-
1
-
-
84907867610
-
20 years of leptin: connecting leptin signaling to biological function
-
M.B. Allison, and M.G. Myers Jr. 20 years of leptin: connecting leptin signaling to biological function J. Endocrinol. 223 2014 T25 T35
-
(2014)
J. Endocrinol.
, vol.223
, pp. T25-T35
-
-
Allison, M.B.1
Myers, Jr.M.G.2
-
2
-
-
84891890600
-
Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation
-
S.U. Amano, J.L. Cohen, P. Vangala, M. Tencerova, S.M. Nicoloro, J.C. Yawe, Y. Shen, M.P. Czech, and M. Aouadi Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation Cell Metab. 19 2014 162 171
-
(2014)
Cell Metab.
, vol.19
, pp. 162-171
-
-
Amano, S.U.1
Cohen, J.L.2
Vangala, P.3
Tencerova, M.4
Nicoloro, S.M.5
Yawe, J.C.6
Shen, Y.7
Czech, M.P.8
Aouadi, M.9
-
3
-
-
80052278497
-
Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment
-
J. Amar, C. Chabo, A. Waget, P. Klopp, C. Vachoux, L.G. Bermúdez-Humarán, N. Smirnova, M. Bergé, T. Sulpice, and S. Lahtinen et al. Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment EMBO Mol. Med. 3 2011 559 572
-
(2011)
EMBO Mol. Med.
, vol.3
, pp. 559-572
-
-
Amar, J.1
Chabo, C.2
Waget, A.3
Klopp, P.4
Vachoux, C.5
Bermúdez-Humarán, L.G.6
Smirnova, N.7
Bergé, M.8
Sulpice, T.9
Lahtinen, S.10
-
4
-
-
80053927990
-
Dynamics of human adipose lipid turnover in health and metabolic disease
-
P. Arner, S. Bernard, M. Salehpour, G. Possnert, J. Liebl, P. Steier, B.A. Buchholz, M. Eriksson, E. Arner, and H. Hauner et al. Dynamics of human adipose lipid turnover in health and metabolic disease Nature 478 2011 110 113
-
(2011)
Nature
, vol.478
, pp. 110-113
-
-
Arner, P.1
Bernard, S.2
Salehpour, M.3
Possnert, G.4
Liebl, J.5
Steier, P.6
Buchholz, B.A.7
Eriksson, M.8
Arner, E.9
Hauner, H.10
-
5
-
-
66349115342
-
Adipocyte metabolism and obesity
-
A.D. Attie, and P.E. Scherer Adipocyte metabolism and obesity J. Lipid Res. 50 2009 S395 S399
-
(2009)
J. Lipid Res.
, vol.50
, pp. S395-S399
-
-
Attie, A.D.1
Scherer, P.E.2
-
6
-
-
77952623888
-
The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation
-
G. Barbatelli, I. Murano, L. Madsen, Q. Hao, M. Jimenez, K. Kristiansen, J.P. Giacobino, R. De Matteis, and S. Cinti The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation Am. J. Physiol. Endocrinol. Metab. 298 2010 E1244 E1253
-
(2010)
Am. J. Physiol. Endocrinol. Metab.
, vol.298
, pp. E1244-E1253
-
-
Barbatelli, G.1
Murano, I.2
Madsen, L.3
Hao, Q.4
Jimenez, M.5
Kristiansen, K.6
Giacobino, J.P.7
De Matteis, R.8
Cinti, S.9
-
7
-
-
85027909934
-
Adipose tissue browning and metabolic health
-
A. Bartelt, and J. Heeren Adipose tissue browning and metabolic health Nat. Rev. Endocrinol. 10 2014 24 36
-
(2014)
Nat. Rev. Endocrinol.
, vol.10
, pp. 24-36
-
-
Bartelt, A.1
Heeren, J.2
-
8
-
-
76749093995
-
Sensory and sympathetic nervous system control of white adipose tissue lipolysis
-
T.J. Bartness, Y.B. Shrestha, C.H. Vaughan, G.J. Schwartz, and C.K. Song Sensory and sympathetic nervous system control of white adipose tissue lipolysis Mol. Cell. Endocrinol. 318 2010 34 43
-
(2010)
Mol. Cell. Endocrinol.
, vol.318
, pp. 34-43
-
-
Bartness, T.J.1
Shrestha, Y.B.2
Vaughan, C.H.3
Schwartz, G.J.4
Song, C.K.5
-
9
-
-
56849128391
-
Gene-environment interactions in the etiology of obesity: defining the fundamentals
-
C. Bouchard Gene-environment interactions in the etiology of obesity: defining the fundamentals Obesity (Silver Spring) 16 3 2008 S5 S10
-
(2008)
Obesity (Silver Spring)
, vol.16
, Issue.3
, pp. S5-S10
-
-
Bouchard, C.1
-
10
-
-
84879369738
-
Commensal bacteria at the interface of host metabolism and the immune system
-
J.R. Brestoff, and D. Artis Commensal bacteria at the interface of host metabolism and the immune system Nat. Immunol. 14 2013 676 684
-
(2013)
Nat. Immunol.
, vol.14
, pp. 676-684
-
-
Brestoff, J.R.1
Artis, D.2
-
11
-
-
84924969384
-
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
-
J.R. Brestoff, B.S. Kim, S.A. Saenz, R.R. Stine, L.A. Monticelli, G.F. Sonnenberg, J.J. Thome, D.L. Farber, K. Lutfy, P. Seale, and D. Artis Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity Nature 519 2015 242 246
-
(2015)
Nature
, vol.519
, pp. 242-246
-
-
Brestoff, J.R.1
Kim, B.S.2
Saenz, S.A.3
Stine, R.R.4
Monticelli, L.A.5
Sonnenberg, G.F.6
Thome, J.J.7
Farber, D.L.8
Lutfy, K.9
Seale, P.10
Artis, D.11
-
12
-
-
0036690683
-
Dietary modification of inflammation with lipids
-
P.C. Calder Dietary modification of inflammation with lipids Proc. Nutr. Soc. 61 2002 345 358
-
(2002)
Proc. Nutr. Soc.
, vol.61
, pp. 345-358
-
-
Calder, P.C.1
-
13
-
-
34347399563
-
Metabolic endotoxemia initiates obesity and insulin resistance
-
P.D. Cani, J. Amar, M.A. Iglesias, M. Poggi, C. Knauf, D. Bastelica, A.M. Neyrinck, F. Fava, K.M. Tuohy, and C. Chabo et al. Metabolic endotoxemia initiates obesity and insulin resistance Diabetes 56 2007 1761 1772
-
(2007)
Diabetes
, vol.56
, pp. 1761-1772
-
-
Cani, P.D.1
Amar, J.2
Iglesias, M.A.3
Poggi, M.4
Knauf, C.5
Bastelica, D.6
Neyrinck, A.M.7
Fava, F.8
Tuohy, K.M.9
Chabo, C.10
-
14
-
-
0347989317
-
Brown adipose tissue: function and physiological significance
-
B. Cannon, and J. Nedergaard Brown adipose tissue: function and physiological significance Physiol. Rev. 84 2004 277 359
-
(2004)
Physiol. Rev.
, vol.84
, pp. 277-359
-
-
Cannon, B.1
Nedergaard, J.2
-
15
-
-
84877292005
-
Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production
-
H. Cao, M. Sekiya, M.E. Ertunc, M.F. Burak, J.R. Mayers, A. White, K. Inouye, L.M. Rickey, B.C. Ercal, and M. Furuhashi et al. Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production Cell Metab. 17 2013 768 778
-
(2013)
Cell Metab.
, vol.17
, pp. 768-778
-
-
Cao, H.1
Sekiya, M.2
Ertunc, M.E.3
Burak, M.F.4
Mayers, J.R.5
White, A.6
Inouye, K.7
Rickey, L.M.8
Ercal, B.C.9
Furuhashi, M.10
-
16
-
-
84871611304
-
Ephedrine activates brown adipose tissue in lean but not obese humans
-
A.L. Carey, M.F. Formosa, B. Van Every, D. Bertovic, N. Eikelis, G.W. Lambert, V. Kalff, S.J. Duffy, M.H. Cherk, and B.A. Kingwell Ephedrine activates brown adipose tissue in lean but not obese humans Diabetologia 56 2013 147 155
-
(2013)
Diabetologia
, vol.56
, pp. 147-155
-
-
Carey, A.L.1
Formosa, M.F.2
Van Every, B.3
Bertovic, D.4
Eikelis, N.5
Lambert, G.W.6
Kalff, V.7
Duffy, S.J.8
Cherk, M.H.9
Kingwell, B.A.10
-
17
-
-
84898651786
-
Reduced UCP-1 content in in vitro differentiated beige/brite adipocytes derived from preadipocytes of human subcutaneous white adipose tissues in obesity
-
A.L. Carey, C. Vorlander, M. Reddy-Luthmoodoo, A.K. Natoli, M.F. Formosa, D.A. Bertovic, M.J. Anderson, S.J. Duffy, and B.A. Kingwell Reduced UCP-1 content in in vitro differentiated beige/brite adipocytes derived from preadipocytes of human subcutaneous white adipose tissues in obesity PLoS ONE 9 2014 e91997
-
(2014)
PLoS ONE
, vol.9
-
-
Carey, A.L.1
Vorlander, C.2
Reddy-Luthmoodoo, M.3
Natoli, A.K.4
Formosa, M.F.5
Bertovic, D.A.6
Anderson, M.J.7
Duffy, S.J.8
Kingwell, B.A.9
-
18
-
-
84907485620
-
Browning of white adipose cells by intermediate metabolites: an adaptive mechanism to alleviate redox pressure
-
A. Carrière, Y. Jeanson, S. Berger-Müller, M. André, V. Chenouard, E. Arnaud, C. Barreau, R. Walther, A. Galinier, and B. Wdziekonski et al. Browning of white adipose cells by intermediate metabolites: an adaptive mechanism to alleviate redox pressure Diabetes 63 2014 3253 3265
-
(2014)
Diabetes
, vol.63
, pp. 3253-3265
-
-
Carrière, A.1
Jeanson, Y.2
Berger-Müller, S.3
André, M.4
Chenouard, V.5
Arnaud, E.6
Barreau, C.7
Walther, R.8
Galinier, A.9
Wdziekonski, B.10
-
19
-
-
84858077267
-
The medical care costs of obesity: an instrumental variables approach
-
J. Cawley, and C. Meyerhoefer The medical care costs of obesity: an instrumental variables approach J. Health Econ. 31 2012 219 230
-
(2012)
J. Health Econ.
, vol.31
, pp. 219-230
-
-
Cawley, J.1
Meyerhoefer, C.2
-
20
-
-
84862338510
-
Regulation of glucose/lipid metabolism and insulin sensitivity by interleukin-4
-
Y.H. Chang, K.T. Ho, S.H. Lu, C.N. Huang, and M.Y. Shiau Regulation of glucose/lipid metabolism and insulin sensitivity by interleukin-4 Int J Obes (Lond) 36 2012 993 998
-
(2012)
Int J Obes (Lond)
, vol.36
, pp. 993-998
-
-
Chang, Y.H.1
Ho, K.T.2
Lu, S.H.3
Huang, C.N.4
Shiau, M.Y.5
-
21
-
-
84919875183
-
An MHC II-dependent activation loop between adipose tissue macrophages and CD4+ T cells controls obesity-induced inflammation
-
K.W. Cho, D.L. Morris, J.L. DelProposto, L. Geletka, B. Zamarron, G. Martinez-Santibanez, K.A. Meyer, K. Singer, R.W. O'Rourke, and C.N. Lumeng An MHC II-dependent activation loop between adipose tissue macrophages and CD4+ T cells controls obesity-induced inflammation Cell Rep. 9 2014 605 617
-
(2014)
Cell Rep.
