메뉴 건너뛰기




Volumn 64, Issue 4, 2015, Pages 1211-1223

Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PROTEIN; PROTEIN KINASE B; SESTRIN 3; UNCLASSIFIED DRUG; ADENYLATE KINASE; GLUCOSE; HEAT SHOCK PROTEIN; INSULIN; MULTIPROTEIN COMPLEX; SESN3 PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

EID: 84962018940     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-0539     Document Type: Article
Times cited : (86)

References (59)
  • 1
    • 84889681863 scopus 로고    scopus 로고
    • Sestrins orchestrate cellular metabolism to attenuate aging
    • Lee JH, Budanov AV, Karin M. Sestrins orchestrate cellular metabolism to attenuate aging. Cell Metab 2013;18: 792-801
    • (2013) Cell Metab , vol.18 , pp. 792-801
    • Lee, J.H.1    Budanov, A.V.2    Karin, M.3
  • 2
    • 84872137966 scopus 로고    scopus 로고
    • Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage
    • Bae SH, Sung SH, Oh SY, et al. Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. Cell Metab 2013;17: 73-84
    • (2013) Cell Metab , vol.17 , pp. 73-84
    • Bae, S.H.1    Sung, S.H.2    Oh, S.Y.3
  • 3
    • 84887999522 scopus 로고    scopus 로고
    • Nelfinavir and bortezomib inhibit mTOR activity via ATF4-mediated sestrin-2 regulation
    • Brüning A, Rahmeh M, Friese K. Nelfinavir and bortezomib inhibit mTOR activity via ATF4-mediated sestrin-2 regulation. Mol Oncol 2013;7: 1012-1018
    • (2013) Mol Oncol , vol.7 , pp. 1012-1018
    • Brüning, A.1    Rahmeh, M.2    Friese, K.3
  • 4
    • 48449101433 scopus 로고    scopus 로고
    • P53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
    • Budanov AV, Karin M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 2008;134: 451-460
    • (2008) Cell , vol.134 , pp. 451-460
    • Budanov, A.V.1    Karin, M.2
  • 5
    • 0037026596 scopus 로고    scopus 로고
    • Identification of a novel stressresponsive gene Hi95 involved in regulation of cell viability
    • Budanov AV, Shoshani T, Faerman A, et al. Identification of a novel stressresponsive gene Hi95 involved in regulation of cell viability. Oncogene 2002;21: 6017-6031
    • (2002) Oncogene , vol.21 , pp. 6017-6031
    • Budanov, A.V.1    Shoshani, T.2    Faerman, A.3
  • 6
    • 84865790501 scopus 로고    scopus 로고
    • Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3
    • Lee JH, Budanov AV, Talukdar S, et al. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab 2012;16: 311-321
    • (2012) Cell Metab , vol.16 , pp. 311-321
    • Lee, J.H.1    Budanov, A.V.2    Talukdar, S.3
  • 7
    • 84903166942 scopus 로고    scopus 로고
    • Hepatoprotective role of Sestrin2 against chronic ER stress
    • Park HW, Park H, Ro SH, et al. Hepatoprotective role of Sestrin2 against chronic ER stress. Nat Commun 2014;5: 4233
    • (2014) Nat Commun , vol.5 , pp. 4233
    • Park, H.W.1    Park, H.2    Ro, S.H.3
  • 8
    • 84888864393 scopus 로고    scopus 로고
    • Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle
    • Nascimento EB, Osler ME, Zierath JR. Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle. Am J Physiol Endocrinol Metab 2013;305: E1408-E1414
    • (2013) Am J Physiol Endocrinol Metab , vol.305 , pp. E1408-E1414
    • Nascimento, E.B.1    Osler, M.E.2    Zierath, J.R.3
  • 10
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003;115: 577-590
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 11
    • 42949139481 scopus 로고    scopus 로고
    • AMPK phosphorylation of raptor mediates a metabolic checkpoint
    • Gwinn DM, Shackelford DB, Egan DF, et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 2008;30: 214-226
    • (2008) Mol Cell , vol.30 , pp. 214-226
    • Gwinn, D.M.1    Shackelford, D.B.2    Egan, D.F.3
  • 12
    • 84907525131 scopus 로고    scopus 로고
    • Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling
    • Peng M, Yin N, Li MO. Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. Cell 2014;159: 122-133
    • (2014) Cell , vol.159 , pp. 122-133
    • Peng, M.1    Yin, N.2    Li, M.O.3
  • 13
