-
1
-
-
20644447562
-
Aging, longevity, and diet: Historical remarks on calorie intake reduction
-
Schäfer, D. Aging, longevity, and diet: historical remarks on calorie intake reduction. Gerontology 51, 126-130 (2005).
-
(2005)
Gerontology
, vol.51
, pp. 126-130
-
-
Schäfer, D.1
-
2
-
-
84925852614
-
Promoting health and longevity through diet: From model organisms to humans
-
Fontana, L. & Partridge, L. Promoting health and longevity through diet: from model organisms to humans. Cell 161, 106-118 (2015).
-
(2015)
Cell
, vol.161
, pp. 106-118
-
-
Fontana, L.1
Partridge, L.2
-
3
-
-
0037147103
-
Rates of behavior and aging specified by mitochondrial function during development
-
Dillin, A. Et al. Rates of behavior and aging specified by mitochondrial function during development. Science 298, 2398-2401 (2002).
-
(2002)
Science
, vol.298
, pp. 2398-2401
-
-
Dillin, A.1
-
4
-
-
0037228016
-
A systematic RNAi screen identifies a critical role for mitochondria in C. Elegans longevity
-
Lee, S.S. Et al. A systematic RNAi screen identifies a critical role for mitochondria in C. Elegans longevity. Nat. Genet. 33, 40-48 (2003).
-
(2003)
Nat. Genet.
, vol.33
, pp. 40-48
-
-
Lee, S.S.1
-
5
-
-
2642580016
-
Premature ageing in mice expressing defective mitochondrial DNA polymerase
-
Trifunovic, A. Et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429, 417-423 (2004).
-
(2004)
Nature
, vol.429
, pp. 417-423
-
-
Trifunovic, A.1
-
6
-
-
22344456832
-
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
-
Kujoth, G.C. Et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 309, 481-484 (2005).
-
(2005)
Science
, vol.309
, pp. 481-484
-
-
Kujoth, G.C.1
-
7
-
-
84923790921
-
Tipping the metabolic scales towards increased longevity in mammals
-
Riera, C.E. & Dillin, A. Tipping the metabolic scales towards increased longevity in mammals. Nat. Cell Biol. 17, 196-203 (2015).
-
(2015)
Nat. Cell Biol.
, vol.17
, pp. 196-203
-
-
Riera, C.E.1
Dillin, A.2
-
9
-
-
0029952098
-
Dwarf mice and the ageing process
-
Brown-Borg, H.M., Borg, K.E., Meliska, C.J. & Bartke, A. Dwarf mice and the ageing process. Nature 384, 33 (1996).
-
(1996)
Nature
, vol.384
, pp. 33
-
-
Brown-Borg, H.M.1
Borg, K.E.2
Meliska, C.J.3
Bartke, A.4
-
10
-
-
0033829362
-
Studies of aging in Ames dwarf mice: Effects of caloric restriction
-
Mattison, J.A. Et al. Studies of aging in Ames dwarf mice: Effects of caloric restriction. J. Am. Aging Assoc. 23, 9-16 (2000).
-
(2000)
J. Am. Aging Assoc.
, vol.23
, pp. 9-16
-
-
Mattison, J.A.1
-
11
-
-
0035936147
-
Extending the lifespan of long-lived mice
-
Bartke, A. Et al. Extending the lifespan of long-lived mice. Nature 414, 412 (2001).
-
(2001)
Nature
, vol.414
, pp. 412
-
-
Bartke, A.1
-
12
-
-
33645526333
-
Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: A randomized controlled trial
-
Heilbronn, L.K. Et al. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. J. Am. Med. Assoc. 295, 1539-1548 (2006).
-
(2006)
J. Am. Med. Assoc.
, vol.295
, pp. 1539-1548
-
-
Heilbronn, L.K.1
-
13
-
-
84943239001
-
A 2-year randomized controlled trial of human caloric restriction: Feasibility and effects on predictors of health span and longevity
-
Ravussin, E. Et al. A 2-year randomized controlled trial of human caloric restriction: feasibility and effects on predictors of health span and longevity. J. Gerontol. A Biol. Sci. Med. Sci. 70, 1097-1104 (2015).
-
(2015)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.70
, pp. 1097-1104
-
-
Ravussin, E.1
-
14
-
-
0019215950
-
Changes in adipose mass and cellularity through the adult life of rats fed ad libitum or a life-prolonging restricted diet
-
Bertrand, H.A., Lynd, F.T., Masoro, E.J. & Yu, B.P. Changes in adipose mass and cellularity through the adult life of rats fed ad libitum or a life-prolonging restricted diet. J. Gerontol. 35, 827-835 (1980).
-
(1980)
J. Gerontol.
, vol.35
, pp. 827-835
-
-
Bertrand, H.A.1
Lynd, F.T.2
Masoro, E.J.3
Yu, B.P.4
-
15
-
-
0000567961
-
Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat
-
Barzilai, N., Banerjee, S., Hawkins, M., Chen, W. & Rossetti, L. Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat. J. Clin. Invest. 101, 1353-1361 (1998).
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 1353-1361
-
-
Barzilai, N.1
Banerjee, S.2
Hawkins, M.3
Chen, W.4
Rossetti, L.5
-
16
-
-
76249097841
-
Genetic variation in the murine lifespan response to dietary restriction: From life extension to life shortening
-
Liao, C.Y., Rikke, B.A., Johnson, T.E., Diaz, V. & Nelson, J.F. Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell 9, 92-95 (2010).
