy 11 (2015), 271–284.
    • (2015) Autophagy , vol.11 , pp. 271-284
    • Liu, K.1    Zhao, E.2    Ilyas, G.3    Lalazar, G.4    Lin, Y.5    Haseeb, M.6    Tanaka, K.E.7    Czaja, M.J.8
  • 102
    • 84893802111 scopus 로고    scopus 로고
    • Fasting: molecular mechanisms and clinical applications
    • Longo, V.D., Mattson, M.P., Fasting: molecular mechanisms and clinical applications. Cell Metab. 19 (2014), 181–192.
    • (2014) Cell Metab. , vol.19 , pp. 181-192
    • Longo, V.D.1    Mattson, M.P.2
  • 106
    • 84946478936 scopus 로고    scopus 로고
    • Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming
    • Ma, T., Li, J., Xu, Y., Yu, C., Xu, T., Wang, H., Liu, K., Cao, N., Nie, B.M., Zhu, S.Y., et al. Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming. Nat. Cell Biol. 17 (2015), 1379–1387.
    • (2015) Nat. Cell Biol. , vol.17 , pp. 1379-1387
    • Ma, T.1    Li, J.2    Xu, Y.3    Yu, C.4    Xu, T.5    Wang, H.6    Liu, K.7    Cao, N.8    Nie, B.M.9    Zhu, S.Y.10
  • 109
    • 84942576978 scopus 로고    scopus 로고
    • Fructose and cardiometabolic health: what the evidence from sugar-sweetened beverages tells us
    • Malik, V.S., Hu, F.B., Fructose and cardiometabolic health: what the evidence from sugar-sweetened beverages tells us. J. Am. Coll. Cardiol. 66 (2015), 1615–1624.
    • (2015) J. Am. Coll. Cardiol. , vol.66 , pp. 1615-1624
    • Malik, V.S.1    Hu, F.B.2
  • 120
    • 84925265469 scopus 로고    scopus 로고
    • Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging
    • Mohrin, M., Shin, J., Liu, Y., Brown, K., Luo, H., Xi, Y., Haynes, C.M., Chen, D., Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging. Science 347 (2015), 1374–1377.
    • (2015) Science , vol.347 , pp. 1374-1377
    • Mohrin, M.1    Shin, J.2    Liu, Y.3    Brown, K.4    Luo, H.5    Xi, Y.6    Haynes, C.M.7    Chen, D.8
  • 123
    • 84924310257 scopus 로고    scopus 로고
    • Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock
    • Muoio, D.M., Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock. Cell 159 (2014), 1253–1262.
    • (2014) Cell , vol.159 , pp. 1253-1262
    • Muoio, D.M.1
  • 126
    • 84942044933 scopus 로고    scopus 로고
    • Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan
    • Obata, F., Miura, M., Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan. Nat. Commun., 6, 2015, 8332.
    • (2015) Nat. Commun. , vol.6 , pp. 8332
    • Obata, F.1    Miura, M.2
  • 127
    • 84872166765 scopus 로고    scopus 로고
    • Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis
    • Odegaard, J.I., Chawla, A., Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science 339 (2013), 172–177.
    • (2013) Science , vol.339 , pp. 172-177
    • Odegaard, J.I.1    Chawla, A.2
  • 131
    • 84930632378 scopus 로고    scopus 로고
    • Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans
    • Palikaras, K., Lionaki, E., Tavernarakis, N., Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans. Nature 521 (2015), 525–528.
    • (2015) Nature , vol.521 , pp. 525-528
    • Palikaras, K.1    Lionaki, E.2    Tavernarakis, N.3
  • 136
    • 84952885402 scopus 로고    scopus 로고
    • Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease
    • Platt, T.L., Beckett, T.L., Kohler, K., Niedowicz, D.M., Murphy, M.P., Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease. Neuroscience 315 (2016), 162–174.
    • (2016) Neuroscience , vol.315 , pp. 162-174
    • Platt, T.L.1    Beckett, T.L.2    Kohler, K.3    Niedowicz, D.M.4    Murphy, M.P.5
  • 140
  • 144
    • 84883461858 scopus 로고    scopus 로고
    • Regulation of longevity and oxidative stress by nutritional interventions: role of methionine restriction
    • Sanchez-Roman, I., Barja, G., Regulation of longevity and oxidative stress by nutritional interventions: role of methionine restriction. Exp. Gerontol. 48 (2013), 1030–1042.
    • (2013) Exp. Gerontol. , vol.48 , pp. 1030-1042
    • Sanchez-Roman, I.1    Barja, G.2
  • 146
    • 79551650355 scopus 로고    scopus 로고
    • Nuclear damage in peripheral lymphocytes of obese and overweight Italian children as evaluated by the gamma-H2AX focus assay and micronucleus test
    • Scarpato, R., Verola, C., Fabiani, B., Bianchi, V., Saggese, G., Federico, G., Nuclear damage in peripheral lymphocytes of obese and overweight Italian children as evaluated by the gamma-H2AX focus assay and micronucleus test. FASEB J. 25 (2011), 685–693.
