Defective mitophagy in XPA via PARP-1 hyperactivation and NAD +/SIRT1 reduction

Cell

Volumn 157, Issue 4, 2014, Pages 882-896

  Fang, Evandro Fei ^a   Scheibye Knudsen, Morten ^a   Brace, Lear E ^b   Kassahun, Henok ^c   Sengupta, Tanima ^c   Nilsen, Hilde ^c   Mitchell, James R ^b   Croteau, Deborah L ^a   Bohr, Vilhelm A ^a,d  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF OSLO   (Norway)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 9; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN KINASE; PROTEIN PINK1; REACTIVE OXYGEN METABOLITE; SIRTUIN 1; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2; XERODERMA PIGMENTOSUM GROUP A PROTEIN; XERODERMA PIGMENTOSUM GROUP C PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATAXIA TELANGIECTASIA; BLOOM SYNDROME; CELL AGING; CELL STRESS; COCKAYNE SYNDROME; COMPUTER MODEL; CONTROLLED STUDY; CROUZON SYNDROME; CYSTIC FIBROSIS; CYTOPATHOLOGY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DNA REPAIR; GENE EXPRESSION; GLYCOLYSIS; HUMAN; HUMAN CELL; IN VIVO STUDY; LIFESPAN; MELAS SYNDROME; MEMBRANE FUSION; MERRF SYNDROME; MICROARRAY ANALYSIS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOPHAGY; MOUSE; NEMATODE; NERVE DEGENERATION; NIJMEGEN BREAKAGE SYNDROME; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PATHOGENESIS; PHENOTYPIC VARIATION; PRECURSOR; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; UPREGULATION; XERODERMA PIGMENTOSUM; AGING; AUTOPHAGY; ENZYME INHIBITION; HYPERTROPHY; LONGEVITY; MOLECULAR INTERACTION; PHENOTYPE; SUPPLEMENTATION;

AGING; ANIMALS; APOPTOSIS; AUTOPHAGY; CAENORHABDITIS ELEGANS; CELL LINE; HUMANS; ION CHANNELS; MICE; MITOCHONDRIAL DEGRADATION; MITOCHONDRIAL PROTEINS; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN KINASES; RATS; SIRTUIN 1; XERODERMA PIGMENTOSUM; XERODERMA PIGMENTOSUM GROUP A PROTEIN;

EID: 84900344357     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2014.03.026     Document Type: Article

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