A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease

Cell Reports

Volumn 9, Issue 3, 2014, Pages 1135-1150

  Brehme, Marc ^a,b,c,d,e   Voisine, Cindy ^d,f   Rolland, Thomas ^b,c   Wachi, Shinichiro ^a   Soper, James H ^a   Zhu, Yitan ^a   Orton, Kai ^d   Villella, Adriana ^a   Garza, Dan ^a   Vidal, Marc ^b,c   Ge, Hui ^a   Morimoto, Richard I ^d  

^a Proteostasis Therapeutics Inc   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

^e ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^f NORTHEASTERN ILLINOIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; HUNTINGTIN; POLYGLUTAMINE; PROTEOME; CHAPERONE; HTT PROTEIN, HUMAN; NERVE PROTEIN;

ADULT; AGED; AGING; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; CAENORHABDITIS ELEGANS; CELL MOTILITY; CELL PROTECTION; CHAPEROME SUBNETWORK; CONTROLLED STUDY; CORRELATIONAL STUDY; CYTOTOXICITY; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; GENE CLUSTER; GENE EXPRESSION; GENE INDUCTION; GENE REPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; HUNTINGTON CHOREA; MUSCLE CELL; NONHUMAN; ORTHOLOGY; PARKINSON DISEASE; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN HOMEOSTASIS; PROTEIN LOCALIZATION; ANIMAL; BIOLOGICAL MODEL; BRAIN; COMPLICATION; DISEASE MODEL; GENE REGULATORY NETWORK; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PATHOLOGY; PROTEINOSIS; PROTEOSTASIS DEFICIENCY;

CAENORHABDITIS ELEGANS;

AGING; ANIMALS; BRAIN; CAENORHABDITIS ELEGANS; DISEASE MODELS, ANIMAL; GENE REGULATORY NETWORKS; HUMANS; MODELS, BIOLOGICAL; MOLECULAR CHAPERONES; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN FOLDING; PROTEOSTASIS DEFICIENCIES;

EID: 84919764653     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.09.042     Document Type: Article

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