-
(2010)
Aging Cell
, vol.9
, pp. 92-95
-
-
Liao, C.Y.1
Rikke, B.A.2
Johnson, T.E.3
Diaz, V.4
Nelson, J.F.5
-
17
-
-
79960329362
-
Fat maintenance is a predictor of the murine lifespan response to dietary restriction
-
Liao, C.Y. Et al. Fat maintenance is a predictor of the murine lifespan response to dietary restriction. Aging Cell 10, 629-639 (2011).
-
(2011)
Aging Cell
, vol.10
, pp. 629-639
-
-
Liao, C.Y.1
-
18
-
-
0033984012
-
Metabolic mass, metabolic rate, caloric restriction, and aging in male Fischer 344 rats
-
Greenberg, J.A. & Boozer, C.N. Metabolic mass, metabolic rate, caloric restriction, and aging in male Fischer 344 rats. Mech. Ageing Dev. 113, 37-48 (2000).
-
(2000)
Mech. Ageing Dev.
, vol.113
, pp. 37-48
-
-
Greenberg, J.A.1
Boozer, C.N.2
-
19
-
-
18944391216
-
Energy expenditure of calorically restricted rats is higher than predicted from their altered body composition
-
Selman, C. Et al. Energy expenditure of calorically restricted rats is higher than predicted from their altered body composition. Mech. Ageing Dev. 126, 783-793 (2005).
-
(2005)
Mech. Ageing Dev.
, vol.126
, pp. 783-793
-
-
Selman, C.1
-
20
-
-
84876077532
-
Metabolic characteristics of long-lived mice
-
Bartke, A. & Westbrook, R. Metabolic characteristics of long-lived mice. Front. Genet. 3, 288 (2012).
-
(2012)
Front. Genet.
, vol.3
, pp. 288
-
-
Bartke, A.1
Westbrook, R.2
-
21
-
-
84941236856
-
Effect of aging on muscle mitochondrial substrate utilization in humans
-
Petersen, K.F. Et al. Effect of aging on muscle mitochondrial substrate utilization in humans. Proc. Natl. Acad. Sci. USA 112, 11330-11334 (2015).
-
(2015)
Proc. Natl. Acad. Sci. USA
, vol.112
, pp. 11330-11334
-
-
Petersen, K.F.1
-
22
-
-
84859816154
-
Caloric restriction alters the metabolic response to a mixed-meal: Results from a randomized, controlled trial
-
Huffman, K.M. Et al. Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial. PLoS ONE 7, e28190 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Huffman, K.M.1
-
23
-
-
84892546590
-
Interleukin-8 and interleukin-10, brain volume and microstructure, and the influence of calorie restriction in old rhesus macaques
-
Willette, A.A. Et al. Interleukin-8 and interleukin-10, brain volume and microstructure, and the influence of calorie restriction in old rhesus macaques. Age (Dordr.) 35, 2215-2227 (2013).
-
(2013)
Age (Dordr.)
, vol.35
, pp. 2215-2227
-
-
Willette, A.A.1
-
24
-
-
84924356420
-
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
-
Youm, Y.H. Et al. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat. Med. 21, 263-269 (2015).
-
(2015)
Nat. Med.
, vol.21
, pp. 263-269
-
-
Youm, Y.H.1
-
25
-
-
70349231092
-
Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution
-
Yang, H., Youm, Y.H. & Dixit, V.D. Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution. J. Immunol. 183, 3040-3052 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 3040-3052
-
-
Yang, H.1
Youm, Y.H.2
Dixit, V.D.3
-
26
-
-
22744445281
-
Overview of caloric restriction and ageing
-
Masoro, E.J. Overview of caloric restriction and ageing. Mech. Ageing Dev. 126, 913-922 (2005).
-
(2005)
Mech. Ageing Dev.
, vol.126
, pp. 913-922
-
-
Masoro, E.J.1
-
27
-
-
67650439330
-
Caloric restriction delays disease onset and mortality in rhesus monkeys
-
Colman, R.J. Et al. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325, 201-204 (2009).
-
(2009)
Science
, vol.325
, pp. 201-204
-
-
Colman, R.J.1
-
28
-
-
84866163081
-
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
-
Mattison, J.A. Et al. Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 489, 318-321 (2012).
-
(2012)
Nature
, vol.489
, pp. 318-321
-
-
Mattison, J.A.1
-
29
-
-
84930363624
-
MTOR signaling in cellular and organismal energetics
-
Albert, V. & Hall, M.N. mTOR signaling in cellular and organismal energetics. Curr. Opin. Cell Biol. 33, 55-66 (2015).
-
(2015)
Curr. Opin. Cell Biol.
, vol.33
, pp. 55-66
-
-
Albert, V.1
Hall, M.N.2
-
30
-
-
0642367846
-
Genetics: Influence of TOR kinase on lifespan in C. Elegans
-
Vellai, T. Et al. Genetics: influence of TOR kinase on lifespan in C. Elegans. Nature 426, 620 (2003).
-
(2003)
Nature
, vol.426
, pp. 620
-
-
Vellai, T.1
-
31
-
-
3042648746
-
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
-
Kapahi, P. Et al. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr. Biol. 14, 885-890 (2004).
-
(2004)
Curr. Biol.
, vol.14
, pp. 885-890
-
-
Kapahi, P.1
-
32
-
-
84859117806
-
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
-
Lamming, D.W. Et al. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 335, 1638-1643 (2012).
-
(2012)
Science
, vol.335
, pp. 1638-1643
-
-
Lamming, D.W.1
-
33
-
-
84884150826
-
Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression
-
Wu, J.J. Et al. Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. Cell Rep. 4, 913-920 (2013).
-
(2013)
Cell Rep.
