NAD+-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease

Cell Metabolism

Volumn 19, Issue 6, 2014, Pages 1042-1049

  Cerutti, Raffaele ^a,g   Pirinen, Eija ^b,c   Lamperti, Costanza ^a   Marchet, Silvia ^a   Sauve, Anthony A ^d   Li, Wei ^d   Leoni, Valerio ^a   Schon, Eric A ^e   Dantzer, Françoise ^f   Auwerx, Johan ^b   Viscomi, Carlo ^a,g   Zeviani, Massimo ^a,g  

^a DEPARTMENT OF NEUROSURGERY   (Italy)

^b EPFL   (Switzerland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e Laboratory of Clinical Pathology and Medical Genetics Foundation Carlo Besta Institute of Neurology IRCCS ^*  (United States)

^f Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg   (France)

^g UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C OXIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE RIBOSIDE; SIRTUIN 1; N-(OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HYDROCHLORIDE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NICOTINAMIDE-BETA-RIBOSIDE; PARP1 PROTEIN, MOUSE; PHENANTHRENE DERIVATIVE; SCO2 PROTEIN, MOUSE; SIRT1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME SYNTHESIS; EXERCISE TOLERANCE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANALOGS AND DERIVATIVES; ANIMAL; BIOSYNTHESIS; DIETARY SUPPLEMENT; DISEASE MODEL; ENERGY METABOLISM; ENZYME ACTIVATION; GENE EXPRESSION; GENETICS; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRIAL DISEASES; MITOCHONDRION; OXIDATIVE PHOSPHORYLATION; PATHOLOGY; PHENOTYPE; PHYSIOLOGY;

ANIMALS; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; ELECTRON TRANSPORT COMPLEX IV; ENERGY METABOLISM; ENZYME ACTIVATION; GENE EXPRESSION; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL DISEASES; NAD; NIACINAMIDE; OXIDATIVE PHOSPHORYLATION; PHENANTHRENES; PHENOTYPE; POLY(ADP-RIBOSE) POLYMERASE INHIBITORS; POLY(ADP-RIBOSE) POLYMERASES; SIRTUIN 1;

EID: 84902245774     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2014.04.001     Document Type: Article

References (34)