    • (2011) FASEB J. , vol.25 , pp. 685-693
    • Scarpato, R.1    Verola, C.2    Fabiani, B.3    Bianchi, V.4    Saggese, G.5    Federico, G.6
  • 148
    • 84913592131 scopus 로고    scopus 로고
    • Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation
    • Schneider, J.L., Suh, Y., Cuervo, A.M., Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation. Cell Metab. 20 (2014), 417–432.
    • (2014) Cell Metab. , vol.20 , pp. 417-432
    • Schneider, J.L.1    Suh, Y.2    Cuervo, A.M.3
  • 153
    • 84919642203 scopus 로고    scopus 로고
    • DNA damage response and metabolic disease
    • Shimizu, I., Yoshida, Y., Suda, M., Minamino, T., DNA damage response and metabolic disease. Cell Metab. 20 (2014), 967–977.
    • (2014) Cell Metab. , vol.20 , pp. 967-977
    • Shimizu, I.1    Yoshida, Y.2    Suda, M.3    Minamino, T.4
  • 154
    • 84894523716 scopus 로고    scopus 로고
    • Making new contacts: the mTOR network in metabolism and signalling crosstalk
    • Shimobayashi, M., Hall, M.N., Making new contacts: the mTOR network in metabolism and signalling crosstalk. Nat. Rev. Mol. Cell Biol. 15 (2014), 155–162.
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , pp. 155-162
    • Shimobayashi, M.1    Hall, M.N.2
  • 155
    • 84875953755 scopus 로고    scopus 로고
    • Stem cell metabolism in tissue development and aging
    • Shyh-Chang, N., Daley, G.Q., Cantley, L.C., Stem cell metabolism in tissue development and aging. Development 140 (2013), 2535–2547.
    • (2013) Development , vol.140 , pp. 2535-2547
    • Shyh-Chang, N.1    Daley, G.Q.2    Cantley, L.C.3
  • 156
  • 158
    • 84923376645 scopus 로고    scopus 로고
    • Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway
    • Song, Y.M., Lee, Y.H., Kim, J.W., Ham, D.S., Kang, E.S., Cha, B.S., Lee, H.C., Lee, B.W., Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway. Autophagy 11 (2015), 46–59.
    • (2015) Autophagy , vol.11 , pp. 46-59
    • Song, Y.M.1    Lee, Y.H.2    Kim, J.W.3    Ham, D.S.4    Kang, E.S.5    Cha, B.S.6    Lee, H.C.7    Lee, B.W.8
  • 166
    • 84962018940 scopus 로고    scopus 로고
    • Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling
    • Tao, R., Xiong, X., Liangpunsakul, S., Dong, X.C., Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling. Diabetes 64 (2015), 1211–1223.
    • (2015) Diabetes , vol.64 , pp. 1211-1223
    • Tao, R.1    Xiong, X.2    Liangpunsakul, S.3    Dong, X.C.4
  • 170
    • 67651174517 scopus 로고    scopus 로고
    • p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress
    • Ventura, N., Rea, S.L., Schiavi, A., Torgovnick, A., Testi, R., Johnson, T.E., p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress. Aging Cell 8 (2009), 380–393.
    • (2009) Aging Cell , vol.8 , pp. 380-393
    • Ventura, N.1    Rea, S.L.2    Schiavi, A.3    Torgovnick, A.4    Testi, R.5    Johnson, T.E.6
  • 171
    • 84949036094 scopus 로고    scopus 로고
    • + in aging, metabolism, and neurodegeneration
    • + in aging, metabolism, and neurodegeneration. Science 350 (2015), 1208–1213.
    • (2015) Science , vol.350 , pp. 1208-1213
    • Verdin, E.1
  • 172
    • 84954155684 scopus 로고    scopus 로고
    • Genome integrity in aging: human syndromes, mouse models, and therapeutic options
    • Vermeij, W.P., Hoeijmakers, J.H., Pothof, J., Genome integrity in aging: human syndromes, mouse models, and therapeutic options. Annu. Rev. Pharmacol. Toxicol. 56 (2016), 427–445.
    • (2016) Annu. Rev. Pharmacol. Toxicol. , vol.56 , pp. 427-445
    • Vermeij, W.P.1    Hoeijmakers, J.H.2    Pothof, J.3
  • 173
    • 84922606978 scopus 로고    scopus 로고
    • The role of protein clearance mechanisms in organismal ageing and age-related diseases
    • Vilchez, D., Saez, I., Dillin, A., The role of protein clearance mechanisms in organismal ageing and age-related diseases. Nat. Commun., 5, 2014, 5659.
