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Volumn 6, Issue JUN, 2015, Pages

Antigen presentation, autoantigens, and immune regulation in multiple sclerosis and other autoimmune diseases

Author keywords

Antigen presentation; Autoantigen; Autoimmune disease; B cell; HLA; MHC; Multiple sclerosis; T cell

Indexed keywords

2',3' CYCLIC NUCLEOTIDE 3' PHOSPHODIESTERASE; AMPA RECEPTOR; AQUAPORIN 4; AUTOANTIGEN; BETA CRYSTALLIN; CHROMOGRANIN A; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; GLUTAMATE DECARBOXYLASE 65; IMMUNOGLOBULIN G; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 7; LEUKOCYTE ANTIGEN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MYELIN ASSOCIATED GLYCOPROTEIN; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NICOTINIC RECEPTOR; PROTEOLIPID PROTEIN; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 9; TRANSALDOLASE; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNINDEXED DRUG;

EID: 84935079207     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00322     Document Type: Review
Times cited : (84)

References (344)
  • 1
    • 33947509525 scopus 로고    scopus 로고
    • The immunopathology of multiple sclerosis: an overview
    • Lassmann H, Brück W, Lucchinetti CF. The immunopathology of multiple sclerosis: an overview. Brain Pathol (2007) 17:210-8. doi:10.1111/j.1750-3639.2007.00064.x
    • (2007) Brain Pathol , vol.17 , pp. 210-218
    • Lassmann, H.1    Brück, W.2    Lucchinetti, C.F.3
  • 2
    • 84875510924 scopus 로고    scopus 로고
    • Pathways of antigen processing
    • Blum JS, Wearsch PA, Cresswell P. Pathways of antigen processing. Annu Rev Immunol (2013) 31:443-73. doi:10.1146/annurev-immunol-032712-095910
    • (2013) Annu Rev Immunol , vol.31 , pp. 443-473
    • Blum, J.S.1    Wearsch, P.A.2    Cresswell, P.3
  • 3
    • 0027980319 scopus 로고
    • Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
    • Rock KL, Gramm C, Rothstein L, Clark K, Stein R, Dick L, et al. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell (1994) 78:761-71. doi:10.1016/S0092-8674(94)90462-6
    • (1994) Cell , vol.78 , pp. 761-771
    • Rock, K.L.1    Gramm, C.2    Rothstein, L.3    Clark, K.4    Stein, R.5    Dick, L.6
  • 4
    • 0028136465 scopus 로고
    • Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7
    • Gaczynska M, Rock KL, Spies T, Goldberg AL. Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7. Proc Natl Acad Sci U S A (1994) 91:9213-7. doi:10.1073/pnas.91.20.9213
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 9213-9217
    • Gaczynska, M.1    Rock, K.L.2    Spies, T.3    Goldberg, A.L.4
  • 5
    • 0036902105 scopus 로고    scopus 로고
    • An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides
    • Saric T, Chang S, Hattori A, York IA, Markant S, Rock KL, et al. An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Nat Immunol (2002) 3:1169-76. doi:10.1038/ni859
    • (2002) Nat Immunol , vol.3 , pp. 1169-1176
    • Saric, T.1    Chang, S.2    Hattori, A.3    York, I.A.4    Markant, S.5    Rock, K.L.6
  • 6
    • 0036884090 scopus 로고    scopus 로고
    • The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues
    • York IA, Chang S, Saric T, Keys JA, Favreau JM, Goldberg AL, et al. The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues. Nat Immunol (2002) 3:1177-84. doi:10.1038/ni860
    • (2002) Nat Immunol , vol.3 , pp. 1177-1184
    • York, I.A.1    Chang, S.2    Saric, T.3    Keys, J.A.4    Favreau, J.M.5    Goldberg, A.L.6
  • 7
    • 0030217926 scopus 로고    scopus 로고
    • Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP
    • Sadasivan B, Lehner PJ, Ortmann B, Spies T, Cresswell P. Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP. Immunity (1996) 5:103-14. doi:10.1016/S1074-7613(00)80487-2
    • (1996) Immunity , vol.5 , pp. 103-114
    • Sadasivan, B.1    Lehner, P.J.2    Ortmann, B.3    Spies, T.4    Cresswell, P.5
  • 9
    • 3242743087 scopus 로고    scopus 로고
    • The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules
    • Watts C. The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules. Nat Immunol (2004) 5:685-92. doi:10.1038/ni1088
    • (2004) Nat Immunol , vol.5 , pp. 685-692
    • Watts, C.1
  • 10
    • 0026440236 scopus 로고
    • HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides
    • Riberdy JM, Newcomb JR, Surman MJ, Barbosa JA, Cresswell P. HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides. Nature (1992) 360:474-7. doi:10.1038/360474a0
    • (1992) Nature , vol.360 , pp. 474-477
    • Riberdy, J.M.1    Newcomb, J.R.2    Surman, M.J.3    Barbosa, J.A.4    Cresswell, P.5
  • 11
    • 0028981178 scopus 로고
    • HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading
    • Denzin LK, Cresswell P. HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading. Cell (1995) 82:155-65. doi:10.1016/0092-8674(95)90061-6
    • (1995) Cell , vol.82 , pp. 155-165
    • Denzin, L.K.1    Cresswell, P.2
