메뉴 건너뛰기




Volumn 15, Issue 6, 2013, Pages 647-658

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB; UNCLASSIFIED DRUG;

EID: 84878606239     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb2718     Document Type: Article
Times cited : (767)

References (56)
  • 1
    • 3843070757 scopus 로고    scopus 로고
    • Starvation response in mouse liver shows strong correlation with life-span-prolonging processes
    • Bauer, M. et al. Starvation response in mouse liver shows strong correlation with life-span-prolonging processes. Physiol. Genomics 17, 230-244 (2004).
    • (2004) Physiol. Genomics , vol.17 , pp. 230-244
    • Bauer, M.1
  • 2
    • 57049127028 scopus 로고    scopus 로고
    • The transcriptomic signature of fasting murine liver
    • Sokolovic, M. et al. The transcriptomic signature of fasting murine liver. BMC Genomics 9, 528 (2008).
    • (2008) BMC Genomics , vol.9 , pp. 528
    • Sokolovic, M.1
  • 3
    • 79955539414 scopus 로고    scopus 로고
    • Interorgan coordination of the murine adaptive response to fasting
    • Hakvoort, T. B. et al. Interorgan coordination of the murine adaptive response to fasting. J. Biol. Chem. 286, 16332-16343 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 16332-16343
    • Hakvoort, T.B.1
  • 4
    • 33745365931 scopus 로고    scopus 로고
    • Proteolytic and lipolytic responses to starvation
    • Finn, P. F. Dice, J. F. Proteolytic and lipolytic responses to starvation. Nutrition 22, 830-844 (2006).
    • (2006) Nutrition , vol.22 , pp. 830-844
    • Finn, P.F.1    Dice, J.F.2
  • 5
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span-from yeast to humans
    • Fontana, L., Partridge, L. Longo, V. D. Extending healthy life span-from yeast to humans. Science 328, 321-326 (2010).
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 6
    • 0037112907 scopus 로고    scopus 로고
    • Nutrient control of gene expression in Drosophila: Microarray analysis of starvation and sugar-dependent response
    • Zinke, I., Schutz, C. S., Katzenberger, J. D., Bauer, M. Pankratz, M. J. Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response. EMBO J. 21, 6162-6173 (2002).
    • (2002) EMBO J. , vol.21 , pp. 6162-6173
    • Zinke, I.1    Schutz, C.S.2    Katzenberger, J.D.3    Bauer, M.4    Pankratz, M.J.5
  • 7
    • 26444442036 scopus 로고    scopus 로고
    • A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49
    • Van Gilst, M. R., Hadjivassiliou, H. Yamamoto, K. R. A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Proc. Natl Acad. Sci. USA 102, 13496-13501 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 13496-13501
    • Van Gilst, M.R.1    Hadjivassiliou, H.2    Yamamoto, K.R.3
  • 8
    • 36249025723 scopus 로고    scopus 로고
    • Autophagy: Process and function
    • Mizushima, N. Autophagy: process and function. Genes Dev. 21, 2861-2873 (2007).
    • (2007) Genes Dev. , vol.21 , pp. 2861-2873
    • Mizushima, N.1
  • 9
    • 65949095803 scopus 로고    scopus 로고
    • Autophagy regulates lipid metabolism
    • Singh, R. et al. Autophagy regulates lipid metabolism. Nature 458, 1131-1135 (2009).
    • (2009) Nature , vol.458 , pp. 1131-1135
    • Singh, R.1
  • 10
    • 79955631150 scopus 로고    scopus 로고
    • Autophagy in the cellular energetic balance
    • Singh, R. Cuervo, A. M. Autophagy in the cellular energetic balance. Cell Metab. 13, 495-504 (2011).
    • (2011) Cell Metab. , vol.13 , pp. 495-504
    • Singh, R.1    Cuervo, A.M.2
  • 11
    • 77956400005 scopus 로고    scopus 로고
    • Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
    • Yang, L., Li, P., Fu, S., Calay, E. S. Hotamisligil, G. S. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab. 11, 467-478 (2010).
    • (2010) Cell Metab. , vol.11 , pp. 467-478
    • Yang, L.1    Li, P.2    Fu, S.3    Calay, E.S.4    Hotamisligil, G.S.5
  • 12
    • 67749122634 scopus 로고    scopus 로고
    • A gene network regulating lysosomal biogenesis and function
    • Sardiello, M. et al. A gene network regulating lysosomal biogenesis and function. Science 325, 473-477 (2009).
