Mitochondrial dysfunction induces senescence with a distinct secretory phenotype

Cell Metabolism

Volumn 23, Issue 2, 2016, Pages 303-314

  Wiley, Christopher D ^a   Velarde, Michael C ^a   Lecot, Pacome ^a   Liu, Su ^a   Sarnoski, Ethan A ^a,b   Freund, Adam ^a   Shirakawa, Kotaro ^c   Lim, Hyung W ^c   Davis, Sonnet S ^a   Ramanathan, Arvind ^a   Gerencser, Akos A ^a   Verdin, Eric ^c   Campisi, Judith ^a,d  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b SENS Foundation   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; CCAAT ENHANCER BINDING PROTEIN BETA; CUTANEOUS T CELL ATTRACTING CHEMOKINE; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LACTATE DEHYDROGENASE; LAMIN B1; MESSENGER RNA; MITOCHONDRIAL DNA; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN P53; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SIRTUIN 3; SIRTUIN 4; SIRTUIN 5; SIRTUIN 6; SIRTUIN 7; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN; DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE GAMMA; NICOTINAMIDE ADENINE DINUCLEOTIDE; POLG PROTEIN, MOUSE; SIRTUIN;

ADIPOGENESIS; ANIMAL CELL; ARTICLE; CELL AGING; CELL DIFFERENTIATION; CELL PROLIFERATION; CITRIC ACID CYCLE; CONTROLLED STUDY; CYTOKINE RELEASE; DEPLETION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; GENE MUTATION; GLYCOLYSIS; HUMAN; HUMAN CELL; IN VIVO STUDY; KERATINOCYTE; MITOSIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SECRETORY CELL; SENESCENCE; SENESCENCE ASSOCIATED SECRETORY PHENOTYPE; ANIMAL; ENZYME ACTIVATION; METABOLISM; MITOCHONDRION; PATHOLOGY; SECRETION (PROCESS);

ADENYLATE KINASE; ANIMALS; CELLULAR SENESCENCE; DNA POLYMERASE GAMMA; DNA-DIRECTED DNA POLYMERASE; ENZYME ACTIVATION; MICE; MITOCHONDRIA; NAD; PHENOTYPE; SIRTUINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84957952429     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2015.11.011     Document Type: Article

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