  • 12
    • 0029848128 scopus 로고    scopus 로고
    • Microglia induce CD4 T lymphocyte final effector function and death
    • Ford AL, Foulcher E, Lemckert FA, Sedgwick JD. Microglia induce CD4 T lymphocyte final effector function and death. J Exp Med (1996) 184:1737-45. doi:10.1084/jem.184.5.1737
    • (1996) J Exp Med , vol.184 , pp. 1737-1745
    • Ford, A.L.1    Foulcher, E.2    Lemckert, F.A.3    Sedgwick, J.D.4
  • 13
    • 0021191999 scopus 로고
    • Astrocytes present myelin basic protein to encephalitogenic T-cell lines
    • Fontana A, Fierz W, Wekerle H. Astrocytes present myelin basic protein to encephalitogenic T-cell lines. Nature (1984) 307:273-6. doi:10.1038/307273a0
    • (1984) Nature , vol.307 , pp. 273-276
    • Fontana, A.1    Fierz, W.2    Wekerle, H.3
  • 14
    • 0034964922 scopus 로고    scopus 로고
    • Immuno-competent astrocytes and microglia display major differences in the processing of the invariant chain and in the expression of active cathepsin L and cathepsin S
    • Gresser O, Weber E, Hellwig A, Riese S, Régnier-Vigouroux A. Immuno-competent astrocytes and microglia display major differences in the processing of the invariant chain and in the expression of active cathepsin L and cathepsin S. Eur J Immunol (2001) 31:1813-24. doi:10.1002/1521-4141(200106)31:6<1813::AID-IMMU1813>3.0.CO;2-8
    • (2001) Eur J Immunol , vol.31 , pp. 1813-1824
    • Gresser, O.1    Weber, E.2    Hellwig, A.3    Riese, S.4    Régnier-Vigouroux, A.5
  • 15
    • 33749522738 scopus 로고    scopus 로고
    • A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells
    • Ackerman AL, Giodini A, Cresswell P. A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells. Immunity (2006) 25:607-17. doi:10.1016/j.immuni.2006.08.017
    • (2006) Immunity , vol.25 , pp. 607-617
    • Ackerman, A.L.1    Giodini, A.2    Cresswell, P.3
  • 16
    • 0026762548 scopus 로고
    • Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells
    • Malnati MS, Marti M, LaVaute T, Jaraquemada D, Biddison W, DeMars R, et al. Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells. Nature (1992) 357:702-4. doi:10.1038/357702a0
    • (1992) Nature , vol.357 , pp. 702-704
    • Malnati, M.S.1    Marti, M.2    LaVaute, T.3    Jaraquemada, D.4    Biddison, W.5    DeMars, R.6
  • 17
    • 67650465638 scopus 로고    scopus 로고
    • IRAP identifies an endosomal compartment required for MHC class I cross-presentation
    • Saveanu L, Carroll O, Weimershaus M, Guermonprez P, Firat E, Lindo V, et al. IRAP identifies an endosomal compartment required for MHC class I cross-presentation. Science (2009) 325:213-7. doi:10.1126/science.1172845
    • (2009) Science , vol.325 , pp. 213-217
    • Saveanu, L.1    Carroll, O.2    Weimershaus, M.3    Guermonprez, P.4    Firat, E.5    Lindo, V.6
  • 18
    • 73949097613 scopus 로고    scopus 로고
    • Different cross-presentation pathways in steady-state and inflammatory dendritic cells
    • Segura E, Albiston AL, Wicks IP, Chai SY, Villadangos JA. Different cross-presentation pathways in steady-state and inflammatory dendritic cells. Proc Natl Acad Sci U S A (2009) 106:20377-81. doi:10.1073/pnas.0910295106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 20377-20381
    • Segura, E.1    Albiston, A.L.2    Wicks, I.P.3    Chai, S.Y.4    Villadangos, J.A.5
  • 19
    • 0024997357 scopus 로고
    • Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals
    • Martin R, Jaraquemada D, Flerlage M, Richert J, Whitaker J, Long EO, et al. Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals. J Immunol (1990) 145:540-8.
    • (1990) J Immunol , vol.145 , pp. 540-548
    • Martin, R.1    Jaraquemada, D.2    Flerlage, M.3    Richert, J.4    Whitaker, J.5    Long, E.O.6
  • 20
    • 0025370870 scopus 로고
    • T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis
    • Ota K, Matsui M, Milford EL, Mackin GA, Weiner HL, Hafler DA. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature (1990) 346:183-7. doi:10.1038/346183a0
    • (1990) Nature , vol.346 , pp. 183-187
    • Ota, K.1    Matsui, M.2    Milford, E.L.3    Mackin, G.A.4    Weiner, H.L.5    Hafler, D.A.6
  • 21
    • 0035949239 scopus 로고    scopus 로고
    • Isolation of CD45RO+, memory T cells recognizing proteolipid protein from neurologically normal subjects
    • Burns JB, Bartholomew BD, Lobo ST. Isolation of CD45RO+, memory T cells recognizing proteolipid protein from neurologically normal subjects. Cell Immunol (2001) 212:44-50. doi:10.1006/cimm.2001.1842
    • (2001) Cell Immunol , vol.212 , pp. 44-50
    • Burns, J.B.1    Bartholomew, B.D.2    Lobo, S.T.3
  • 22
    • 0026575557 scopus 로고
    • T cells from normal and myasthenic individuals recognize the human acetylcholine receptor: heterogeneity of antigenic sites on the alpha-subunit
