-
1
-
-
84927743782
-
-
Available from.
-
NIA. Global health and aging, 2011. Available from http://wwwnianihgov/sites/default/files/global_health_and_agingpdf.
-
(2011)
-
-
-
3
-
-
84927743781
-
-
Hear Disease and Stroke Prevention. Addressing the Nation's Leading Killers: At a Glance 2011, Available from.
-
CDC. Hear Disease and Stroke Prevention. Addressing the Nation's Leading Killers: At a Glance 2011, 2011. Available from http://wwwcdcgov/chronicdisease/resources/publications/AAG/dhdsphtm.
-
(2011)
-
-
-
4
-
-
84866405502
-
Medicare spending and financing fact sheet
-
Kaiser Family Foundation, Available from.
-
Medicare spending and financing fact sheet. Kaiser Family Foundation, 2011. Available from http://kfforg/medicare/fact-sheet/medicare-spending-and-financing-fact-sheet/.
-
(2011)
-
-
-
5
-
-
84875893421
-
Prevalence of obesity among older adults in the United States, 2007-2010
-
NCHS data brief, no 106
-
Fakhouri TH, Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity among older adults in the United States, 2007-2010. NCHS data brief, no 106, 2012.
-
(2012)
-
-
Fakhouri, T.H.1
Ogden, C.L.2
Carroll, M.D.3
Kit, B.K.4
Flegal, K.M.5
-
6
-
-
0037397789
-
Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes
-
Pedersen M, et al. Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes. Mech Ageing Dev 2003;124:495-502.
-
(2003)
Mech Ageing Dev
, vol.124
, pp. 495-502
-
-
Pedersen, M.1
-
7
-
-
15244348518
-
The origins of age-related proinflammatory state
-
Ferrucci L, et al. The origins of age-related proinflammatory state. Blood 2005;105:2294-2299.
-
(2005)
Blood
, vol.105
, pp. 2294-2299
-
-
Ferrucci, L.1
-
8
-
-
33644854500
-
Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process
-
Dinarello CA. Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process. Am J Clin Nutr 2006;83:447S-455S.
-
(2006)
Am J Clin Nutr
, vol.83
, pp. 447S-455S
-
-
Dinarello, C.A.1
-
10
-
-
0036068710
-
Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: a pilot study
-
Leng S, Chaves P, Koenig K, Walston J. Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: a pilot study. J Am Geriatr Soc 2002;50:1268-1271.
-
(2002)
J Am Geriatr Soc
, vol.50
, pp. 1268-1271
-
-
Leng, S.1
Chaves, P.2
Koenig, K.3
Walston, J.4
-
11
-
-
33846111415
-
Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
-
Franceschi C, et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 2007;128:92-105.
-
(2007)
Mech Ageing Dev
, vol.128
, pp. 92-105
-
-
Franceschi, C.1
-
12
-
-
84866163789
-
Evolution of inflammatory diseases
-
Okin D, Medzhitov R. Evolution of inflammatory diseases. Curr Biol 2012;22:R733-R740.
-
(2012)
Curr Biol
, vol.22
, pp. R733-R740
-
-
Okin, D.1
Medzhitov, R.2
-
13
-
-
0033911488
-
Inflamm-aging. An evolutionary perspective on immunosenescence
-
Franceschi C, et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000;908:244-254.
-
(2000)
Ann N Y Acad Sci
, vol.908
, pp. 244-254
-
-
Franceschi, C.1
-
14
-
-
77952302657
-
Inflammaging (inflammation + aging): a driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?
-
Goto M. Inflammaging (inflammation + aging): a driving force for human aging based on an evolutionarily antagonistic pleiotropy theory? Bioscience trends 2008;2:218-230.
-
(2008)
Bioscience trends
, vol.2
, pp. 218-230
-
-
Goto, M.1
-
15
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
Xu H, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003;112:1821-1830.
-
(2003)
J Clin Invest
, vol.112
, pp. 1821-1830
-
-
Xu, H.1
-
16
-
-
84899948384
-
Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity
-
Nagareddy PR, et al. Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. Cell Metab 2014;19:821-835.
-
(2014)
Cell Metab
, vol.19
, pp. 821-835
-
-
Nagareddy, P.R.1
-
17
-
-
84900988267
-
Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases
-
Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci 2014;69(Suppl):S4-S9.