, vol.9
, pp. 605-617
-
-
Cho, K.W.1
Morris, D.L.2
Delproposto, J.L.3
Geletka, L.4
Zamarron, B.5
Martinez-Santibanez, G.6
Meyer, K.A.7
Singer, K.8
O'Rourke, R.W.9
Lumeng, C.N.10
-
22
-
-
84881029152
-
Chronic adipose tissue inflammation: all immune cells on the stage
-
G. Cildir, S.C. AkIncIlar, and V. Tergaonkar Chronic adipose tissue inflammation: all immune cells on the stage Trends Mol. Med. 19 2013 487 500
-
(2013)
Trends Mol. Med.
, vol.19
, pp. 487-500
-
-
Cildir, G.1
Akincilar, S.C.2
Tergaonkar, V.3
-
23
-
-
84862986986
-
PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells
-
D. Cipolletta, M. Feuerer, A. Li, N. Kamei, J. Lee, S.E. Shoelson, C. Benoist, and D. Mathis PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells Nature 486 2012 549 553
-
(2012)
Nature
, vol.486
, pp. 549-553
-
-
Cipolletta, D.1
Feuerer, M.2
Li, A.3
Kamei, N.4
Lee, J.5
Shoelson, S.E.6
Benoist, C.7
Mathis, D.8
-
24
-
-
84892702771
-
Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch
-
P. Cohen, J.D. Levy, Y. Zhang, A. Frontini, D.P. Kolodin, K.J. Svensson, J.C. Lo, X. Zeng, L. Ye, and M.J. Khandekar et al. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch Cell 156 2014 304 316
-
(2014)
Cell
, vol.156
, pp. 304-316
-
-
Cohen, P.1
Levy, J.D.2
Zhang, Y.3
Frontini, A.4
Kolodin, D.P.5
Svensson, K.J.6
Lo, J.C.7
Zeng, X.8
Ye, L.9
Khandekar, M.J.10
-
25
-
-
77951842594
-
Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction
-
J.M. Curtis, P.A. Grimsrud, W.S. Wright, X. Xu, R.E. Foncea, D.W. Graham, J.R. Brestoff, B.M. Wiczer, O. Ilkayeva, and K. Cianflone et al. Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction Diabetes 59 2010 1132 1142
-
(2010)
Diabetes
, vol.59
, pp. 1132-1142
-
-
Curtis, J.M.1
Grimsrud, P.A.2
Wright, W.S.3
Xu, X.4
Foncea, R.E.5
Graham, D.W.6
Brestoff, J.R.7
Wiczer, B.M.8
Ilkayeva, O.9
Cianflone, K.10
-
26
-
-
84866533507
-
Protein carbonylation and adipocyte mitochondrial function
-
J.M. Curtis, W.S. Hahn, M.D. Stone, J.J. Inda, D.J. Droullard, J.P. Kuzmicic, M.A. Donoghue, E.K. Long, A.G. Armien, and S. Lavandero et al. Protein carbonylation and adipocyte mitochondrial function J. Biol. Chem. 287 2012 32967 32980
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 32967-32980
-
-
Curtis, J.M.1
Hahn, W.S.2
Stone, M.D.3
Inda, J.J.4
Droullard, D.J.5
Kuzmicic, J.P.6
Donoghue, M.A.7
Long, E.K.8
Armien, A.G.9
Lavandero, S.10
-
27
-
-
79551529432
-
Visceral adipose inflammation in obesity is associated with critical alterations in tregulatory cell numbers
-
J. Deiuliis, Z. Shah, N. Shah, B. Needleman, D. Mikami, V. Narula, K. Perry, J. Hazey, T. Kampfrath, and M. Kollengode et al. Visceral adipose inflammation in obesity is associated with critical alterations in tregulatory cell numbers PLoS ONE 6 2011 e16376
-
(2011)
PLoS ONE
, vol.6
-
-
Deiuliis, J.1
Shah, Z.2
Shah, N.3
Needleman, B.4
Mikami, D.5
Narula, V.6
Perry, K.7
Hazey, J.8
Kampfrath, T.9
Kollengode, M.10
-
28
-
-
84875280888
-
Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation
-
T. Deng, C.J. Lyon, L.J. Minze, J. Lin, J. Zou, J.Z. Liu, Y. Ren, Z. Yin, D.J. Hamilton, and P.R. Reardon et al. Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation Cell Metab. 17 2013 411 422
-
(2013)
Cell Metab.
, vol.17
, pp. 411-422
-
-
Deng, T.1
Lyon, C.J.2
Minze, L.J.3
Lin, J.4
Zou, J.5
Liu, J.Z.6
Ren, Y.7
Yin, Z.8
Hamilton, D.J.9
Reardon, P.R.10
-
29
-
-
84915803968
-
Interplay between the immune system and adipose tissue in obesity
-
M.A. Exley, L. Hand, D. O'Shea, and L. Lynch Interplay between the immune system and adipose tissue in obesity J. Endocrinol. 223 2014 R41 R48
-
(2014)
J. Endocrinol.
, vol.223
, pp. R41-R48
-
-
Exley, M.A.1
Hand, L.2
O'Shea, D.3
Lynch, L.4
-
30
-
-
84867564026
-
Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria
-
A. Fedorenko, P.V. Lishko, and Y. Kirichok Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria Cell 151 2012 400 413
-
(2012)
Cell
, vol.151
, pp. 400-413
-
-
Fedorenko, A.1
Lishko, P.V.2
Kirichok, Y.3
-
31
-
-
58749091645
-
UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
-
H.M. Feldmann, V. Golozoubova, B. Cannon, and J. Nedergaard UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality Cell Metab. 9 2009 203 209
-
(2009)
Cell Metab.
, vol.9
, pp. 203-209
-
-
Feldmann, H.M.1
Golozoubova, V.2
Cannon, B.3
Nedergaard, J.4
-
32
-
-
68349148211
-
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
-
M. Feuerer, L. Herrero, D. Cipolletta, A. Naaz, J. Wong, A. Nayer, J. Lee, A.B. Goldfine, C. Benoist, S. Shoelson, and D. Mathis Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters Nat. Med. 15 2009 930 939
-
(2009)
Nat. Med.
, vol.15
, pp. 930-939
-
-
Feuerer, M.1
Herrero, L.2
Cipolletta, D.3
Naaz, A.4
Wong, J.5
Nayer, A.6
Lee, J.7
Goldfine, A.B.8
Benoist, C.9
Shoelson, S.10
Mathis, D.11
-
33
-
-
70349207410
-
Annual medical spending attributable to obesity: payer-and service-specific estimates
-
E.A. Finkelstein, J.G. Trogdon, J.W. Cohen, and W. Dietz Annual medical spending attributable to obesity: payer-and service-specific estimates Health Aff. (Millwood) 28 2009 w822 w831
-
(2009)
Health Aff. (Millwood)
, vol.28
, pp. w822-w831
-
-
Finkelstein, E.A.1
Trogdon, J.G.2
Cohen, J.W.3
Dietz, W.4
-
34
-
-
84863012022
-
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
-
F.M. Fisher, S. Kleiner, N. Douris, E.C. Fox, R.J. Mepani, F. Verdeguer, J. Wu, A. Kharitonenkov, J.S. Flier, E. Maratos-Flier, and B.M. Spiegelman FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis Genes Dev. 26 2012 271 281
-
(2012)
Genes Dev.
, vol.26
, pp. 271-281
-
-
Fisher, F.M.1
Kleiner, S.2
Douris, N.3
Fox, E.C.4
Mepani, R.J.5
Verdeguer, F.6
Wu, J.7
Kharitonenkov, A.8
Flier, J.S.9
Maratos-Flier, E.10
Spiegelman, B.M.11
-
35
-
-
84856487711
-
Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010
-
K.M. Flegal, M.D. Carroll, B.K. Kit, and C.L. Ogden Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010 JAMA 307 2012 491 497
-
(2012)
JAMA
, vol.307
, pp. 491-497
-
-
Flegal, K.M.1
Carroll, M.D.2
Kit, B.K.3
Ogden, C.L.4
-
36
-
-
84871784819
-
Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis
-
K.M. Flegal, B.K. Kit, H. Orpana, and B.I. Graubard Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis JAMA 309 2013 71 82
-
(2013)
JAMA
, vol.309
, pp. 71-82
-
-
Flegal, K.M.1
Kit, B.K.2
Orpana, H.3
Graubard, B.I.4
-
37
-
-
33845421680
-
Sympathetic but not sensory denervation stimulates white adipocyte proliferation
-
M.T. Foster, and T.J. Bartness Sympathetic but not sensory denervation stimulates white adipocyte proliferation Am. J. Physiol. Regul. Integr. Comp. Physiol. 291 2006 R1630 R1637
-
(2006)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.291
, pp. R1630-R1637
-
-
Foster, M.T.1
Bartness, T.J.2
-
38
-
-
77951602823
-
Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells
-
C.K. Glass, and K. Saijo Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells Nat. Rev. Immunol. 10 2010 365 376
-
(2010)
Nat. Rev. Immunol.
, vol.10
, pp. 365-376
-
-
Glass, C.K.1
Saijo, K.2
-
39
-
-
84920052826
-
Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors
-
T. Gnad, S. Scheibler, I. von Kügelgen, C. Scheele, A. Kilić, A. Glöde, L.S. Hoffmann, L. Reverte-Salisa, P. Horn, and S. Mutlu et al. Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors Nature 516 2014 395 399
-
(2014)
Nature
, vol.516
, pp. 395-399
-
-
Gnad, T.1
Scheibler, S.2
Von Kügelgen, I.3
Scheele, C.4
Kilić, A.5
Glöde, A.6
Hoffmann, L.S.7
Reverte-Salisa, L.8
Horn, P.9
Mutlu, S.10
-
40
-
-
77953268611
-
Alternative activation of macrophages: mechanism and functions
-
S. Gordon, and F.O. Martinez Alternative activation of macrophages: mechanism and functions Immunity 32 2010 593 604
-
(2010)
Immunity
, vol.32
, pp. 593-604
-
-
Gordon, S.1
Martinez, F.O.2
-
41
-
-
33745095399
-
Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects
-
T.E. Graham, Q. Yang, M. Blüher, A. Hammarstedt, T.P. Ciaraldi, R.R. Henry, C.J. Wason, A. Oberbach, P.A. Jansson, U. Smith, and B.B. Kahn Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects N. Engl. J. Med. 354 2006 2552 2563
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 2552-2563
-
-
Graham, T.E.1
Yang, Q.2
Blüher, M.3
Hammarstedt, A.4
Ciaraldi, T.P.5
Henry, R.R.6
Wason, C.J.7
Oberbach, A.8
Jansson, P.A.9
Smith, U.10
Kahn, B.B.11
-
42
-
-
33644856005
-
Obesity and the role of adipose tissue in inflammation and metabolism
-
A.S. Greenberg, and M.S. Obin Obesity and the role of adipose tissue in inflammation and metabolism Am. J. Clin. Nutr. 83 2006 461S 465S
-
(2006)
Am. J. Clin. Nutr.
, vol.83
, pp. 461S-465S
-
-
Greenberg, A.S.1
Obin, M.S.2
-
44
-
-
84888346690
-
Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice
-
E. Hams, R.M. Locksley, A.N. McKenzie, and P.G. Fallon Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice J. Immunol. 191 2013 5349 5353
-
(2013)
J. Immunol.
, vol.191
, pp. 5349-5353
-
-
Hams, E.1
Locksley, R.M.2
McKenzie, A.N.3
Fallon, P.G.4
-
45
-
-
84872142459
-
JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation
-
M.S. Han, D.Y. Jung, C. Morel, S.A. Lakhani, J.K. Kim, R.A. Flavell, and R.J. Davis JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation Science 339 2013 218 222
-
(2013)
Science
, vol.339
, pp. 218-222
-
-
Han, M.S.1
Jung, D.Y.2
Morel, C.3
Lakhani, S.A.4
Kim, J.K.5
Flavell, R.A.6
Davis, R.J.7
-
46
-
-
84887431711
-
Brown and beige fat: development, function and therapeutic potential
-
M. Harms, and P. Seale Brown and beige fat: development, function and therapeutic potential Nat. Med. 19 2013 1252 1263
-
(2013)
Nat. Med.