    • Melms A, Malcherek G, Gern U, Wiethölter H, Müller CA, Schoepfer R, et al. T cells from normal and myasthenic individuals recognize the human acetylcholine receptor: heterogeneity of antigenic sites on the alpha-subunit. Ann Neurol (1992) 31:311-8. doi:10.1002/ana.410310314
    • (1992) Ann Neurol , vol.31 , pp. 311-318
    • Melms, A.1    Malcherek, G.2    Gern, U.3    Wiethölter, H.4    Müller, C.A.5    Schoepfer, R.6
  • 23
    • 0027957780 scopus 로고
    • Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis
    • Zhang J, Markovic-Plese S, Lacet B, Raus J, Weiner HL, Hafler DA. Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J Exp Med (1994) 179:973-84. doi:10.1084/jem.179.3.973
    • (1994) J Exp Med , vol.179 , pp. 973-984
    • Zhang, J.1    Markovic-Plese, S.2    Lacet, B.3    Raus, J.4    Weiner, H.L.5    Hafler, D.A.6
  • 24
    • 0029086439 scopus 로고
    • Isolation and characterization of autoreactive proteolipid protein-peptide specific T-cell clones from multiple sclerosis patients
    • Correale J, McMillan M, McCarthy K, Le T, Weiner LP. Isolation and characterization of autoreactive proteolipid protein-peptide specific T-cell clones from multiple sclerosis patients. Neurology (1995) 45:1370-8. doi:10.1212/WNL.45.7.1370
    • (1995) Neurology , vol.45 , pp. 1370-1378
    • Correale, J.1    McMillan, M.2    McCarthy, K.3    Le, T.4    Weiner, L.P.5
  • 25
    • 0033976207 scopus 로고    scopus 로고
    • Repertoire dynamics of autoreactive T cells in multiple sclerosis patients and healthy subjects: epitope spreading versus clonal persistence
    • Goebels N, Hofstetter H, Schmidt S, Brunner C, Wekerle H, Hohlfeld R. Repertoire dynamics of autoreactive T cells in multiple sclerosis patients and healthy subjects: epitope spreading versus clonal persistence. Brain (2000) 123:508-18. doi:10.1093/brain/123.3.508
    • (2000) Brain , vol.123 , pp. 508-518
    • Goebels, N.1    Hofstetter, H.2    Schmidt, S.3    Brunner, C.4    Wekerle, H.5    Hohlfeld, R.6
  • 27
    • 0033984067 scopus 로고    scopus 로고
    • Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells
    • Klein L, Klugmann M, Nave KA, Tuohy VK, Kyewski B. Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. Nat Med (2000) 6:56-61. doi:10.1038/71540
    • (2000) Nat Med , vol.6 , pp. 56-61
    • Klein, L.1    Klugmann, M.2    Nave, K.A.3    Tuohy, V.K.4    Kyewski, B.5
  • 28
    • 72949104779 scopus 로고    scopus 로고
    • Antigen presentation in the thymus for positive selection and central tolerance induction
    • Klein L, Hinterberger M, Wirnsberger G, Kyewski B. Antigen presentation in the thymus for positive selection and central tolerance induction. Nat Rev Immunol (2009) 9:833-44. doi:10.1038/nri2669
    • (2009) Nat Rev Immunol , vol.9 , pp. 833-844
    • Klein, L.1    Hinterberger, M.2    Wirnsberger, G.3    Kyewski, B.4
  • 29
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self shadow within the thymus by the aire protein
    • Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ, et al. Projection of an immunological self shadow within the thymus by the aire protein. Science (2002) 298:1395-401. doi:10.1126/science.1075958
    • (2002) Science , vol.298 , pp. 1395-1401
    • Anderson, M.S.1    Venanzi, E.S.2    Klein, L.3    Chen, Z.4    Berzins, S.P.5    Turley, S.J.6
  • 31
    • 84896388831 scopus 로고    scopus 로고
    • Association of AIRE polymorphisms with genetic susceptibility to rheumatoid arthritis in a Chinese population
    • Shao S, Li X, Cen H, Yin Z. Association of AIRE polymorphisms with genetic susceptibility to rheumatoid arthritis in a Chinese population. Inflammation (2014) 37:495-9. doi:10.1007/s10753-013-9763-3
    • (2014) Inflammation , vol.37 , pp. 495-499
    • Shao, S.1    Li, X.2    Cen, H.3    Yin, Z.4
  • 32
    • 34548151158 scopus 로고    scopus 로고
    • An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus
    • Giraud M, Taubert R, Vandiedonck C, Ke X, Lévi-Strauss M, Pagani F, et al. An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus. Nature (2007) 448:934-7. doi:10.1038/nature06066
    • (2007) Nature , vol.448 , pp. 934-937
    • Giraud, M.1    Taubert, R.2    Vandiedonck, C.3    Ke, X.4    Lévi-Strauss, M.5    Pagani, F.6
  • 33
    • 84880855085 scopus 로고    scopus 로고
    • Thymic epithelial cells use macroautophagy to turn their inside out for CD4 T cell tolerance
    • Wu C, Aichinger M, Nedjic J, Klein L. Thymic epithelial cells use macroautophagy to turn their inside out for CD4 T cell tolerance. Autophagy (2013) 9:931-2. doi:10.4161/auto.24374
    • (2013) Autophagy , vol.9 , pp. 931-932
    • Wu, C.1    Aichinger, M.2    Nedjic, J.3    Klein, L.4
  • 34
    • 84879626985 scopus 로고    scopus 로고
    • Exploring the MHC-peptide matrix of central tolerance in the human thymus
    • Adamopoulou E, Tenzer S, Hillen N, Klug P, Rota IA, Tietz S, et al. Exploring the MHC-peptide matrix of central tolerance in the human thymus. Nat Commun (2013) 4:2039. doi:10.1038/ncomms3039
    • (2013) Nat Commun , vol.4 , pp. 2039