, vol.4
, pp. 913-920
-
-
Wu, J.J.1
-
34
-
-
27744511769
-
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
-
Kaeberlein, M. Et al. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310, 1193-1196 (2005).
-
(2005)
Science
, vol.310
, pp. 1193-1196
-
-
Kaeberlein, M.1
-
35
-
-
33846423520
-
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
-
Hansen, M. Et al. Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6, 95-110 (2007).
-
(2007)
Aging Cell
, vol.6
, pp. 95-110
-
-
Hansen, M.1
-
36
-
-
84872527628
-
MTOR is a key modulator of ageing and age-related disease
-
Johnson, S.C., Rabinovitch, P.S. & Kaeberlein, M. mTOR is a key modulator of ageing and age-related disease. Nature 493, 338-345 (2013).
-
(2013)
Nature
, vol.493
, pp. 338-345
-
-
Johnson, S.C.1
Rabinovitch, P.S.2
Kaeberlein, M.3
-
37
-
-
0037007014
-
FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction
-
Desai, B.N., Myers, B.R. & Schreiber, S.L. FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. Proc. Natl. Acad. Sci. USA 99, 4319-4324 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 4319-4324
-
-
Desai, B.N.1
Myers, B.R.2
Schreiber, S.L.3
-
38
-
-
33748752151
-
The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
-
Schieke, S.M. Et al. The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J. Biol. Chem. 281, 27643-27652 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 27643-27652
-
-
Schieke, S.M.1
-
39
-
-
76049099052
-
Direct control of mitochondrial function by mTOR
-
Ramanathan, A. & Schreiber, S.L. Direct control of mitochondrial function by mTOR. Proc. Natl. Acad. Sci. USA 106, 22229-22232 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 22229-22232
-
-
Ramanathan, A.1
Schreiber, S.L.2
-
40
-
-
33947574775
-
Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression
-
Bonawitz, N.D., Chatenay-Lapointe, M., Pan, Y. & Shadel, G.S. Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. Cell Metab. 5, 265-277 (2007).
-
(2007)
Cell Metab.
, vol.5
, pp. 265-277
-
-
Bonawitz, N.D.1
Chatenay-Lapointe, M.2
Pan, Y.3
Shadel, G.S.4
-
41
-
-
54849426651
-
Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy
-
Bentzinger, C.F. Et al. Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metab. 8, 411-424 (2008).
-
(2008)
Cell Metab.
, vol.8
, pp. 411-424
-
-
Bentzinger, C.F.1
-
42
-
-
54849431380
-
Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration
-
Polak, P. Et al. Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab. 8, 399-410 (2008).
-
(2008)
Cell Metab.
, vol.8
, pp. 399-410
-
-
Polak, P.1
-
43
-
-
84862994618
-
MTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
-
Yilmaz, Ö.H. Et al. mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature 486, 490-495 (2012).
-
(2012)
Nature
, vol.486
, pp. 490-495
-
-
Yilmaz, Ö.H.1
-
44
-
-
84939203943
-
Metabolic regulation by lysine malonylation, succinylation and glutarylation
-
Hirschey, M.D. & Zhao, Y. Metabolic regulation by lysine malonylation, succinylation and glutarylation. Mol. Cell. Proteomics 14, 2308-2315 (2015).
-
(2015)
Mol. Cell. Proteomics
, vol.14
, pp. 2308-2315
-
-
Hirschey, M.D.1
Zhao, Y.2
-
45
-
-
0034703217
-
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
-
Lin, S.J., Defossez, P.A. & Guarente, L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-2128 (2000).
-
(2000)
Science
, vol.289
, pp. 2126-2128
-
-
Lin, S.J.1
Defossez, P.A.2
Guarente, L.3
-
46
-
-
8644224064
-
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
-
Rogina, B. & Helfand, S.L. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Natl. Acad. Sci. USA 101, 15998-16003 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 15998-16003
-
-
Rogina, B.1
Helfand, S.L.2
-
47
-
-
19344374925
-
Sir2-independent life span extension by calorie restriction in yeast
-
Kaeberlein, M., Kirkland, K.T., Fields, S. & Kennedy, B.K. Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol. 2, e296 (2004).
-
(2004)
PLoS Biol.
, vol.2
, pp. e296
-
-
Kaeberlein, M.1
Kirkland, K.T.2
Fields, S.3
Kennedy, B.K.4
-
48
-
-
10844236451
-
Nutrient availability regulates SIRT1 through a Forkhead-dependent pathway
-
Nemoto, S., Fergusson, M.M. & Finkel, T. Nutrient availability regulates SIRT1 through a Forkhead-dependent pathway. Science 306, 2105-2108 (2004).
-
(2004)
Science
, vol.306
, pp. 2105-2108
-
-
Nemoto, S.1
Fergusson, M.M.2
Finkel, T.3
-
49
-
-
3142740860
-
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
-
Cohen, H.Y. Et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305, 390-392 (2004).
-
(2004)
Science
, vol.305
, pp. 390-392
-
-
Cohen, H.Y.1
-
50
-
-
46249100836
-
Tissue-specific regulation of SIRT1 by calorie restriction
-
Chen, D. Et al. Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev. 22, 1753-1757 (2008).
-
(2008)
Genes Dev.
, vol.22
, pp. 1753-1757
-
-
Chen, D.1
-
51
-
-
84892500218
-
SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice
-
Mercken, E.M. Et al. SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice. Aging Cell 13, 193-196 (2014).
-
(2014)
Aging Cell
, vol.13
, pp. 193-196
-
-
Mercken, E.M.1
-
52
-
-
84883476818
-
Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH
-
Satoh, A. Et al. Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. Cell Metab. 18, 416-430 (2013).