-
(2014)
J Gerontol A Biol Sci Med Sci
, vol.69
, Issue.Suppl
, pp. S4-S9
-
-
Franceschi, C.1
Campisi, J.2
-
18
-
-
84884332722
-
Mechanisms of NOD-like receptor-associated inflammasome activation
-
Wen H, Miao EA, Ting JP. Mechanisms of NOD-like receptor-associated inflammasome activation. Immunity 2013;39:432-441.
-
(2013)
Immunity
, vol.39
, pp. 432-441
-
-
Wen, H.1
Miao, E.A.2
Ting, J.P.3
-
19
-
-
70249138036
-
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
-
Bauernfeind FG, et al. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 2009;183:787-791.
-
(2009)
J Immunol
, vol.183
, pp. 787-791
-
-
Bauernfeind, F.G.1
-
20
-
-
80053589126
-
Cross-regulation between the IL-1beta/IL-18 processing inflammasome and other inflammatory cytokines
-
Barker BR, Taxman DJ, Ting JP. Cross-regulation between the IL-1beta/IL-18 processing inflammasome and other inflammatory cytokines. Curr Opin Immunol 2011;23:591-597.
-
(2011)
Curr Opin Immunol
, vol.23
, pp. 591-597
-
-
Barker, B.R.1
Taxman, D.J.2
Ting, J.P.3
-
21
-
-
43249125839
-
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
-
Dostert C, Petrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 2008;320:674-677.
-
(2008)
Science
, vol.320
, pp. 674-677
-
-
Dostert, C.1
Petrilli, V.2
Van Bruggen, R.3
Steele, C.4
Mossman, B.T.5
Tschopp, J.6
-
22
-
-
77951800951
-
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
-
Duewell P, et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 2010;464:1357-1361.
-
(2010)
Nature
, vol.464
, pp. 1357-1361
-
-
Duewell, P.1
-
23
-
-
32944468985
-
Gout-associated uric acid crystals activate the NALP3 inflammasome
-
Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006;440:237-241.
-
(2006)
Nature
, vol.440
, pp. 237-241
-
-
Martinon, F.1
Petrilli, V.2
Mayor, A.3
Tardivel, A.4
Tschopp, J.5
-
24
-
-
79751512463
-
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
-
Vandanmagsar B, et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med 2011;17:179-188.
-
(2011)
Nat Med
, vol.17
, pp. 179-188
-
-
Vandanmagsar, B.1
-
25
-
-
79951818190
-
Differential expression of NLRP3 among hematopoietic cells
-
Guarda G, et al. Differential expression of NLRP3 among hematopoietic cells. J Immunol 2011;186:2529-2534.
-
(2011)
J Immunol
, vol.186
, pp. 2529-2534
-
-
Guarda, G.1
-
26
-
-
0842309938
-
Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression
-
Boehmer ED, Goral J, Faunce DE, Kovacs EJ. Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. J Leukoc Biol 2004;75:342-349.
-
(2004)
J Leukoc Biol
, vol.75
, pp. 342-349
-
-
Boehmer, E.D.1
Goral, J.2
Faunce, D.E.3
Kovacs, E.J.4
-
27
-
-
0036838909
-
Cutting edge: impaired Toll-like receptor expression and function in aging
-
Renshaw M, Rockwell J, Engleman C, Gewirtz A, Katz J, Sambhara S. Cutting edge: impaired Toll-like receptor expression and function in aging. J Immunol 2002;169:4697-4701.
-
(2002)
J Immunol
, vol.169
, pp. 4697-4701
-
-
Renshaw, M.1
Rockwell, J.2
Engleman, C.3
Gewirtz, A.4
Katz, J.5
Sambhara, S.6
-
28
-
-
84890165434
-
Impaired innate mucosal immunity in aged mice permits prolonged Streptococcus pneumoniae colonization
-
Krone CL, Trzcinski K, Zborowski T, Sanders EA, Bogaert D. Impaired innate mucosal immunity in aged mice permits prolonged Streptococcus pneumoniae colonization. Infect Immun 2013;81:4615-4625.