    • Adamopoulou, E.1    Tenzer, S.2    Hillen, N.3    Klug, P.4    Rota, I.A.5    Tietz, S.6
  • 35
    • 0036773624 scopus 로고    scopus 로고
    • Multiple sclerosis candidate autoantigens except myelin oligodendrocyte glycoprotein are transcribed in human thymus
    • Bruno R, Sabater L, Sospedra M, Ferrer-Francesch X, Escudero D, Martínez-Cáceres E, et al. Multiple sclerosis candidate autoantigens except myelin oligodendrocyte glycoprotein are transcribed in human thymus. Eur J Immunol (2002) 32:2737-47. doi:10.1002/1521-4141(2002010)32:10<2737::AID-IMMU2737>3.0.CO;2-0
    • (2002) Eur J Immunol , vol.32 , pp. 2737-2747
    • Bruno, R.1    Sabater, L.2    Sospedra, M.3    Ferrer-Francesch, X.4    Escudero, D.5    Martínez-Cáceres, E.6
  • 36
    • 0027504747 scopus 로고
    • The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems
    • Pribyl TM, Campagnoni CW, Kampf K, Kashima T, Handley VW, McMahon J, et al. The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems. Proc Natl Acad Sci U S A (1993) 90:10695-9. doi:10.1073/pnas.90.22.10695
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 10695-10699
    • Pribyl, T.M.1    Campagnoni, C.W.2    Kampf, K.3    Kashima, T.4    Handley, V.W.5    McMahon, J.6
  • 37
    • 67349216357 scopus 로고    scopus 로고
    • Autoimmune T cell responses in the central nervous system
    • Goverman J. Autoimmune T cell responses in the central nervous system. Nat Rev Immunol (2009) 9:393-407. doi:10.1038/nri2550
    • (2009) Nat Rev Immunol , vol.9 , pp. 393-407
    • Goverman, J.1
  • 38
    • 0035337501 scopus 로고    scopus 로고
    • Thiopalmitoylation of myelin proteolipid protein epitopes enhances immunogenicity and encephalitogenicity
    • Greer JM, Denis B, Sobel RA, Trifilieff E. Thiopalmitoylation of myelin proteolipid protein epitopes enhances immunogenicity and encephalitogenicity. J Immunol (2001) 166:6907-13. doi:10.4049/jimmunol.166.11.6907
    • (2001) J Immunol , vol.166 , pp. 6907-6913
    • Greer, J.M.1    Denis, B.2    Sobel, R.A.3    Trifilieff, E.4
  • 39
    • 84904104045 scopus 로고    scopus 로고
    • Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis
    • Bradford CM, Ramos I, Cross AK, Haddock G, McQuaid S, Nicholas AP, et al. Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis. J Neuroimmunol (2014) 273:85-95. doi:10.1016/j.jneuroim.2014.05.007
    • (2014) J Neuroimmunol , vol.273 , pp. 85-95
    • Bradford, C.M.1    Ramos, I.2    Cross, A.K.3    Haddock, G.4    McQuaid, S.5    Nicholas, A.P.6
  • 40
    • 78651519759 scopus 로고    scopus 로고
    • A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC
    • Sethi DK, Schubert DA, Anders A, Heroux A, Bonsor DA, Thomas CP, et al. A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC. J Exp Med (2011) 208:91-102. doi:10.1084/jem.20100725
    • (2011) J Exp Med , vol.208 , pp. 91-102
    • Sethi, D.K.1    Schubert, D.A.2    Anders, A.3    Heroux, A.4    Bonsor, D.A.5    Thomas, C.P.6
  • 41
    • 84856874763 scopus 로고    scopus 로고
    • Self-reactive human CD4 T cell clones form unusual immunological synapses
    • Schubert DA, Gordo S, Sabatino JJ, Vardhana S, Gagnon E, Sethi DK, et al. Self-reactive human CD4 T cell clones form unusual immunological synapses. J Exp Med (2012) 209:335-52. doi:10.1084/jem.20111485
    • (2012) J Exp Med , vol.209 , pp. 335-352
    • Schubert, D.A.1    Gordo, S.2    Sabatino, J.J.3    Vardhana, S.4    Gagnon, E.5    Sethi, D.K.6
  • 42
    • 0035283175 scopus 로고    scopus 로고
    • Tolerance and autoimmunity
    • Kamradt T, Mitchison NA. Tolerance and autoimmunity. N Engl J Med (2001) 344:655-64. doi:10.1056/NEJM200103013440907
    • (2001) N Engl J Med , vol.344 , pp. 655-664
    • Kamradt, T.1    Mitchison, N.A.2
  • 43
    • 84901393374 scopus 로고    scopus 로고
    • CTLA-4 gene and the susceptibility of multiple sclerosis: an updated meta-analysis study including 12,916 cases and 15,455 controls
    • Liu J, Zhang H. CTLA-4 gene and the susceptibility of multiple sclerosis: an updated meta-analysis study including 12,916 cases and 15,455 controls. J Neurogenet (2014) 28:153-63. doi:10.3109/01677063.2014.880703
    • (2014) J Neurogenet , vol.28 , pp. 153-163
    • Liu, J.1    Zhang, H.2
  • 44
    • 0032519421 scopus 로고    scopus 로고
    • Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells.
    • Lovett-Racke AE, Trotter JL, Lauber J, Perrin PJ, June CH, Racke MK. Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells. J Clin Invest (1998) 101:725-30. doi:10.1172/JCI1528
    • (1998) J Clin Invest , vol.101 , pp. 725-730
    • Lovett-Racke, A.E.1    Trotter, J.L.2    Lauber, J.3    Perrin, P.J.4    June, C.H.5    Racke, M.K.6
  • 45
    • 0031892792 scopus 로고    scopus 로고
    • Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation
    • Scholz C, Patton KT, Anderson DE, Freeman GJ, Hafler DA. Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation. J Immunol (1998) 160:1532-8.