-
(2013)
Cell Metab.
, vol.18
, pp. 416-430
-
-
Satoh, A.1
-
53
-
-
84858000209
-
The sirtuin SIRT6 regulates lifespan in male mice
-
Kanfi, Y. Et al. The sirtuin SIRT6 regulates lifespan in male mice. Nature 483, 218-221 (2012).
-
(2012)
Nature
, vol.483
, pp. 218-221
-
-
Kanfi, Y.1
-
54
-
-
55749084738
-
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
-
Ahn, B.H. Et al. A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc. Natl. Acad. Sci. USA 105, 14447-14452 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 14447-14452
-
-
Ahn, B.H.1
-
55
-
-
77950806433
-
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
-
Hirschey, M.D. Et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature 464, 121-125 (2010).
-
(2010)
Nature
, vol.464
, pp. 121-125
-
-
Hirschey, M.D.1
-
56
-
-
78649521247
-
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
-
Qiu, X., Brown, K., Hirschey, M.D., Verdin, E. & Chen, D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab. 12, 662-667 (2010).
-
(2010)
Cell Metab.
, vol.12
, pp. 662-667
-
-
Qiu, X.1
Brown, K.2
Hirschey, M.D.3
Verdin, E.4
Chen, D.5
-
57
-
-
78650248160
-
Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress
-
Tao, R. Et al. Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol. Cell 40, 893-904 (2010).
-
(2010)
Mol. Cell
, vol.40
, pp. 893-904
-
-
Tao, R.1
-
58
-
-
84872276165
-
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome
-
Hebert, A.S. Et al. Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Mol. Cell 49, 186-199 (2013).
-
(2013)
Mol. Cell
, vol.49
, pp. 186-199
-
-
Hebert, A.S.1
-
59
-
-
78651468722
-
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
-
Someya, S. Et al. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 143, 802-812 (2010).
-
(2010)
Cell
, vol.143
, pp. 802-812
-
-
Someya, S.1
-
60
-
-
84926644968
-
A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3
-
Barger, J.L. Et al. A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3. PLoS ONE 10, e0120738 (2015).
-
(2015)
PLoS ONE
, vol.10
-
-
Barger, J.L.1
-
61
-
-
84907545906
-
AMPK: Positive and negative regulation, and its role in whole-body energy homeostasis
-
Hardie, D.G. AMPK: positive and negative regulation, and its role in whole-body energy homeostasis. Curr. Opin. Cell Biol. 33, 1-7 (2015).
-
(2015)
Curr. Opin. Cell Biol.
, vol.33
, pp. 1-7
-
-
Hardie, D.G.1
-
62
-
-
34848850156
-
An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. Elegans
-
Greer, E.L. Et al. An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. Elegans. Curr. Biol. 17, 1646-1656 (2007).
-
(2007)
Curr. Biol.
, vol.17
, pp. 1646-1656
-
-
Greer, E.L.1
-
63
-
-
34748850786
-
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
-
Schulz, T.J. Et al. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. 6, 280-293 (2007).
-
(2007)
Cell Metab.
, vol.6
, pp. 280-293
-
-
Schulz, T.J.1
-
64
-
-
84872137308
-
Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies
-
Stenesen, D. Et al. Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies. Cell Metab. 17, 101-112 (2013).
-
(2013)
Cell Metab.
, vol.17
, pp. 101-112
-
-
Stenesen, D.1
-
65
-
-
84904038165
-
AMPK at the nexus of energetics and aging
-
Burkewitz, K., Zhang, Y. & Mair, W.B. AMPK at the nexus of energetics and aging. Cell Metab. 20, 10-25 (2014).
-
(2014)
Cell Metab.
, vol.20
, pp. 10-25
-
-
Burkewitz, K.1
Zhang, Y.2
Mair, W.B.3
-
66
-
-
80051609656
-
Calorie restriction: Is AMPK a key sensor and effector?
-
Cantó, C. & Auwerx, J. Calorie restriction: is AMPK a key sensor and effector? Physiology (Bethesda) 26, 214-224 (2011).
-
(2011)
Physiology (Bethesda)
, vol.26
, pp. 214-224
-
-
Cantó, C.1
Auwerx, J.2
-
67
-
-
84907393377
-
AMPK modulates tissue and organismal aging in a non-cell-autonomous manner
-
Ulgherait, M., Rana, A., Rera, M., Graniel, J. & Walker, D.W. AMPK modulates tissue and organismal aging in a non-cell-autonomous manner. Cell Rep. 8, 1767-1780 (2014).
-
(2014)
Cell Rep.
, vol.8
, pp. 1767-1780
-
-
Ulgherait, M.1
Rana, A.2
Rera, M.3
Graniel, J.4
Walker, D.W.5
-
68
-
-
0042691506
-
Autophagy genes are essential for dauer development and life-span extension in C. Elegans
-
Meléndez, A. Et al. Autophagy genes are essential for dauer development and life-span extension in C. Elegans. Science 301, 1387-1391 (2003).
-
(2003)
Science
, vol.301
, pp. 1387-1391
-
-
Meléndez, A.1
-
69
-
-
79953043473
-
Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
-
Morselli, E. Et al. Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis. 1, e10 (2010).
-
(2010)
Cell Death Dis.
, vol.1
, pp. e10
-
-
Morselli, E.1
-
70
-
-
84901615928
-
Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification
-
Ruckenstuhl, C. Et al. Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification. PLoS Genet. 10, e1004347 (2014).
-
(2014)
PLoS Genet.
