Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

Molecular Cell

Volumn 53, Issue 5, 2014, Pages 710-725

  Mariño, Guillermo ^a,b,c   Pietrocola, Federico ^a,b,c   Eisenberg, Tobias ^d   Kong, Yongli ^e   Malik, ShoaibAhmad ^a,b,c   Andryushkova, Aleksandra ^d   Schroeder, Sabrina ^d   Pendl, Tobias ^d   Harger, Alexandra ^f   Niso Santano, Mireia ^a,b,c   Zamzami, Naoufal ^a,b,c   Scoazec, Marie ^a,b   Durand, Silvère ^a,b   Enot, DavidP ^a,b   Fernández, ÁlvaroF ^g   Martins, Isabelle ^a,b,c   Kepp, Oliver ^a,b,c   Senovilla, Laura ^a,b,c   Bauvy, Chantal ^c,h   Morselli, Eugenia ^a,b,c   Vacchelli, Erika ^a,b,c   Bennetzen, Martin ⁱ   Magnes, Christoph ^f   Sinner, Frank ^f   Pieber, Thomas ^f,j   López Otín, Carlos ^g   Maiuri, MariaChiara ^a,b,c   Codogno, Patrice ^c,h   Andersen, JensS ⁱ   Hill, JosephA ^e   Madeo, Frank ^d   Kroemer, Guido ^a,b,c,k   more..

^a CENTRE DE RECHERCHE DES CORDELIERS   (France)

^b Metabolomics and Cell Biology Platforms Gustave Roussy Cancer Campus   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d UNIVERSITY OF GRAZ   (Austria)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^f JOANNEUM RESEARCH   (Austria)

^g DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^h INSERM   (France)

ⁱ UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^j MEDICAL UNIVERSITY OF GRAZ   (Austria)

^k HÔpital Européen Georges Pompidou   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; ACYLTRANSFERASE; CYTOPLASM PROTEIN; ACETYLTRANSFERASE EP300; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; CYTOSOL; DEACYLATION; FEMALE; HEART VENTRICLE OVERLOAD; HEART VENTRICLE PRESSURE; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; METABOLIC REGULATION; MITOCHONDRION; MOUSE; NONHUMAN; NUTRIENT; PROTEIN DEGRADATION; PROTEIN DEPLETION; STARVATION; CONCENTRATION (PARAMETERS); DEACETYLATION; DECARBOXYLATION; ENZYME ACTIVITY; ENZYME INHIBITION; METABOLITE; PROTEIN ACETYLATION;

MUS;

ACETYL COENZYME A; ADENOSINE TRIPHOSPHATE; ANIMALS; AUTOPHAGY; CELL LINE, TUMOR; CELL NUCLEUS; CYTOPLASM; CYTOSOL; E1A-ASSOCIATED P300 PROTEIN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GREEN FLUORESCENT PROTEINS; HCT116 CELLS; HELA CELLS; HUMANS; KETOGLUTARIC ACIDS; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; RNA, SMALL INTERFERING;

EID: 84896713080     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2014.01.016     Document Type: Article

References (51)