    • (2014) Nat. Commun. , vol.5 , pp. 5659
    • Vilchez, D.1    Saez, I.2    Dillin, A.3
  • 176
    • 84948953210 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and longevity in animals: Untangling the knot
    • Wang, Y., Hekimi, S., Mitochondrial dysfunction and longevity in animals: Untangling the knot. Science 350 (2015), 1204–1207.
    • (2015) Science , vol.350 , pp. 1204-1207
    • Wang, Y.1    Hekimi, S.2
  • 177
    • 84962420919 scopus 로고    scopus 로고
    • Circulating and dietary trans fatty acids and incident type 2 diabetes in older adults: the Cardiovascular Health Study
    • Wang, Q., Imamura, F., Ma, W., Wang, M., Lemaitre, R.N., King, I.B., Song, X., Biggs, M.L., Delaney, J.A., Mukamal, K.J., et al. Circulating and dietary trans fatty acids and incident type 2 diabetes in older adults: the Cardiovascular Health Study. Diabetes Care 38 (2015), 1099–1107.
    • (2015) Diabetes Care , vol.38 , pp. 1099-1107
    • Wang, Q.1    Imamura, F.2    Ma, W.3    Wang, M.4    Lemaitre, R.N.5    King, I.B.6    Song, X.7    Biggs, M.L.8    Delaney, J.A.9    Mukamal, K.J.10
  • 182
    • 84908344159 scopus 로고    scopus 로고
    • Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response
    • Yan, J., Zhang, H., Yin, Y., Li, J., Tang, Y., Purkayastha, S., Li, L., Cai, D., Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response. Nat. Med. 20 (2014), 1001–1008.
    • (2014) Nat. Med. , vol.20 , pp. 1001-1008
    • Yan, J.1    Zhang, H.2    Yin, Y.3    Li, J.4    Tang, Y.5    Purkayastha, S.6    Li, L.7    Cai, D.8
  • 183
    • 77956400005 scopus 로고    scopus 로고
    • Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
    • Yang, L., Li, P., Fu, S., Calay, E.S., Hotamisligil, G.S., Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab. 11 (2010), 467–478.
    • (2010) Cell Metab. , vol.11 , pp. 467-478
    • Yang, L.1    Li, P.2    Fu, S.3    Calay, E.S.4    Hotamisligil, G.S.5
  • 185
    • 84924365662 scopus 로고    scopus 로고
    • Proteasomes, Sir2, and Hxk2 form an interconnected aging network that impinges on the AMPK/Snf1-regulated transcriptional repressor Mig1
    • Yao, Y., Tsuchiyama, S., Yang, C., Bulteau, A.L., He, C., Robison, B., Tsuchiya, M., Miller, D., Briones, V., Tar, K., et al. Proteasomes, Sir2, and Hxk2 form an interconnected aging network that impinges on the AMPK/Snf1-regulated transcriptional repressor Mig1. PLoS Genet., 11, 2015, e1004968.
    • (2015) PLoS Genet. , vol.11 , pp. e1004968
    • Yao, Y.1    Tsuchiyama, S.2    Yang, C.3    Bulteau, A.L.4    He, C.5    Robison, B.6    Tsuchiya, M.7    Miller, D.8    Briones, V.9    Tar, K.10
  • 186
    • 84900299463 scopus 로고    scopus 로고
    • The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans
    • Yee, C., Yang, W., Hekimi, S., The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans. Cell 157 (2014), 897–909.
    • (2014) Cell , vol.157 , pp. 897-909
    • Yee, C.1    Yang, W.2    Hekimi, S.3
  • 187
    • 84873390153 scopus 로고    scopus 로고
    • The emerging role of the mitochondrial-derived peptide humanin in stress resistance
    • Yen, K., Lee, C., Mehta, H., Cohen, P., The emerging role of the mitochondrial-derived peptide humanin in stress resistance. J. Mol. Endocrinol. 50 (2013), R11–R19.
    • (2013) J. Mol. Endocrinol. , vol.50 , pp. R11-R19
    • Yen, K.1    Lee, C.2    Mehta, H.3    Cohen, P.4
  • 193
    • 79953647105 scopus 로고    scopus 로고
    • Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis
    • Zhang, X., Li, L., Chen, S., Yang, D., Wang, Y., Zhang, X., Wang, Z., Le, W., Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Autophagy 7 (2011), 412–425.
    • (2011) Autophagy , vol.7 , pp. 412-425
    • Zhang, X.1    Li, L.2    Chen, S.3    Yang, D.4    Wang, Y.5    Zhang, X.6    Wang, Z.7    Le, W.8


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