    • 84907991157 scopus 로고    scopus 로고
    • The sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
    • Chantranupong L, Wolfson RL, Orozco JM, et al. The sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Rep 2014;9: 1-8
    • (2014) Cell Rep , vol.9 , pp. 1-8
    • Chantranupong, L.1    Wolfson, R.L.2    Orozco, J.M.3
  • 14
    • 84866122780 scopus 로고    scopus 로고
    • Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
    • Copps KD, White MF. Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia 2012;55: 2565-2582
    • (2012) Diabetologia , vol.55 , pp. 2565-2582
    • Copps, K.D.1    White, M.F.2
  • 15
    • 33644886769 scopus 로고    scopus 로고
    • Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
    • Tzatsos A, Kandror KV. Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol 2006;26: 63-76
    • (2006) Mol Cell Biol , vol.26 , pp. 63-76
    • Tzatsos, A.1    Kandror, K.V.2
  • 16
    • 16844370268 scopus 로고    scopus 로고
    • Regulation of insulin signalling by hyperinsulinaemia: Role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway
    • Ueno M, Carvalheira JB, Tambascia RC, et al. Regulation of insulin signalling by hyperinsulinaemia: Role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway. Diabetologia 2005;48: 506-518
    • (2005) Diabetologia , vol.48 , pp. 506-518
    • Ueno, M.1    Carvalheira, J.B.2    Tambascia, R.C.3
  • 17
    • 4544343980 scopus 로고    scopus 로고
    • Inappropriate activation of the TSC/Rheb/ mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
    • Shah OJ, Wang Z, Hunter T. Inappropriate activation of the TSC/Rheb/ mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr Biol 2004;14: 1650-1656
    • (2004) Curr Biol , vol.14 , pp. 1650-1656
    • Shah, O.J.1    Wang, Z.2    Hunter, T.3
  • 18
    • 4544220704 scopus 로고    scopus 로고
    • Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity
    • Um SH, Frigerio F, Watanabe M, et al. Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity. Nature 2004; 431: 200-205
    • (2004) Nature , vol.431 , pp. 200-205
    • Um, S.H.1    Frigerio, F.2    Watanabe, M.3
  • 19
    • 0035368548 scopus 로고    scopus 로고
    • Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
    • Cho H, Mu J, Kim JK, et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 2001;292: 1728-1731
    • (2001) Science , vol.292 , pp. 1728-1731
    • Cho, H.1    Mu, J.2    Kim, J.K.3
  • 20
    • 2542528670 scopus 로고    scopus 로고
    • A family with severe insulin resistance and diabetes due to a mutation in AKT2
    • George S, Rochford JJ, Wolfrum C, et al. A family with severe insulin resistance and diabetes due to a mutation in AKT2. Science 2004;304: 1325-1328
    • (2004) Science , vol.304 , pp. 1325-1328
    • George, S.1    Rochford, J.J.2    Wolfrum, C.3
  • 21
    • 84857934301 scopus 로고    scopus 로고
    • Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
    • Lu M, Wan M, Leavens KF, et al. Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nat Med 2012;18: 388-395
    • (2012) Nat Med , vol.18 , pp. 388-395
    • Lu, M.1    Wan, M.2    Leavens, K.F.3
  • 22
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell 2012;149: 274-293
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 23
    • 84884676252 scopus 로고    scopus 로고
    • Nutrient signaling to mTOR and cell growth
    • Jewell JL, Guan KL. Nutrient signaling to mTOR and cell growth. Trends Biochem Sci 2013;38: 233-242
    • (2013) Trends Biochem Sci , vol.38 , pp. 233-242
    • Jewell, J.L.1    Guan, K.L.2
  • 24
    • 84884729110 scopus 로고    scopus 로고
    • The Bardet-Biedl syndromerelated protein CCDC28B modulates mTORC2 function and interacts with SIN1 to control cilia length independently of the mTOR complex
    • Cardenas-Rodriguez M, Irigoín F, Osborn DP, et al. The Bardet-Biedl syndromerelated protein CCDC28B modulates mTORC2 function and interacts with SIN1 to control cilia length independently of the mTOR complex. Hum Mol Genet 2013;22: 4031-4042