    • (2009) Science , vol.325 , pp. 473-477
    • Sardiello, M.1
  • 13
    • 80955177196 scopus 로고    scopus 로고
    • TFEB links autophagy to lysosomal biogenesis
    • Settembre, C. et al. TFEB links autophagy to lysosomal biogenesis. Science 332, 1429-1433 (2011).
    • (2011) Science , vol.332 , pp. 1429-1433
    • Settembre, C.1
  • 14
    • 80052716148 scopus 로고    scopus 로고
    • Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways
    • Palmieri, M. et al. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. Hum. Mol. Genet. 20, 3852-3866 (2011).
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 3852-3866
    • Palmieri, M.1
  • 15
    • 0038005018 scopus 로고    scopus 로고
    • DAVID: Database for annotation visualization and integrated discovery
    • Dennis, G. Jr. et al. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 4, P3 (2003).
    • (2003) Genome Biol. , vol.4
    • Dennis Jr., G.1
  • 16
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang da, W., Sherman, B. T. Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44-57 (2009).
    • (2009) Nat. Protoc. , vol.4 , pp. 44-57
    • Huang Da, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 17
    • 33644660537 scopus 로고    scopus 로고
    • PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease
    • Finck, B. N. Kelly, D. P. PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J. Clin. Invest. 116, 615-622 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 615-622
    • Finck, B.N.1    Kelly, D.P.2
  • 18
    • 5444264003 scopus 로고    scopus 로고
    • Biological control through regulated transcriptional coactivators
    • Spiegelman, B. M. Heinrich, R. Biological control through regulated transcriptional coactivators. Cell 119, 157-167 (2004).
    • (2004) Cell , vol.119 , pp. 157-167
    • Spiegelman, B.M.1    Heinrich, R.2
  • 19
    • 0033977890 scopus 로고    scopus 로고
    • The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor-in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
    • Vega, R. B., Huss, J. M. Kelly, D. P. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor-in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol. Cell Biol. 20, 1868-1876 (2000).
    • (2000) Mol. Cell Biol. , vol.20 , pp. 1868-1876
    • Vega, R.B.1    Huss, J.M.2    Kelly, D.P.3
  • 20
    • 24144463983 scopus 로고    scopus 로고
    • Metabolic control through the PGC-1 family of transcription coactivators
    • Lin, J., Handschin, C. Spiegelman, B. M. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 1, 361-370 (2005).
    • (2005) Cell Metab. , vol.1 , pp. 361-370
    • Lin, J.1    Handschin, C.2    Spiegelman, B.M.3
  • 21
    • 21044455137 scopus 로고    scopus 로고
    • Impairment of starvation-induced and constitutive autophagy in Atg7-de-cient mice
    • Komatsu, M. et al. Impairment of starvation-induced and constitutive autophagy in Atg7-de-cient mice. J. Cell Biol. 169, 425-434 (2005).
    • (2005) J. Cell Biol. , vol.169 , pp. 425-434
    • Komatsu, M.1
  • 22
    • 36849089101 scopus 로고    scopus 로고
    • Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-de-cient mice
    • Komatsu, M. et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-de-cient mice. Cell 131, 1149-1163 (2007).
    • (2007) Cell , vol.131 , pp. 1149-1163
    • Komatsu, M.1
  • 23
    • 36248975293 scopus 로고    scopus 로고
    • SIRT1 transgenic mice show phenotypes resembling calorie restriction
    • Bordone, L. et al. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 6, 759-767 (2007).
    • (2007) Aging Cell , vol.6 , pp. 759-767
    • Bordone, L.1
  • 24
    • 0029739826 scopus 로고    scopus 로고
    • Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
    • Vaisse, C. et al. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet. 14, 95-97 (1996).
    • (1996) Nat Genet. , vol.14 , pp. 95-97
    • Vaisse, C.1
  • 25
    • 0034029917 scopus 로고    scopus 로고
    • Identi-cation of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics
    • Lai, C. H., Chou, C. Y., Ch'ang, L. Y., Liu, C. S. Lin, W. Identi-cation of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Genome Res. 10, 703-713 (2000).