, vol.19
, pp. 1252-1263
-
-
Harms, M.1
Seale, P.2
-
47
-
-
0035502460
-
The biology of white adipocyte proliferation
-
D.B. Hausman, M. DiGirolamo, T.J. Bartness, G.J. Hausman, and R.J. Martin The biology of white adipocyte proliferation Obes. Rev. 2 2001 239 254
-
(2001)
Obes. Rev.
, vol.2
, pp. 239-254
-
-
Hausman, D.B.1
DiGirolamo, M.2
Bartness, T.J.3
Hausman, G.J.4
Martin, R.J.5
-
48
-
-
84911164076
-
A decade of progress in adipose tissue macrophage biology
-
A.A. Hill, W. Reid Bolus, and A.H. Hasty A decade of progress in adipose tissue macrophage biology Immunol. Rev. 262 2014 134 152
-
(2014)
Immunol. Rev.
, vol.262
, pp. 134-152
-
-
Hill, A.A.1
Reid Bolus, W.2
Hasty, A.H.3
-
49
-
-
84894058844
-
Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue
-
E. Hondares, J.M. Gallego-Escuredo, P. Flachs, A. Frontini, R. Cereijo, A. Goday, J. Perugini, P. Kopecky, M. Giralt, and S. Cinti et al. Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue Metabolism 63 2014 312 317
-
(2014)
Metabolism
, vol.63
, pp. 312-317
-
-
Hondares, E.1
Gallego-Escuredo, J.M.2
Flachs, P.3
Frontini, A.4
Cereijo, R.5
Goday, A.6
Perugini, J.7
Kopecky, P.8
Giralt, M.9
Cinti, S.10
-
50
-
-
56749164791
-
Nutrient sensing and inflammation in metabolic diseases
-
G.S. Hotamisligil, and E. Erbay Nutrient sensing and inflammation in metabolic diseases Nat. Rev. Immunol. 8 2008 923 934
-
(2008)
Nat. Rev. Immunol.
, vol.8
, pp. 923-934
-
-
Hotamisligil, G.S.1
Erbay, E.2
-
51
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
-
G.S. Hotamisligil, N.S. Shargill, and B.M. Spiegelman Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance Science 259 1993 87 91
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
52
-
-
0028931724
-
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
-
G.S. Hotamisligil, P. Arner, J.F. Caro, R.L. Atkinson, and B.M. Spiegelman Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance J. Clin. Invest. 95 1995 2409 2415
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 2409-2415
-
-
Hotamisligil, G.S.1
Arner, P.2
Caro, J.F.3
Atkinson, R.L.4
Spiegelman, B.M.5
-
53
-
-
84871871453
-
A novel function of adipocytes in lipid antigen presentation to iNKT cells
-
J.Y. Huh, J.I. Kim, Y.J. Park, I.J. Hwang, Y.S. Lee, J.H. Sohn, S.K. Lee, A.A. Alfadda, S.S. Kim, and S.H. Choi et al. A novel function of adipocytes in lipid antigen presentation to iNKT cells Mol. Cell. Biol. 33 2013 328 339
-
(2013)
Mol. Cell. Biol.
, vol.33
, pp. 328-339
-
-
Huh, J.Y.1
Kim, J.I.2
Park, Y.J.3
Hwang, I.J.4
Lee, Y.S.5
Sohn, J.H.6
Lee, S.K.7
Alfadda, A.A.8
Kim, S.S.9
Choi, S.H.10
-
54
-
-
74049159942
-
Subcutaneous and visceral adipose tissue: structural and functional differences
-
M.M. Ibrahim Subcutaneous and visceral adipose tissue: structural and functional differences Obes. Rev. 11 2010 11 18
-
(2010)
Obes. Rev.
, vol.11
, pp. 11-18
-
-
Ibrahim, M.M.1
-
55
-
-
77953110535
-
Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice
-
Y. Ilan, R. Maron, A.M. Tukpah, T.U. Maioli, G. Murugaiyan, K. Yang, H.Y. Wu, and H.L. Weiner Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice Proc. Natl. Acad. Sci. USA 107 2010 9765 9770
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 9765-9770
-
-
Ilan, Y.1
Maron, R.2
Tukpah, A.M.3
Maioli, T.U.4
Murugaiyan, G.5
Yang, K.6
Wu, H.Y.7
Weiner, H.L.8
-
56
-
-
84905394061
-
FGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and Diseases
-
N. Itoh FGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and Diseases Front. Endocrinol. (Lausanne) 5 2014 107
-
(2014)
Front. Endocrinol. (Lausanne)
, vol.5
, pp. 107
-
-
Itoh, N.1
-
57
-
-
84878812591
-
Innate immune receptors: key regulators of metabolic disease progression
-
C. Jin, J. Henao-Mejia, and R.A. Flavell Innate immune receptors: key regulators of metabolic disease progression Cell Metab. 17 2013 873 882
-
(2013)
Cell Metab.
, vol.17
, pp. 873-882
-
-
Jin, C.1
Henao-Mejia, J.2
Flavell, R.A.3
-
58
-
-
84898638844
-
Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease
-
U.J. Jung, and M.S. Choi Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease Int. J. Mol. Sci. 15 2014 6184 6223
-
(2014)
Int. J. Mol. Sci.
, vol.15
, pp. 6184-6223
-
-
Jung, U.J.1
Choi, M.S.2
-
59
-
-
33745834319
-
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
-
T. Kadowaki, T. Yamauchi, N. Kubota, K. Hara, K. Ueki, and K. Tobe Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome J. Clin. Invest. 116 2006 1784 1792
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1784-1792
-
-
Kadowaki, T.1
Yamauchi, T.2
Kubota, N.3
Hara, K.4
Ueki, K.5
Tobe, K.6
-
60
-
-
84908148732
-
The identification of the endogenous ligands of natural killer T cells reveals the presence of mammalian α-linked glycosylceramides
-
L. Kain, B. Webb, B.L. Anderson, S. Deng, M. Holt, A. Costanzo, M. Zhao, K. Self, A. Teyton, and C. Everett et al. The identification of the endogenous ligands of natural killer T cells reveals the presence of mammalian α-linked glycosylceramides Immunity 41 2014 543 554
-
(2014)
Immunity
, vol.41
, pp. 543-554
-
-
Kain, L.1
Webb, B.2
Anderson, B.L.3
Deng, S.4
Holt, M.5
Costanzo, A.6
Zhao, M.7
Self, K.8
Teyton, A.9
Everett, C.10
-
61
-
-
69349088117
-
Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex
-
S. Kajimura, P. Seale, K. Kubota, E. Lunsford, J.V. Frangioni, S.P. Gygi, and B.M. Spiegelman Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex Nature 460 2009 1154 1158
-
(2009)
Nature
, vol.460
, pp. 1154-1158
-
-
Kajimura, S.1
Seale, P.2
Kubota, K.3
Lunsford, E.4
Frangioni, J.V.5
Gygi, S.P.6
Spiegelman, B.M.7
-
62
-
-
51849146897
-
Global burden of obesity in 2005 and projections to 2030
-
T. Kelly, W. Yang, C.S. Chen, K. Reynolds, and J. He Global burden of obesity in 2005 and projections to 2030 Int J Obes (Lond) 32 2008 1431 1437
-
(2008)
Int J Obes (Lond)
, vol.32
, pp. 1431-1437
-
-
Kelly, T.1
Yang, W.2
Chen, C.S.3
Reynolds, K.4
He, J.5
-
63
-
-
0028968879
-
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
-
P.A. Kern, M. Saghizadeh, J.M. Ong, R.J. Bosch, R. Deem, and R.B. Simsolo The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase J. Clin. Invest. 95 1995 2111 2119
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 2111-2119
-
-
Kern, P.A.1
Saghizadeh, M.2
Ong, J.M.3
Bosch, R.J.4
Deem, R.5
Simsolo, R.B.6
-
65
-
-
84922507921
-
Innate Lymphoid Cells in the Skin
-
B.S. Kim Innate Lymphoid Cells in the Skin J. Invest. Dermatol. 135 2015 673 678
-
(2015)
J. Invest. Dermatol.
, vol.135
, pp. 673-678
-
-
Kim, B.S.1
-
66
-
-
84907195502
-
Basophils promote innate lymphoid cell responses in inflamed skin
-
B.S. Kim, K. Wang, M.C. Siracusa, S.A. Saenz, J.R. Brestoff, L.A. Monticelli, M. Noti, E.D. Tait Wojno, T.C. Fung, M. Kubo, and D. Artis Basophils promote innate lymphoid cell responses in inflamed skin J. Immunol. 193 2014 3717 3725
-
(2014)
J. Immunol.
, vol.193
, pp. 3717-3725
-
-
Kim, B.S.1
Wang, K.2
Siracusa, M.C.3
Saenz, S.A.4
Brestoff, J.R.5
Monticelli, L.A.6
Noti, M.7
Tait Wojno, E.D.8
Fung, T.C.9
Kubo, M.10
Artis, D.11
-
68
-
-
0033212964
-
PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
-
N. Kubota, Y. Terauchi, H. Miki, H. Tamemoto, T. Yamauchi, K. Komeda, S. Satoh, R. Nakano, C. Ishii, and T. Sugiyama et al. PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance Mol. Cell 4 1999 597 609
-
(1999)
Mol. Cell
, vol.4
, pp. 597-609
-
-
Kubota, N.1
Terauchi, Y.2
Miki, H.3
Tamemoto, H.4
Yamauchi, T.5
Komeda, K.6
Satoh, S.7
Nakano, R.8
Ishii, C.9
Sugiyama, T.10
-
69
-
-
34247170807
-
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
-
C.M. Larsen, M. Faulenbach, A. Vaag, A. Volund, J.A. Ehses, B. Seifert, T. Mandrup-Poulsen, and M.Y. Donath Interleukin-1-receptor antagonist in type 2 diabetes mellitus N. Engl. J. Med. 356 2007 1517 1526
-
(2007)
N. Engl. J. Med.
, vol.356
, pp. 1517-1526
-
-
Larsen, C.M.1
Faulenbach, M.2
Vaag, A.3
Volund, A.4
Ehses, J.A.5
Seifert, B.6
Mandrup-Poulsen, T.7
Donath, M.Y.8
-
70
-
-
36048981001
-
Resistin- and Obesity-associated metabolic diseases
-
M.A. Lazar Resistin- and Obesity-associated metabolic diseases Horm. Metab. Res. 39 2007 710 716
-
(2007)
Horm. Metab. Res.