-
(2013)
Infect Immun
, vol.81
, pp. 4615-4625
-
-
Krone, C.L.1
Trzcinski, K.2
Zborowski, T.3
Sanders, E.A.4
Bogaert, D.5
-
29
-
-
84923607878
-
Complement C5a potentiates uric acid crystal-induced IL-1beta production
-
An LL, et al. Complement C5a potentiates uric acid crystal-induced IL-1beta production. Eur J Immunol 2014;44:3669-3679.
-
(2014)
Eur J Immunol
, vol.44
, pp. 3669-3679
-
-
An, L.L.1
-
30
-
-
84888240043
-
C3a modulates IL-1beta secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation
-
Asgari E, et al. C3a modulates IL-1beta secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation. Blood 2013;122:3473-3481.
-
(2013)
Blood
, vol.122
, pp. 3473-3481
-
-
Asgari, E.1
-
31
-
-
84880667818
-
Cutting edge: the NLRP3 inflammasome links complement-mediated inflammation and IL-1beta release
-
Laudisi F, et al. Cutting edge: the NLRP3 inflammasome links complement-mediated inflammation and IL-1beta release. J Immunol 2013;191:1006-1010.
-
(2013)
J Immunol
, vol.191
, pp. 1006-1010
-
-
Laudisi, F.1
-
32
-
-
47949099098
-
Origin and physiological roles of inflammation
-
Medzhitov R. Origin and physiological roles of inflammation. Nature 2008;454:428-435.
-
(2008)
Nature
, vol.454
, pp. 428-435
-
-
Medzhitov, R.1
-
33
-
-
84885167222
-
Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging
-
Youm YH, et al. Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab 2013;18:519-532.
-
(2013)
Cell Metab
, vol.18
, pp. 519-532
-
-
Youm, Y.H.1
-
34
-
-
84873087532
-
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
-
Heneka MT, et al. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 2013;493:674-678.
-
(2013)
Nature
, vol.493
, pp. 674-678
-
-
Heneka, M.T.1
-
36
-
-
84876775203
-
Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes
-
Hashimoto D, et al. Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity 2013;38:792-804.
-
(2013)
Immunity
, vol.38
, pp. 792-804
-
-
Hashimoto, D.1
-
37
-
-
84859508307
-
A lineage of myeloid cells independent of Myb and hematopoietic stem cells
-
Schulz C, et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science 2012;336:86-90.
-
(2012)
Science
, vol.336
, pp. 86-90
-
-
Schulz, C.1
-
38
-
-
84920724791
-
Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
-
Lavin Y, et al. Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell 2014;159:1312-1326.
-
(2014)
Cell
, vol.159
, pp. 1312-1326
-
-
Lavin, Y.1
-
39
-
-
84861164794
-
The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence
-
Youm YH, et al. The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence. Cell Rep 2012;1:56-68.
-
(2012)
Cell Rep
, vol.1
, pp. 56-68
-
-
Youm, Y.H.1
-
40
-
-
84868208782
-
Impact of immune-metabolic interactions on age-related thymic demise and T cell senescence
-
Dixit VD. Impact of immune-metabolic interactions on age-related thymic demise and T cell senescence. Semin Immunol 2012;24:321-330.
-
(2012)
Semin Immunol
, vol.24
, pp. 321-330
-
-
Dixit, V.D.1
-
41
-
-
84897491455
-
Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release
-
Samstad EO, et al. Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release. J Immunol 2014;192:2837-2845.
-
(2014)
J Immunol
, vol.192
, pp. 2837-2845
-
-
Samstad, E.O.1
-
42
-
-
84884350730
-
NLRP3 inflammasomes show high expression in aorta of patients with atherosclerosis
-
Zheng F, Xing S, Gong Z, Xing Q. NLRP3 inflammasomes show high expression in aorta of patients with atherosclerosis. Heart Lung Circ 2013;22:746-750.
-
(2013)
Heart Lung Circ
, vol.22
, pp. 746-750
-
-
Zheng, F.1
Xing, S.2
Gong, Z.3
Xing, Q.4
-
43
-
-
84907463613
-
NLRP3 and downstream cytokine expression elevated in the monocytes of patients with coronary artery disease
-
Wang L, Qu P, Zhao J, Chang Y. NLRP3 and downstream cytokine expression elevated in the monocytes of patients with coronary artery disease. Arch Med Sci 2014;10:791-800.