    • (2013) Hum Mol Genet , vol.22 , pp. 4031-4042
    • Cardenas-Rodriguez, M.1    Irigoín, F.2    Osborn, D.P.3
  • 25
    • 44949215822 scopus 로고    scopus 로고
    • The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
    • Huang J, Dibble CC, Matsuzaki M, Manning BD. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol 2008;28: 4104-4115
    • (2008) Mol Cell Biol , vol.28 , pp. 4104-4115
    • Huang, J.1    Dibble, C.C.2    Matsuzaki, M.3    Manning, B.D.4
  • 26
    • 84879469402 scopus 로고    scopus 로고
    • Inhibition of 14-3-3 binding to Rictor of mTORC2 for Akt phosphorylation at Ser473 is regulated by selenoprotein W
    • Jeon YH, Park YH, Kwon JH, Lee JH, Kim IY. Inhibition of 14-3-3 binding to Rictor of mTORC2 for Akt phosphorylation at Ser473 is regulated by selenoprotein W. Biochim Biophys Acta 2013;1833: 2135-2142
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 2135-2142
    • Jeon, Y.H.1    Park, Y.H.2    Kwon, J.H.3    Lee, J.H.4    Kim, I.Y.5
  • 27
    • 84858336307 scopus 로고    scopus 로고
    • GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells
    • Joha S, Nugues AL, Hétuin D, et al. GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells. Oncogene 2012;31: 1419-1430
    • (2012) Oncogene , vol.31 , pp. 1419-1430
    • Joha, S.1    Nugues, A.L.2    Hétuin, D.3
  • 29
    • 84882584665 scopus 로고    scopus 로고
    • IKK interacts with rictor and regulates mTORC2
    • Xu Y, Lai E, Liu J, et al. IKK interacts with rictor and regulates mTORC2. Cell Signal 2013;25: 2239-2245
    • (2013) Cell Signal , vol.25 , pp. 2239-2245
    • Xu, Y.1    Lai, E.2    Liu, J.3
  • 30
    • 0032898369 scopus 로고    scopus 로고
    • Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase
    • Postic C, Shiota M, Niswender KD, et al. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 1999;274: 305-315
    • (1999) J Biol Chem , vol.274 , pp. 305-315
    • Postic, C.1    Shiota, M.2    Niswender, K.D.3
  • 31
    • 34547941361 scopus 로고    scopus 로고
    • MIR-150 controls B cell differentiation by targeting the transcription factor c-Myb
    • Xiao C, Calado DP, Galler G, et al. MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell 2007;131: 146-159
    • (2007) Cell , vol.131 , pp. 146-159
    • Xiao, C.1    Calado, D.P.2    Galler, G.3
  • 32
    • 33646928066 scopus 로고    scopus 로고
    • Changes in gene expression foreshadow diet-induced obesity in genetically identical mice
    • Koza RA, Nikonova L, Hogan J, et al. Changes in gene expression foreshadow diet-induced obesity in genetically identical mice. PLoS Genet 2006;2: E81
    • (2006) PLoS Genet , vol.2 , pp. e81
    • Koza, R.A.1    Nikonova, L.2    Hogan, J.3
  • 33
    • 17844383478 scopus 로고    scopus 로고
    • Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome
    • Biddinger SB, Almind K, Miyazaki M, Kokkotou E, Ntambi JM, Kahn CR. Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome. Diabetes 2005;54: 1314-1323
    • (2005) Diabetes , vol.54 , pp. 1314-1323
    • Biddinger, S.B.1    Almind, K.2    Miyazaki, M.3    Kokkotou, E.4    Ntambi, J.M.5    Kahn, C.R.6
  • 34
    • 78649811793 scopus 로고    scopus 로고
    • Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
    • Nakada D, Saunders TL, Morrison SJ. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 2010;468: 653-658
    • (2010) Nature , vol.468 , pp. 653-658
    • Nakada, D.1    Saunders, T.L.2    Morrison, S.J.3
  • 35
    • 84883205274 scopus 로고    scopus 로고
    • Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis
    • Xiong X, Tao R, DePinho RA, Dong XC. Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis. PLoS One 2013;8: E74340
    • (2013) PLoS One , vol.8 , pp. e74340
    • Xiong, X.1    Tao, R.2    DePinho, R.A.3    Dong, X.C.4
  • 36
    • 84881097499 scopus 로고    scopus 로고
    • Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes
    • Tao R, Xiong X, Harris RA, White MF, Dong XC. Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes. PLoS One 2013;8: E71997