, vol.39
, pp. 710-716
-
-
Lazar, M.A.1
-
71
-
-
84896710569
-
Functional thermogenic beige adipogenesis is inducible in human neck fat
-
P. Lee, C.D. Werner, E. Kebebew, and F.S. Celi Functional thermogenic beige adipogenesis is inducible in human neck fat Int J Obes (Lond) 38 2014 170 176
-
(2014)
Int J Obes (Lond)
, vol.38
, pp. 170-176
-
-
Lee, P.1
Werner, C.D.2
Kebebew, E.3
Celi, F.S.4
-
72
-
-
84902075318
-
Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity
-
Y.S. Lee, J.W. Kim, O. Osborne, Y. Oh, R. Sasik, S. Schenk, A. Chen, H. Chung, A. Murphy, and S.M. Watkins et al. Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity Cell 157 2014 1339 1352
-
(2014)
Cell
, vol.157
, pp. 1339-1352
-
-
Lee, Y.S.1
Kim, J.W.2
Osborne, O.3
Oh, Y.4
Sasik, R.5
Schenk, S.6
Chen, A.7
Chung, H.8
Murphy, A.9
Watkins, S.M.10
-
73
-
-
84920940721
-
Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis
-
M. Lee, J.I. Odegaard, L. Mukundan, Y. Qiu, A.B. Molofsky, J.C. Nussbaum, K. Yun, R.M. Locksley, and A. Chawla Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis Cell 160 2015 74 87
-
(2015)
Cell
, vol.160
, pp. 74-87
-
-
Lee, M.1
Odegaard, J.I.2
Mukundan, L.3
Qiu, Y.4
Molofsky, A.B.5
Nussbaum, J.C.6
Yun, K.7
Locksley, R.M.8
Chawla, A.9
-
74
-
-
84911934883
-
Reducing RIP140 expression in macrophage alters ATM infiltration, facilitates white adipose tissue browning, and prevents high-fat diet-induced insulin resistance
-
P.S. Liu, Y.W. Lin, B. Lee, S.K. McCrady-Spitzer, J.A. Levine, and L.N. Wei Reducing RIP140 expression in macrophage alters ATM infiltration, facilitates white adipose tissue browning, and prevents high-fat diet-induced insulin resistance Diabetes 63 2014 4021 4031
-
(2014)
Diabetes
, vol.63
, pp. 4021-4031
-
-
Liu, P.S.1
Lin, Y.W.2
Lee, B.3
McCrady-Spitzer, S.K.4
Levine, J.A.5
Wei, L.N.6
-
75
-
-
84900325394
-
A smooth muscle-like origin for beige adipocytes
-
J.Z. Long, K.J. Svensson, L. Tsai, X. Zeng, H.C. Roh, X. Kong, R.R. Rao, J. Lou, I. Lokurkar, and W. Baur et al. A smooth muscle-like origin for beige adipocytes Cell Metab. 19 2014 810 820
-
(2014)
Cell Metab.
, vol.19
, pp. 810-820
-
-
Long, J.Z.1
Svensson, K.J.2
Tsai, L.3
Zeng, X.4
Roh, H.C.5
Kong, X.6
Rao, R.R.7
Lou, J.8
Lokurkar, I.9
Baur, W.10
-
76
-
-
79957920754
-
Inflammatory links between obesity and metabolic disease
-
C.N. Lumeng, and A.R. Saltiel Inflammatory links between obesity and metabolic disease J. Clin. Invest. 121 2011 2111 2117
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 2111-2117
-
-
Lumeng, C.N.1
Saltiel, A.R.2
-
77
-
-
33846026712
-
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
-
C.N. Lumeng, J.L. Bodzin, and A.R. Saltiel Obesity induces a phenotypic switch in adipose tissue macrophage polarization J. Clin. Invest. 117 2007 175 184
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 175-184
-
-
Lumeng, C.N.1
Bodzin, J.L.2
Saltiel, A.R.3
-
78
-
-
84866520055
-
Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production
-
L. Lynch, M. Nowak, B. Varghese, J. Clark, A.E. Hogan, V. Toxavidis, S.P. Balk, D. O'Shea, C. O'Farrelly, and M.A. Exley Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production Immunity 37 2012 574 587
-
(2012)
Immunity
, vol.37
, pp. 574-587
-
-
Lynch, L.1
Nowak, M.2
Varghese, B.3
Clark, J.4
Hogan, A.E.5
Toxavidis, V.6
Balk, S.P.7
O'Shea, D.8
O'Farrelly, C.9
Exley, M.A.10
-
79
-
-
84923384136
-
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T cells and macrophages in adipose tissue
-
L. Lynch, X. Michelet, S. Zhang, P.J. Brennan, A. Moseman, C. Lester, G. Besra, E.E. Vomhof-Dekrey, M. Tighe, and H.F. Koay et al. Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T cells and macrophages in adipose tissue Nat. Immunol. 16 2015 85 95
-
(2015)
Nat. Immunol.
, vol.16
, pp. 85-95
-
-
Lynch, L.1
Michelet, X.2
Zhang, S.3
Brennan, P.J.4
Moseman, A.5
Lester, C.6
Besra, G.7
Vomhof-Dekrey, E.E.8
Tighe, M.9
Koay, H.F.10
-
80
-
-
77955333533
-
UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity
-
L. Madsen, L.M. Pedersen, H.H. Lillefosse, E. Fjaere, I. Bronstad, Q. Hao, R.K. Petersen, P. Hallenborg, T. Ma, and R. De Matteis et al. UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity PLoS ONE 5 2010 e11391
-
(2010)
PLoS ONE
, vol.5
-
-
Madsen, L.1
Pedersen, L.M.2
Lillefosse, H.H.3
Fjaere, E.4
Bronstad, I.5
Hao, Q.6
Petersen, R.K.7
Hallenborg, P.8
Ma, T.9
De Matteis, R.10
-
81
-
-
67650485985
-
Alternative activation of macrophages: an immunologic functional perspective
-
F.O. Martinez, L. Helming, and S. Gordon Alternative activation of macrophages: an immunologic functional perspective Annu. Rev. Immunol. 27 2009 451 483
-
(2009)
Annu. Rev. Immunol.
, vol.27
, pp. 451-483
-
-
Martinez, F.O.1
Helming, L.2
Gordon, S.3
-
82
-
-
0034682795
-
Thermogenic responses in brown fat cells are fully UCP1-dependent. UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty scid-induced thermogenesis
-
A. Matthias, K.B. Ohlson, J.M. Fredriksson, A. Jacobsson, J. Nedergaard, and B. Cannon Thermogenic responses in brown fat cells are fully UCP1-dependent. UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty scid-induced thermogenesis J. Biol. Chem. 275 2000 25073 25081
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 25073-25081
-
-
Matthias, A.1
Ohlson, K.B.2
Fredriksson, J.M.3
Jacobsson, A.4
Nedergaard, J.5
Cannon, B.6
-
83
-
-
78649842241
-
Genomics, type 2 diabetes, and obesity
-
M.I. McCarthy Genomics, type 2 diabetes, and obesity N. Engl. J. Med. 363 2010 2339 2350
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 2339-2350
-
-
McCarthy, M.I.1
-
84
-
-
84904392112
-
Macrophages, immunity, and metabolic disease
-
J.C. McNelis, and J.M. Olefsky Macrophages, immunity, and metabolic disease Immunity 41 2014 36 48
-
(2014)
Immunity
, vol.41
, pp. 36-48
-
-
McNelis, J.C.1
Olefsky, J.M.2
-
85
-
-
77957043879
-
Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice
-
A.M. Miller, D.L. Asquith, A.J. Hueber, L.A. Anderson, W.M. Holmes, A.N. McKenzie, D. Xu, N. Sattar, I.B. McInnes, and F.Y. Liew Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice Circ. Res. 107 2010 650 658
-
(2010)
Circ. Res.
, vol.107
, pp. 650-658
-
-
Miller, A.M.1
Asquith, D.L.2
Hueber, A.J.3
Anderson, L.A.4
Holmes, W.M.5
McKenzie, A.N.6
Xu, D.7
Sattar, N.8
McInnes, I.B.9
Liew, F.Y.10
-
86
-
-
84925857018
-
White-to-brown metabolic conversion of human adipocytes by JAK inhibition
-
A. Moisan, Y.K. Lee, J.D. Zhang, C.S. Hudak, C.A. Meyer, M. Prummer, S. Zoffmann, H.H. Truong, M. Ebeling, and A. Kiialainen et al. White-to-brown metabolic conversion of human adipocytes by JAK inhibition Nat. Cell Biol. 17 2015 57 67
-
(2015)
Nat. Cell Biol.
, vol.17
, pp. 57-67
-
-
Moisan, A.1
Lee, Y.K.2
Zhang, J.D.3
Hudak, C.S.4
Meyer, C.A.5
Prummer, M.6
Zoffmann, S.7
Truong, H.H.8
Ebeling, M.9
Kiialainen, A.10
-
87
-
-
84876746655
-
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages
-
A.B. Molofsky, J.C. Nussbaum, H.E. Liang, S.J. Van Dyken, L.E. Cheng, A. Mohapatra, A. Chawla, and R.M. Locksley Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages J. Exp. Med. 210 2013 535 549
-
(2013)
J. Exp. Med.
, vol.210
, pp. 535-549
-
-
Molofsky, A.B.1
Nussbaum, J.C.2
Liang, H.E.3
Van Dyken, S.J.4
Cheng, L.E.5
Mohapatra, A.6
Chawla, A.7
Locksley, R.M.8
-
88
-
-
85027948313
-
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
-
L.A. Monticelli, G.F. Sonnenberg, M.C. Abt, T. Alenghat, C.G. Ziegler, T.A. Doering, J.M. Angelosanto, B.J. Laidlaw, C.Y. Yang, and T. Sathaliyawala et al. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus Nat. Immunol. 12 2011 1045 1054
-
(2011)
Nat. Immunol.
, vol.12
, pp. 1045-1054
-
-
Monticelli, L.A.1
Sonnenberg, G.F.2
Abt, M.C.3
Alenghat, T.4
Ziegler, C.G.5
Doering, T.A.6
Angelosanto, J.M.7
Laidlaw, B.J.8
Yang, C.Y.9
Sathaliyawala, T.10
-
89
-
-
84862688241
-
Innate lymphoid cells: critical regulators of allergic inflammation and tissue repair in the lung
-
L.A. Monticelli, G.F. Sonnenberg, and D. Artis Innate lymphoid cells: critical regulators of allergic inflammation and tissue repair in the lung Curr. Opin. Immunol. 24 2012 284 289
-
(2012)
Curr. Opin. Immunol.
, vol.24
, pp. 284-289
-
-
Monticelli, L.A.1
Sonnenberg, G.F.2
Artis, D.3
-
90
-
-
84895741552
-
RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance
-
P.M. Moraes-Vieira, M.M. Yore, P.M. Dwyer, I. Syed, P. Aryal, and B.B. Kahn RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance Cell Metab. 19 2014 512 526
-
(2014)
Cell Metab.
, vol.19
, pp. 512-526
-
-
Moraes-Vieira, P.M.1
Yore, M.M.2
Dwyer, P.M.3
Syed, I.4
Aryal, P.5
Kahn, B.B.6
-
91
-
-
75749122181
-
Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
-
K. Moro, T. Yamada, M. Tanabe, T. Takeuchi, T. Ikawa, H. Kawamoto, J. Furusawa, M. Ohtani, H. Fujii, and S. Koyasu Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells Nature 463 2010 540 544
-
(2010)
Nature
, vol.463
, pp. 540-544
-
-
Moro, K.1
Yamada, T.2
Tanabe, M.3
Takeuchi, T.4
Ikawa, T.5
Kawamoto, H.6
Furusawa, J.7
Ohtani, M.8
Fujii, H.9
Koyasu, S.10
-
92
-
-
84878800136
-
Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice
-
D.L. Morris, K.W. Cho, J.L. Delproposto, K.E. Oatmen, L.M. Geletka, G. Martinez-Santibanez, K. Singer, and C.N. Lumeng Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice Diabetes 62 2013 2762 2772
-
(2013)
Diabetes
, vol.62
, pp. 2762-2772
-
-
Morris, D.L.1
Cho, K.W.2
Delproposto, J.L.3
Oatmen, K.E.4
Geletka, L.M.5
Martinez-Santibanez, G.6
Singer, K.7
Lumeng, C.N.8
-
93
-
-
84907321291
-
The role of adipose tissue immune cells in obesity and low-grade inflammation
-
M. Mraz, and M. Haluzik The role of adipose tissue immune cells in obesity and low-grade inflammation J. Endocrinol. 222 2014 R113 R127
-
(2014)
J. Endocrinol.
, vol.222
, pp. R113-R127
-
-
Mraz, M.1
Haluzik, M.2
-
94
-
-
33746377553
-
Obesity-related derangements in metabolic regulation
-
D.M. Muoio, and C.B. Newgard Obesity-related derangements in metabolic regulation Annu. Rev. Biochem. 75 2006 367 401
-
(2006)
Annu. Rev. Biochem.
