The mitochondrial-derived peptide MOTS-c: A player in exceptional longevity?

Aging Cell

Volumn 14, Issue 6, 2015, Pages 921-923

  Fuku, Noriyuki ^a   Pareja Galeano, Helios ^b,c   Zempo, Hirofumi ^a   Alis, Rafael ^d   Arai, Yasumichi ^e   Lucia, Alejandro ^b,c   Hirose, Nobuyoshi ^e  

^a JUNTENDO UNIVERSITY   (Japan)

^b UNIVERSIDAD EUROPEA DE MADRID   (Spain)

^c HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^d UNIVERSIDAD CATÓLICA DE VALENCIA SAN VICENTE MÁRTIR   (Spain)

^e KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Aging; Centenarians; Longevity gene; Longevity regulation; Mitochondria; Mitochondrial DNA; Mitochondrial DNA abnormalities; Molecular biology of aging

Indexed keywords

MITOCHONDRIAL DNA; MITOCHONDRIAL OPEN READING FRAME OF THE 12S RRNA C; UNCLASSIFIED DRUG; PEPTIDE; RIBOSOME RNA; RNA, RIBOSOMAL, 12S;

AMINO ACID SUBSTITUTION; HUMAN; LIFESPAN; LONGEVITY; MITOCHONDRIAL HAPLOGROUP; NOTE; OPEN READING FRAME; PRIORITY JOURNAL; AGING; ASIAN CONTINENTAL ANCESTRY GROUP; GENETICS; JAPAN; MITOCHONDRION; SINGLE NUCLEOTIDE POLYMORPHISM;

AGING; ASIAN CONTINENTAL ANCESTRY GROUP; DNA, MITOCHONDRIAL; HUMANS; JAPAN; LONGEVITY; MITOCHONDRIA; OPEN READING FRAMES; PEPTIDES; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, RIBOSOMAL;

EID: 84954391956     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12389     Document Type: Note

References (22)

