Metabolomics profiling reveals novel markers for leukocyte telomere length

Aging

Volumn 8, Issue 1, 2016, Pages 77-94

  Zierer, Jonas ^a,b   Kastenmüller, Gabi ^a,b   Suhre, Karsten ^b,c   Gieger, Christian ^b,d   Codd, Veryan ^e   Tsai, Pei Chien ^a   Bell, Jordana ^a   Peters, Annette ^b   Strauch, Konstantin ^b   Schulz, Holger ^b,f   Weidinger, Stephan ^g   Mohney, Robert P ^h   Samani, Nilesh J ^e,i   Spector, Tim ^a   Mangino, Massimo ^a,j   Menni, Cristina ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c WEILL CORNELL MEDICAL COLLEGE   (Qatar)

^d GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^e UNIVERSITY OF LEICESTER   (United Kingdom)

^f Center for Lung Research   (Germany)

^g UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^h METABOLON INC   (United States)

ⁱ GLENFIELD HOSPITAL   (United Kingdom)

^j GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

more..

Author keywords

Biological aging; Glutathione; Metabolomics; Oxidative stress; Telomere length

Indexed keywords

BIOLOGICAL MARKER; FATTY ACID;

ADULT; AGE; AGED; AGING; BLOOD; CLINICAL TRIAL; ENERGY METABOLISM; FEMALE; GENETICS; GERMANY; HUMAN; LEUKOCYTE; METABOLISM; METABOLOMICS; MIDDLE AGED; MULTICENTER STUDY; OXIDATIVE STRESS; PHENOTYPE; PROCEDURES; REGISTER; TELOMERE; TELOMERE HOMEOSTASIS; TWINS; UNITED KINGDOM;

ADULT; AGE FACTORS; AGED; AGING; BIOMARKERS; ENERGY METABOLISM; FATTY ACIDS; FEMALE; GERMANY; HUMANS; LEUKOCYTES; METABOLOMICS; MIDDLE AGED; OXIDATIVE STRESS; PHENOTYPE; REGISTRIES; TELOMERE; TELOMERE HOMEOSTASIS; TWINS; UNITED KINGDOM;

EID: 84986616815     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100874     Document Type: Article

References (53)