    • (1998) J Immunol , vol.160 , pp. 1532-1538
    • Scholz, C.1    Patton, K.T.2    Anderson, D.E.3    Freeman, G.J.4    Hafler, D.A.5
  • 46
    • 0037320336 scopus 로고    scopus 로고
    • CTLA-4 dysregulation in the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy controls
    • Oliveira EM, Bar-Or A, Waliszewska AI, Cai G, Anderson DE, Krieger JI, et al. CTLA-4 dysregulation in the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy controls. J Autoimmun (2003) 20:71-81. doi:10.1016/S0896-8411(02)00106-3
    • (2003) J Autoimmun , vol.20 , pp. 71-81
    • Oliveira, E.M.1    Bar-Or, A.2    Waliszewska, A.I.3    Cai, G.4    Anderson, D.E.5    Krieger, J.I.6
  • 48
    • 0030973198 scopus 로고    scopus 로고
    • Increased CD80(+) B cells in active multiple sclerosis and reversal by interferon beta-1b therapy
    • Genç K, Dona DL, Reder AT. Increased CD80(+) B cells in active multiple sclerosis and reversal by interferon beta-1b therapy. J Clin Invest (1997) 99:2664-71. doi:10.1172/JCI119455
    • (1997) J Clin Invest , vol.99 , pp. 2664-2671
    • Genç, K.1    Dona, D.L.2    Reder, A.T.3
  • 49
    • 84901976684 scopus 로고    scopus 로고
    • Activation-induced cell death in T lymphocytes from multiple sclerosis patients
    • Moreno M, Negrotto L, Río J, Moubarak R, Martín I, Bustamante MF, et al. Activation-induced cell death in T lymphocytes from multiple sclerosis patients. J Neuroimmunol (2014) 272:51-5. doi:10.1016/j.jneuroim.2014.04.007
    • (2014) J Neuroimmunol , vol.272 , pp. 51-55
    • Moreno, M.1    Negrotto, L.2    Río, J.3    Moubarak, R.4    Martín, I.5    Bustamante, M.F.6
  • 50
    • 0033525162 scopus 로고    scopus 로고
    • Impaired apoptosis in mitogen-stimulated lymphocytes of patients with multiple sclerosis
    • Macchi B, Matteucci C, Nocentini U, Caltagirone C, Mastino A. Impaired apoptosis in mitogen-stimulated lymphocytes of patients with multiple sclerosis. Neuroreport (1999) 10:399-402. doi:10.1097/00001756-199902050-00034
    • (1999) Neuroreport , vol.10 , pp. 399-402
    • Macchi, B.1    Matteucci, C.2    Nocentini, U.3    Caltagirone, C.4    Mastino, A.5
  • 51
    • 84935070637 scopus 로고    scopus 로고
    • FAS-ligand regulates differential activation-induced cell death of human T-helper 1 and 17 cells in healthy donors and multiple sclerosis patients
    • Cencioni MT, Santini S, Ruocco G, Borsellino G, De Bardi M, Grasso MG, et al. FAS-ligand regulates differential activation-induced cell death of human T-helper 1 and 17 cells in healthy donors and multiple sclerosis patients. Cell Death Dis (2015) 6:e1741. doi:10.1038/cddis.2015.100
    • (2015) Cell Death Dis , vol.6
    • Cencioni, M.T.1    Santini, S.2    Ruocco, G.3    Borsellino, G.4    De Bardi, M.5    Grasso, M.G.6
  • 52
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol (2003) 4:330-6. doi:10.1038/ni904
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 53
  • 54
    • 34248598295 scopus 로고    scopus 로고
    • Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
    • Aschenbrenner K, D'Cruz LM, Vollmann EH, Hinterberger M, Emmerich J, Swee LK, et al. Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells. Nat Immunol (2007) 8:351-8. doi:10.1038/ni1444
    • (2007) Nat Immunol , vol.8 , pp. 351-358
    • Aschenbrenner, K.1    D'Cruz, L.M.2    Vollmann, E.H.3    Hinterberger, M.4    Emmerich, J.5    Swee, L.K.6
  • 55
    • 0037816192 scopus 로고    scopus 로고
    • Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin
    • Kivisäkk P, Mahad DJ, Callahan MK, Trebst C, Tucky B, Wei T, et al. Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin. Proc Natl Acad Sci U S A (2003) 100:8389-94. doi:10.1073/pnas.1433000100
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8389-8394
    • Kivisäkk, P.1    Mahad, D.J.2    Callahan, M.K.3    Trebst, C.4    Tucky, B.5    Wei, T.6
  • 56
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol (2005) 23:683-747. doi:10.1146/annurev.immunol.23.021704.115707
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 57
    • 0030001675 scopus 로고    scopus 로고
    • Lymphocyte homing and homeostasis
    • Butcher EC, Picker LJ. Lymphocyte homing and homeostasis. Science (1996) 272:60-6. doi:10.1126/science.272.5258.60
    • (1996) Science , vol.272 , pp. 60-66
    • Butcher, E.C.1    Picker, L.J.2
  • 58
    • 0142259710 scopus 로고    scopus 로고
    • Three or more routes for leukocyte migration into the central nervous system
    • Ransohoff RM, Kivisäkk P, Kidd G. Three or more routes for leukocyte migration into the central nervous system. Nat Rev Immunol (2003) 3:569-81. doi:10.1038/nri1130
    • (2003) Nat Rev Immunol , vol.3 , pp. 569-581
    • Ransohoff, R.M.1    Kivisäkk, P.2    Kidd, G.3
  • 59
    • 0037111199 scopus 로고    scopus 로고
    • Transfer of central nervous system autoantigens and presentation in secondary lymphoid organs
    • de Vos AF, van Meurs M, Brok HP, Boven LA, Hintzen RQ, van der Valk P, et al. Transfer of central nervous system autoantigens and presentation in secondary lymphoid organs. J Immunol (2002) 169:5415-23. doi:10.4049/jimmunol.169.10.5415
    • (2002) J Immunol , vol.169 , pp. 5415-5423
    • de Vos, A.F.1    van Meurs, M.2    Brok, H.P.3    Boven, L.A.4    Hintzen, R.Q.5    van der Valk, P.6
  • 60
    • 14844337878 scopus 로고    scopus 로고
    • In vivo detection of myelin proteins in cervical lymph nodes of MS patients using ultrasound-guided fine-needle aspiration cytology
    • Fabriek BO, Zwemmer JN, Teunissen CE, Dijkstra CD, Polman CH, Laman JD, et al. In vivo detection of myelin proteins in cervical lymph nodes of MS patients using ultrasound-guided fine-needle aspiration cytology. J Neuroimmunol (2005) 161:190-4. doi:10.1016/j.jneuroim.2004.12.018
    • (2005) J Neuroimmunol , vol.161 , pp. 190-194
    • Fabriek, B.O.1    Zwemmer, J.N.2    Teunissen, C.E.3    Dijkstra, C.D.4    Polman, C.H.5    Laman, J.D.6