    • (2013) PLoS One , vol.8 , pp. e71997
    • Tao, R.1    Xiong, X.2    Harris, R.A.3    White, M.F.4    Dong, X.C.5
  • 37
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov DD, Ali SM, Kim DH, et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004;14: 1296-1302
    • (2004) Curr Biol , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3
  • 38
    • 84884134120 scopus 로고    scopus 로고
    • Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6
    • Tao R, Xiong X, DePinho RA, Deng CX, Dong XC. Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6. J Lipid Res 2013;54: 2745-2753
    • (2013) J Lipid Res , vol.54 , pp. 2745-2753
    • Tao, R.1    Xiong, X.2    DePinho, R.A.3    Deng, C.X.4    Dong, X.C.5
  • 39
    • 84885637201 scopus 로고    scopus 로고
    • FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression
    • Tao R, Xiong X, DePinho RA, Deng CX, Dong XC. FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression. J Biol Chem 2013;288: 29252-29259
    • (2013) J Biol Chem , vol.288 , pp. 29252-29259
    • Tao, R.1    Xiong, X.2    DePinho, R.A.3    Deng, C.X.4    Dong, X.C.5
  • 40
    • 81155123660 scopus 로고    scopus 로고
    • The mTOR (mammalian target of rapamycin) kinase maintains integrity of mTOR complex 2
    • Chen CH, Sarbassov D. The mTOR (mammalian target of rapamycin) kinase maintains integrity of mTOR complex 2. J Biol Chem 2011;286: 40386-40394
    • (2011) J Biol Chem , vol.286 , pp. 40386-40394
    • Chen, C.H.1    Sarbassov, D.2
  • 41
    • 77749264562 scopus 로고    scopus 로고
    • Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
    • Lee JH, Budanov AV, Park EJ, et al. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science 2010;327: 1223-1228
    • (2010) Science , vol.327 , pp. 1223-1228
    • Lee, J.H.1    Budanov, A.V.2    Park, E.J.3
  • 42
    • 33748471980 scopus 로고    scopus 로고
    • MSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
    • Frias MA, Thoreen CC, Jaffe JD, et al. mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr Biol 2006; 16: 1865-1870
    • (2006) Curr Biol , vol.16 , pp. 1865-1870
    • Frias, M.A.1    Thoreen, C.C.2    Jaffe, J.D.3
  • 43
    • 33749076673 scopus 로고    scopus 로고
    • SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
    • Jacinto E, Facchinetti V, Liu D, et al. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 2006;127: 125-137
    • (2006) Cell , vol.127 , pp. 125-137
    • Jacinto, E.1    Facchinetti, V.2    Liu, D.3
  • 44
    • 78650848337 scopus 로고    scopus 로고
    • MTORC1 controls fasting-induced ketogenesis and its modulation by ageing
    • Sengupta S, Peterson TR, Laplante M, Oh S, Sabatini DM. mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature 2010;468: 1100-1104
    • (2010) Nature , vol.468 , pp. 1100-1104
    • Sengupta, S.1    Peterson, T.R.2    Laplante, M.3    Oh, S.4    Sabatini, D.M.5
  • 45
    • 2142815107 scopus 로고    scopus 로고
    • Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD
    • Budanov AV, Sablina AA, Feinstein E, Koonin EV, Chumakov PM. Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science 2004;304: 596-600
    • (2004) Science , vol.304 , pp. 596-600
    • Budanov, A.V.1    Sablina, A.A.2    Feinstein, E.3    Koonin, E.V.4    Chumakov, P.M.5
  • 46
    • 60749125535 scopus 로고    scopus 로고
    • Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins
    • Woo HA, Bae SH, Park S, Rhee SG. Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins. Antioxid Redox Signal 2009;11: 739-745
    • (2009) Antioxid Redox Signal , vol.11 , pp. 739-745
    • Woo, H.A.1    Bae, S.H.2    Park, S.3    Rhee, S.G.4
  • 47
    • 84901684204 scopus 로고    scopus 로고
    • Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species
    • Ro SH, Nam M, Jang I, et al. Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species. Proc Natl Acad Sci U S A 2014;111: 7849-7854
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 7849-7854
    • Ro, S.H.1    Nam, M.2    Jang, I.3