    • (2000) Genome Res. , vol.10 , pp. 703-713
    • Lai, C.H.1    Chou, C.Y.2    Ch'Ang, L.Y.3    Liu, C.S.4    Lin, W.5
  • 26
    • 67650594823 scopus 로고    scopus 로고
    • A multiparameter network reveals extensive divergence between Celegans bHLH transcription factors
    • Grove, C. A. et al. A multiparameter network reveals extensive divergence between Celegans bHLH transcription factors. Cell 138, 314-327 (2009).
    • (2009) Cell , vol.138 , pp. 314-327
    • Grove, C.A.1
  • 27
    • 33751250243 scopus 로고    scopus 로고
    • Lifespan extension in Caenorhabditis elegans by complete removal of food
    • Kaeberlein, T. L. et al. Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging Cell 5, 487-494 (2006).
    • (2006) Aging Cell , vol.5 , pp. 487-494
    • Kaeberlein, T.L.1
  • 28
    • 0021686137 scopus 로고
    • Arresting development arrests ageing in the nematode Caenorhabditis elegans
    • Johnson, T. E., Mitchell, D. H., Kline, S., Kemal, R. Foy, J. Arresting development arrests ageing in the nematode Caenorhabditis elegans. Mech. Ageing Dev. 28, 23-40 (1984).
    • (1984) Mech. Ageing Dev. , vol.28 , pp. 23-40
    • Johnson, T.E.1    Mitchell, D.H.2    Kline, S.3    Kemal, R.4    Foy, J.5
  • 29
    • 84857997408 scopus 로고    scopus 로고
    • A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
    • Settembre, C. et al. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J. 1095-1108 (2012).
    • (2012) EMBO J. , pp. 1095-1108
    • Settembre, C.1
  • 30
    • 84864874958 scopus 로고    scopus 로고
    • MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
    • Martina, J. A., Chen, Y., Gucek, M. Puertollano, R. MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB. Autophagy 8, 903-914 (2012).
    • (2012) Autophagy , vol.8 , pp. 903-914
    • Martina, J.A.1    Chen, Y.2    Gucek, M.3    Puertollano, R.4
  • 31
    • 84862539692 scopus 로고    scopus 로고
    • The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis
    • Roczniak-Ferguson, A. et al. The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. Sci. Signal 5, ra42 (2012).
    • (2012) Sci. Signal , vol.5
    • Roczniak-Ferguson, A.1
  • 32
    • 17144456808 scopus 로고    scopus 로고
    • Positive feedback in eukaryotic gene networks: Cell differentiation by graded to binary response conversion
    • Becskei, A., Seraphin, B. Serrano, L. Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion. EMBO J. 20, 2528-2535 (2001).
    • (2001) EMBO J. , vol.20 , pp. 2528-2535
    • Becskei, A.1    Seraphin, B.2    Serrano, L.3
  • 33
    • 79959814519 scopus 로고    scopus 로고
    • Construction and modelling of an inducible positive feedback loop stably integrated in a mammalian cell-line
    • Siciliano, V. et al. Construction and modelling of an inducible positive feedback loop stably integrated in a mammalian cell-line. PLoS Comput. Biol. 7, e1002074 (2011).
    • (2011) PLoS Comput. Biol. , vol.7
    • Siciliano, V.1
  • 34
    • 52449123371 scopus 로고    scopus 로고
    • Transcriptional autoregulatory loops are highly conserved in vertebrate evolution
    • Kielbasa, S. M. Vingron, M. Transcriptional autoregulatory loops are highly conserved in vertebrate evolution. PLoS One 3, e3210 (2008).
    • (2008) PLoS One , vol.3
    • Kielbasa, S.M.1    Vingron, M.2
  • 35
    • 0038810035 scopus 로고    scopus 로고
    • An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1-expression in muscle
    • Handschin, C., Rhee, J., Lin, J., Tarr, P. T. Spiegelman, B. M. An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1-expression in muscle. Proc. Natl Acad. Sci. USA 100, 7111-7116 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 7111-7116
    • Handschin, C.1    Rhee, J.2    Lin, J.3    Tarr, P.T.4    Spiegelman, B.M.5
  • 36
    • 84863923855 scopus 로고    scopus 로고
    • PGC-1-rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function
    • Tsunemi, T. et al. PGC-1-rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function. Sci. Transl. Med. 4, 142ra197 (2012).