  • 61
    • 2142821465 scopus 로고    scopus 로고
    • Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease
    • Waldner H, Collins M, Kuchroo VK. Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease. J Clin Invest (2004) 113:990-7. doi:10.1172/JCI19388
    • (2004) J Clin Invest , vol.113 , pp. 990-997
    • Waldner, H.1    Collins, M.2    Kuchroo, V.K.3
  • 62
    • 84901295133 scopus 로고    scopus 로고
    • Deconstructing the peptide-MHC specificity of T cell recognition
    • Birnbaum ME, Mendoza JL, Sethi DK, Dong S, Glanville J, Dobbins J, et al. Deconstructing the peptide-MHC specificity of T cell recognition. Cell (2014) 157:1073-87. doi:10.1016/j.cell.2014.03.047
    • (2014) Cell , vol.157 , pp. 1073-1087
    • Birnbaum, M.E.1    Mendoza, J.L.2    Sethi, D.K.3    Dong, S.4    Glanville, J.5    Dobbins, J.6
  • 63
    • 0028926223 scopus 로고
    • Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein
    • Wucherpfennig KW, Strominger JL. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell (1995) 80:695-705. doi:10.1016/0092-8674(95)90348-8
    • (1995) Cell , vol.80 , pp. 695-705
    • Wucherpfennig, K.W.1    Strominger, J.L.2
  • 64
    • 0037309220 scopus 로고    scopus 로고
    • Cross-reactivity with myelin basic protein and human herpesvirus-6 in multiple sclerosis
    • Tejada-Simon MV, Zang YC, Hong J, Rivera VM, Zhang JZ. Cross-reactivity with myelin basic protein and human herpesvirus-6 in multiple sclerosis. Ann Neurol (2003) 53:189-97. doi:10.1002/ana.10425
    • (2003) Ann Neurol , vol.53 , pp. 189-197
    • Tejada-Simon, M.V.1    Zang, Y.C.2    Hong, J.3    Rivera, V.M.4    Zhang, J.Z.5
  • 65
    • 0035956494 scopus 로고    scopus 로고
    • Epstein-Barr virus antibodies and risk of multiple sclerosis: a prospective study
    • Ascherio A, Munger KL, Lennette ET, Spiegelman D, Hernán MA, Olek MJ, et al. Epstein-Barr virus antibodies and risk of multiple sclerosis: a prospective study. JAMA (2001) 286:3083-8. doi:10.1001/jama.286.24.3083
    • (2001) JAMA , vol.286 , pp. 3083-3088
    • Ascherio, A.1    Munger, K.L.2    Lennette, E.T.3    Spiegelman, D.4    Hernán, M.A.5    Olek, M.J.6
  • 66
    • 20744437262 scopus 로고    scopus 로고
    • Initiation and exacerbation of autoimmune demyelination of the central nervous system via virus-induced molecular mimicry: implications for the pathogenesis of multiple sclerosis
    • Croxford JL, Olson JK, Anger HA, Miller SD. Initiation and exacerbation of autoimmune demyelination of the central nervous system via virus-induced molecular mimicry: implications for the pathogenesis of multiple sclerosis. J Virol (2005) 79:8581-90. doi:10.1128/JVI.79.13.8581-8590.2005
    • (2005) J Virol , vol.79 , pp. 8581-8590
    • Croxford, J.L.1    Olson, J.K.2    Anger, H.A.3    Miller, S.D.4
  • 67
    • 67349207476 scopus 로고    scopus 로고
    • Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis
    • Krishnamoorthy G, Saxena A, Mars LT, Domingues HS, Mentele R, Ben-Nun A, et al. Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis. Nat Med (2009) 15:626-32. doi:10.1038/nm.1975
    • (2009) Nat Med , vol.15 , pp. 626-632
    • Krishnamoorthy, G.1    Saxena, A.2    Mars, L.T.3    Domingues, H.S.4    Mentele, R.5    Ben-Nun, A.6
  • 68
    • 0036681780 scopus 로고    scopus 로고
    • Bystander CD8 T cell-mediated demyelination after viral infection of the central nervous system
    • Haring JS, Pewe LL, Perlman S. Bystander CD8 T cell-mediated demyelination after viral infection of the central nervous system. J Immunol (2002) 169:1550-5. doi:10.4049/jimmunol.169.3.1550
    • (2002) J Immunol , vol.169 , pp. 1550-1555
    • Haring, J.S.1    Pewe, L.L.2    Perlman, S.3
  • 69
    • 77953758560 scopus 로고    scopus 로고
    • Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs
    • Ji Q, Perchellet A, Goverman JM. Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs. Nat Immunol (2010) 11:628-34. doi:10.1038/ni.1888
    • (2010) Nat Immunol , vol.11 , pp. 628-634
    • Ji, Q.1    Perchellet, A.2    Goverman, J.M.3
  • 70
    • 81855167104 scopus 로고    scopus 로고
    • Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
    • Berer K, Mues M, Koutrolos M, Rasbi ZA, Boziki M, Johner C, et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature (2011) 479:538-41. doi:10.1038/nature10554
    • (2011) Nature , vol.479 , pp. 538-541
    • Berer, K.1    Mues, M.2    Koutrolos, M.3    Rasbi, Z.A.4    Boziki, M.5    Johner, C.6
  • 71
    • 1842685035 scopus 로고    scopus 로고
    • T cell epitope spreading to myelin oligodendrocyte glycoprotein in HLA-DR4 transgenic mice during experimental autoimmune encephalomyelitis
    • Klehmet J, Shive C, Guardia-Wolff R, Petersen I, Spack EG, Boehm BO, et al. T cell epitope spreading to myelin oligodendrocyte glycoprotein in HLA-DR4 transgenic mice during experimental autoimmune encephalomyelitis. Clin Immunol (2004) 111:53-60. doi:10.1016/j.clim.2003.12.012
    • (2004) Clin Immunol , vol.111 , pp. 53-60
    • Klehmet, J.1    Shive, C.2    Guardia-Wolff, R.3    Petersen, I.4    Spack, E.G.5    Boehm, B.O.6
  • 72
    • 0026664422 scopus 로고
    • Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen
    • Lehmann PV, Forsthuber T, Miller A, Sercarz EE. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature (1992) 358:155-7. doi:10.1038/358155a0
    • (1992) Nature , vol.358 , pp. 155-157
    • Lehmann, P.V.1    Forsthuber, T.2    Miller, A.3    Sercarz, E.E.4
  • 73
    • 0033558081 scopus 로고    scopus 로고
    • Determinant spreading associated with demyelination in a nonhuman primate model of multiple sclerosis
    • McFarland HI, Lobito AA, Johnson MM, Nyswaner JT, Frank JA, Palardy GR, et al. Determinant spreading associated with demyelination in a nonhuman primate model of multiple sclerosis. J Immunol (1999) 162:2384-90.