, vol.10
-
-
Ruckenstuhl, C.1
-
71
-
-
84883114523
-
Overexpression of Atg5 in mice activates autophagy and extends lifespan
-
Pyo, J.O. Et al. Overexpression of Atg5 in mice activates autophagy and extends lifespan. Nat. Commun. 4, 2300 (2013).
-
(2013)
Nat. Commun.
, vol.4
, pp. 2300
-
-
Pyo, J.O.1
-
72
-
-
84883063789
-
The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans
-
Lapierre, L.R. Et al. The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans. Nat. Commun. 4, 2267 (2013).
-
(2013)
Nat. Commun.
, vol.4
, pp. 2267
-
-
Lapierre, L.R.1
-
73
-
-
0027771804
-
Elegans mutant that lives twice as long as wild type
-
Kenyon, C., Chang, J., Gensch, E., Rudner, A. & Tabtiang, R.A. C. Elegans mutant that lives twice as long as wild type. Nature 366, 461-464 (1993).
-
(1993)
Nature
, vol.366
, pp. 461-464
-
-
Kenyon, C.1
Chang, J.2
Gensch, E.3
Rudner, A.4
Tabtiang, R.A.C.5
-
74
-
-
0030813398
-
Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
-
Kimura, K.D., Tissenbaum, H.A., Liu, Y. & Ruvkun, G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277, 942-946 (1997).
-
(1997)
Science
, vol.277
, pp. 942-946
-
-
Kimura, K.D.1
Tissenbaum, H.A.2
Liu, Y.3
Ruvkun, G.4
-
75
-
-
0042092531
-
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
-
Murphy, C.T. Et al. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-283 (2003).
-
(2003)
Nature
, vol.424
, pp. 277-283
-
-
Murphy, C.T.1
-
76
-
-
0035815445
-
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
-
Tatar, M. Et al. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292, 107-110 (2001).
-
(2001)
Science
, vol.292
, pp. 107-110
-
-
Tatar, M.1
-
77
-
-
0347664057
-
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
-
Holzenberger, M. Et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421, 182-187 (2003).
-
(2003)
Nature
, vol.421
, pp. 182-187
-
-
Holzenberger, M.1
-
78
-
-
84892530622
-
Longevity effect of IGF-1R+/-mutation depends on genetic background-specific receptor activation
-
Xu, J. Et al. Longevity effect of IGF-1R+/-mutation depends on genetic background-specific receptor activation. Aging Cell 13, 19-28 (2014).
-
(2014)
Aging Cell
, vol.13
, pp. 19-28
-
-
Xu, J.1
-
79
-
-
34547097247
-
Brain IRS2 signaling coordinates life span and nutrient homeostasis
-
Taguchi, A., Wartschow, L.M. & White, M.F. Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317, 369-372 (2007).
-
(2007)
Science
, vol.317
, pp. 369-372
-
-
Taguchi, A.1
Wartschow, L.M.2
White, M.F.3
-
80
-
-
34548614737
-
Loss of pregnancy-associated plasma protein A extends lifespan in mice
-
Conover, C.A. & Bale, L.K. Loss of pregnancy-associated plasma protein A extends lifespan in mice. Aging Cell 6, 727-729 (2007).
-
(2007)
Aging Cell
, vol.6
, pp. 727-729
-
-
Conover, C.A.1
Bale, L.K.2
-
81
-
-
42149141146
-
Functionally significant insulin-like growth factor i receptor mutations in centenarians
-
Suh, Y. Et al. Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc. Natl. Acad. Sci. USA 105, 3438-3442 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 3438-3442
-
-
Suh, Y.1
-
83
-
-
84941618969
-
The somatotropic axis and longevity in mice
-
Brown-Borg, H.M. The somatotropic axis and longevity in mice. Am. J. Physiol. Endocrinol. Metab. 309, E503-E510 (2015).
-
(2015)
Am. J. Physiol. Endocrinol. Metab.
, vol.309
, pp. E503-E510
-
-
Brown-Borg, H.M.1
-
84
-
-
84877734347
-
Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH
-
Zhang, G. Et al. Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH. Nature 497, 211-216 (2013).
-
(2013)
Nature
, vol.497
, pp. 211-216
-
-
Zhang, G.1
-
85
-
-
84920421073
-
Essential role for autophagy in lifespan extension
-
Madeo, F., Zimmermann, A., Maiuri, M.C. & Kroemer, G. Essential role for autophagy in lifespan extension. J. Clin. Invest. 125, 85-93 (2015).
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 85-93
-
-
Madeo, F.1
Zimmermann, A.2
Maiuri, M.C.3
Kroemer, G.4
-
86
-
-
41549138483
-
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
-
Lee, I.H. Et al. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc. Natl. Acad. Sci. USA 105, 3374-3379 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 3374-3379
-
-
Lee, I.H.1
-
87
-
-
17244363631
-
Decline in skeletal muscle mitochondrial function with aging in humans
-
Short, K.R. Et al. Decline in skeletal muscle mitochondrial function with aging in humans. Proc. Natl. Acad. Sci. USA 102, 5618-5623 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 5618-5623
-
-
Short, K.R.1
-
88
-
-
35648947912
-
Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans
-
Rea, S.L., Ventura, N. & Johnson, T.E. Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. PLoS Biol. 5, e259 (2007).
-
(2007)
PLoS Biol.
, vol.5
, pp. e259
-
-
Rea, S.L.1
Ventura, N.2
Johnson, T.E.3
-
89
-
-
26944501617
-
Evolutionary conservation of the clk-1-dependent mechanism of longevity: Loss of mclk1 increases cellular fitness and lifespan in mice
-
Liu, X. Et al. Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. Genes Dev. 19, 2424-2434 (2005).
