A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

Science

Volumn 347, Issue 6228, 2015, Pages 1374-1377

  Mohrin, Mary ^a   Shin, Jiyung ^a   Liu, Yufei ^b   Brown, Katharine ^a   Luo, Hanzhi ^a   Xi, Yannan ^a   Haynes, Cole M ^c,d   Chen, Danica ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL PROTEIN; SIRTUIN 7; TRANSCRIPTION FACTOR NRF1; NRF1 PROTEIN, HUMAN; NUCLEAR RESPIRATORY FACTOR 1; SIRT7 PROTEIN, HUMAN; SIRTUIN;

AGING; CELL ORGANELLE; GENE EXPRESSION; HOMEOSTASIS; METABOLISM; MITOCHONDRION;

ADULT; AGED; ARTICLE; CELL AGING; CELL CYCLE CHECKPOINT; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL REGENERATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENERGY METABOLISM; GENE; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; METABOLIC REGULATION; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; UNFOLDED PROTEIN RESPONSE; UPREGULATION; ANIMAL; GENETICS; HEK293 CELL LINE; METABOLISM; MOUSE; MUTANT MOUSE STRAIN; PHYSIOLOGY; PROTEIN SYNTHESIS;

ANIMALS; CELL AGING; CELL CYCLE CHECKPOINTS; ENERGY METABOLISM; HEK293 CELLS; HEMATOPOIETIC STEM CELLS; HUMANS; MICE; MICE, MUTANT STRAINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NUCLEAR RESPIRATORY FACTOR 1; PROTEIN BIOSYNTHESIS; SIRTUINS; UNFOLDED PROTEIN RESPONSE;

EID: 84925265469     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaa2361     Document Type: Article

References (25)

1. C. J. Kenyon, Nature 464, 504-512 (2010).
2. C. López-Otín, M. A. Blasco, L. Partridge, M. Serrano, G. Kroemer, Cell 153, 1194-1217 (2013).
3. J. Vijg, J. Campisi, Nature 454, 1065-1071 (2008).
4. C. D. Folmes, P. P. Dzeja, T. J. Nelson, A. Terzic, Cell Stem Cell 11, 596-606 (2012).
5. L. Liu et al., Cell Rep. 4, 189-204 (2013).
6. A. E. Webb et al., Cell Rep. 4, 477-491 (2013).
7. M. F. Barber et al., Nature 487, 114-118 (2012).
8. R. C. Scarpulla, Physiol. Rev. 88, 611-638 (2008).
9. J. Shin et al., Cell Rep. 5, 654-665 (2013).
10. J. Y. Lu, Y. Zhang, Y. F. Shen, Acta Academiae Medicinae Sinicae 31, 724-727 (2009).
11. O. Vakhrusheva, D. Braeuer, Z. Liu, T. Braun, E. Bober, J. Physiol. Pharmacol. 59 (suppl. 9), 201-212 (2008).
12. K. Brown et al., Cell Rep. 3, 319-327 (2013).
13. W. Giblin, M. E. Skinner, D. B. Lombard, Trends Genet. 30, 271-286 (2014).
14. X. Qiu, K. Brown, M. D. Hirschey, E. Verdin, D. Chen, Cell Metab. 12, 662-667 (2010).
15. K. Inoki, T. Zhu, K. L. Guan, Cell 115, 577-590 (2003).
16. M. Laplante, D. M. Sabatini, Cell 149, 274-293 (2012).
17. C. M. Haynes, D. Ron, J. Cell Sci. 123, 3849-3855 (2010).
18. Q. Zhao et al., EMBO J. 21, 4411-4419 (2002).
19. C. M. Haynes, C. J. Fiorese, Y. F. Lin, Trends Cell Biol. 23, 311-318 (2013).
20. D. Ryu et al., Cell Metab. 20, 856-869 (2014).
21. K. Miyamoto et al., Cell Stem Cell 1, 101-112 (2007).
22. S. M. Chambers et al., PLOS Biol. 5, e201 (2007).
23. V. Janzen et al., Nature 443, 421-426 (2006).
24. J. Oh, Y. D. Lee, A. J. Wagers, Nat. Med. 20, 870-880 (2014).
25. R. A. Signer, S. J. Morrison, Cell Stem Cell 12, 152-165 (2013).