The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

Science

Volumn 349, Issue 6255, 2015, Pages

  Kang, Chanhee ^a   Xu, Qikai ^a   Martin, Timothy D ^a   Li, Mamie Z ^a   Demaria, Marco ^b   Aron, Liviu ^c   Lu, Tao ^c   Yankner, Bruce A ^c   Campisi, Judith ^b   Elledge, Stephen J ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P53; PROTEIN P62; TRANSCRIPTION FACTOR GATA 4; ATM PROTEIN; ATM PROTEIN, HUMAN; ATR PROTEIN, HUMAN; GATA4 PROTEIN, HUMAN; IL1A PROTEIN, HUMAN; INTERLEUKIN 1ALPHA; MICRORNA; MIRN146 MICRORNA, HUMAN; TRAF3IP2 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR;

AGING; BIODEGRADATION; BRAIN; CELLS AND CELL COMPONENTS; DNA; GENE EXPRESSION; INHIBITION; PHENOTYPE; PROTEIN; SENESCENCE; TUMOR;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOLYSOSOME; AUTOPHAGY; CONTROLLED STUDY; DNA DAMAGE; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATION; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SELECTIVE AUTOPHAGY; SENESCENCE; SENESCENCE ASSOCIATED SECRETORY PHENOTYPE; ANIMAL; BRAIN; C57BL MOUSE; CELL AGING; CELL CULTURE; CELL CYCLE; FIBROBLAST; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; PROMOTER REGION;

AGING; ANIMALS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; AUTOPHAGY; BRAIN; CELL AGING; CELL CYCLE; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA DAMAGE; FIBROBLASTS; GATA4 TRANSCRIPTION FACTOR; GENE EXPRESSION PROFILING; HUMANS; INFLAMMATION; INTERLEUKIN-1ALPHA; MICE; MICE, INBRED C57BL; MICRORNAS; NF-KAPPA B; PHENOTYPE; PROMOTER REGIONS, GENETIC; TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PEPTIDES AND PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84942456107     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaa5612     Document Type: Article

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