1. Alexe G, Fuku N, Bilal E, Ueno H, Nishigaki Y, Fujita Y, Ito M, Arai Y, Hirose N, Bhanot G, Tanaka M (2007) Enrichment of longevity phenotype in mtDNA haplogroups D4b2b, D4a, and D5 in the Japanese population. Hum. Genet. 121, 347-356.
2. Alis R, Lucia A, Blesa JR, Sanchis-Gomar F (2015) The role of mitochondrial derived peptides (MDPs) in metabolism. J. Cell. Physiol.
3. Andersen SL, Sebastiani P, Dworkis DA, Feldman L, Perls TT (2012) Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span. J. Gerontol. A Biol. Sci. Med. Sci. 67, 395-405.
4. Basile G, Paffumi I, D'Angelo AG, Figliomeni P, Cucinotta MD, Pace E, Ferraro M, Saitta S, Lasco A, Gangemi S (2012) Healthy centenarians show high levels of circulating interleukin-22 (IL-22). Arch. Gerontol. Geriatr. 54, 459-461.
5. Bilal E, Rabadan R, Alexe G, Fuku N, Ueno H, Nishigaki Y, Fujita Y, Ito M, Arai Y, Hirose N, Ruckenstein A, Bhanot G, Tanaka M (2008) Mitochondrial DNA haplogroup D4a is a marker for extreme longevity in Japan. PLoS ONE 3, e2421.
6. Choi Y, Sims GE, Murphy S, Miller JR, Chan AP (2012) Predicting the functional effect of amino acid substitutions and indels. PLoS ONE 7, e46688.
7. Domínguez-Garrido E, Martínez-Redondo D, Martín-Ruiz C, Gómez-Durán A, Ruiz-Pesini E, Madero P, Tamparillas M, Montoya J, von Zglinicki T, Díez-Sánchez C, López-Pérez MJ (2009) Association of mitochondrial haplogroup J and mtDNA oxidative damage in two different North Spain elderly populations. Biogerontology 10, 435-442.
8. Emanuele E, Minoretti P, Pareja-Galeano H, Sanchis-Gomar F, Garatachea N, Lucia A (2014) Serum irisin levels, precocious myocardial infarction, and healthy exceptional longevity. Am. J. Med. 127, 888-890.
9. Fuku N, Park KS, Yamada Y, Nishigaki Y, Cho YM, Matsuo H, Segawa T, Watanabe S, Kato K, Yokoi K, Nozawa Y, Lee HK, Tanaka M (2007) Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians. Am. J. Hum. Genet. 80, 407-415.
10. Garatachea N, Fuku N, He ZH, Tian Y, Arai Y, Abe Y, Murakami H, Miyachi M, Yvert T, Venturini L, Santiago C, Santos-Lozano A, Rodriguez G, Ricevuti G, Pareja-Galeano H, Sanchis-Gomar F, Emanuele E, Hirose N, Lucia A (2014) PTK2 rs7460 and rs7843014 polymorphisms and exceptional longevity: a functional replication study. Rejuvenation Res. 17, 430-438.
11. Gomez-Cabrera MC, Sanchis-Gomar F, Garcia-Valles R, Pareja-Galeano H, Gambini J, Borras C, Vina J (2012) Mitochondria as sources and targets of damage in cellular aging. Clin. Chem. Lab. Med. 50, 1287-1295.
12. Grantham R (1974) Amino acid difference formula to help explain protein evolution. Science 185, 862-864.
13. Hashimoto Y, Niikura T, Tajima H, Yasukawa T, Sudo H, Ito Y, Kita Y, Kawasumi M, Kouyama K, Doyu M, Sobue G, Koide T, Tsuji S, Lang J, Kurokawa K, Nishimoto I (2001) A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. Proc. Natl Acad. Sci. USA 98, 6336-6341.
14. He YH, Lu X, Wu H, Cai WW, Yang LQ, Xu LY, Sun HP, Kong QP (2014) Mitochondrial DNA content contributes to healthy aging in Chinese: a study from nonagenarians and centenarians. Neurobiol. Aging 35, 1779 e1771-1774.
15. Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P (2015) The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 21, 443-454.
16. Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013) The hallmarks of aging. Cell 153, 1194-1217.
17. Mercer TR, Neph S, Dinger ME, Crawford J, Smith MA, Shearwood AM, Haugen E, Bracken CP, Rackham O, Stamatoyannopoulos JA, Filipovska A, Mattick JS (2011) The human mitochondrial transcriptome. Cell 146, 645-658.
18. Pareja-Galeano H, Sanchis-Gomar F, Santos-Lozano A, Garatachea N, Fiuza-Luces C, Lucia A, Emanuele E (2015) Serum eicosapentaenoic acid to arachidonic acid ratio is associated with cardio-healthy exceptional longevity. Int. J. Cardiol. 184, 655-656.
19. Pinos T, Nogales-Gadea G, Ruiz JR, Rodriguez-Romo G, Santiago-Dorrego C, Fiuza-Luces C, Gomez-Gallego F, Cano-Nieto A, Garatachea N, Moran M, Angel Martin M, Arenas J, Andreu AL, Lucia A (2012) Are mitochondrial haplogroups associated with extreme longevity? A study on a Spanish cohort. Age (Dordr). 34, 227-233.
20. Ruiz JR, Fiuza-Luces C, Buxens A, Cano-Nieto A, Gomez-Gallego F, Santiago C, Rodriguez-Romo G, Garatachea N, Lao JI, Moran M, Lucia A (2012) Are centenarians genetically predisposed to lower disease risk? Age (Dordr). 34, 1269-1283.
21. Santos-Lozano A, Sanchis-Gomar F, Pareja-Galeano H, Fiuza-Luces C, Emanuele E, Lucia A, Garatachea N (2015) Where are supercentenarians located? A worldwide demographic study Rejuvenation Res. 18, 14-19.
22. Waite LJ (2004) The demographic faces of the elderly. Popul. Dev. Rev. 30, 3-16.