1. Lange T De. Shelterin: The protein complex that shapes and safeguards human telomeres. Genes and Development. 2005; 19:2100-2110.
2. Harley CB, Vaziri H, Counter CM, and Allsopp RC. The telomere hypothesis of cellular aging. Experimental gerontology. 1992; 27:375-382.
3. Valdes AM, Andrew T, Gardner JP, Kimura M, Oelsner E, Cherkas LF, Aviv A, and Spector TD. Obesity, cigarette smoking, and telomere length in women. Lancet. 2005; 366:662-664.
4. Panossian L. Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiology of Aging. 2003; 24:77-84.
5. Thomas P, O' Callaghan NJ, and Fenech M. Telomere length in white blood cells, buccal cells and brain tissue and its variation with ageing and Alzheimer's disease. Mechanisms of Ageing and Development. 2008; 129:183-190.
6. Fitzpatrick AL, Kronmal RA., Gardner JP, Psaty BM, Jenny NS, Tracy RP, Walston J, Kimura M, and Aviv A. Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. American Journal of Epidemiology. 2007; 165:14-21.
7. Brouilette S, Singh RK, Thompson JR, Goodall AH, and Samani NJ. White cell telomere length and risk of premature myocardial infarction. Arteriosclerosis, Thrombosis, and Vascular Biology. 2003; 23:842-846.
8. Shay JW and Wright WE. Role of telomeres and telomerase in cancer. Seminars in Cancer Biology. 2011; 21:349-353.
9. Artandi SE and DePinho R a. Telomeres and telomerase in cancer. Carcinogenesis. 2009; 31:9-18.
10. Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, and Kerber RA. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet. 2003; 361:393-395.
11. Kimura M, Hjelmborg JVB, Gardner JP, Bathum L, Brimacombe M, Lu X, Christiansen L, Vaupel JW, Aviv A, and Christensen K. Telomere length and mortality: A study of leukocytes in elderly danish twins. American Journal of Epidemiology. 2008; 167:799-806.
12. Vera E, Bernardes de Jesus B, Foronda M, Flores JM, and Blasco M a. The rate of increase of short telomeres predicts longevity in mammals. Cell reports. 2012; 2:732-737.
13. Mather KA, Jorm AF, Parslow RA, and Christensen H. Is telomere length a biomarker of aging? A review. Journals of Gerontology-Series A Biological Sciences and Medical Sciences. 2011; 66 A:202-213.
14. Codd V, Mangino M, Harst P van der, Braund PS, Kaiser M, Beveridge AJ, Rafelt S, Moore J, Nelson C, Soranzo N, Zhai G, Valdes AM, Blackburn H, et al. Common variants near TERC are associated with mean telomere length. Nature genetics. 2010; 42:197-199.
15. Codd V, Nelson CP, Albrecht E, Mangino M, Deelen J, Buxton JL, Hottenga JJ, Fischer K, Esko T, Surakka I, Broer L, Nyholt DR, Leach IM, et al. Identification of seven loci affecting mean telomere length and their association with disease. Nature Genetics. 2013; 45:422-427.
16. Mangino M, Christiansen L, Stone R, Hunt SC, Horvath K, Eisenberg DT a., Kimura M, Petersen I, Kark JD, Herbig U, Reiner a. P, Benetos A, Codd V, et al. DCAF4, a novel gene associated with leucocyte telomere length. Journal of Medical Genetics. 2015; 52:157-162.
17. Mangino M, Hwang S-J, Spector TD, Hunt SC, Kimura M, Fitzpatrick AL, Christiansen L, Petersen I, Elbers CC, Harris T, Chen W, Srinivasan SR, Kark JD, et al. Genome-wide metaanalysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Human Molecular Genetics. 2012; 21:5385-5394.
18. Holmes E, Wilson ID, and Nicholson JK. Metabolic Phenotyping in Health and Disease. Cell. 2008; 134:714-717.
19. Hollywood K, Brison DR, and Goodacre R. Metabolomics: Current technologies and future trends. Proteomics. 2006; 6:4716-4723.
20. Zhao J, Zhu Y, Uppal K, Tran VT, Yu T, Lin J, Matsuguchi T, Blackburn E, Jones D, Lee ET, and Howard B V. Metabolic profiles of biological aging in american indians: The strong heart family study. Aging (Albany, NY). 2014; 6:176-186.
21. Petersen A.-KAK, Zeilinger S, Kastenmüller G, Werner RM, Brugger M, Peters A, Meisinger C, Strauch K, Hengstenberg C, Pagel P, Huber F, Mohney RP, Grallert H, et al. Epigenetics meets metabolomics: an epigenome-wide association study with blood serum metabolic traits. Human Molecular Genetics. 2014; 23:534-545.
22. Zeilinger S, Kühnel B, Klopp N, Baurecht H, Kleinschmidt A, Gieger C, Weidinger S, Lattka E, Adamski J, Peters A, Strauch K, Waldenberger M, and Illig T. Tobacco Smoking Leads to Extensive Genome-Wide Changes in DNA Methylation. PLoS ONE. 2013; 8:e63812.
23. Dennis E. Diversity of group types, regulation, and function of phospholipase A2. Journal of Biological Chemistry. 1994; 269:13057-13060.
24. Farooqui, AA. and Horrocks, LA. Glycerophospholipids in the Brain. Springer New York: New York, NY 2007.
25. Cantin B, Brun LD, Gagné C, Murthy MR, Lupien PJ, and Julien P. Alterations in erythrocyte membrane lipid composition and fluidity in primary lipoprotein lipase deficiency. Biochimica et biophysica acta. 1992; 1139:25-31.
26. Hulbert A. Life, death and membrane bilayers. The Journal of experimental biology. 2003; 206:2303-2311.
27. Rabini R, Moretti N, Staffolani R, Salvolini E, Nanetti L, Franceschi C, and Mazzanti L. Reduced susceptibility to peroxidation of erythrocyte plasma membranes from centenarians. Experimental Gerontology. 2002; 37:657-663.
