메뉴 건너뛰기




Volumn 63, Issue 4, 2016, Pages 1190-1204

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; APOLIPOPROTEIN E; CHOLESTEROL; EARLY PREGNANCY FACTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE RIBOSIDE; SIRTUIN 1; SIRTUIN 3; SUCROSE; TRIACYLGLYCEROL; NICOTINAMIDE; NICOTINAMIDE-BETA-RIBOSIDE;

EID: 84950327004     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.28245     Document Type: Article
Times cited : (285)

References (43)
  • 1
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: old questions and new insights
    • Cohen JC, Horton JD, Hobbs HH. Human fatty liver disease: old questions and new insights. Science 2011;332:1519-1523.
    • (2011) Science , vol.332 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 2
    • 84900453365 scopus 로고    scopus 로고
    • Liver transplantation for nonalcoholic fatty liver disease: new challenges and new opportunities
    • Shaker M, Tabbaa A, Albeldawi M, Alkhouri N. Liver transplantation for nonalcoholic fatty liver disease: new challenges and new opportunities. World J Gastroenterol 2014;20:5320-5330.
    • (2014) World J Gastroenterol , vol.20 , pp. 5320-5330
    • Shaker, M.1    Tabbaa, A.2    Albeldawi, M.3    Alkhouri, N.4
  • 3
    • 84862517200 scopus 로고    scopus 로고
    • Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials
    • Musso G, Cassader M, Rosina F, Gambino R. Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials. Diabetologia 2012;55:885-904.
    • (2012) Diabetologia , vol.55 , pp. 885-904
    • Musso, G.1    Cassader, M.2    Rosina, F.3    Gambino, R.4
  • 4
    • 84930651833 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: a practical approach to treatment
    • Dyson JK, Anstee QM, McPherson S. Non-alcoholic fatty liver disease: a practical approach to treatment. Frontline Gastroenterol 2014;5:277-286.
    • (2014) Frontline Gastroenterol , vol.5 , pp. 277-286
    • Dyson, J.K.1    Anstee, Q.M.2    McPherson, S.3
  • 6
    • 84884984539 scopus 로고    scopus 로고
    • Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease
    • Begriche K, Massart J, Robin MA, Bonnet F, Fromenty B. Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease. Hepatology 2013;58:1497-1507.
    • (2013) Hepatology , vol.58 , pp. 1497-1507
    • Begriche, K.1    Massart, J.2    Robin, M.A.3    Bonnet, F.4    Fromenty, B.5
  • 7
    • 0035991444 scopus 로고    scopus 로고
    • In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases
    • Seki S, Kitada T, Yamada T, Sakaguchi H, Nakatani K, Wakasa K. In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases. J Hepatol 2002;37:56-62.
    • (2002) J Hepatol , vol.37 , pp. 56-62
    • Seki, S.1    Kitada, T.2    Yamada, T.3    Sakaguchi, H.4    Nakatani, K.5    Wakasa, K.6
  • 8
    • 84924026861 scopus 로고    scopus 로고
    • Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease
    • Gentric G, Maillet V, Paradis V, Couton D, L'Hermitte A, Panasyuk G, et al. Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease. J Clin Invest 2015;125:981-992.
    • (2015) J Clin Invest , vol.125 , pp. 981-992
    • Gentric, G.1    Maillet, V.2    Paradis, V.3    Couton, D.4    L'Hermitte, A.5    Panasyuk, G.6
  • 9
    • 84902270555 scopus 로고    scopus 로고
    • Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle
    • Pirinen E, Canto C, Jo YS, Morato L, Zhang H, Menzies KJ, et al. Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle. Cell Metab 2014;19:1034-1041.
    • (2014) Cell Metab , vol.19 , pp. 1034-1041
    • Pirinen, E.1    Canto, C.2    Jo, Y.S.3    Morato, L.4    Zhang, H.5    Menzies, K.J.6
  • 10
    • 84862022077 scopus 로고    scopus 로고
    • The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity
    • Canto C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab 2012;15:838-847.
    • (2012) Cell Metab , vol.15 , pp. 838-847
    • Canto, C.1    Houtkooper, R.H.2    Pirinen, E.3    Youn, D.Y.4    Oosterveer, M.H.5    Cen, Y.6
  • 11
    • 80053920774 scopus 로고    scopus 로고
    • Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice
    • Yoshino J, Mills KF, Yoon MJ, Imai SI. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab 2011;14:528-536.
