Obesity accelerates epigenetic aging of human liver

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 43, 2014, Pages 15538-15543

  Horvath, Steve ^a,b   Erhart, Wiebke ^c   Brosch, Mario ^d   Ammerpohl, Ole ^c   Von Schönfels, Witigo ^c   Ahrens, Markus ^c   Heits, Nils ^c   Bell, Jordana T ^e   Tsai, Pei Chien ^e   Spector, Tim D ^e   Deloukas, Panos ^f,g,h   Siebert, Reiner ^c   Sipos, Bence ⁱ   Becker, Thomas ^c   Röcken, Christoph ^j   Schafmayer, Clemens ^c   Hampe, Jochen ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF KIEL   (Germany)

^d UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^g WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^h KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

ⁱ UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^j UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

more..

Author keywords

Aging; Biological age; DNA methylation; Epigenetics; Obesity

Indexed keywords

ADIPOSE TISSUE; AGING; ARTICLE; BLOOD; BODY MASS; CROSS-SECTIONAL STUDY; DNA METHYLATION; EPIGENETICS; GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER; MITOCHONDRIAL GENE; MUSCLE; NONALCOHOLIC FATTY LIVER DISEASE ACTIVITY SCORE; NUCLEAR GENE; OBESITY; WEIGHT REDUCTION; BIOLOGICAL MODEL; GENETIC DATABASE; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; NONALCOHOLIC FATTY LIVER; PATHOLOGY; REPRODUCIBILITY; TIME;

MESSENGER RNA;

AGING; BODY MASS INDEX; CROSS-SECTIONAL STUDIES; DATABASES, GENETIC; DNA METHYLATION; EPIGENESIS, GENETIC; HUMANS; LIVER; MODELS, GENETIC; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION, GENETIC; WEIGHT LOSS;

EID: 84908441328     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1412759111     Document Type: Article

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