, vol.75
, pp. 367-401
-
-
Muoio, D.M.1
Newgard, C.B.2
-
95
-
-
50949108719
-
Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice
-
I. Murano, G. Barbatelli, V. Parisani, C. Latini, G. Muzzonigro, M. Castellucci, and S. Cinti Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice J. Lipid Res. 49 2008 1562 1568
-
(2008)
J. Lipid Res.
, vol.49
, pp. 1562-1568
-
-
Murano, I.1
Barbatelli, G.2
Parisani, V.3
Latini, C.4
Muzzonigro, G.5
Castellucci, M.6
Cinti, S.7
-
96
-
-
77951817855
-
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
-
D.R. Neill, S.H. Wong, A. Bellosi, R.J. Flynn, M. Daly, T.K. Langford, C. Bucks, C.M. Kane, P.G. Fallon, and R. Pannell et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity Nature 464 2010 1367 1370
-
(2010)
Nature
, vol.464
, pp. 1367-1370
-
-
Neill, D.R.1
Wong, S.H.2
Bellosi, A.3
Flynn, R.J.4
Daly, M.5
Langford, T.K.6
Bucks, C.7
Kane, C.M.8
Fallon, P.G.9
Pannell, R.10
-
97
-
-
0019797494
-
The lipolytic activity of met-enkephalin, leu-enkephalin, morphine, methadone and naloxone in human adipose tissue
-
P. Nencini, and E. Paroli The lipolytic activity of met-enkephalin, leu-enkephalin, morphine, methadone and naloxone in human adipose tissue Pharmacol. Res. Commun. 13 1981 535 540
-
(1981)
Pharmacol. Res. Commun.
, vol.13
, pp. 535-540
-
-
Nencini, P.1
Paroli, E.2
-
98
-
-
84906882822
-
Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013
-
M. Ng, T. Fleming, M. Robinson, B. Thomson, N. Graetz, C. Margono, E.C. Mullany, S. Biryukov, C. Abbafati, and S.F. Abera et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013 Lancet 384 2014 766 781
-
(2014)
Lancet
, vol.384
, pp. 766-781
-
-
Ng, M.1
Fleming, T.2
Robinson, M.3
Thomson, B.4
Graetz, N.5
Margono, C.6
Mullany, E.C.7
Biryukov, S.8
Abbafati, C.9
Abera, S.F.10
-
99
-
-
36849005372
-
A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways
-
M.T. Nguyen, S. Favelyukis, A.K. Nguyen, D. Reichart, P.A. Scott, A. Jenn, R. Liu-Bryan, C.K. Glass, J.G. Neels, and J.M. Olefsky A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways J. Biol. Chem. 282 2007 35279 35292
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 35279-35292
-
-
Nguyen, M.T.1
Favelyukis, S.2
Nguyen, A.K.3
Reichart, D.4
Scott, P.A.5
Jenn, A.6
Liu-Bryan, R.7
Glass, C.K.8
Neels, J.G.9
Olefsky, J.M.10
-
100
-
-
82555186955
-
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
-
K.D. Nguyen, Y. Qiu, X. Cui, Y.P. Goh, J. Mwangi, T. David, L. Mukundan, F. Brombacher, R.M. Locksley, and A. Chawla Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis Nature 480 2011 104 108
-
(2011)
Nature
, vol.480
, pp. 104-108
-
-
Nguyen, K.D.1
Qiu, Y.2
Cui, X.3
Goh, Y.P.4
Mwangi, J.5
David, T.6
Mukundan, L.7
Brombacher, F.8
Locksley, R.M.9
Chawla, A.10
-
101
-
-
68349150756
-
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
-
S. Nishimura, I. Manabe, M. Nagasaki, K. Eto, H. Yamashita, M. Ohsugi, M. Otsu, K. Hara, K. Ueki, and S. Sugiura et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity Nat. Med. 15 2009 914 920
-
(2009)
Nat. Med.
, vol.15
, pp. 914-920
-
-
Nishimura, S.1
Manabe, I.2
Nagasaki, M.3
Eto, K.4
Yamashita, H.5
Ohsugi, M.6
Otsu, M.7
Hara, K.8
Ueki, K.9
Sugiura, S.10
-
102
-
-
34948813665
-
Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice
-
T. Nomiyama, D. Perez-Tilve, D. Ogawa, F. Gizard, Y. Zhao, E.B. Heywood, K.L. Jones, R. Kawamori, L.A. Cassis, M.H. Tschöp, and D. Bruemmer Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice J. Clin. Invest. 117 2007 2877 2888
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2877-2888
-
-
Nomiyama, T.1
Perez-Tilve, D.2
Ogawa, D.3
Gizard, F.4
Zhao, Y.5
Heywood, E.B.6
Jones, K.L.7
Kawamori, R.8
Cassis, L.A.9
Tschöp, M.H.10
Bruemmer, D.11
-
103
-
-
84861403641
-
Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism
-
J. Norseen, T. Hosooka, A. Hammarstedt, M.M. Yore, S. Kant, P. Aryal, U.A. Kiernan, D.A. Phillips, H. Maruyama, and B.J. Kraus et al. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism Mol. Cell. Biol. 32 2012 2010 2019
-
(2012)
Mol. Cell. Biol.
, vol.32
, pp. 2010-2019
-
-
Norseen, J.1
Hosooka, T.2
Hammarstedt, A.3
Yore, M.M.4
Kant, S.5
Aryal, P.6
Kiernan, U.A.7
Phillips, D.A.8
Maruyama, H.9
Kraus, B.J.10
-
104
-
-
84885572626
-
Type 2 innate lymphoid cells control eosinophil homeostasis
-
J.C. Nussbaum, S.J. Van Dyken, J. von Moltke, L.E. Cheng, A. Mohapatra, A.B. Molofsky, E.E. Thornton, M.F. Krummel, A. Chawla, H.E. Liang, and R.M. Locksley Type 2 innate lymphoid cells control eosinophil homeostasis Nature 502 2013 245 248
-
(2013)
Nature
, vol.502
, pp. 245-248
-
-
Nussbaum, J.C.1
Van Dyken, S.J.2
Von Moltke, J.3
Cheng, L.E.4
Mohapatra, A.5
Molofsky, A.B.6
Thornton, E.E.7
Krummel, M.F.8
Chawla, A.9
Liang, H.E.10
Locksley, R.M.11
-
105
-
-
79751496064
-
Alternative macrophage activation and metabolism
-
J.I. Odegaard, and A. Chawla Alternative macrophage activation and metabolism Annu. Rev. Pathol. 6 2011 275 297
-
(2011)
Annu. Rev. Pathol.
, vol.6
, pp. 275-297
-
-
Odegaard, J.I.1
Chawla, A.2
-
106
-
-
84876771596
-
The immune system as a sensor of the metabolic state
-
J.I. Odegaard, and A. Chawla The immune system as a sensor of the metabolic state Immunity 38 2013 644 654
-
(2013)
Immunity
, vol.38
, pp. 644-654
-
-
Odegaard, J.I.1
Chawla, A.2
-
107
-
-
84872166765
-
Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis
-
J.I. Odegaard, and A. Chawla Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis Science 339 2013 172 177
-
(2013)
Science
, vol.339
, pp. 172-177
-
-
Odegaard, J.I.1
Chawla, A.2
-
108
-
-
34347354309
-
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
-
J.I. Odegaard, R.R. Ricardo-Gonzalez, M.H. Goforth, C.R. Morel, V. Subramanian, L. Mukundan, A. Red Eagle, D. Vats, F. Brombacher, A.W. Ferrante, and A. Chawla Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance Nature 447 2007 1116 1120
-
(2007)
Nature
, vol.447
, pp. 1116-1120
-
-
Odegaard, J.I.1
Ricardo-Gonzalez, R.R.2
Goforth, M.H.3
Morel, C.R.4
Subramanian, V.5
Mukundan, L.6
Red Eagle, A.7
Vats, D.8
Brombacher, F.9
Ferrante, A.W.10
Chawla, A.11
-
109
-
-
44349161098
-
Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance
-
J.I. Odegaard, R.R. Ricardo-Gonzalez, A. Red Eagle, D. Vats, C.R. Morel, M.H. Goforth, V. Subramanian, L. Mukundan, A.W. Ferrante, and A. Chawla Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance Cell Metab. 7 2008 496 507
-
(2008)
Cell Metab.
, vol.7
, pp. 496-507
-
-
Odegaard, J.I.1
Ricardo-Gonzalez, R.R.2
Red Eagle, A.3
Vats, D.4
Morel, C.R.5
Goforth, M.H.6
Subramanian, V.7
Mukundan, L.8
Ferrante, A.W.9
Chawla, A.10
-
110
-
-
84856433589
-
Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010
-
C.L. Ogden, M.D. Carroll, B.K. Kit, and K.M. Flegal Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010 JAMA 307 2012 483 490
-
(2012)
JAMA
, vol.307
, pp. 483-490
-
-
Ogden, C.L.1
Carroll, M.D.2
Kit, B.K.3
Flegal, K.M.4
-
111
-
-
84896690513
-
Prevalence of childhood and adult obesity in the United States, 2011-2012
-
C.L. Ogden, M.D. Carroll, B.K. Kit, and K.M. Flegal Prevalence of childhood and adult obesity in the United States, 2011-2012 JAMA 311 2014 806 814
-
(2014)
JAMA
, vol.311
, pp. 806-814
-
-
Ogden, C.L.1
Carroll, M.D.2
Kit, B.K.3
Flegal, K.M.4
-
112
-
-
84856533216
-
Increased macrophage migration into adipose tissue in obese mice
-
D.Y. Oh, H. Morinaga, S. Talukdar, E.J. Bae, and J.M. Olefsky Increased macrophage migration into adipose tissue in obese mice Diabetes 61 2012 346 354
-
(2012)
Diabetes
, vol.61
, pp. 346-354
-
-
Oh, D.Y.1
Morinaga, H.2
Talukdar, S.3
Bae, E.J.4
Olefsky, J.M.5
-
113
-
-
77951918926
-
Macrophages, inflammation, and insulin resistance
-
J.M. Olefsky, and C.K. Glass Macrophages, inflammation, and insulin resistance Annu. Rev. Physiol. 72 2010 219 246
-
(2010)
Annu. Rev. Physiol.
, vol.72
, pp. 219-246
-
-
Olefsky, J.M.1
Glass, C.K.2
-
114
-
-
40149100614
-
Obesity and mortality in critically ill adults: a systematic review and meta-analysis
-
H. Oliveros, and E. Villamor Obesity and mortality in critically ill adults: a systematic review and meta-analysis Obesity (Silver Spring) 16 2008 515 521
-
(2008)
Obesity (Silver Spring)
, vol.16
, pp. 515-521
-
-
Oliveros, H.1
Villamor, E.2
-
115
-
-
84893116082
-
Obesity alters adipose tissue macrophage iron content and tissue iron distribution
-
J.S. Orr, A. Kennedy, E.K. Anderson-Baucum, C.D. Webb, S.C. Fordahl, K.M. Erikson, Y. Zhang, A. Etzerodt, S.K. Moestrup, and A.H. Hasty Obesity alters adipose tissue macrophage iron content and tissue iron distribution Diabetes 63 2014 421 432
-
(2014)
Diabetes
, vol.63
, pp. 421-432
-
-
Orr, J.S.1
Kennedy, A.2
Anderson-Baucum, E.K.3
Webb, C.D.4
Fordahl, S.C.5
Erikson, K.M.6
Zhang, Y.7
Etzerodt, A.8
Moestrup, S.K.9
Hasty, A.H.10
-
116
-
-
84857985148
-
The cellular and signaling networks linking the immune system and metabolism in disease
-
O. Osborn, and J.M. Olefsky The cellular and signaling networks linking the immune system and metabolism in disease Nat. Med. 18 2012 363 374
-
(2012)
Nat. Med.
