Sestrin2 is a leucine sensor for the mTORC1 pathway

Science

Volumn 351, Issue 6268, 2016, Pages 43-48

  Wolfson, Rachel L ^a,b,c   Chantranupong, Lynne ^a,b,c   Saxton, Robert A ^a,b,c   Shen, Kuang ^a,b,c   Scaria, Sonia M ^a,b   Cantor, Jason R ^a,b,c   Sabatini, David M ^a,b,c  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ARGININE; GATOR 2 PROTEIN; GUANOSINE TRIPHOSPHATASE; ISOLEUCINE; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; METHIONINE; PROTEIN; SESTRIN 2 PROTEIN; UNCLASSIFIED DRUG; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; NUCLEAR PROTEIN; PROTEIN BINDING; SESN2 PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE; WDR24 PROTEIN, HUMAN;

AMINO ACID; PROTEIN; RNA; SENSOR;

ARTICLE; BINDING AFFINITY; CONCENTRATION PROCESS; DISSOCIATION CONSTANT; GENE OVEREXPRESSION; HUMAN; LYSOSOME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; CHEMISTRY; GENETICS; HEK293 CELL LINE; METABOLISM;

GTPASE-ACTIVATING PROTEINS; HEK293 CELLS; HUMANS; LEUCINE; METABOLIC NETWORKS AND PATHWAYS; MULTIPROTEIN COMPLEXES; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEINS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84952915479     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aab2674     Document Type: Article

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