1. Bánréti A., Sass M., Graba Y. The emerging role of acetylation in the regulation of autophagy. Autophagy 2013, 9:819-829.
2. Behrends C., Sowa M.E., Gygi S.P., Harper J.W. Network organization of the human autophagy system. Nature 2010, 466:68-76.
3. Bowers E.M., Yan G., Mukherjee C., Orry A., Wang L., Holbert M.A., Crump N.T., Hazzalin C.A., Liszczak G., Yuan H., et al. Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem. Biol. 2010, 17:471-482.
4. Campbell B., Roberts M., Kerksick C., Wilborn C., Marcello B., Taylor L., Nassar E., Leutholtz B., Bowden R., Rasmussen C., et al. Pharmacokinetics, safety, and effects on exercise performance of L-arginine alpha-ketoglutarate in trained adult men. Nutrition 2006, 22:872-881.
5. Cantó C., Gerhart-Hines Z., Feige J.N., Lagouge M., Noriega L., Milne J.C., Elliott P.J., Puigserver P., Auwerx J. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 2009, 458:1056-1060.
6. Chuang D. Branched-chain amino acids. Encyclopedia of Biological Chemistry 2013, 244-249. Academic Press, Waltham, MA. Second Edition. W. Lennarz, M. Lane (Eds.).
7. Contreras G.A., Bell C.S., Del Bianco G.P., Pérez N., Kleinosky M.T., Murphy J.R., Heresi G.P. Prevalence and risk factors associated with resistance-associated mutations to etravirine in a cohort of perinatally HIV-infected children. J.Antimicrob. Chemother. 2013, 68:2344-2348.
8. Donohoe D.R., Collins L.B., Wali A., Bigler R., Sun W., Bultman S.J. The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. Mol. Cell 2012, 48:612-626.
9. Eisenberg T., Knauer H., Schauer A., Büttner S., Ruckenstuhl C., Carmona-Gutierrez D., Ring J., Schroeder S., Magnes C., Antonacci L., et al. Induction of autophagy by spermidine promotes longevity. Nat. Cell Biol. 2009, 11:1305-1314.
10. Foster D.W. The role of the carnitine system in human metabolism. Ann. N Y Acad. Sci. 2004, 1033:1-16.
11. Geeraert C., Ratier A., Pfisterer S.G., Perdiz D., Cantaloube I., Rouault A., Pattingre S., Proikas-Cezanne T., Codogno P., Poüs C. Starvation-induced hyperacetylation of tubulin is required for the stimulation of autophagy by nutrient deprivation. J.Biol. Chem. 2010, 285:24184-24194.
12. Hebert A.S., Dittenhafer-Reed K.E., Yu W., Bailey D.J., Selen E.S., Boersma M.D., Carson J.J., Tonelli M., Balloon A.J., Higbee A.J., et al. Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Mol. Cell 2013, 49:186-199.
13. Herzig S., Raemy E., Montessuit S., Veuthey J.L., Zamboni N., Westermann B., Kunji E.R., Martinou J.C. Identification and functional expression of the mitochondrial pyruvate carrier. Science 2012, 337:93-96.
14. Jang S.Y., Kang H.T., Hwang E.S. Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation. J.Biol. Chem. 2012, 287:19304-19314.
15. Kim J., Kim Y.C., Fang C., Russell R.C., Kim J.H., Fan W., Liu R., Zhong Q., Guan K.L. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 2013, 152:290-303.
16. Kroemer G., Mariño G., Levine B. Autophagy and the integrated stress response. Mol. Cell 2010, 40:280-293.
17. Lan F., Cacicedo J.M., Ruderman N., Ido Y. SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J.Biol. Chem. 2008, 283:27628-27635.
18. Lee I.H., Finkel T. Regulation of autophagy by the p300 acetyltransferase. J.Biol. Chem. 2009, 284:6322-6328.
19. Lee I.H., Cao L., Mostoslavsky R., Lombard D.B., Liu J., Bruns N.E., Tsokos M., Alt F.W., Finkel T. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc. Natl. Acad. Sci. USA 2008, 105:3374-3379.
20. Lee J.Y., Koga H., Kawaguchi Y., Tang W., Wong E., Gao Y.S., Pandey U.B., Kaushik S., Tresse E., Lu J., et al. HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J. 2010, 29:969-980.
21. Levine B., Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008, 132:27-42.
22. Lin S.Y., Li T.Y., Liu Q., Zhang C., Li X., Chen Y., Zhang S.M., Lian G., Liu Q., Ruan K., et al. GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science 2012, 336:477-481.
23. Lin T.C., Chen Y.R., Kensicki E., Li A.Y., Kong M., Li Y., Mohney R.P., Shen H.M., Stiles B., Mizushima N., et al. Autophagy: resetting glutamine-dependent metabolism and oxygen consumption. Autophagy 2012, 8:1477-1493.
24. López-Otín C., Blasco M.A., Partridge L., Serrano M., Kroemer G. The hallmarks of aging. Cell 2013, 153:1194-1217.
25. Lowenstein J.M., Brunengraber H. Hydroxycitrate. Methods Enzymol. 1981, 72:486-497.
26. Mariño G., Fernández A.F., Cabrera S., Lundberg Y.W., Cabanillas R., Rodríguez F., Salvador-Montoliu N., Vega J.A., Germanà A., Fueyo A., et al. Autophagy is essential for mouse sense of balance. J.Clin. Invest. 2010, 120:2331-2344.
27. Masri S., Patel V.R., Eckel-Mahan K.L., Peleg S., Forne I., Ladurner A.G., Baldi P., Imhof A., Sassone-Corsi P. Circadian acetylome reveals regulation of mitochondrial metabolic pathways. Proc. Natl. Acad. Sci. USA 2013, 110:3339-3344.
