NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

Science

Volumn 352, Issue 6292, 2016, Pages 1436-1443

  Zhang, Hongbo ^a   Ryu, Dongryeol ^a   Wu, Yibo ^b   Gariani, Karim ^a   Wang, Xu ^a   Luan, Peiling ^a   D’Amico, Davide ^a   Ropelle, Eduardo R ^a,c   Lutolf, Matthias P ^a   Aebersold, Ruedi ^b,d   Schoonjans, Kristina ^e   Menzies, Keir J ^a,f   Auwerx, Johan ^a  

^a EPFL   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c UNIVERSITY OF CAMPINAS   (Brazil)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e Laboratory of Mechanical Metallurgy Ecole Polytechnique Federale de Lausanne   (Switzerland)

^f UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE RIBOSIDE; PROHIBITIN; NICOTINAMIDE; NICOTINAMIDE-BETA-RIBOSIDE; REPRESSOR PROTEIN;

CELLS AND CELL COMPONENTS; DISEASE INCIDENCE; MITOCHONDRION; MUSCLE; OXIDATION; PROTEIN; RODENT; SENESCENCE;

ARTICLE; CELL FUNCTION; DUCHENNE MUSCULAR DYSTROPHY; GENE EXPRESSION; HUMAN; LIFESPAN; MELANOCYTE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MUSCLE DEVELOPMENT; MUSCLE REGENERATION; NONHUMAN; PRIORITY JOURNAL; SENESCENCE; STEM CELL; ANALOGS AND DERIVATIVES; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL AGING; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; LONGEVITY; METABOLISM; MITOCHONDRION; MOUSE; MUSCULAR DYSTROPHIES; NEURAL STEM CELL; NUCLEAR REPROGRAMMING; OXIDATIVE STRESS; PHYSIOLOGY; SKELETAL MYOBLAST; UNFOLDED PROTEIN RESPONSE; X CHROMOSOME LINKED MUSCULAR DYSTROPHIC MOUSE;

MAMMALIA; MUS;

ANIMALS; CELL AGING; CELLULAR REPROGRAMMING; DISEASE MODELS, ANIMAL; LONGEVITY; MELANOCYTES; MICE; MICE, INBRED C57BL; MICE, INBRED MDX; MITOCHONDRIA; MUSCULAR DYSTROPHIES; MYOBLASTS, SKELETAL; NAD; NEURAL STEM CELLS; NIACINAMIDE; OXIDATIVE STRESS; REPRESSOR PROTEINS; UNFOLDED PROTEIN RESPONSE;

EID: 84965034275     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf2693     Document Type: Article

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