    • (2012) Sci. Transl. Med. , vol.4
    • Tsunemi, T.1
  • 37
    • 84862776702 scopus 로고    scopus 로고
    • A PGC1dependent myokine that drives brown-fat-like development of white fat and thermogenesis
    • Bostrom, P. et al. A PGC1-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481, 463-468 (2012).
    • (2012) Nature , vol.481 , pp. 463-468
    • Bostrom, P.1
  • 38
    • 34249711964 scopus 로고    scopus 로고
    • Hepatic-broblast growth factor 21 is regulated by PPAR-and is a key mediator of hepatic lipid metabolism in ketotic states
    • Badman, M. K. et al. Hepatic-broblast growth factor 21 is regulated by PPAR-and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 5, 426-437 (2007).
    • (2007) Cell Metab. , vol.5 , pp. 426-437
    • Badman, M.K.1
  • 39
    • 34249686631 scopus 로고    scopus 로고
    • Endocrine regulation of the fasting response by PPAR-mediated induction of-broblast growth factor
    • Inagaki, T. et al. Endocrine regulation of the fasting response by PPAR-mediated induction of-broblast growth factor Cell Metab. 5, 415-425 (2007).
    • (2007) Cell Metab. , vol.5 , pp. 415-425
    • Inagaki, T.1
  • 40
    • 0027049847 scopus 로고
    • Cell-Epeci-C expression of cytosolic phosphoenolpyruvate carboxykinase in transgenic mice
    • Beale, E. G., Clouthier, D. E. Hammer, R. E. Cell-speci-c expression of cytosolic phosphoenolpyruvate carboxykinase in transgenic mice. FASEB J. 6, 3330-3337 (1992).
    • (1992) FASEB J , vol.6 , pp. 3330-3337
    • Beale, E.G.1    Clouthier, D.E.2    Hammer, R.E.3
  • 41
    • 0346872991 scopus 로고    scopus 로고
    • Improved system for helper-dependent adenoviral vector production
    • Palmer, D. Ng, P. Improved system for helper-dependent adenoviral vector production. Mol. Ther. 8, 846-852 (2003).
    • (2003) Mol.Ther. , vol.8 , pp. 846-852
    • Palmer, D.1    Ng, P.2
  • 42
    • 0035988782 scopus 로고    scopus 로고
    • Preparation of helper-dependent adenoviral vectors
    • Ng, P., Parks, R. J. Graham, F. L. Preparation of helper-dependent adenoviral vectors. Methods Mol. Med. 69, 371-388 (2002).
    • (2002) Methods Mol.Med. , vol.69 , pp. 371-388
    • Ng, P.1    Parks, R.J.2    Graham, F.L.3
  • 43
    • 84878557321 scopus 로고    scopus 로고
    • Gene therapy targeting LDL cholesterol but not HDL cholesterol induces regression of advanced atherosclerosis in a mouse model of familial hypercholesterolemia
    • Li, R. et al. Gene therapy targeting LDL cholesterol but not HDL cholesterol induces regression of advanced atherosclerosis in a mouse model of familial hypercholesterolemia. J Genet Syndr. Gene Ther. 2, 106 (2011).
    • (2011) J Genet Syndr.Gene Ther. , vol.2 , pp. 106
    • Li, R.1
  • 44
    • 84861222690 scopus 로고    scopus 로고
    • The ancient drug salicylate directly activates AMP-activated protein kinase
    • Hawley, S. A. et al. The ancient drug salicylate directly activates AMP-activated protein kinase. Science 8, 918-922 (2012).
    • (2012) Science , vol.8 , pp. 918-922
    • Hawley, S.A.1
  • 45
    • 0036090027 scopus 로고    scopus 로고
    • Oral [13C]glucose and endogenous energy substrate oxidation during prolonged treadmill running
    • Couture, S., Massicotte, D., Lavoie, C., Hillaire-Marcel, C. Peronnet, F. Oral [(13)C]glucose and endogenous energy substrate oxidation during prolonged treadmill running. J. Appl. Physiol. 92, 1255-1260 (2002).