-
(2014)
Arch Med Sci
, vol.10
, pp. 791-800
-
-
Wang, L.1
Qu, P.2
Zhao, J.3
Chang, Y.4
-
44
-
-
0024317904
-
Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported
-
Evans DA, et al. Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. JAMA 1989;262:2551-2556.
-
(1989)
JAMA
, vol.262
, pp. 2551-2556
-
-
Evans, D.A.1
-
45
-
-
0032983334
-
Beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease
-
Bianca VD, Dusi S, Bianchini E, Dal Pra I, Rossi F. Beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease. J Biol Chem 1999;274:15493-15499.
-
(1999)
J Biol Chem
, vol.274
, pp. 15493-15499
-
-
Bianca, V.D.1
Dusi, S.2
Bianchini, E.3
Dal Pra, I.4
Rossi, F.5
-
46
-
-
47849085872
-
The NALP3 inflammasome is involved in the innate immune response to amyloid-beta
-
Halle A, et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol 2008;9:857-865.
-
(2008)
Nat Immunol
, vol.9
, pp. 857-865
-
-
Halle, A.1
-
47
-
-
74949127437
-
Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia
-
Grathwohl SA, et al. Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nat Neurosci 2009;12:1361-1363.
-
(2009)
Nat Neurosci
, vol.12
, pp. 1361-1363
-
-
Grathwohl, S.A.1
-
48
-
-
84877832333
-
Identification of a metabolic signature for multidimensional impairment and mortality risk in hospitalized older patients
-
Fontana L, et al. Identification of a metabolic signature for multidimensional impairment and mortality risk in hospitalized older patients. Aging Cell 2013;12:459-466.
-
(2013)
Aging Cell
, vol.12
, pp. 459-466
-
-
Fontana, L.1
-
49
-
-
84896690513
-
Prevalence of childhood and adult obesity in the United States, 2011-2012
-
Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA 2014;311:806-814.
-
(2014)
JAMA
, vol.311
, pp. 806-814
-
-
Ogden, C.L.1
Carroll, M.D.2
Kit, B.K.3
Flegal, K.M.4
-
50
-
-
70349231092
-
Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution
-
Yang H, Youm YH, Dixit VD. Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution. J Immunol 2009;183:3040-3052.
-
(2009)
J Immunol
, vol.183
, pp. 3040-3052
-
-
Yang, H.1
Youm, Y.H.2
Dixit, V.D.3
-
51
-
-
31544457103
-
Mechanisms of disease: is osteoporosis the obesity of bone?
-
Rosen CJ, Bouxsein ML. Mechanisms of disease: is osteoporosis the obesity of bone? Nat Clin Pract Rheumatol 2006;2:35-43.
-
(2006)
Nat Clin Pract Rheumatol
, vol.2
, pp. 35-43
-
-
Rosen, C.J.1
Bouxsein, M.L.2
-
52
-
-
23444450084
-
The association between obesity and the frailty syndrome in older women: the Women's Health and Aging Studies
-
Blaum CS, Xue QL, Michelon E, Semba RD, Fried LP. The association between obesity and the frailty syndrome in older women: the Women's Health and Aging Studies. J Am Geriatr Soc 2005;53:927-934.
-
(2005)
J Am Geriatr Soc
, vol.53
, pp. 927-934
-
-
Blaum, C.S.1
Xue, Q.L.2
Michelon, E.3
Semba, R.D.4
Fried, L.P.5
-
53
-
-
68349148211
-
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
-
Feuerer M, et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 2009;15:930-939.
-
(2009)
Nat Med
, vol.15
, pp. 930-939
-
-
Feuerer, M.1
-
54
-
-
68349150756
-
+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
-
+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 2009;15:914-920.
-
(2009)
Nat Med
, vol.15
, pp. 914-920
-
-
Nishimura, S.1
-
55
-
-
68349137821
-
Normalization of obesity-associated insulin resistance through immunotherapy
-
Winer S, et al. Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med 2009;15:921-929.
-
(2009)
Nat Med
, vol.15
, pp. 921-929
-
-
Winer, S.1
-
56
-
-
83755178932
-
Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue
-
Lumeng CN, et al. Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue. J Immunol 2011;187:6208-6216.