    • (1999) J Immunol , vol.162 , pp. 2384-2390
    • McFarland, H.I.1    Lobito, A.A.2    Johnson, M.M.3    Nyswaner, J.T.4    Frank, J.A.5    Palardy, G.R.6
  • 74
    • 0034650422 scopus 로고    scopus 로고
    • Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis
    • Vanderlugt CL, Neville KL, Nikcevich KM, Eagar TN, Bluestone JA, Miller SD. Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis. J Immunol (2000) 164:670-8. doi:10.4049/jimmunol.164.2.670
    • (2000) J Immunol , vol.164 , pp. 670-678
    • Vanderlugt, C.L.1    Neville, K.L.2    Nikcevich, K.M.3    Eagar, T.N.4    Bluestone, J.A.5    Miller, S.D.6
  • 75
    • 16244417773 scopus 로고    scopus 로고
    • Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis
    • McMahon EJ, Bailey SL, Castenada CV, Waldner H, Miller SD. Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nat Med (2005) 11:335-9. doi:10.1038/nm1202
    • (2005) Nat Med , vol.11 , pp. 335-339
    • McMahon, E.J.1    Bailey, S.L.2    Castenada, C.V.3    Waldner, H.4    Miller, S.D.5
  • 76
    • 0030796646 scopus 로고    scopus 로고
    • Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading
    • Miller SD, Vanderlugt CL, Begolka WS, Pao W, Yauch RL, Neville KL, et al. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading. Nat Med (1997) 3:1133-6. doi:10.1038/nm1097-1133
    • (1997) Nat Med , vol.3 , pp. 1133-1136
    • Miller, S.D.1    Vanderlugt, C.L.2    Begolka, W.S.3    Pao, W.4    Yauch, R.L.5    Neville, K.L.6
  • 77
    • 0034597044 scopus 로고    scopus 로고
    • Myelin basic protein intramolecular spreading without disease progression in a patient with multiple sclerosis
    • Ristori G, Giubilei F, Giunti D, Perna A, Gasperini C, Buttinelli C, et al. Myelin basic protein intramolecular spreading without disease progression in a patient with multiple sclerosis. J Neuroimmunol (2000) 110:240-3. doi:10.1016/S0165-5728(00)00342-8
    • (2000) J Neuroimmunol , vol.110 , pp. 240-243
    • Ristori, G.1    Giubilei, F.2    Giunti, D.3    Perna, A.4    Gasperini, C.5    Buttinelli, C.6
  • 79
    • 0030899404 scopus 로고    scopus 로고
    • Diversity and plasticity of self recognition during the development of multiple sclerosis
    • Tuohy VK, Yu M, Weinstock-Guttman B, Kinkel RP. Diversity and plasticity of self recognition during the development of multiple sclerosis. J Clin Invest (1997) 99:1682-90. doi:10.1172/JCI119331
    • (1997) J Clin Invest , vol.99 , pp. 1682-1690
    • Tuohy, V.K.1    Yu, M.2    Weinstock-Guttman, B.3    Kinkel, R.P.4
  • 80
    • 0037228871 scopus 로고    scopus 로고
    • Molecular tracking of antigen-specific T cell clones in neurological immune-mediated disorders
    • Muraro PA, Wandinger K, Bielekova B, Gran B, Marques A, Utz U, et al. Molecular tracking of antigen-specific T cell clones in neurological immune-mediated disorders. Brain (2003) 126:20-31. doi:10.1093/brain/awg021
    • (2003) Brain , vol.126 , pp. 20-31
    • Muraro, P.A.1    Wandinger, K.2    Bielekova, B.3    Gran, B.4    Marques, A.5    Utz, U.6
  • 81
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, Moutsianas L, et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 476:214-9. doi:10.1038/nature10251
    • (2011) Nature , vol.476 , pp. 214-219
    • Sawcer, S.1    Hellenthal, G.2    Pirinen, M.3    Spencer, C.C.4    Patsopoulos, N.A.5    Moutsianas, L.6
  • 82
    • 0036105484 scopus 로고    scopus 로고
    • Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
    • Lock C, Hermans G, Pedotti R, Brendolan A, Schadt E, Garren H, et al. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med (2002) 8:500-8. doi:10.1038/nm0502-500
    • (2002) Nat Med , vol.8 , pp. 500-508
    • Lock, C.1    Hermans, G.2    Pedotti, R.3    Brendolan, A.4    Schadt, E.5    Garren, H.6
  • 84
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand
    • Bielekova B, Goodwin B, Richert N, Cortese I, Kondo T, Afshar G, et al. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat Med (2000) 6:1167-75. doi:10.1038/80516
    • (2000) Nat Med , vol.6 , pp. 1167-1175
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3    Cortese, I.4    Kondo, T.5    Afshar, G.6
  • 85
    • 9244249879 scopus 로고    scopus 로고
    • Expression of Th1/Th2-related chemokine receptors on peripheral T cells and correlation with clinical disease activity in patients with multiple sclerosis
    • Nakajima H, Fukuda K, Doi Y, Sugino M, Kimura F, Hanafusa T, et al. Expression of Th1/Th2-related chemokine receptors on peripheral T cells and correlation with clinical disease activity in patients with multiple sclerosis. Eur Neurol (2004) 52:162-8. doi:10.1159/000081856
    • (2004) Eur Neurol , vol.52 , pp. 162-168
    • Nakajima, H.1    Fukuda, K.2    Doi, Y.3    Sugino, M.4    Kimura, F.5    Hanafusa, T.6
  • 86
    • 80051581129 scopus 로고    scopus 로고
    • Association of Th1/Th2-related chemokine receptors in peripheral T cells with disease activity in patients with multiple sclerosis and neuromyelitis optica
    • Shimizu Y, Ota K, Kubo S, Kabasawa C, Kobayashi M, Ohashi T, et al. Association of Th1/Th2-related chemokine receptors in peripheral T cells with disease activity in patients with multiple sclerosis and neuromyelitis optica. Eur Neurol (2011) 66:91-7. doi:10.1159/000329576
    • (2011) Eur Neurol , vol.66 , pp. 91-97
    • Shimizu, Y.1    Ota, K.2    Kubo, S.3    Kabasawa, C.4    Kobayashi, M.5    Ohashi, T.6
  • 87
    • 0034526179 scopus 로고    scopus 로고
    • Aberrant T cell responses to myelin antigens during clinical exacerbation in patients with multiple sclerosis
    • Tejada-Simon MV, Zang YC, Yang D, Hong J, Li S, Singh RA, et al. Aberrant T cell responses to myelin antigens during clinical exacerbation in patients with multiple sclerosis. Int Immunol (2000) 12:1641-50. doi:10.1093/intimm/12.12.1641
    • (2000) Int Immunol , vol.12 , pp. 1641-1650
    • Tejada-Simon, M.V.1    Zang, Y.C.2    Yang, D.3    Hong, J.4    Li, S.5    Singh, R.A.6
  • 88
    • 0028906889 scopus 로고
    • Patterns of cytokine secretion by autoreactive proteolipid protein-specific T cell clones during the course of multiple sclerosis
    • Correale J, Gilmore W, McMillan M, Li S, McCarthy K, Le T, et al. Patterns of cytokine secretion by autoreactive proteolipid protein-specific T cell clones during the course of multiple sclerosis. J Immunol (1995) 154:2959-68.