    • (2011) Cell Metab , vol.14 , pp. 528-536
    • Yoshino, J.1    Mills, K.F.2    Yoon, M.J.3    Imai, S.I.4
  • 12
    • 84901848955 scopus 로고    scopus 로고
    • Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3
    • Khan NA, Auranen M, Paetau I, Pirinen E, Euro L, Forsstrom S, et al. Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3. EMBO Mol Med 2014;6:721-731.
    • (2014) EMBO Mol Med , vol.6 , pp. 721-731
    • Khan, N.A.1    Auranen, M.2    Paetau, I.3    Pirinen, E.4    Euro, L.5    Forsstrom, S.6
  • 13
    • 84962030356 scopus 로고    scopus 로고
    • Evidence for a direct effect of the NAD+ precursor Acipimox on muscle mitochondrial function in humans
    • van de Weijer T, Phielix E, Bilet L, Williams EG, Ropelle ER, Bierwagen A, et al. Evidence for a direct effect of the NAD+ precursor Acipimox on muscle mitochondrial function in humans. Diabetes 2015;64:1193-1201.
    • (2015) Diabetes , vol.64 , pp. 1193-1201
    • van de Weijer, T.1    Phielix, E.2    Bilet, L.3    Williams, E.G.4    Ropelle, E.R.5    Bierwagen, A.6
  • 14
    • 84902245774 scopus 로고    scopus 로고
    • NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease
    • Cerutti R, Pirinen E, Lamperti C, Marchet S, Sauve AA, Li W, et al. NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease. Cell Metab 2014;19:1042-1049.
    • (2014) Cell Metab , vol.19 , pp. 1042-1049
    • Cerutti, R.1    Pirinen, E.2    Lamperti, C.3    Marchet, S.4    Sauve, A.A.5    Li, W.6
  • 15
    • 77953631698 scopus 로고    scopus 로고
    • The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways
    • Houtkooper RH, Canto C, Wanders RJ, Auwerx J. The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev 2010;31:194-223.
    • (2010) Endocr Rev , vol.31 , pp. 194-223
    • Houtkooper, R.H.1    Canto, C.2    Wanders, R.J.3    Auwerx, J.4
  • 16
    • 84862022077 scopus 로고    scopus 로고
    • The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity
    • Cantó C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab 2012;15:838-847.
    • (2012) Cell Metab , vol.15 , pp. 838-847
    • Cantó, C.1    Houtkooper, R.H.2    Pirinen, E.3    Youn, D.Y.4    Oosterveer, M.H.5    Cen, Y.6
  • 17
    • 79957549799 scopus 로고    scopus 로고
    • Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation
    • Nikiforov A, Dolle C, Niere M, Ziegler M. Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation. J Biol Chem 2011;286:21767-21778.
    • (2011) J Biol Chem , vol.286 , pp. 21767-21778
    • Nikiforov, A.1    Dolle, C.2    Niere, M.3    Ziegler, M.4
  • 18
    • 2342550554 scopus 로고    scopus 로고
    • Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans
    • Bieganowski P, Brenner C. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Cell 2004;117:495-502.
    • (2004) Cell , vol.117 , pp. 495-502
    • Bieganowski, P.1    Brenner, C.2
  • 19
    • 14244253957 scopus 로고    scopus 로고
    • Feeding apolipoprotein E-knockout mice with cholesterol and fat enriched diets may be a model of non-alcoholic steatohepatitis
    • Tous M, Ferré N, Camps J, Riu F, Joven J. Feeding apolipoprotein E-knockout mice with cholesterol and fat enriched diets may be a model of non-alcoholic steatohepatitis. Mol Cell Biochem 2005;268:53-58.
    • (2005) Mol Cell Biochem , vol.268 , pp. 53-58
    • Tous, M.1    Ferré, N.2    Camps, J.3    Riu, F.4    Joven, J.5
  • 20
    • 84924364818 scopus 로고    scopus 로고
    • Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis
    • Verbeek J, Lannoo M, Pirinen E, Ryu D, Spincemaille P, Vander Elst I, et al. Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis. Gut 2015;64:673-683.
    • (2015) Gut , vol.64 , pp. 673-683
    • Verbeek, J.1    Lannoo, M.2    Pirinen, E.3    Ryu, D.4    Spincemaille, P.5    Vander Elst, I.6
  • 21
    • 84880517634 scopus 로고    scopus 로고
    • The NAD(+)/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling
    • Mouchiroud L, Houtkooper RH, Moullan N, Katsyuba E, Ryu D, Cantó C, et al. The NAD(+)/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling. Cell 2013;154:430-441.
