Microbiota depletion promotes browning of white adipose tissue and reduces obesity

Nature Medicine

Volumn 21, Issue 12, 2015, Pages 1497-1501

  Suárez Zamorano, Nicolas ^a   Fabbiano, Salvatore ^a   Chevalier, Claire ^a   Stojanović, Ozren ^a   Colin, Didier J ^b   Stevanović, Ana ^a   Veyrat Durebex, Christelle ^a   Tarallo, Valentina ^a   Rigo, Dorothée ^a   Germain, Stéphane ^b   Ilievska, Miroslava ^c   Montet, Xavier ^b   Seimbille, Yann ^b   Hapfelmeier, Siegfried ^d   Trajkovski, Mirko ^a,e  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c Alkaloid AD Skopje   (Macedonia)

^d UNIVERSITY OF BERN   (Switzerland)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CYTOKINE; GLUCOSE; INSULIN; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; CELL INFILTRATION; CELL POPULATION; CELL SIZE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; EOSINOPHIL; FLOW CYTOMETRY; GERMFREE MOUSE; GLUCOSE TOLERANCE; HEMATOPOIETIC CELL; INGUINAL SUBCUTANEOUS ADIPOSE TISSUE; INSULIN SENSITIVITY; INTESTINE FLORA; INTRAABDOMINAL FAT; LEPTIN DEFICIENCY; LIPID DIET; MACROPHAGE; MALE; MOUSE; MULTIDETECTOR COMPUTED TOMOGRAPHY; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PERIGONADAL VISCERAL ADIPOSE TISSUE; POLARIZATION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUBCUTANEOUS FAT; WHITE ADIPOSE TISSUE; ADIPOCYTE; ANIMAL; BAGG ALBINO MOUSE; BROWN ADIPOSE TISSUE; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; GERMFREE ANIMAL; GLUCOSE TOLERANCE TEST; METABOLISM; MICROBIOLOGY; MICROFLORA; PATHOLOGY;

ADIPOCYTES; ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ANIMALS; CELL SIZE; CYTOKINES; GENE EXPRESSION REGULATION; GERM-FREE LIFE; GLUCOSE; GLUCOSE TOLERANCE TEST; INSULIN; INTRA-ABDOMINAL FAT; MICE, INBRED BALB C; MICE, INBRED C57BL; MICROBIOTA; OBESITY; RNA, MESSENGER; SIGNAL TRANSDUCTION; SUBCUTANEOUS FAT;

EID: 84949551974     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3994     Document Type: Article

References (24)

1. Stanford, K.I. et al. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J. Clin. Invest. 123, 215-223 (2013).
2. Wu, J. et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150, 366-376 (2012).
3. Wu, J., Cohen, P. & Spiegelman, B. M. Adaptive thermogenesis in adipocytes: Is beige the new brown? Genes Dev. 27, 234-250 (2013).
4. Peirce, V., Carobbio, S. & Vidal-Puig, A. The different shades of fat. Nature 510, 76-83 (2014).
5. Koren, O. et al. Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell 150, 470-480 (2012).
6. Ridaura, V.K. et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 341, 1241214 (2013).
7. Liou, A. P. et al. Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity. Sci. Transl. Med. 5, 178ra141 (2013).
8. Tremaroli, V. & Backhed, F. Functional interactions between the gut microbiota and host metabolism. Nature 489, 242-249 (2012).
9. Cox, L.M. & Blaser, M.J. Antibiotics in early life and obesity. Nat. Rev. Endocrinol. 11, 182-190 (2015).
10. Chou, C.J., Membrez, M. & Blancher, F. Gut decontamination with norfloxacin and ampicillin enhances insulin sensitivity in mice. Nestle Nutr. Workshop Ser. Pediatr. Program. 62, 127-137 discussion 137-140 (2008).
11. Bäckhed, F. et al. The gut microbiota as an environmental factor that regulates fat storage. Proc. Natl. Acad. Sci. USA 101, 15718-15723 (2004).
12. Hwang, I. et al. Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity. FASEB J. 29, 2397-2411 (2015).
13. El Kaoutari, A., Armougom, F., Gordon, J.I., Raoult, D. & Henrissat, B. The abundance and variety of carbohydrate-Active enzymes in the human gut microbiota. Nat. Rev. Microbiol. 11, 497-504 (2013).
14. Feldmann, H.M., Golozoubova, V., Cannon, B. & Nedergaard, J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 9, 203-209 (2009).
15. Ganeshan, K. & Chawla, A. Metabolic regulation of immune responses. Annu. Rev. Immunol. 32, 609-634 (2014).
16. Lee, M.W. et al. Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell 160, 74-87 (2015).
17. Qiu, Y. et al. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 157, 1292-1308 (2014).
18. Martinez, F.O., Helming, L. & Gordon, S. Alternative activation of macrophages: an immunologic functional perspective. Annu. Rev. Immunol. 27, 451-483 (2009).
19. Nguyen, K.D. et al. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 480, 104-108 (2011).
20. Molofsky, A.B. et al. Interleukin-33 and interferon-? counter-regulate group 2 innate lymphoid cell activation during immune perturbation. Immunity 43, 161-174 (2015).
21. Grivennikov, S.I. et al. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature 491, 254-258 (2012).
22. Sun, L. & Trajkovski, M. MiR-27 orchestrates the transcriptional regulation of brown adipogenesis. Metabolism 63, 272-282 (2014).
23. Trajkovski, M., Ahmed, K., Esau, C.C. & Stoffel, M. MyomiR-133 regulates brown fat differentiation through Prdm16. Nat. Cell Biol. 14, 1330-1335 (2012).
24. Trajkovski, M. et al. Micrornas 103 and 107 regulate insulin sensitivity. Nature 474, 649-653 (2011).