-
(2011)
J Immunol
, vol.187
, pp. 6208-6216
-
-
Lumeng, C.N.1
-
57
-
-
80054903245
-
Elimination of the NLRP3-ASC inflammasome protects against chronic obesity-induced pancreatic damage
-
Youm YH, Adijiang A, Vandanmagsar B, Burk D, Ravussin A, Dixit VD. Elimination of the NLRP3-ASC inflammasome protects against chronic obesity-induced pancreatic damage. Endocrinology 2011;152:4039-4045.
-
(2011)
Endocrinology
, vol.152
, pp. 4039-4045
-
-
Youm, Y.H.1
Adijiang, A.2
Vandanmagsar, B.3
Burk, D.4
Ravussin, A.5
Dixit, V.D.6
-
58
-
-
37549002511
-
The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock
-
Shao W, Yeretssian G, Doiron K, Hussain SN, Saleh M. The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock. J Biol Chem 2007;282:36321-36329.
-
(2007)
J Biol Chem
, vol.282
, pp. 36321-36329
-
-
Shao, W.1
Yeretssian, G.2
Doiron, K.3
Hussain, S.N.4
Saleh, M.5
-
59
-
-
78349299099
-
Fat tissue, aging, and cellular senescence
-
Tchkonia T, et al. Fat tissue, aging, and cellular senescence. Aging Cell 2010;9:667-684.
-
(2010)
Aging Cell
, vol.9
, pp. 667-684
-
-
Tchkonia, T.1
-
60
-
-
80855138775
-
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
-
Baker DJ, et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 2011;479:232-236.
-
(2011)
Nature
, vol.479
, pp. 232-236
-
-
Baker, D.J.1
-
61
-
-
0019942628
-
Changes in bone mineral density of the proximal femur and spine with aging. Differences between the postmenopausal and senile osteoporosis syndromes
-
Riggs BL, et al. Changes in bone mineral density of the proximal femur and spine with aging. Differences between the postmenopausal and senile osteoporosis syndromes. J Clin Invest 1982;70:716-723.
-
(1982)
J Clin Invest
, vol.70
, pp. 716-723
-
-
Riggs, B.L.1
-
62
-
-
84898842035
-
The Frailty syndrome: clinical measurements and basic underpinnings in humans and animals
-
Mohler MJ, Fain MJ, Wertheimer AM, Najafi B, Nikolich-Zugich J. The Frailty syndrome: clinical measurements and basic underpinnings in humans and animals. Exp Gerontol 2014;54:6-13.
-
(2014)
Exp Gerontol
, vol.54
, pp. 6-13
-
-
Mohler, M.J.1
Fain, M.J.2
Wertheimer, A.M.3
Najafi, B.4
Nikolich-Zugich, J.5
-
63
-
-
84890123550
-
Recent advances: osteoporosis in the "oldest old"
-
Colon-Emeric CS. Recent advances: osteoporosis in the "oldest old". Curr Osteoporo Rep 2013;11:270-275.
-
(2013)
Curr Osteoporo Rep
, vol.11
, pp. 270-275
-
-
Colon-Emeric, C.S.1
-
64
-
-
31044432767
-
Pathogenesis of osteoporosis: concepts, conflicts, and prospects
-
Raisz LG. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest 2005;115:3318-3325.
-
(2005)
J Clin Invest
, vol.115
, pp. 3318-3325
-
-
Raisz, L.G.1
-
65
-
-
33846219617
-
Arthropathy of neonatal onset multisystem inflammatory disease (NOMID/CINCA)
-
Hill SC, Namde M, Dwyer A, Poznanski A, Canna S, Goldbach-Mansky R. Arthropathy of neonatal onset multisystem inflammatory disease (NOMID/CINCA). Pediatr Radiol 2007;37:145-152.
-
(2007)
Pediatr Radiol
, vol.37
, pp. 145-152
-
-
Hill, S.C.1
Namde, M.2
Dwyer, A.3
Poznanski, A.4
Canna, S.5
Goldbach-Mansky, R.6
-
66
-
-
84860475314
-
Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice
-
Bonar SL, et al. Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice. PLoS ONE 2012;7:e35979.