  • 48
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: A nutrient and energy sensor that maintains energy homeostasis
    • Hardie DG, Ross FA, Hawley SA. AMPK: A nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 2012;13: 251-262
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 49
    • 3142594193 scopus 로고    scopus 로고
    • The LKB1 tumor suppressor negatively regulates mTOR signaling
    • Shaw RJ, Bardeesy N, Manning BD, et al. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 2004;6: 91-99
    • (2004) Cancer Cell , vol.6 , pp. 91-99
    • Shaw, R.J.1    Bardeesy, N.2    Manning, B.D.3
  • 51
    • 84860454425 scopus 로고    scopus 로고
    • Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c
    • Hagiwara A, Cornu M, Cybulski N, et al. Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c. Cell Metab 2012;15: 725-738
    • (2012) Cell Metab , vol.15 , pp. 725-738
    • Hagiwara, A.1    Cornu, M.2    Cybulski, N.3
  • 52
    • 84894225988 scopus 로고    scopus 로고
    • Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)
    • Lamming DW, Demirkan G, Boylan JM, et al. Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2). FASEB J 2014;28: 300-315
    • (2014) FASEB J , vol.28 , pp. 300-315
    • Lamming, D.W.1    Demirkan, G.2    Boylan, J.M.3
  • 53
    • 70350545722 scopus 로고    scopus 로고
    • Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1
    • Dibble CC, Asara JM, Manning BD. Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol Cell Biol 2009;29: 5657-5670
    • (2009) Mol Cell Biol , vol.29 , pp. 5657-5670
    • Dibble, C.C.1    Asara, J.M.2    Manning, B.D.3
  • 54
    • 79952119614 scopus 로고    scopus 로고
    • ER stress inhibits mTORC2 and Akt signaling through GSK-3b-mediated phosphorylation of rictor
    • Chen CH, Shaikenov T, Peterson TR, et al. ER stress inhibits mTORC2 and Akt signaling through GSK-3b-mediated phosphorylation of rictor. Sci Signal 2011;4: Ra10
    • (2011) Sci Signal , vol.4 , pp. ra10
    • Chen, C.H.1    Shaikenov, T.2    Peterson, T.R.3
  • 55
    • 84855282748 scopus 로고    scopus 로고
    • Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein
    • Glidden EJ, Gray LG, Vemuru S, Li D, Harris TE, Mayo MW. Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein. J Biol Chem 2012;287: 581-588
    • (2012) J Biol Chem , vol.287 , pp. 581-588
    • Glidden, E.J.1    Gray, L.G.2    Vemuru, S.3    Li, D.4    Harris, T.E.5    Mayo, M.W.6
  • 56
    • 40949083412 scopus 로고    scopus 로고
    • Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival
    • McDonald PC, Oloumi A, Mills J, et al. Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. Cancer Res 2008;68: 1618-1624
    • (2008) Cancer Res , vol.68 , pp. 1618-1624
    • McDonald, P.C.1    Oloumi, A.2    Mills, J.3
  • 57
    • 54249156545 scopus 로고    scopus 로고
    • Metabolic syndrome: From epidemiology to systems biology
    • Lusis AJ, Attie AD, Reue K. Metabolic syndrome: From epidemiology to systems biology. Nat Rev Genet 2008;9: 819-830
    • (2008) Nat Rev Genet , vol.9 , pp. 819-830
    • Lusis, A.J.1    Attie, A.D.2    Reue, K.3
  • 58
    • 77649251207 scopus 로고    scopus 로고
    • MTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis
    • Laplante M, Sabatini DM. mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis. Proc Natl Acad Sci U S A 2010;107: 3281-3282
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 3281-3282
    • Laplante, M.1    Sabatini, D.M.2
  • 59
    • 77649264504 scopus 로고    scopus 로고
    • Bifurcation of insulin signaling pathway in rat liver: MTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
    • Li S, Brown MS, Goldstein JL. Bifurcation of insulin signaling pathway in rat liver: MTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc Natl Acad Sci U S A 2010;107: 3441-3446
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 3441-3446
    • Li, S.1    Brown, M.S.2    Goldstein, J.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.