28. Collino S, Montoliu I, Martin FPJ, Scherer M, Mari D, Salvioli S, Bucci L, Ostan R, Monti D, Biagi E, Brigidi P, Franceschi C, and Rezzi S. Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism. PLoS ONE. 2013; 8:1-12.
29. Kamada T and Otsuji S. Lower levels of erythrocyte membrane fluidity in diabetic patients. A spin label study. Diabetes. 1983; 32:585-591.
30. Aozaki S. Decreased membrane fluidity in erythrocytes from patients with Crohn's disease. Gastroenterol.Jpn. 1989; 24:246-254.
31. Mecocci P, Cherubini A, Beal MF, Cecchetti R, Chionne F, Polidori MC, Romano G, and Senin U. Altered mitochondrial membrane fluidity in AD brain. Neuroscience Letters. 1996; 207:129-132.
32. Caprari P, Scuteri A, Salvati AM, Bauco C, Cantafora A, Masella R, Modesti D, Tarzia A, and Marigliano V. Aging and red blood cell membrane: A study of centenarians. Experimental Gerontology. 1999; 34:47-57.
33. Zhang H, Forman HJ, and Choi J. Gamma-Glutamyl Transpeptidase in Glutathione Biosynthesis. Methods in Enzymology. 2005; 401:468-483.
34. Wu G, Fang Y-Z, Yang S, Lupton JR, and Turner ND. Glutathione metabolism and its implications for health. The Journal of nutrition. 2004; 134:489-492.
35. Maher P. The effects of stress and aging on glutathione metabolism. Ageing Research Reviews. 2005; 4:288-314.
36. Pandur S, Pankiv S, Johannessen M, Moens U, and Huseby NE. Gamma-glutamyltransferase is upregulated after oxidative stress through the Ras signal transduction pathway in rat colon carcinoma cells. Free radical research. 2007; 41:1376-1384.
37. Whitfield JB. Gamma glutamyl transferase. Critical reviews in clinical laboratory sciences. 2001; 38:263-355.
38. Rahman I and MacNee W. Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease. The American journal of physiology. 1999; 277:L1067-L1088.
39. Manini P, Palma G De, Andreoli R, Goldoni M, Poli D, Lasagni G, and Mutti A. Urinary excretion of 4-vinyl phenol after experimental and occupational exposure to styrene. Giornale italiano di medicina del lavoro ed ergonomia. 2003; 25 Suppl:61-62.
40. Hu X-X, Zhong L, Zhang X, Gao Y-M, and Liu B-Z. NLS-RARa Promotes Proliferation and Inhibits Differentiation in HL-60 Cells. International Journal of Medical Sciences. 2014; 11:247-254.
41. Krumsiek J, Mittelstrass K, Do KT, Stückler F, Ried J, Adamski J, Peters A, Illig T, Kronenberg F, Friedrich N, Nauck M, Pietzner M, Mook-Kanamori DO, et al. Gender-specific pathway differences in the human serum metabolome. Metabolomics. 2015; 11:1815-1833.
42. Moayyeri A, Hammond CJ, Valdes AM, and Spector TD. Cohort Profile: TwinsUK and healthy ageing twin study. International journal of epidemiology. 2013; 42:76-85.
43. Holle R, Happich M, Löwel H, and Wichmann H. KORA-A Research Platform for Population Based Health Research. Das Gesundheitswesen. 2005; 67:19-25.
44. Karrasch S, Flexeder C, Behr J, Holle R, Huber RM, Jörres RA, Nowak D, Peters A, Wichmann H-E, Heinrich J, Schulz H, and KORA Study Group. Spirometric reference values for advanced age from a South german population. Respiration; international review of thoracic diseases. 2013; 85:210-219.
45. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic acids research. 2002; 30:e47.
46. Menni C, Kastenmüller G, Petersen AK, Bell JT, Psatha M, Tsai P-C, Gieger C, Schulz H, Erte I, John S, Brosnan MJ, Wilson SG, Tsaprouni L, et al. Metabolomic markers reveal novel pathways of ageing and early development in human populations. International journal of epidemiology. 2013; 42:1111-1119.
47. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates a., Crapo R, Enright P, Grinten CPM van der, Gustafsson P, Jensen R, Johnson DC, MacIntrye N, et al. Standardisation of spirometry. European Respiratory Journal. 2005; 26:319-338.
48. Levey AS, Stevens L a, Schmid CH, Zhang YL, Castro AF, Feldman HI, Kusek JW, Eggers P, Lente F Van, Greene T, and Coresh J. A new equation to estimate glomerular filtration rate. Annals of internal medicine. 2009; 150:604-612.
49. Grundberg E, Small KS, Hedman ÅK, Nica AC, Buil A, Keildson S, Bell JT, Yang T-P, Meduri E, Barrett A, Nisbett J, Sekowska M, Wilk A, et al. Mapping cis-and trans-regulatory effects across multiple tissues in twins. Nature genetics. 2012; 44:1084-1089.
50. Tsai P-C, Dongen J Van, Tan Q, Willemsen G, Christiansen L, Boomsma DI, Spector TD, Valdes AM, and Bell JT. DNA methylation changes in the IGF1R gene in birth weight discordant adult monozygotic twins. Twin Research and Human Genetics. 2015; (in press)
51. Teschendorff AE, Marabita F, Lechner M, Bartlett T, Tegner J, Gomez-Cabrero D, and Beck S. A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data. Bioinformatics (Oxford, England). 2013; 29:189-196.
52. Cohen, J. Statistical power analysis for the behavioral sciences. Routledge: Hillsdale, New Jersey 1988.
53. Tibshirani R. Regression Selection and Shrinkage via the Lasso. Journal of the Royal Statistical Society B. 1994; 58:267-288.