-
(2012)
PLoS ONE
, vol.7
, pp. e35979
-
-
Bonar, S.L.1
-
67
-
-
79955979408
-
Preservation of femoral bone thickness in middle age predicts survival in genetically heterogeneous mice
-
Miller RA, Kreider J, Galecki A, Goldstein SA. Preservation of femoral bone thickness in middle age predicts survival in genetically heterogeneous mice. Aging Cell 2011;10:383-391.
-
(2011)
Aging Cell
, vol.10
, pp. 383-391
-
-
Miller, R.A.1
Kreider, J.2
Galecki, A.3
Goldstein, S.A.4
-
68
-
-
78651393239
-
A role for mitochondria in NLRP3 inflammasome activation
-
Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011;469:221-225.
-
(2011)
Nature
, vol.469
, pp. 221-225
-
-
Zhou, R.1
Yazdi, A.S.2
Menu, P.3
Tschopp, J.4
-
69
-
-
84908574562
-
Mitochondrial oxidative stress in aging and healthspan
-
Dai DF, Chiao YA, Marcinek DJ, Szeto HH, Rabinovitch PS. Mitochondrial oxidative stress in aging and healthspan. Longev Healthspan 2014;3:6.
-
(2014)
Longev Healthspan
, vol.3
, pp. 6
-
-
Dai, D.F.1
Chiao, Y.A.2
Marcinek, D.J.3
Szeto, H.H.4
Rabinovitch, P.S.5
-
70
-
-
84919712770
-
Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers
-
Marino G, Pietrocola F, Madeo F, Kroemer G. Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers. Autophagy 2014;10:1879-1882.
-
(2014)
Autophagy
, vol.10
, pp. 1879-1882
-
-
Marino, G.1
Pietrocola, F.2
Madeo, F.3
Kroemer, G.4
-
71
-
-
84857195479
-
Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction
-
Shi CS, et al. Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction. Nat Immunol 2012;13:255-263.
-
(2012)
Nat Immunol
, vol.13
, pp. 255-263
-
-
Shi, C.S.1
-
72
-
-
84890364356
-
Inflammasome activation by altered proteostasis
-
Shin JN, Fattah EA, Bhattacharya A, Ko S, Eissa NT. Inflammasome activation by altered proteostasis. J Biol Chem 2013;288:35886-35895.
-
(2013)
J Biol Chem
, vol.288
, pp. 35886-35895
-
-
Shin, J.N.1
Fattah, E.A.2
Bhattacharya, A.3
Ko, S.4
Eissa, N.T.5
-
73
-
-
84922606978
-
The role of protein clearance mechanisms in organismal ageing and age-related diseases
-
Vilchez D, Saez I, Dillin A. The role of protein clearance mechanisms in organismal ageing and age-related diseases. Nat Commun 2014;5:5659.
-
(2014)
Nat Commun
, vol.5
, pp. 5659
-
-
Vilchez, D.1
Saez, I.2
Dillin, A.3
-
74
-
-
84924356420
-
Ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
-
PMID 25686106. [Epub ahead of print].
-
Youm YH, et al. Ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med 2015;PMID 25686106. [Epub ahead of print].
-
(2015)
Nat Med
-
-
Youm, Y.H.1
-
75
-
-
84879582536
-
Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation
-
Yan Y, et al. Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity 2013;38:1154-1163.
-
(2013)
Immunity
, vol.38
, pp. 1154-1163
-
-
Yan, Y.1
-
76
-
-
84907089341
-
D-beta-hydroxybutyrate extends lifespan in C. elegans
-
Edwards C, Canfield J, Copes N, Rehan M, Lipps D, Bradshaw PC. D-beta-hydroxybutyrate extends lifespan in C. elegans. Aging 2014;6:621-644.
-
(2014)
Aging
, vol.6
, pp. 621-644
-
-
Edwards, C.1
Canfield, J.2
Copes, N.3
Rehan, M.4
Lipps, D.5
Bradshaw, P.C.6
-
77
-
-
0141611988
-
Subfield history: caloric restriction, slowing aging, and extending life
-
Masoro EJ. Subfield history: caloric restriction, slowing aging, and extending life. Sci Aging Knowledge Environ 2003;2003:RE2.
-
(2003)
Sci Aging Knowledge Environ
, vol.2003
, pp. RE2
-
-
Masoro, E.J.1
-
79
-
-
84872166360
-
Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor
-
Shimazu T, et al. Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science 2013;339:211-214.