-
(2005)
Genes Dev.
, vol.19
, pp. 2424-2434
-
-
Liu, X.1
-
90
-
-
33847304164
-
Increased longevity and refractoriness to Ca2+-dependent neurodegeneration in Surf1 knockout mice
-
Dell'Agnello, C. Et al. Increased longevity and refractoriness to Ca2+-dependent neurodegeneration in Surf1 knockout mice. Hum. Mol. Genet. 16, 431-444 (2007).
-
(2007)
Hum. Mol. Genet.
, vol.16
, pp. 431-444
-
-
Dell'Agnello, C.1
-
91
-
-
84916628779
-
Collaboration between mitochondria and the nucleus is key to long life in Caenorhabditis elegans
-
Chang, H.W., Shtessel, L. & Lee, S.S. Collaboration between mitochondria and the nucleus is key to long life in Caenorhabditis elegans. Free Radic. Biol. Med. 78, 168-178 (2015).
-
(2015)
Free Radic. Biol. Med.
, vol.78
, pp. 168-178
-
-
Chang, H.W.1
Shtessel, L.2
Lee, S.S.3
-
92
-
-
78650177082
-
Inhibition of respiration extends C. Elegans life span via reactive oxygen species that increase HIF-1 activity
-
Lee, S.J., Hwang, A.B. & Kenyon, C. Inhibition of respiration extends C. Elegans life span via reactive oxygen species that increase HIF-1 activity. Curr. Biol. 20, 2131-2136 (2010).
-
(2010)
Curr. Biol.
, vol.20
, pp. 2131-2136
-
-
Lee, S.J.1
Hwang, A.B.2
Kenyon, C.3
-
93
-
-
84908068704
-
Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans
-
Hwang, A.B. Et al. Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 111, E4458-E4467 (2014).
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. E4458-E4467
-
-
Hwang, A.B.1
-
94
-
-
67651174517
-
P53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress
-
Ventura, N. Et al. p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress. Aging Cell 8, 380-393 (2009).
-
(2009)
Aging Cell
, vol.8
, pp. 380-393
-
-
Ventura, N.1
-
95
-
-
79959791906
-
The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. Elegans
-
Walter, L., Baruah, A., Chang, H.W., Pace, H.M. & Lee, S.S. The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. Elegans. PLoS Biol. 9, e1001084 (2011).
-
(2011)
PLoS Biol.
, vol.9
-
-
Walter, L.1
Baruah, A.2
Chang, H.W.3
Pace, H.M.4
Lee, S.S.5
-
96
-
-
84900299463
-
The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. Elegans
-
Yee, C., Yang, W. & Hekimi, S. The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. Elegans. Cell 157, 897-909 (2014).
-
(2014)
Cell
, vol.157
, pp. 897-909
-
-
Yee, C.1
Yang, W.2
Hekimi, S.3
-
97
-
-
84877681309
-
Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension
-
Schmeisser, S. Et al. Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension. Mol. Metab. 2, 92-102 (2013).
-
(2013)
Mol. Metab.
, vol.2
, pp. 92-102
-
-
Schmeisser, S.1
-
98
-
-
84969760294
-
Oxidative stress response and Nrf2 signaling in aging
-
Zhang, H., Davies, K.J. & Forman, H.J. Oxidative stress response and Nrf2 signaling in aging. Free Radic. Biol. Med. 88, 314-336 (2015).
-
(2015)
Free Radic. Biol. Med.
, vol.88
, pp. 314-336
-
-
Zhang, H.1
Davies, K.J.2
Forman, H.J.3
-
99
-
-
84867040616
-
Mitochondrial SKN-1/Nrf mediates a conserved starvation response
-
Paek, J. Et al. Mitochondrial SKN-1/Nrf mediates a conserved starvation response. Cell Metab. 16, 526-537 (2012).
-
(2012)
Cell Metab.
, vol.16
, pp. 526-537
-
-
Paek, J.1
-
100
-
-
84877794094
-
Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension
-
Schmeisser, S. Et al. Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Aging Cell 12, 508-517 (2013).
-
(2013)
Aging Cell
, vol.12
, pp. 508-517
-
-
Schmeisser, S.1
-
101
-
-
40649108843
-
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction
-
Pearson, K.J. Et al. Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc. Natl. Acad. Sci. USA 105, 2325-2330 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 2325-2330
-
-
Pearson, K.J.1
-
102
-
-
77049308856
-
Aging: A theory based on free radical and radiation chemistry
-
Harman, D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11, 298-300 (1956).
-
(1956)
J. Gerontol.
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
103
-
-
84906656463
-
The mitochondrial free radical theory of aging
-
Barja, G. The mitochondrial free radical theory of aging. Prog. Mol. Biol. Transl. Sci. 127, 1-27 (2014).
-
(2014)
Prog. Mol. Biol. Transl. Sci.
, vol.127
, pp. 1-27
-
-
Barja, G.1
-
104
-
-
84900295547
-
Mitohormesis
-
Yun, J. & Finkel, T. Mitohormesis. Cell Metab. 19, 757-766 (2014).
-
(2014)
Cell Metab.
, vol.19
, pp. 757-766
-
-
Yun, J.1
Finkel, T.2
-
105
-
-
84903936008
-
Unraveling the truth about antioxidants: Mitohormesis explains ROS-induced health benefits
-
Ristow, M. Unraveling the truth about antioxidants: mitohormesis explains ROS-induced health benefits. Nat. Med. 20, 709-711 (2014).
