Reduced expression of MYC increases longevity and enhances healthspan

Cell

Volumn 160, Issue 3, 2015, Pages 477-488

  Hofmann, Jeffrey W ^a   Zhao, Xiaoai ^a   De Cecco, Marco ^a   Peterson, Abigail L ^a   Pagliaroli, Luca ^a   Manivannan, Jayameenakshi ^a   Hubbard, Gene B ^b   Ikeno, Yuji ^b   Zhang, Yongqing ^c   Feng, Bin ^d   Li, Xiaxi ^d   Serre, Thomas ^d   Qi, Wenbo ^b   Van Remmen, Holly ^b   Miller, Richard A ^e   Bath, Kevin G ^d   De Cabo, Rafael ^c   Xu, Haiyan ^d   Neretti, Nicola ^a   Sedivy, John M ^a  

^a BROWN UNIVERSITY   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

^d BROWN UNIVERSITY   (United States)

^e UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; MYC PROTEIN; PROTEIN; PROTEIN KINASE B; S6K PROTEIN; SOMATOMEDIN C; TARGET OF RAPAMYCIN KINASE; UNCLASSIFIED DRUG; MYC PROTEIN, MOUSE; TRANSCRIPTOME;

ARTICLE; BIOGENESIS; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENOTYPE; HAPLOINSUFFICIENCY; HEART MUSCLE FIBROSIS; LIPID METABOLISM; LONGEVITY; MALE; METABOLIC RATE; MOUSE; NONHUMAN; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RIBOSOME; SENESCENCE; SIGNAL TRANSDUCTION; STRESS MANAGEMENT; 129 MOUSE; AGING; ANIMAL; BODY SIZE; C57BL MOUSE; GENETICS; LYMPHOMA; METABOLISM;

MAMMALIA; MUS;

AGING; ANIMALS; BODY SIZE; FEMALE; LONGEVITY; LYMPHOMA; MALE; METABOLIC NETWORKS AND PATHWAYS; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; PROTO-ONCOGENE PROTEINS C-MYC; TRANSCRIPTOME;

EID: 84922178023     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2014.12.016     Document Type: Article

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