28. Mizushima N., Komatsu M. Autophagy: renovation of cells and tissues. Cell 2011, 147:728-741.
29. Mizushima N., Yamamoto A., Matsui M., Yoshimori T., Ohsumi Y. Invivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol. Biol. Cell 2004, 15:1101-1111.
30. Morselli E., Mariño G., Bennetzen M.V., Eisenberg T., Megalou E., Schroeder S., Cabrera S., Bénit P., Rustin P., Criollo A., et al. Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J.Cell Biol. 2011, 192:615-629.
31. Nakamura A., Kawakami K., Kametani F., Nakamoto H., Goto S. Biological significance of protein modifications in aging and calorie restriction. Ann. N Y Acad. Sci. 2010, 1197:33-39.
32. Onakpoya I., Hung S.K., Perry R., Wider B., Ernst E. The use of garcinia extract (hydroxycitric acid) as a weight loss supplement: a systematic review and meta-analysis of randomised clinical trials. J.Obes. 2011, 2011:509038.
33. Pietrocola F., Mariño G., Lissa D., Vacchelli E., Malik S.A., Niso-Santano M., Zamzami N., Galluzzi L., Maiuri M.C., Kroemer G. Pro-autophagic polyphenols reduce the acetylation of cytoplasmic proteins. Cell Cycle 2012, 11:3851-3860.
34. Roche T.E., Hiromasa Y. Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer. Cell. Mol. Life Sci. 2007, 64:830-849.
35. Rubinsztein D.C., Gestwicki J.E., Murphy L.O., Klionsky D.J. Potential therapeutic applications of autophagy. Nat. Rev. Drug Discov. 2007, 6:304-312.
36. Settembre C., Di Malta C., Polito V.A., Garcia Arencibia M., Vetrini F., Erdin S., Erdin S.U., Huynh T., Medina D., Colella P., et al. TFEB links autophagy to lysosomal biogenesis. Science 2011, 332:1429-1433.
37. Tasdemir E., Maiuri M.C., Galluzzi L., Vitale I., Djavaheri-Mergny M., D'Amelio M., Criollo A., Morselli E., Zhu C., Harper F., et al. Regulation of autophagy by cytoplasmic p53. Nat. Cell Biol. 2008, 10:676-687.
38. Thompson P.R., Wang D., Wang L., Fulco M., Pediconi N., Zhang D., An W., Ge Q., Roeder R.G., Wong J., et al. Regulation of the p300 HAT domain via a novel activation loop. Nat. Struct. Mol. Biol. 2004, 11:308-315.
39. Warr M.R., Binnewies M., Flach J., Reynaud D., Garg T., Malhotra R., Debnath J., Passegué E. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature 2013, 494:323-327.
40. Wellen K.E., Thompson C.B. A two-way street: reciprocal regulation of metabolism and signalling. Nat. Rev. Mol. Cell Biol. 2012, 13:270-276.
41. Wellen K.E., Hatzivassiliou G., Sachdeva U.M., Bui T.V., Cross J.R., Thompson C.B. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 2009, 324:1076-1080.
42. Willenborg M., Panten U., Rustenbeck I. Triggering and amplification of insulin secretion by dimethyl alpha-ketoglutarate, a membrane permeable alpha-ketoglutarate analogue. Eur. J. Pharmacol. 2009, 607:41-46.
43. Williams A., Sarkar S., Cuddon P., Ttofi E.K., Saiki S., Siddiqi F.H., Jahreiss L., Fleming A., Pask D., Goldsmith P., et al. Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat. Chem. Biol. 2008, 4:295-305.
44. Yang W., Hong Y.H., Shen X.Q., Frankowski C., Camp H.S., Leff T. Regulation of transcription by AMP-activated protein kinase: phosphorylation of p300 blocks its interaction with nuclear receptors. J.Biol. Chem. 2001, 276:38341-38344.
45. Yang F.C., Tan B.C., Chen W.H., Lin Y.H., Huang J.Y., Chang H.Y., Sun H.Y., Hsu P.H., Liou G.G., Shen J., et al. Reversible acetylation regulates salt-inducible kinase (SIK2) and its function in autophagy. J.Biol. Chem. 2013, 288:6227-6237.
46. Yeh L.A., Kim K.H. Regulation of acetyl-coA carboxylase: properties of coA activation of acetyl-coA carboxylase. Proc. Natl. Acad. Sci. USA 1980, 77:3351-3355.
47. Yi C., Ma M., Ran L., Zheng J., Tong J., Zhu J., Ma C., Sun Y., Zhang S., Feng W., et al. Function and molecular mechanism of acetylation in autophagy regulation. Science 2012, 336:474-477.
48. Zachar Z., Marecek J., Maturo C., Gupta S., Stuart S.D., Howell K., Schauble A., Lem J., Piramzadian A., Karnik S., et al. Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents invivo. J.Mol. Med. 2011, 89:1137-1148.
49. Zanchi N.E., Gerlinger-Romero F., Guimarães-Ferreira L., de Siqueira Filho M.A., Felitti V., Lira F.S., Seelaender M., Lancha A.H. HMB supplementation: clinical and athletic performance-related effects and mechanisms of action. Amino Acids 2011, 40:1015-1025.
50. Zaugg K., Yao Y., Reilly P.T., Kannan K., Kiarash R., Mason J., Huang P., Sawyer S.K., Fuerth B., Faubert B., et al. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev. 2011, 25:1041-1051.
51. Zhu H., Tannous P., Johnstone J.L., Kong Y., Shelton J.M., Richardson J.A., Le V., Levine B., Rothermel B.A., Hill J.A. Cardiac autophagy is a maladaptive response to hemodynamic stress. J.Clin. Invest. 2007, 117:1782-1793.