    • (2002) J.Appl.Physiol. , vol.92 , pp. 1255-1260
    • Couture, S.1    Massicotte, D.2    Lavoie, C.3    Hillaire-Marcel, C.4    Peronnet, F.5
  • 46
    • 0036081355 scopus 로고    scopus 로고
    • Gene expression omnibus: NCBI gene expression and hybridization array data repository
    • Edgar, R., Domrachev, M. Lash, A. E. Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30, 207-210 (2002).
    • (2002) Nucleic Acids Res , vol.30 , pp. 207-210
    • Edgar, R.1    Domrachev, M.2    Lash, A.E.3
  • 47
    • 28744458859 scopus 로고    scopus 로고
    • Bioconductor: Open software development for computational biology and bioinformatics
    • Gentleman, R. C. et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 5, R80 (2004).
    • (2004) Genome Biol , vol.5
    • Gentleman, R.C.1
  • 48
    • 0034948896 scopus 로고    scopus 로고
    • A Bayesian framework for the analysis of microarray expression data:Regularized t-test and statistical inferences of gene changes
    • Baldi, P. Long, A. D. A Bayesian framework for the analysis of microarray expression data: regularized t-test and statistical inferences of gene changes. Bioinformatics 17, 509-519 (2001).
    • (2001) Bioinformatics , vol.17 , pp. 509-519
    • Baldi, P.1    Long, A.D.2
  • 49
    • 0028857136 scopus 로고
    • Mathematical formulae for the prediction of the residual-Cell function during the rst two years of disease in children and adolescents with insulin-dependent diabetes mellitus
    • Klipper-Aurbach, Y. et al. Mathematical formulae for the prediction of the residual-cell function during the-rst two years of disease in children and adolescents with insulin-dependent diabetes mellitus. Med. Hypotheses 45, 486-490 (1995).
    • (1995) Med.Hypotheses , vol.45 , pp. 486-490
    • Klipper-Aurbach, Y.1
  • 50
    • 0034069495 scopus 로고    scopus 로고
    • Gene ontology : Tool for the uni-cation of biology
    • Ashburner, M. et al. Gene ontology: tool for the uni-cation of biology. The Gene Ontology Consortium. Nat. Genet. 25, 25-29 (2000).
    • (2000) The Gene Ontology Consortium.Nat.Genet. , vol.25 , pp. 25-29
    • Ashburner, M.1
  • 51
    • 58349111875 scopus 로고    scopus 로고
    • AmiGO : Online access to ontology and annotation data
    • Carbon, S. et al. AmiGO: online access to ontology and annotation data. Bioinformatics 25, 288-289 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 288-289
    • Carbon, S.1
  • 52
    • 0242490780 scopus 로고    scopus 로고
    • Cytoscape : A software environment for integrated models of biomolecular interaction networks
    • Shannon, P. et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498-2504 (2003).
    • (2003) Genome Res , vol.13 , pp. 2498-2504
    • Shannon, P.1
  • 53
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • Brenner, S. The genetics of Caenorhabditis elegans. Genetics 77, 71-94 (1974).
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 54
    • 56249116997 scopus 로고    scopus 로고
    • Role for-Catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions
    • USA
    • Irazoqui, J. E., Ng, A., Xavier, R. J. Ausubel, F. M. Role for-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions. Proc. Natl Acad. Sci. USA 105, 17469-17474 (2008).
    • (2008) Proc.Natl Acad.Sci. , vol.105 , pp. 17469-17474
    • Irazoqui, J.E.1    Ng, A.2    Xavier, R.J.3    Ausubel, F.M.4
  • 55
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quanti-cation in real-time RT-PCR
    • Pfaf-, M. W. A new mathematical model for relative quanti-cation in real-time RT-PCR. Nucleic Acids Res. 29, e45 (2001).
    • (2001) Nucleic Acids Res , vol.29 , pp. 45
    • Pfaf, M.W.1
  • 56
    • 70350365111 scopus 로고    scopus 로고
    • Celegans major fats are stored in vesicles distinct from lysosome-related organelles
    • O'Rourke, E. J., Soukas, A. A., Carr, C. E. Ruvkun, G. Celegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab. 10, 430-435 (2009).
    • (2009) Cell Metab , vol.10 , pp. 430-435
    • O'Rourke, E.J.1    Soukas, A.A.2    Carr, C.E.3    Ruvkun, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.