, vol.18
, pp. 363-374
-
-
Osborn, O.1
Olefsky, J.M.2
-
117
-
-
84905902581
-
Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation
-
L.C. Osborne, L.A. Monticelli, T.J. Nice, T.E. Sutherland, M.C. Siracusa, M.R. Hepworth, V.T. Tomov, D. Kobuley, S.V. Tran, and K. Bittinger et al. Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation Science 345 2014 578 582
-
(2014)
Science
, vol.345
, pp. 578-582
-
-
Osborne, L.C.1
Monticelli, L.A.2
Nice, T.J.3
Sutherland, T.E.4
Siracusa, M.C.5
Hepworth, M.R.6
Tomov, V.T.7
Kobuley, D.8
Tran, S.V.9
Bittinger, K.10
-
119
-
-
85028251189
-
Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism
-
H.K. Park, and R.S. Ahima Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism Metabolism 64 2015 24 34
-
(2015)
Metabolism
, vol.64
, pp. 24-34
-
-
Park, H.K.1
Ahima, R.S.2
-
120
-
-
62749167010
-
Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response
-
M. Pasarica, O.R. Sereda, L.M. Redman, D.C. Albarado, D.T. Hymel, L.E. Roan, J.C. Rood, D.H. Burk, and S.R. Smith Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response Diabetes 58 2009 718 725
-
(2009)
Diabetes
, vol.58
, pp. 718-725
-
-
Pasarica, M.1
Sereda, O.R.2
Redman, L.M.3
Albarado, D.C.4
Hymel, D.T.5
Roan, L.E.6
Rood, J.C.7
Burk, D.H.8
Smith, S.R.9
-
122
-
-
84920841451
-
Brown, beige, and white: the new color code of fat and its pharmacological implications
-
A. Pfeifer, and L.S. Hoffmann Brown, beige, and white: the new color code of fat and its pharmacological implications Annu. Rev. Pharmacol. Toxicol. 55 2015 207 227
-
(2015)
Annu. Rev. Pharmacol. Toxicol.
, vol.55
, pp. 207-227
-
-
Pfeifer, A.1
Hoffmann, L.S.2
-
123
-
-
0344541694
-
Comorbidities of overweight and obesity: current evidence and research issues
-
F.X. Pi-Sunyer Comorbidities of overweight and obesity: current evidence and research issues Med. Sci. Sports Exerc. 31 1999 S602 S608
-
(1999)
Med. Sci. Sports Exerc.
, vol.31
, pp. S602-S608
-
-
Pi-Sunyer, F.X.1
-
124
-
-
79951678085
-
Long-term prevention of mortality in morbid obesity through bariatric surgery. a systematic review and meta-analysis of trials performed with gastric banding and gastric bypass
-
A.E. Pontiroli, and A. Morabito Long-term prevention of mortality in morbid obesity through bariatric surgery. a systematic review and meta-analysis of trials performed with gastric banding and gastric bypass Ann. Surg. 253 2011 484 487
-
(2011)
Ann. Surg.
, vol.253
, pp. 484-487
-
-
Pontiroli, A.E.1
Morabito, A.2
-
125
-
-
77954926597
-
Systemically dispersed innate IL-13-expressing cells in type 2 immunity
-
A.E. Price, H.E. Liang, B.M. Sullivan, R.L. Reinhardt, C.J. Eisley, D.J. Erle, and R.M. Locksley Systemically dispersed innate IL-13-expressing cells in type 2 immunity Proc. Natl. Acad. Sci. USA 107 2010 11489 11494
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 11489-11494
-
-
Price, A.E.1
Liang, H.E.2
Sullivan, B.M.3
Reinhardt, R.L.4
Eisley, C.J.5
Erle, D.J.6
Locksley, R.M.7
-
126
-
-
62849107573
-
Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies
-
Prospective Studies Collaboration G. Whitlock, S. Lewington, P. Sherliker, R. Clarke, J. Emberson, J. Halsey, N. Qizilbash, R. Collins, and R. Peto Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies Lancet 373 2009 1083 1096
-
(2009)
Lancet
, vol.373
, pp. 1083-1096
-
-
Whitlock, G.1
Lewington, S.2
Sherliker, P.3
Clarke, R.4
Emberson, J.5
Halsey, J.6
Qizilbash, N.7
Collins, R.8
Peto, R.9
-
127
-
-
84874450879
-
BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis
-
S.W. Qian, Y. Tang, X. Li, Y. Liu, Y.Y. Zhang, H.Y. Huang, R.D. Xue, H.Y. Yu, L. Guo, and H.D. Gao et al. BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis Proc. Natl. Acad. Sci. USA 110 2013 E798 E807
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. E798-E807
-
-
Qian, S.W.1
Tang, Y.2
Li, X.3
Liu, Y.4
Zhang, Y.Y.5
Huang, H.Y.6
Xue, R.D.7
Yu, H.Y.8
Guo, L.9
Gao, H.D.10
-
128
-
-
84902094655
-
Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat
-
Y. Qiu, K.D. Nguyen, J.I. Odegaard, X. Cui, X. Tian, R.M. Locksley, R.D. Palmiter, and A. Chawla Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat Cell 157 2014 1292 1308
-
(2014)
Cell
, vol.157
, pp. 1292-1308
-
-
Qiu, Y.1
Nguyen, K.D.2
Odegaard, J.I.3
Cui, X.4
Tian, X.5
Locksley, R.M.6
Palmiter, R.D.7
Chawla, A.8
-
129
-
-
84905852276
-
CD1d-mediated presentation of endogenous lipid antigens by adipocytes requires microsomal triglyceride transfer protein
-
M. Rakhshandehroo, S.M. Gijzel, R. Siersbæk, M.F. Broekema, C. de Haar, H.S. Schipper, M. Boes, S. Mandrup, and E. Kalkhoven CD1d-mediated presentation of endogenous lipid antigens by adipocytes requires microsomal triglyceride transfer protein J. Biol. Chem. 289 2014 22128 22139
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 22128-22139
-
-
Rakhshandehroo, M.1
Gijzel, S.M.2
Siersbæk, R.3
Broekema, M.F.4
De Haar, C.5
Schipper, H.S.6
Boes, M.7
Mandrup, S.8
Kalkhoven, E.9
-
130
-
-
84902097377
-
Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis
-
R.R. Rao, J.Z. Long, J.P. White, K.J. Svensson, J. Lou, I. Lokurkar, M.P. Jedrychowski, J.L. Ruas, C.D. Wrann, and J.C. Lo et al. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis Cell 157 2014 1279 1291
-
(2014)
Cell
, vol.157
, pp. 1279-1291
-
-
Rao, R.R.1
Long, J.Z.2
White, J.P.3
Svensson, K.J.4
Lou, J.5
Lokurkar, I.6
Jedrychowski, M.P.7
Ruas, J.L.8
Wrann, C.D.9
Lo, J.C.10
-
131
-
-
38149142633
-
Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration
-
M.E. Rausch, S. Weisberg, P. Vardhana, and D.V. Tortoriello Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration Int J Obes (Lond) 32 2008 451 463
-
(2008)
Int J Obes (Lond)
, vol.32
, pp. 451-463
-
-
Rausch, M.E.1
Weisberg, S.2
Vardhana, P.3
Tortoriello, D.V.4
-
132
-
-
84905918361
-
Coinfection. Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter
-
T.A. Reese, B.S. Wakeman, H.S. Choi, M.M. Hufford, S.C. Huang, X. Zhang, M.D. Buck, A. Jezewski, A. Kambal, and C.Y. Liu et al. Coinfection. Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter Science 345 2014 573 577
-
(2014)
Science
, vol.345
, pp. 573-577
-
-
Reese, T.A.1
Wakeman, B.S.2
Choi, H.S.3
Hufford, M.M.4
Huang, S.C.5
Zhang, X.6
Buck, M.D.7
Jezewski, A.8
Kambal, A.9
Liu, C.Y.10
-
133
-
-
79960255886
-
Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review
-
J.J. Reilly, and J. Kelly Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review Int J Obes (Lond) 35 2011 891 898
-
(2011)
Int J Obes (Lond)
, vol.35
, pp. 891-898
-
-
Reilly, J.J.1
Kelly, J.2
-
134
-
-
84920034829
-
Perforin is a Novel Immune Regulator of Obesity Related Insulin Resistance
-
X.S. Revelo, S. Tsai, H. Lei, H. Luck, M. Ghazarian, H. Tsui, S.Y. Shi, S. Schroer, C. Luk, and G.H. Lin et al. Perforin is a Novel Immune Regulator of Obesity Related Insulin Resistance Diabetes 64 2015 90 103
-
(2015)
Diabetes
, vol.64
, pp. 90-103
-
-
Revelo, X.S.1
Tsai, S.2
Lei, H.3
Luck, H.4
Ghazarian, M.5
Tsui, H.6
Shi, S.Y.7
Schroer, S.8
Luk, C.9
Lin, G.H.10
-
135
-
-
78651073627
-
IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity
-
R.R. Ricardo-Gonzalez, A. Red Eagle, J.I. Odegaard, H. Jouihan, C.R. Morel, J.E. Heredia, L. Mukundan, D. Wu, R.M. Locksley, and A. Chawla IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity Proc. Natl. Acad. Sci. USA 107 2010 22617 22622
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 22617-22622
-
-
Ricardo-Gonzalez, R.R.1
Red Eagle, A.2
Odegaard, J.I.3
Jouihan, H.4
Morel, C.R.5
Heredia, J.E.6
Mukundan, L.7
Wu, D.8
Locksley, R.M.9
Chawla, A.10
-
136
-
-
84870619337
-
Effects of interleukin-1β inhibition with canakinumab on hemoglobin A1c, lipids, C-reactive protein, interleukin-6, and fibrinogen: a phase IIb randomized, placebo-controlled trial
-
P.M. Ridker, C.P. Howard, V. Walter, B. Everett, P. Libby, J. Hensen, T. Thuren CANTOS Pilot Investigative Group Effects of interleukin-1β inhibition with canakinumab on hemoglobin A1c, lipids, C-reactive protein, interleukin-6, and fibrinogen: a phase IIb randomized, placebo-controlled trial Circulation 126 2012 2739 2748
-
(2012)
Circulation
, vol.126
, pp. 2739-2748
-
-
Ridker, P.M.1
Howard, C.P.2
Walter, V.3
Everett, B.4
Libby, P.5
Hensen, J.6
Thuren, T.7
-
137
-
-
84891840977
-
β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors
-
L.D. Roberts, P. Boström, J.F. O'Sullivan, R.T. Schinzel, G.D. Lewis, A. Dejam, Y.K. Lee, M.J. Palma, S. Calhoun, and A. Georgiadi et al. β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors Cell Metab. 19 2014 96 108
-
(2014)
Cell Metab.
, vol.19
, pp. 96-108
-
-
Roberts, L.D.1
Boström, P.2
O'Sullivan, J.F.3
Schinzel, R.T.4
Lewis, G.D.5
Dejam, A.6
Lee, Y.K.7
Palma, M.J.8
Calhoun, S.9
Georgiadi, A.10
-
138
-
-
0034899087
-
Body mass index, height, and prostate cancer mortality in two large cohorts of adult men in the United States
-
C. Rodriguez, A.V. Patel, E.E. Calle, E.J. Jacobs, A. Chao, and M.J. Thun Body mass index, height, and prostate cancer mortality in two large cohorts of adult men in the United States Cancer Epidemiol. Biomarkers Prev. 10 2001 345 353
-
(2001)
Cancer Epidemiol. Biomarkers Prev.