    • (2013) Cell , vol.154 , pp. 430-441
    • Mouchiroud, L.1    Houtkooper, R.H.2    Moullan, N.3    Katsyuba, E.4    Ryu, D.5    Cantó, C.6
  • 22
    • 84945488022 scopus 로고    scopus 로고
    • Phosphorylation of the nuclear receptor co-repressor 1 by protein kinase B (PKB/Akt) switches its co-repressor targets in the liver
    • [Epub ahead of print]
    • Jo YS, Ryu D, Maida A, Wang X, Evans RM, Schoonjans K, Auwerx J. Phosphorylation of the nuclear receptor co-repressor 1 by protein kinase B (PKB/Akt) switches its co-repressor targets in the liver. Hepatology 2015 May 22. doi: 10.1002/hep.27907. [Epub ahead of print]
    • (2015) Hepatology
    • Jo, Y.S.1    Ryu, D.2    Maida, A.3    Wang, X.4    Evans, R.M.5    Schoonjans, K.6    Auwerx, J.7
  • 23
    • 84861589885 scopus 로고    scopus 로고
    • Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis
    • Fernandez-Marcos PJ, Jeninga EH, Cantó C, Harach T, de Boer VC, Andreux P, et al. Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis. Sci Rep 2012;2:425.
    • (2012) Sci Rep , vol.2 , pp. 425
    • Fernandez-Marcos, P.J.1    Jeninga, E.H.2    Cantó, C.3    Harach, T.4    de Boer, V.C.5    Andreux, P.6
  • 24
    • 84907992528 scopus 로고    scopus 로고
    • SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport
    • Stein S, Oosterveer MH, Mataki C, Xu P, Lemos V, Havinga R, et al. SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport. Cell Metab 2014;20:603-613.
    • (2014) Cell Metab , vol.20 , pp. 603-613
    • Stein, S.1    Oosterveer, M.H.2    Mataki, C.3    Xu, P.4    Lemos, V.5    Havinga, R.6
  • 25
    • 33750445309 scopus 로고    scopus 로고
    • NAD metabolism and sirtuins: metabolic regulation of protein deacetylation in stress and toxicity
    • Yang T, Sauve AA. NAD metabolism and sirtuins: metabolic regulation of protein deacetylation in stress and toxicity. AAPS J 2006;8:E632-E643.
    • (2006) AAPS J , vol.8 , pp. E632-E643
    • Yang, T.1    Sauve, A.A.2
  • 26
    • 84908077262 scopus 로고    scopus 로고
    • Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population
    • Wu Y, Williams EG, Dubuis S, Mottis A, Jovaisaite V, Houten SM, et al. Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population. Cell 2014;158:1415-1430.
    • (2014) Cell , vol.158 , pp. 1415-1430
    • Wu, Y.1    Williams, E.G.2    Dubuis, S.3    Mottis, A.4    Jovaisaite, V.5    Houten, S.M.6
  • 27
    • 84919497464 scopus 로고    scopus 로고
    • Inhibition of De Novo NAD(+) Synthesis by Oncogenic URI Causes Liver Tumorigenesis through DNA Damage
    • Tummala KS, Gomes AL, Yilmaz M, Graña O, Bakiri L, Ruppen I, et al. Inhibition of De Novo NAD(+) Synthesis by Oncogenic URI Causes Liver Tumorigenesis through DNA Damage. Cancer Cell 2014;26:826-839.
    • (2014) Cancer Cell , vol.26 , pp. 826-839
    • Tummala, K.S.1    Gomes, A.L.2    Yilmaz, M.3    Graña, O.4    Bakiri, L.5    Ruppen, I.6
  • 28
    • 45149108420 scopus 로고    scopus 로고
    • Mapping the genetic architecture of gene expression in human liver
    • Schadt EE, Molony C, Chudin E, Hao K, Yang X, Lum PY, et al. Mapping the genetic architecture of gene expression in human liver. PLoS Biol 2008;6:e107.
    • (2008) PLoS Biol , vol.6 , pp. e107
    • Schadt, E.E.1    Molony, C.2    Chudin, E.3    Hao, K.4    Yang, X.5    Lum, P.Y.6
  • 29
    • 84899494248 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis
    • Mukhopadhyay P, Rajesh M, Cao Z, Horvath B, Park O, Wang H, et al. Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis. Hepatology 2013;59:1998-2009.