-
(2014)
Nat. Med.
, vol.20
, pp. 709-711
-
-
Ristow, M.1
-
106
-
-
84902382985
-
Mitohormesis: Promoting health and lifespan by increased levels of reactive oxygen species (ROS)
-
Ristow, M. & Schmeisser, K. Mitohormesis: promoting health and lifespan by increased levels of reactive oxygen species (ROS). Dose Response 12, 288-341 (2014).
-
(2014)
Dose Response
, vol.12
, pp. 288-341
-
-
Ristow, M.1
Schmeisser, K.2
-
107
-
-
78650944949
-
The cell-non-autonomous nature of electron transport chain-mediated longevity
-
Durieux, J., Wolff, S. & Dillin, A. The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell 144, 79-91 (2011).
-
(2011)
Cell
, vol.144
, pp. 79-91
-
-
Durieux, J.1
Wolff, S.2
Dillin, A.3
-
108
-
-
84886786722
-
Muscle mitohormesis promotes longevity via systemic repression of insulin signaling
-
Owusu-Ansah, E., Song, W. & Perrimon, N. Muscle mitohormesis promotes longevity via systemic repression of insulin signaling. Cell 155, 699-712 (2013).
-
(2013)
Cell
, vol.155
, pp. 699-712
-
-
Owusu-Ansah, E.1
Song, W.2
Perrimon, N.3
-
109
-
-
84919775416
-
The mitochondrial unfolded protein response-synchronizing genomes
-
Jovaisaite, V. & Auwerx, J. The mitochondrial unfolded protein response-synchronizing genomes. Curr. Opin. Cell Biol. 33, 74-81 (2015).
-
(2015)
Curr. Opin. Cell Biol.
, vol.33
, pp. 74-81
-
-
Jovaisaite, V.1
Auwerx, J.2
-
110
-
-
84864744900
-
Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation
-
Nargund, A.M., Pellegrino, M.W., Fiorese, C.J., Baker, B.M. & Haynes, C.M. Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation. Science 337, 587-590 (2012).
-
(2012)
Science
, vol.337
, pp. 587-590
-
-
Nargund, A.M.1
Pellegrino, M.W.2
Fiorese, C.J.3
Baker, B.M.4
Haynes, C.M.5
-
111
-
-
84898975844
-
Caenorhabditis elegans pathways that surveil and defend mitochondria
-
Liu, Y., Samuel, B.S., Breen, P.C. & Ruvkun, G. Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature 508, 406-410 (2014).
-
(2014)
Nature
, vol.508
, pp. 406-410
-
-
Liu, Y.1
Samuel, B.S.2
Breen, P.C.3
Ruvkun, G.4
-
112
-
-
84921774753
-
Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection
-
Pellegrino, M.W. Et al. Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection. Nature 516, 414-417 (2014).
-
(2014)
Nature
, vol.516
, pp. 414-417
-
-
Pellegrino, M.W.1
-
113
-
-
84878138385
-
Mitonuclear protein imbalance as a conserved longevity mechanism
-
Houtkooper, R.H. Et al. Mitonuclear protein imbalance as a conserved longevity mechanism. Nature 497, 451-457 (2013).
-
(2013)
Nature
, vol.497
, pp. 451-457
-
-
Houtkooper, R.H.1
-
114
-
-
32444437067
-
Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency
-
López-Lluch, G. Et al. Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proc. Natl. Acad. Sci. USA 103, 1768-1773 (2006).
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 1768-1773
-
-
López-Lluch, G.1
-
115
-
-
84863119126
-
Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction
-
Finley, L.W. Et al. Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction. Proc. Natl. Acad. Sci. USA 109, 2931-2936 (2012).
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 2931-2936
-
-
Finley, L.W.1
-
116
-
-
84893442805
-
Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
-
Gomes, A.P. Et al. Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell 155, 1624-1638 (2013).
-
(2013)
Cell
, vol.155
, pp. 1624-1638
-
-
Gomes, A.P.1
-
117
-
-
33745026738
-
Autophagy and aging: The importance of maintaining "clean" cells
-
Cuervo, A.M. Et al. Autophagy and aging: the importance of maintaining "clean" cells. Autophagy 1, 131-140 (2005).
-
(2005)
Autophagy
, vol.1
, pp. 131-140
-
-
Cuervo, A.M.1
-
118
-
-
84930632378
-
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. Elegans
-
Palikaras, K., Lionaki, E. & Tavernarakis, N. Coordination of mitophagy and mitochondrial biogenesis during ageing in C. Elegans. Nature 521, 525-528 (2015).
-
(2015)
Nature
, vol.521
, pp. 525-528
-
-
Palikaras, K.1
Lionaki, E.2
Tavernarakis, N.3
-
119
-
-
84878118233
-
Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
-
Rana, A., Rera, M. & Walker, D.W. Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan. Proc. Natl. Acad. Sci. USA 110, 8638-8643 (2013).
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 8638-8643
-
-
Rana, A.1
Rera, M.2
Walker, D.W.3
-
120
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
Howitz, K.T. Et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191-196 (2003).
-
(2003)
Nature
, vol.425
, pp. 191-196
-
-
Howitz, K.T.1
-
121
-
-
84901192644
-
The controversial world of sirtuins
-
Dang, W. The controversial world of sirtuins. Drug Discov. Today. Technol. 12, e9-e17 (2014).
-
(2014)
Drug Discov. Today. Technol.
, vol.12
, pp. e9-e17
-
-
Dang, W.1
-
122
-
-
33845399894
-
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
-
Lagouge, M. Et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Cell 127, 1109-1122 (2006).