, vol.10
, pp. 345-353
-
-
Rodriguez, C.1
Patel, A.V.2
Calle, E.E.3
Jacobs, E.J.4
Chao, A.5
Thun, M.J.6
-
139
-
-
79958266484
-
Role of nuclear receptor corepressor RIP140 in metabolic syndrome
-
M. Rosell, M.C. Jones, and M.G. Parker Role of nuclear receptor corepressor RIP140 in metabolic syndrome Biochim. Biophys. Acta 1812 2011 919 928
-
(2011)
Biochim. Biophys. Acta
, vol.1812
, pp. 919-928
-
-
Rosell, M.1
Jones, M.C.2
Parker, M.G.3
-
140
-
-
84892727198
-
What we talk about when we talk about fat
-
E.D. Rosen, and B.M. Spiegelman What we talk about when we talk about fat Cell 156 2014 20 44
-
(2014)
Cell
, vol.156
, pp. 20-44
-
-
Rosen, E.D.1
Spiegelman, B.M.2
-
143
-
-
67650242165
-
High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity
-
M. Saito, Y. Okamatsu-Ogura, M. Matsushita, K. Watanabe, T. Yoneshiro, J. Nio-Kobayashi, T. Iwanaga, M. Miyagawa, T. Kameya, and K. Nakada et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity Diabetes 58 2009 1526 1531
-
(2009)
Diabetes
, vol.58
, pp. 1526-1531
-
-
Saito, M.1
Okamatsu-Ogura, Y.2
Matsushita, M.3
Watanabe, K.4
Yoneshiro, T.5
Nio-Kobayashi, J.6
Iwanaga, T.7
Miyagawa, M.8
Kameya, T.9
Nakada, K.10
-
145
-
-
84906571227
-
The alarmin IL-33 promotes regulatory T-cell function in the intestine
-
C. Schiering, T. Krausgruber, A. Chomka, A. Fröhlich, K. Adelmann, E.A. Wohlfert, J. Pott, T. Griseri, J. Bollrath, and A.N. Hegazy et al. The alarmin IL-33 promotes regulatory T-cell function in the intestine Nature 513 2014 564 568
-
(2014)
Nature
, vol.513
, pp. 564-568
-
-
Schiering, C.1
Krausgruber, T.2
Chomka, A.3
Fröhlich, A.4
Adelmann, K.5
Wohlfert, E.A.6
Pott, J.7
Griseri, T.8
Bollrath, J.9
Hegazy, A.N.10
-
146
-
-
0842266786
-
Interferon-gamma: an overview of signals, mechanisms and functions
-
K. Schroder, P.J. Hertzog, T. Ravasi, and D.A. Hume Interferon-gamma: an overview of signals, mechanisms and functions J. Leukoc. Biol. 75 2004 163 189
-
(2004)
J. Leukoc. Biol.
, vol.75
, pp. 163-189
-
-
Schroder, K.1
Hertzog, P.J.2
Ravasi, T.3
Hume, D.A.4
-
147
-
-
78651094465
-
Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
-
T.J. Schulz, T.L. Huang, T.T. Tran, H. Zhang, K.L. Townsend, J.L. Shadrach, M. Cerletti, L.E. McDougall, N. Giorgadze, and T. Tchkonia et al. Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat Proc. Natl. Acad. Sci. USA 108 2011 143 148
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 143-148
-
-
Schulz, T.J.1
Huang, T.L.2
Tran, T.T.3
Zhang, H.4
Townsend, K.L.5
Shadrach, J.L.6
Cerletti, M.7
McDougall, L.E.8
Giorgadze, N.9
Tchkonia, T.10
-
148
-
-
50049122271
-
PRDM16 controls a brown fat/skeletal muscle switch
-
P. Seale, B. Bjork, W. Yang, S. Kajimura, S. Chin, S. Kuang, A. Scimè, S. Devarakonda, H.M. Conroe, and H. Erdjument-Bromage et al. PRDM16 controls a brown fat/skeletal muscle switch Nature 454 2008 961 967
-
(2008)
Nature
, vol.454
, pp. 961-967
-
-
Seale, P.1
Bjork, B.2
Yang, W.3
Kajimura, S.4
Chin, S.5
Kuang, S.6
Scimè, A.7
Devarakonda, S.8
Conroe, H.M.9
Erdjument-Bromage, H.10
-
149
-
-
84890234667
-
UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic
-
I.G. Shabalina, N. Petrovic, J.M. de Jong, A.V. Kalinovich, B. Cannon, and J. Nedergaard UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic Cell Rep. 5 2013 1196 1203
-
(2013)
Cell Rep.
, vol.5
, pp. 1196-1203
-
-
Shabalina, I.G.1
Petrovic, N.2
De Jong, J.M.3
Kalinovich, A.V.4
Cannon, B.5
Nedergaard, J.6
-
150
-
-
84869233588
-
Human BAT possesses molecular signatures that resemble beige/brite cells
-
L.Z. Sharp, K. Shinoda, H. Ohno, D.W. Scheel, E. Tomoda, L. Ruiz, H. Hu, L. Wang, Z. Pavlova, V. Gilsanz, and S. Kajimura Human BAT possesses molecular signatures that resemble beige/brite cells PLoS ONE 7 2012 e49452
-
(2012)
PLoS ONE
, vol.7
-
-
Sharp, L.Z.1
Shinoda, K.2
Ohno, H.3
Scheel, D.W.4
Tomoda, E.5
Ruiz, L.6
Hu, H.7
Wang, L.8
Pavlova, Z.9
Gilsanz, V.10
Kajimura, S.11
-
151
-
-
34247857663
-
Obesity, inflammation, and insulin resistance
-
S.E. Shoelson, L. Herrero, and A. Naaz Obesity, inflammation, and insulin resistance Gastroenterology 132 2007 2169 2180
-
(2007)
Gastroenterology
, vol.132
, pp. 2169-2180
-
-
Shoelson, S.E.1
Herrero, L.2
Naaz, A.3
-
152
-
-
0036434112
-
Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules
-
H. Song, N. Shojima, H. Sakoda, T. Ogihara, M. Fujishiro, H. Katagiri, M. Anai, Y. Onishi, H. Ono, and K. Inukai et al. Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules Biochem. Biophys. Res. Commun. 299 2002 291 298
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.299
, pp. 291-298
-
-
Song, H.1
Shojima, N.2
Sakoda, H.3
Ogihara, T.4
Fujishiro, M.5
Katagiri, H.6
Anai, M.7
Onishi, Y.8
Ono, H.9
Inukai, K.10
-
154
-
-
44849132591
-
Dynamics of fat cell turnover in humans
-
K.L. Spalding, E. Arner, P.O. Westermark, S. Bernard, B.A. Buchholz, O. Bergmann, L. Blomqvist, J. Hoffstedt, E. Näslund, and T. Britton et al. Dynamics of fat cell turnover in humans Nature 453 2008 783 787
-
(2008)
Nature
, vol.453
, pp. 783-787
-
-
Spalding, K.L.1
Arner, E.2
Westermark, P.O.3
Bernard, S.4
Buchholz, B.A.5
Bergmann, O.6
Blomqvist, L.7
Hoffstedt, J.8
Näslund, E.9
Britton, T.10
-
155
-
-
84859384082
-
Innate lymphoid cells: emerging insights in development, lineage relationships, and function
-
H. Spits, and T. Cupedo Innate lymphoid cells: emerging insights in development, lineage relationships, and function Annu. Rev. Immunol. 30 2012 647 675
-
(2012)
Annu. Rev. Immunol.
, vol.30
, pp. 647-675
-
-
Spits, H.1
Cupedo, T.2
-
156
-
-
84872977452
-
Innate lymphoid cells - a proposal for uniform nomenclature
-
H. Spits, D. Artis, M. Colonna, A. Diefenbach, J.P. Di Santo, G. Eberl, S. Koyasu, R.M. Locksley, A.N. McKenzie, and R.E. Mebius et al. Innate lymphoid cells - a proposal for uniform nomenclature Nat. Rev. Immunol. 13 2013 145 149
-
(2013)
Nat. Rev. Immunol.
, vol.13
, pp. 145-149
-
-
Spits, H.1
Artis, D.2
Colonna, M.3
Diefenbach, A.4
Di Santo, J.P.5
Eberl, G.6
Koyasu, S.7
Locksley, R.M.8
McKenzie, A.N.9
Mebius, R.E.10
-
157
-
-
84867634265
-
Chronic bystander infections and immunity to unrelated antigens
-
E. Stelekati, and E.J. Wherry Chronic bystander infections and immunity to unrelated antigens Cell Host Microbe 12 2012 458 469
-
(2012)
Cell Host Microbe
, vol.12
, pp. 458-469
-
-
Stelekati, E.1
Wherry, E.J.2
-
158
-
-
0035905758
-
The hormone resistin links obesity to diabetes
-
C.M. Steppan, S.T. Bailey, S. Bhat, E.J. Brown, R.R. Banerjee, C.M. Wright, H.R. Patel, R.S. Ahima, and M.A. Lazar The hormone resistin links obesity to diabetes Nature 409 2001 307 312
-
(2001)
Nature
, vol.409
, pp. 307-312
-
-
Steppan, C.M.1
Bailey, S.T.2
Bhat, S.3
Brown, E.J.4
Banerjee, R.R.5
Wright, C.M.6
Patel, H.R.7
Ahima, R.S.8
Lazar, M.A.9
-
159
-
-
84875883411
-
Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-bet
-
E. Stolarczyk, C.T. Vong, E. Perucha, I. Jackson, M.A. Cawthorne, E.T. Wargent, N. Powell, J.B. Canavan, G.M. Lord, and J.K. Howard Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-bet Cell Metab. 17 2013 520 533
-
(2013)
Cell Metab.
, vol.17
, pp. 520-533
-
-
Stolarczyk, E.1
Vong, C.T.2
Perucha, E.3
Jackson, I.4
Cawthorne, M.A.5
Wargent, E.T.6
Powell, N.7
Canavan, J.B.8
Lord, G.M.9
Howard, J.K.10
-
161
-
-
83455242995
-
Iron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and inflammation in obese and type 2 diabetes KKAy mice
-
S. Tajima, Y. Ikeda, K. Sawada, N. Yamano, Y. Horinouchi, Y. Kihira, K. Ishizawa, Y. Izawa-Ishizawa, K. Kawazoe, and S. Tomita et al. Iron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and inflammation in obese and type 2 diabetes KKAy mice Am. J. Physiol. Endocrinol. Metab. 302 2012 E77 E86
-
(2012)
Am. J. Physiol. Endocrinol. Metab.
, vol.302
, pp. E77-E86
-
-
Tajima, S.1
Ikeda, Y.2
Sawada, K.3
Yamano, N.4
Horinouchi, Y.5
Kihira, Y.6
Ishizawa, K.7
Izawa-Ishizawa, Y.8
Kawazoe, K.9
Tomita, S.10
-
162
-
-
79953249421
-
FABP 4 is associated with inflammatory markers and metabolic syndrome in morbidly obese women
-
X. Terra, Y. Quintero, T. Auguet, J.A. Porras, M. Hernández, F. Sabench, C. Aguilar, A.M. Luna, D. Del Castillo, and C. Richart FABP 4 is associated with inflammatory markers and metabolic syndrome in morbidly obese women Eur. J. Endocrinol. 164 2011 539 547
-
(2011)
Eur. J. Endocrinol.