    • (2013) Hepatology , vol.59 , pp. 1998-2009
    • Mukhopadhyay, P.1    Rajesh, M.2    Cao, Z.3    Horvath, B.4    Park, O.5    Wang, H.6
  • 32
    • 4644353364 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage
    • Nakajima T, Kamijo Y, Tanaka N, Sugiyama E, Tanaka E, Kiyosawa K, et al. Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage. Hepatology 2004;40:972-980.
    • (2004) Hepatology , vol.40 , pp. 972-980
    • Nakajima, T.1    Kamijo, Y.2    Tanaka, N.3    Sugiyama, E.4    Tanaka, E.5    Kiyosawa, K.6
  • 33
    • 0035914298 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines
    • Akiyama TE, Nicol CJ, Fievet C, Staels B, Ward JM, Auwerx J, et al. Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines. J Biol Chem 2001;276:39088-39093.
    • (2001) J Biol Chem , vol.276 , pp. 39088-39093
    • Akiyama, T.E.1    Nicol, C.J.2    Fievet, C.3    Staels, B.4    Ward, J.M.5    Auwerx, J.6
  • 36
    • 84893442805 scopus 로고    scopus 로고
    • Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
    • Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, et al. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell 2013;155:1624-1638.
    • (2013) Cell , vol.155 , pp. 1624-1638
    • Gomes, A.P.1    Price, N.L.2    Ling, A.J.3    Moslehi, J.J.4    Montgomery, M.K.5    Rajman, L.6
  • 37
    • 79952708723 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in liver disease
    • Malhi H, Kaufman RJ. Endoplasmic reticulum stress in liver disease. J Hepatol 2011;54:795-809.
    • (2011) J Hepatol , vol.54 , pp. 795-809
    • Malhi, H.1    Kaufman, R.J.2
  • 38
    • 84892989225 scopus 로고    scopus 로고
    • SirT3 regulates the mitochondrial unfolded protein response
    • Papa L, Germain D. SirT3 regulates the mitochondrial unfolded protein response. Mol Cell Biol 2014;34:699-710.
    • (2014) Mol Cell Biol , vol.34 , pp. 699-710
    • Papa, L.1    Germain, D.2
  • 39
    • 84937522438 scopus 로고    scopus 로고
    • NAD(+) metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus
    • Cantó C, Menzies KJ, Auwerx J. NAD(+) metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus. Cell Metab 2015;22:31-53.
    • (2015) Cell Metab , vol.22 , pp. 31-53
    • Cantó, C.1    Menzies, K.J.2    Auwerx, J.3
  • 40
    • 84901848955 scopus 로고    scopus 로고
    • Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3
    • Khan NA, Auranen M, Paetau I, Pirinen E, Euro L, Forsström S, et al. Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3. EMBO Mol Med 2014;6:721-731.
    • (2014) EMBO Mol Med , vol.6 , pp. 721-731
    • Khan, N.A.1    Auranen, M.2    Paetau, I.3    Pirinen, E.4    Euro, L.5    Forsström, S.6
  • 41
    • 84900410413 scopus 로고    scopus 로고
    • Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity
    • Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature 2014;508:258-262.
    • (2014) Nature , vol.508 , pp. 258-262
    • Kraus, D.1    Yang, Q.2    Kong, D.3    Banks, A.S.4    Zhang, L.5    Rodgers, J.T.6
  • 42
    • 84942553596 scopus 로고    scopus 로고
    • Novel role for carbohydrate responsive element binding protein in the control of ethanol metabolism and susceptibility to binge drinking
    • Marmier S, Dentin R, Daujat-Chavanieu M, Guillou H, Bertrand-Michel J, Gerbal-Chaloin S, et al. Novel role for carbohydrate responsive element binding protein in the control of ethanol metabolism and susceptibility to binge drinking. Hepatology 2015;62:1086-1100.
    • (2015) Hepatology , vol.62 , pp. 1086-1100
    • Marmier, S.1    Dentin, R.2    Daujat-Chavanieu, M.3    Guillou, H.4    Bertrand-Michel, J.5    Gerbal-Chaloin, S.6
  • 43
    • 79952768723 scopus 로고    scopus 로고
    • Signaling mechanism of poly(ADP-ribose) polymerase-1 (PARP-1) in inflammatory diseases
    • Ba X, Garg NJ. Signaling mechanism of poly(ADP-ribose) polymerase-1 (PARP-1) in inflammatory diseases. Am J Pathol 2011;178:946-955.
    • (2011) Am J Pathol , vol.178 , pp. 946-955
    • Ba, X.1    Garg, N.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.