1. P. Adamietz Poly(ADP-ribose) synthase is the major endogenous nonhistone acceptor for poly(ADP-ribose) in alkylated rat hepatoma cells Eur. J. Biochem. 169 1987 365 372
2. P.A. Andreux, R.H. Houtkooper, and J. Auwerx Pharmacological approaches to restore mitochondrial function Nat. Rev. Drug Discov. 12 2013 465 483
3. P. Bai, C. Cantó, H. Oudart, A. Brunyánszki, Y. Cen, C. Thomas, H. Yamamoto, A. Huber, B. Kiss, and R.H. Houtkooper et al. PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation Cell Metab. 13 2011 461 468
4. P. Bieganowski, and C. Brenner Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans Cell 117 2004 495 502
5. M. Bugiani, F. Invernizzi, S. Alberio, E. Briem, E. Lamantea, F. Carrara, I. Moroni, L. Farina, M. Spada, and M.A. Donati et al. Clinical and molecular findings in children with complex I deficiency Biochim. Biophys. Acta 1659 2004 136 147
6. N. Bundred, J. Gardovskis, J. Jaskiewicz, J. Eglitis, V. Paramonov, P. McCormack, H. Swaisland, M. Cavallin, T. Parry, J. Carmichael, and J.M. Dixon Evaluation of the pharmacodynamics and pharmacokinetics of the PARP inhibitor olaparib: a phase I multicentre trial in patients scheduled for elective breast cancer surgery Invest. New Drugs 31 2013 949 958
7. C. Cantó, and J. Auwerx Caloric restriction, SIRT1 and longevity Trends Endocrinol. Metab. 20 2009 325 331
8. C. Cantó, and J. Auwerx Clking on PGC-1alpha to inhibit gluconeogenesis Cell Metab. 11 2010 6 7
9. C. Cantó, R.H. Houtkooper, E. Pirinen, D.Y. Youn, M.H. Oosterveer, Y. Cen, P.J. Fernandez-Marcos, H. Yamamoto, P.A. Andreux, and P. Cettour-Rose et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity Cell Metab. 15 2012 838 847
10. D. Chen, J. Bruno, E. Easlon, S.J. Lin, H.L. Cheng, F.W. Alt, and L. Guarente Tissue-specific regulation of SIRT1 by calorie restriction Genes Dev. 22 2008 1753 1757
11. J.M. de Murcia, C. Niedergang, C. Trucco, M. Ricoul, B. Dutrillaux, M. Mark, F.J. Oliver, M. Masson, A. Dierich, and M. LeMeur et al. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells Proc. Natl. Acad. Sci. USA 94 1997 7303 7307
12. J. Durieux, S. Wolff, and A. Dillin The cell-non-autonomous nature of electron transport chain-mediated longevity Cell 144 2011 79 91
13. B.W. Durkacz, O. Omidiji, D.A. Gray, and S. Shall (ADP-ribose)n participates in DNA excision repair Nature 283 1980 593 596
14. A.P. Gomes, N.L. Price, A.J. Ling, J.J. Moslehi, M.K. Montgomery, L. Rajman, J.P. White, J.S. Teodoro, C.D. Wrann, and B.P. Hubbard et al. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging Cell 155 2013 1624 1638
15. B. Gong, Y. Pan, P. Vempati, W. Zhao, L. Knable, L. Ho, J. Wang, M. Sastre, K. Ono, A.A. Sauve, and G.M. Pasinetti Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models Neurobiol. Aging 34 2013 1581 1588
16. R.H. Houtkooper, C. Cantó, R.J. Wanders, and J. Auwerx The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways Endocr. Rev. 31 2010 194 223
17. R.H. Houtkooper, E. Pirinen, and J. Auwerx Sirtuins as regulators of metabolism and healthspan Nat. Rev. Mol. Cell Biol. 13 2012 225 238
18. S. Imai, C.M. Armstrong, M. Kaeberlein, and L. Guarente Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase Nature 403 2000 795 800
19. G. Karamanlidis, C.F. Lee, L. Garcia-Menendez, S.C. Kolwicz Jr., W. Suthammarak, G. Gong, M.M. Sedensky, P.G. Morgan, W. Wang, and R. Tian Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure Cell Metab. 18 2013 239 250
20. W.J. Koopman, P.H. Willems, and J.A. Smeitink Monogenic mitochondrial disorders N. Engl. J. Med. 366 2012 1132 1141
21. S.C. Leary, F. Sasarman, T. Nishimura, and E.A. Shoubridge Human SCO2 is required for the synthesis of CO II and as a thiol-disulphide oxidoreductase for SCO1 Hum. Mol. Genet. 18 2009 2230 2240
22. L. Mouchiroud, R.H. Houtkooper, N. Moullan, E. Katsyuba, D. Ryu, C. Cantó, A. Mottis, Y.S. Jo, M. Viswanathan, and K. Schoonjans et al. The NAD(+)/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling Cell 154 2013 430 441
23. P. Mukhopadhyay, M. Rajesh, Z. Cao, B. Horváth, O. Park, H. Wang, K. Erdelyi, E. Holovac, Y. Wang, and L. Liaudet et al. Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis Hepatology 2013 10.1002/hep.26763 Published online April 1, 2014
24. L.C. Papadopoulou, C.M. Sue, M.M. Davidson, K. Tanji, I. Nishino, J.E. Sadlock, S. Krishna, W. Walker, J. Selby, and D.M. Glerum et al. Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene Nat. Genet. 23 1999 333 337
25. C.B. Peek, A.H. Affinati, K.M. Ramsey, H.Y. Kuo, W. Yu, L.A. Sena, O. Ilkayeva, B. Marcheva, Y. Kobayashi, and C. Omura et al. Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice Science 342 2013 1243417
26. E. Pirinen, C. Cantó, Y.S. Jo, L. Morato, H. Zhang, K.J. Menzies, E.G. Williams, L. Mouchiroud, N. Moullan, and C. Hagberg et al. Pharmacological inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle Cell Metab. 19 2014 1034 1041 this issue
27. J.T. Rodgers, C. Lerin, W. Haas, S.P. Gygi, B.M. Spiegelman, and P. Puigserver Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1 Nature 434 2005 113 118
28. M. Sciacco, and E. Bonilla Cytochemistry and immunocytochemistry of mitochondria in tissue sections Methods Enzymol. 264 1996 509 521
29. A. Tutt, M. Robson, J.E. Garber, S.M. Domchek, M.W. Audeh, J.N. Weitzel, M. Friedlander, B. Arun, N. Loman, and R.K. Schmutzler et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial Lancet 376 2010 235 244
30. H. Vaziri, S.K. Dessain, E. Ng Eaton, S.I. Imai, R.A. Frye, T.K. Pandita, L. Guarente, and R.A. Weinberg hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase Cell 107 2001 149 159
31. C. Viscomi, E. Bottani, G. Civiletto, R. Cerutti, M. Moggio, G. Fagiolari, E.A. Schon, C. Lamperti, and M. Zeviani In vivo correction of COX deficiency by activation of the AMPK/PGC-1α axis Cell Metab. 14 2011 80 90
32. T. Wenz, F. Diaz, B.M. Spiegelman, and C.T. Moraes Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype Cell Metab. 8 2008 249 256
33. T. Yang, and A.A. Sauve NAD metabolism and sirtuins: metabolic regulation of protein deacetylation in stress and toxicity AAPS J. 8 2006 E632 E643
34. H. Yang, S. Brosel, R. Acin-Perez, V. Slavkovich, I. Nishino, R. Khan, I.J. Goldberg, J. Graziano, G. Manfredi, and E.A. Schon Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2 Hum. Mol. Genet. 19 2010 170 180