OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 27, 2014, Pages 9983-9988

  Chen, Ligong ^a,b   Shu, Yan ^a   Liang, Xiaomin ^a   Chen, Eugene C ^a   Yee, Sook Wah ^a   Zur, Arik A ^a   Li, Shuanglian ^a   Xu, Lu ^a,d   Keshari, Kayvan R ^c   Lin, Michael J ^a   Chien, Huan Chieh ^a   Zhang, Youcai ^a   Morrissey, Kari M ^a   Liu, Jason ^c   Ostrem, Jonathan ^c   Younger, Noah S ^c   Kurhanewicz, John ^c   Shokat, Kevan M ^c   Ashrafi, Kaveh ^c   Giacomini, Kathleen M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Tsinghua University   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

Diabetes; Fatty liver disease; Vitamin B1

Indexed keywords

ACETIC ACID DERIVATIVE; ACETYL COENZYME A CARBOXYLASE; BIGUANIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; ORGANIC CATION TRANSPORTER 1; THIAMINE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; FATTY LIVER; HUMAN; HUMAN CELL; LIPID DIET; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; THIAMINE DEFICIENCY; WILD TYPE;

DIABETES; FATTY LIVER DISEASE; VITAMIN B1;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CARRIER PROTEINS; FATTY LIVER; HYPOGLYCEMIC AGENTS; METFORMIN; MICE; MICE, KNOCKOUT; OCTAMER TRANSCRIPTION FACTOR-1; OXIDATION-REDUCTION; THIAMINE;

EID: 84903977464     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1314939111     Document Type: Article

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