-
(2006)
Cell
, vol.127
, pp. 1109-1122
-
-
Lagouge, M.1
-
123
-
-
48349144852
-
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
-
Pearson, K.J. Et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 8, 157-168 (2008).
-
(2008)
Cell Metab.
, vol.8
, pp. 157-168
-
-
Pearson, K.J.1
-
124
-
-
84885148256
-
Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet
-
Jimenez-Gomez, Y. Et al. Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet. Cell Metab. 18, 533-545 (2013).
-
(2013)
Cell Metab.
, vol.18
, pp. 533-545
-
-
Jimenez-Gomez, Y.1
-
125
-
-
84904063673
-
Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates
-
Mattison, J.A. Et al. Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates. Cell Metab. 20, 183-190 (2014).
-
(2014)
Cell Metab.
, vol.20
, pp. 183-190
-
-
Mattison, J.A.1
-
126
-
-
80455143206
-
Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
-
Timmers, S. Et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 14, 612-622 (2011).
-
(2011)
Cell Metab.
, vol.14
, pp. 612-622
-
-
Timmers, S.1
-
127
-
-
84895925833
-
The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet
-
Mitchell, S.J. Et al. The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet. Cell Rep. 6, 836-843 (2014).
-
(2014)
Cell Rep.
, vol.6
, pp. 836-843
-
-
Mitchell, S.J.1
-
128
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison, D.E. Et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460, 392-395 (2009).
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
-
129
-
-
84902603273
-
Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2
-
De Haes, W. Et al. Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2. Proc. Natl. Acad. Sci. USA 111, E2501-E2509 (2014).
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. E2501-E2509
-
-
De Haes, W.1
-
130
-
-
84881347302
-
Metformin improves healthspan and lifespan in mice
-
Martin-Montalvo, A. Et al. Metformin improves healthspan and lifespan in mice. Nat. Commun. 4, 2192 (2013).
-
(2013)
Nat. Commun.
, vol.4
, pp. 2192
-
-
Martin-Montalvo, A.1
-
131
-
-
85015471827
-
Metformin in cancer prevention and therapy
-
Kasznicki, J., Sliwinska, A. & Drzewoski, J. Metformin in cancer prevention and therapy. Ann. Transl. Med. 2, 57 (2014).
-
(2014)
Ann. Transl. Med.
, vol.2
, pp. 57
-
-
Kasznicki, J.1
Sliwinska, A.2
Drzewoski, J.3
-
132
-
-
70449529855
-
Induction of autophagy by spermidine promotes longevity
-
Eisenberg, T. Et al. Induction of autophagy by spermidine promotes longevity. Nat. Cell Biol. 11, 1305-1314 (2009).
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1305-1314
-
-
Eisenberg, T.1
-
133
-
-
84884878909
-
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner
-
Gupta, V.K. Et al. Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner. Nat. Neurosci. 16, 1453-1460 (2013).
-
(2013)
Nat. Neurosci.
, vol.16
, pp. 1453-1460
-
-
Gupta, V.K.1
-
134
-
-
84937522438
-
NAD+ metabolism and the control of energy homeostasis: A balancing act between mitochondria and the nucleus
-
Cantó, C., Menzies, K.J. & Auwerx, J. NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus. Cell Metab. 22, 31-53 (2015).
-
(2015)
Cell Metab.
, vol.22
, pp. 31-53
-
-
Cantó, C.1
Menzies, K.J.2
Auwerx, J.3
-
135
-
-
84880517634
-
The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling
-
Mouchiroud, L. Et al. The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling. Cell 154, 430-441 (2013).
-
(2013)
Cell
, vol.154
, pp. 430-441
-
-
Mouchiroud, L.1
-
136
-
-
80053920774
-
Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet-and age-induced diabetes in mice
-
Yoshino, J., Mills, K.F., Yoon, M.J. & Imai, S. Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet-and age-induced diabetes in mice. Cell Metab. 14, 528-536 (2011).
-
(2011)
Cell Metab.
, vol.14
, pp. 528-536
-
-
Yoshino, J.1
Mills, K.F.2
Yoon, M.J.3
Imai, S.4
-
137
-
-
84862022077
-
The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity
-
Cantó, C. Et al. The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab. 15, 838-847 (2012).
-
(2012)
Cell Metab.
, vol.15
, pp. 838-847
-
-
Cantó, C.1
-
138
-
-
84904751060
-
NAD+ and sirtuins in aging and disease
-
Imai, S. & Guarente, L. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 24, 464-471 (2014).
-
(2014)
Trends Cell Biol.
, vol.24
, pp. 464-471
-
-
Imai, S.1
Guarente, L.2
-
139
-
-
73249135184
-
Methusaleh's zoo: How nature provides us with clues for extending human health span
-
Austad, S.N. Methusaleh's zoo: how nature provides us with clues for extending human health span. J. Comp. Pathol. 142 (suppl. 1), S10-S21 (2010).
-
(2010)
J. Comp. Pathol.
, vol.142
, pp. S10-S21
-
-
Austad, S.N.1
-
140
-
-
84937137980
-
High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice
-
Wall, C.E. Et al. High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice. Proc. Natl. Acad. Sci. USA 112, 8714-8719 (2015).
-
(2015)
Proc. Natl. Acad. Sci. USA
, vol.112
, pp. 8714-8719
-
-
Wall, C.E.1
-
141
-
-
84881508008
-
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
-
Zhang, Y. Et al. The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. Elife 1, e00065 (2012).
-
(2012)
Elife
, vol.1
-
-
Zhang, Y.1
|