, vol.164
, pp. 539-547
-
-
Terra, X.1
Quintero, Y.2
Auguet, T.3
Porras, J.A.4
Hernández, M.5
Sabench, F.6
Aguilar, C.7
Luna, A.M.8
Del Castillo, D.9
Richart, C.10
-
163
-
-
0030756346
-
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
-
K.T. Uysal, S.M. Wiesbrock, M.W. Marino, and G.S. Hotamisligil Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function Nature 389 1997 610 614
-
(1997)
Nature
, vol.389
, pp. 610-614
-
-
Uysal, K.T.1
Wiesbrock, S.M.2
Marino, M.W.3
Hotamisligil, G.S.4
-
164
-
-
64349095231
-
Cold-activated brown adipose tissue in healthy men
-
W.D. van Marken Lichtenbelt, J.W. Vanhommerig, N.M. Smulders, J.M. Drossaerts, G.J. Kemerink, N.D. Bouvy, P. Schrauwen, and G.J. Teule Cold-activated brown adipose tissue in healthy men N. Engl. J. Med. 360 2009 1500 1508
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 1500-1508
-
-
Van Marken Lichtenbelt, W.D.1
Vanhommerig, J.W.2
Smulders, N.M.3
Drossaerts, J.M.4
Kemerink, G.J.5
Bouvy, N.D.6
Schrauwen, P.7
Teule, G.J.8
-
165
-
-
64349123664
-
Functional brown adipose tissue in healthy adults
-
K.A. Virtanen, M.E. Lidell, J. Orava, M. Heglind, R. Westergren, T. Niemi, M. Taittonen, J. Laine, N.J. Savisto, S. Enerbäck, and P. Nuutila Functional brown adipose tissue in healthy adults N. Engl. J. Med. 360 2009 1518 1525
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 1518-1525
-
-
Virtanen, K.A.1
Lidell, M.E.2
Orava, J.3
Heglind, M.4
Westergren, R.5
Niemi, T.6
Taittonen, M.7
Laine, J.8
Savisto, N.J.9
Enerbäck, S.10
Nuutila, P.11
-
166
-
-
84876461373
-
Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk
-
N.M. Wagner, G. Brandhorst, F. Czepluch, M. Lankeit, C. Eberle, S. Herzberg, V. Faustin, J. Riggert, M. Oellerich, and G. Hasenfuss et al. Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk Obesity (Silver Spring) 21 2013 461 468
-
(2013)
Obesity (Silver Spring)
, vol.21
, pp. 461-468
-
-
Wagner, N.M.1
Brandhorst, G.2
Czepluch, F.3
Lankeit, M.4
Eberle, C.5
Herzberg, S.6
Faustin, V.7
Riggert, J.8
Oellerich, M.9
Hasenfuss, G.10
-
167
-
-
67649793700
-
The genetic contribution to non-syndromic human obesity
-
A.J. Walley, J.E. Asher, and P. Froguel The genetic contribution to non-syndromic human obesity Nat. Rev. Genet. 10 2009 431 442
-
(2009)
Nat. Rev. Genet.
, vol.10
, pp. 431-442
-
-
Walley, A.J.1
Asher, J.E.2
Froguel, P.3
-
168
-
-
84893371365
-
Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch
-
J. Wang, R. Liu, F. Wang, J. Hong, X. Li, M. Chen, Y. Ke, X. Zhang, Q. Ma, and R. Wang et al. Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch Nat. Cell Biol. 15 2013 1455 1463
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 1455-1463
-
-
Wang, J.1
Liu, R.2
Wang, F.3
Hong, J.4
Li, X.5
Chen, M.6
Ke, Y.7
Zhang, X.8
Ma, Q.9
Wang, R.10
-
169
-
-
84887502374
-
Tracking adipogenesis during white adipose tissue development, expansion and regeneration
-
Q.A. Wang, C. Tao, R.K. Gupta, and P.E. Scherer Tracking adipogenesis during white adipose tissue development, expansion and regeneration Nat. Med. 19 2013 1338 1344
-
(2013)
Nat. Med.
, vol.19
, pp. 1338-1344
-
-
Wang, Q.A.1
Tao, C.2
Gupta, R.K.3
Scherer, P.E.4
-
170
-
-
84920617544
-
The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis
-
G.X. Wang, X.Y. Zhao, Z.X. Meng, M. Kern, A. Dietrich, Z. Chen, Z. Cozacov, D. Zhou, A.L. Okunade, and X. Su et al. The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis Nat. Med. 20 2014 1436 1443
-
(2014)
Nat. Med.
, vol.20
, pp. 1436-1443
-
-
Wang, G.X.1
Zhao, X.Y.2
Meng, Z.X.3
Kern, M.4
Dietrich, A.5
Chen, Z.6
Cozacov, Z.7
Zhou, D.8
Okunade, A.L.9
Su, X.10
-
171
-
-
79952856377
-
Chronic TNF-α neutralization does not improve insulin resistance or endothelial function in "healthy" men with metabolic syndrome
-
T.C. Wascher, J.H. Lindeman, H. Sourij, T. Kooistra, G. Pacini, and M. Roden Chronic TNF-α neutralization does not improve insulin resistance or endothelial function in "healthy" men with metabolic syndrome Mol. Med. 17 2011 189 193
-
(2011)
Mol. Med.
, vol.17
, pp. 189-193
-
-
Wascher, T.C.1
Lindeman, J.H.2
Sourij, H.3
Kooistra, T.4
Pacini, G.5
Roden, M.6
-
172
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
S.P. Weisberg, D. McCann, M. Desai, M. Rosenbaum, R.L. Leibel, and A.W. Ferrante Jr. Obesity is associated with macrophage accumulation in adipose tissue J. Clin. Invest. 112 2003 1796 1808
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
Ferrante, Jr.A.W.6
-
173
-
-
78851468865
-
The economic burden of obesity worldwide: a systematic review of the direct costs of obesity
-
D. Withrow, and D.A. Alter The economic burden of obesity worldwide: a systematic review of the direct costs of obesity Obes. Rev. 12 2011 131 141
-
(2011)
Obes. Rev.
, vol.12
, pp. 131-141
-
-
Withrow, D.1
Alter, D.A.2
-
174
-
-
79953815551
-
Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis
-
D. Wu, A.B. Molofsky, H.E. Liang, R.R. Ricardo-Gonzalez, H.A. Jouihan, J.K. Bando, A. Chawla, and R.M. Locksley Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis Science 332 2011 243 247
-
(2011)
Science
, vol.332
, pp. 243-247
-
-
Wu, D.1
Molofsky, A.B.2
Liang, H.E.3
Ricardo-Gonzalez, R.R.4
Jouihan, H.A.5
Bando, J.K.6
Chawla, A.7
Locksley, R.M.8
-
175
-
-
84864287504
-
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
-
J. Wu, P. Boström, L.M. Sparks, L. Ye, J.H. Choi, A.H. Giang, M. Khandekar, K.A. Virtanen, P. Nuutila, and G. Schaart et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human Cell 150 2012 366 376
-
(2012)
Cell
, vol.150
, pp. 366-376
-
-
Wu, J.1
Boström, P.2
Sparks, L.M.3
Ye, L.4
Choi, J.H.5
Giang, A.H.6
Khandekar, M.7
Virtanen, K.A.8
Nuutila, P.9
Schaart, G.10
-
176
-
-
84873518501
-
Adaptive thermogenesis in adipocytes: is beige the new brown?
-
J. Wu, P. Cohen, and B.M. Spiegelman Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev. 27 2013 234 250
-
(2013)
Genes Dev.
, vol.27
, pp. 234-250
-
-
Wu, J.1
Cohen, P.2
Spiegelman, B.M.3
-
177
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
H. Xu, G.T. Barnes, Q. Yang, G. Tan, D. Yang, C.J. Chou, J. Sole, A. Nichols, J.S. Ross, L.A. Tartaglia, and H. Chen Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance J. Clin. Invest. 112 2003 1821 1830
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1821-1830
-
-
Xu, H.1
Barnes, G.T.2
Yang, Q.3
Tan, G.4
Yang, D.5
Chou, C.J.6
Sole, J.7
Nichols, A.8
Ross, J.S.9
Tartaglia, L.A.10
Chen, H.11
-
178
-
-
22944434929
-
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
-
Q. Yang, T.E. Graham, N. Mody, F. Preitner, O.D. Peroni, J.M. Zabolotny, K. Kotani, L. Quadro, and B.B. Kahn Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes Nature 436 2005 356 362
-
(2005)
Nature
, vol.436
, pp. 356-362
-
-
Yang, Q.1
Graham, T.E.2
Mody, N.3
Preitner, F.4
Peroni, O.D.5
Zabolotny, J.M.6
Kotani, K.7
Quadro, L.8
Kahn, B.B.9
-
179
-
-
84877814914
-
Parasitic nematode-induced modulation of body weight and associated metabolic dysfunction in mouse models of obesity
-
Z. Yang, V. Grinchuk, A. Smith, B. Qin, J.A. Bohl, R. Sun, L. Notari, Z. Zhang, H. Sesaki, and J.F. Urban Jr. et al. Parasitic nematode-induced modulation of body weight and associated metabolic dysfunction in mouse models of obesity Infect. Immun. 81 2013 1905 1914
-
(2013)
Infect. Immun.
, vol.81
, pp. 1905-1914
-
-
Yang, Z.1
Grinchuk, V.2
Smith, A.3
Qin, B.4
Bohl, J.A.5
Sun, R.6
Notari, L.7
Zhang, Z.8
Sesaki, H.9
Urban, Jr.J.F.10
-
180
-
-
84921845458
-
Fibroblast growth factor 21 (FGF21) ameliorates collagen-induced arthritis through modulating oxidative stress and suppressing nuclear factor-kappa B pathway
-
Y. Yu, S. Li, Y. Liu, G. Tian, Q. Yuan, F. Bai, W. Wang, Z. Zhang, G. Ren, Y. Zhang, and D. Li Fibroblast growth factor 21 (FGF21) ameliorates collagen-induced arthritis through modulating oxidative stress and suppressing nuclear factor-kappa B pathway Int. Immunopharmacol. 25 2015 74 82
-
(2015)
Int. Immunopharmacol.
, vol.25
, pp. 74-82
-
-
Yu, Y.1
Li, S.2
Liu, Y.3
Tian, G.4
Yuan, Q.5
Bai, F.6
Wang, W.7
Zhang, Z.8
Ren, G.9
Zhang, Y.10
Li, D.11
-
181
-
-
33644651160
-
Liver X receptors as integrators of metabolic and inflammatory signaling
-
N. Zelcer, and P. Tontonoz Liver X receptors as integrators of metabolic and inflammatory signaling J. Clin. Invest. 116 2006 607 614
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 607-614
-
-
Zelcer, N.1
Tontonoz, P.2
-
182
-
-
78650176649
-
Newly identified adipose tissue macrophage populations in obesity with distinct chemokine and chemokine receptor expression
-
M. Zeyda, K. Gollinger, E. Kriehuber, F.W. Kiefer, A. Neuhofer, and T.M. Stulnig Newly identified adipose tissue macrophage populations in obesity with distinct chemokine and chemokine receptor expression Int J Obes (Lond) 34 2010 1684 1694
-
(2010)
Int J Obes (Lond)
, vol.34
, pp. 1684-1694
-
-
Zeyda, M.1
Gollinger, K.2
Kriehuber, E.3
Kiefer, F.W.4
Neuhofer, A.5
Stulnig, T.M.6
-
183
-
-
84877582160
-
Severe obesity increases adipose tissue expression of interleukin-33 and its receptor ST2, both predominantly detectable in endothelial cells of human adipose tissue
-
M. Zeyda, B. Wernly, S. Demyanets, C. Kaun, M. Hämmerle, B. Hantusch, M. Schranz, A. Neuhofer, B.K. Itariu, and M. Keck et al. Severe obesity increases adipose tissue expression of interleukin-33 and its receptor ST2, both predominantly detectable in endothelial cells of human adipose tissue Int J Obes (Lond) 37 2013 658 665
-
(2013)
Int J Obes (Lond)
, vol.37
, pp. 658-665
-
-
Zeyda, M.1
Wernly, B.2
Demyanets, S.3
Kaun, C.4
Hämmerle, M.5
Hantusch, B.6
Schranz, M.7
Neuhofer, A.8
Itariu, B.K.9
Keck, M.10
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