-
(2013)
Science
, vol.339
, pp. 211-214
-
-
Shimazu, T.1
-
80
-
-
84879596906
-
K(+) efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter
-
Munoz-Planillo R, Kuffa P, Martinez-Colon G, Smith BL, Rajendiran TM, Nunez G. K(+) efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity 2013;38:1142-1153.
-
(2013)
Immunity
, vol.38
, pp. 1142-1153
-
-
Munoz-Planillo, R.1
Kuffa, P.2
Martinez-Colon, G.3
Smith, B.L.4
Rajendiran, T.M.5
Nunez, G.6
-
81
-
-
84896332642
-
Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes
-
Lu A, et al. Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell 2014;156:1193-1206.
-
(2014)
Cell
, vol.156
, pp. 1193-1206
-
-
Lu, A.1
-
82
-
-
84885467630
-
Inflammasome-mediated secretion of IL-1beta in human monocytes through TLR2 activation; modulation by dietary fatty acids
-
Snodgrass RG, Huang S, Choi IW, Rutledge JC, Hwang DH. Inflammasome-mediated secretion of IL-1beta in human monocytes through TLR2 activation; modulation by dietary fatty acids. J Immunol 2013;191:4337-4347.
-
(2013)
J Immunol
, vol.191
, pp. 4337-4347
-
-
Snodgrass, R.G.1
Huang, S.2
Choi, I.W.3
Rutledge, J.C.4
Hwang, D.H.5
-
83
-
-
84902673006
-
Omega-3 free fatty acids suppress macrophage inflammasome activation by inhibiting NF-kappaB activation and enhancing autophagy
-
Williams-Bey Y, et al. Omega-3 free fatty acids suppress macrophage inflammasome activation by inhibiting NF-kappaB activation and enhancing autophagy. PLoS ONE 2014;9:e97957.
-
(2014)
PLoS ONE
, vol.9
, pp. e97957
-
-
Williams-Bey, Y.1
-
84
-
-
84888036882
-
Chronic caloric restriction partially protects against age-related alteration in serum metabolome
-
De Guzman JM, et al. Chronic caloric restriction partially protects against age-related alteration in serum metabolome. Age 2013;35:1091-1104.
-
(2013)
Age
, vol.35
, pp. 1091-1104
-
-
De Guzman, J.M.1
-
85
-
-
79951631209
-
Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy
-
Rochon J, et al. Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy. J Gerontol A Biol Sci Med Sci 2011;66:97-108.
-
(2011)
J Gerontol A Biol Sci Med Sci
, vol.66
, pp. 97-108
-
-
Rochon, J.1
-
86
-
-
2342647592
-
Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans
-
Fontana L, Meyer TE, Klein S, Holloszy JO. Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc Natl Acad Sci USA 2004;101:6659-6663.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 6659-6663
-
-
Fontana, L.1
Meyer, T.E.2
Klein, S.3
Holloszy, J.O.4
-
87
-
-
0034678402
-
Infectious agents are not necessary for murine atherogenesis
-
Wright SD, et al. Infectious agents are not necessary for murine atherogenesis. J Exp Med 2000;191:1437-1442.
-
(2000)
J Exp Med
, vol.191
, pp. 1437-1442
-
-
Wright, S.D.1
-
88
-
-
70449701826
-
Obesity accelerates thymic aging
-
Yang H, et al. Obesity accelerates thymic aging. Blood 2009;114:3803-3812.
-
(2009)
Blood
, vol.114
, pp. 3803-3812
-
-
Yang, H.1
-
89
-
-
84925273129
-
Adipose tissue as an immunological organ
-
Grant RW, Dixit VD. Adipose tissue as an immunological organ. Obesity 2015;23:512-518.
-
(2015)
Obesity
, vol.23
, pp. 512-518
-
-
Grant, R.W.1
Dixit, V.D.2
-
90
-
-
84927743780
-
-
University of Washington, Data Released March 2013. Available from.
-
Global Burden of Disease Study 2010. Institute for Health Metrics and Evaluation. University of Washington, Data Released March 2013. Available from http://vizhub.healthdata.org/gbd-compare/.
-
-
-
|