    • (1995) J Immunol , vol.154 , pp. 2959-2968
    • Correale, J.1    Gilmore, W.2    McMillan, M.3    Li, S.4    McCarthy, K.5    Le, T.6
  • 89
    • 0035086802 scopus 로고    scopus 로고
    • Reactivity pattern and cytokine profile of T cells primed by myelin peptides in multiple sclerosis and healthy individuals
    • Tejada-Simon MV, Hong J, Rivera VM, Zhang JZ. Reactivity pattern and cytokine profile of T cells primed by myelin peptides in multiple sclerosis and healthy individuals. Eur J Immunol (2001) 31:907-17. doi:10.1002/1521-4141(200103)31:3<907::AID-IMMU907>3.0.CO;2-1
    • (2001) Eur J Immunol , vol.31 , pp. 907-917
    • Tejada-Simon, M.V.1    Hong, J.2    Rivera, V.M.3    Zhang, J.Z.4
  • 90
    • 0032524181 scopus 로고    scopus 로고
    • ELI-spot of Th-1 cytokine secreting PBMC's in multiple sclerosis: correlation with MRI lesions
    • Calabresi PA, Fields NS, Farnon EC, Frank JA, Bash CN, Kawanashi T, et al. ELI-spot of Th-1 cytokine secreting PBMC's in multiple sclerosis: correlation with MRI lesions. J Neuroimmunol (1998) 85:212-9. doi:10.1016/S0165-5728(98)00008-3
    • (1998) J Neuroimmunol , vol.85 , pp. 212-219
    • Calabresi, P.A.1    Fields, N.S.2    Farnon, E.C.3    Frank, J.A.4    Bash, C.N.5    Kawanashi, T.6
  • 91
    • 1542723658 scopus 로고    scopus 로고
    • Expansion and functional relevance of high-avidity myelin-specific CD4+ T cells in multiple sclerosis
    • Bielekova B, Sung M, Kadom N, Simon R, McFarland H, Martin R. Expansion and functional relevance of high-avidity myelin-specific CD4+ T cells in multiple sclerosis. J Immunol (2004) 172:3893-904. doi:10.4049/jimmunol.172.6.3893
    • (2004) J Immunol , vol.172 , pp. 3893-3904
    • Bielekova, B.1    Sung, M.2    Kadom, N.3    Simon, R.4    McFarland, H.5    Martin, R.6
  • 92
    • 84885476681 scopus 로고    scopus 로고
    • Th1 not Th17 cells drive spontaneous MS-like disease despite a functional regulatory T cell response
    • Lowther DE, Chong DL, Ascough S, Ettorre A, Ingram RJ, Boyton RJ, et al. Th1 not Th17 cells drive spontaneous MS-like disease despite a functional regulatory T cell response. Acta Neuropathol (2013) 126:501-15. doi:10.1007/s00401-013-1159-9
    • (2013) Acta Neuropathol , vol.126 , pp. 501-515
    • Lowther, D.E.1    Chong, D.L.2    Ascough, S.3    Ettorre, A.4    Ingram, R.J.5    Boyton, R.J.6
  • 93
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature (2006) 441:235-8. doi:10.1038/nature04753
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6
  • 94
    • 34547232503 scopus 로고    scopus 로고
    • IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
    • Korn T, Bettelli E, Gao W, Awasthi A, Jäger A, Strom TB, et al. IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells. Nature (2007) 448:484-7. doi:10.1038/nature05970
    • (2007) Nature , vol.448 , pp. 484-487
    • Korn, T.1    Bettelli, E.2    Gao, W.3    Awasthi, A.4    Jäger, A.5    Strom, T.B.6
  • 95
    • 13244283212 scopus 로고    scopus 로고
    • IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    • Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD, et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med (2005) 201:233-40. doi:10.1084/jem.20041257
    • (2005) J Exp Med , vol.201 , pp. 233-240
    • Langrish, C.L.1    Chen, Y.2    Blumenschein, W.M.3    Mattson, J.4    Basham, B.5    Sedgwick, J.D.6
  • 96
    • 34948909646 scopus 로고    scopus 로고
    • Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
    • Kebir H, Kreymborg K, Ifergan I, Dodelet-Devillers A, Cayrol R, Bernard M, et al. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med (2007) 13:1173-5. doi:10.1038/nm1651
    • (2007) Nat Med , vol.13 , pp. 1173-1175
    • Kebir, H.1    Kreymborg, K.2    Ifergan, I.3    Dodelet-Devillers, A.4    Cayrol, R.5    Bernard, M.6
  • 97
    • 84874361447 scopus 로고    scopus 로고
    • Impaired regulatory function and enhanced intrathecal activation of B cells in neuromyelitis optica: distinct from multiple sclerosis
    • Quan C, Yu H, Qiao J, Xiao B, Zhao G, Wu Z, et al. Impaired regulatory function and enhanced intrathecal activation of B cells in neuromyelitis optica: distinct from multiple sclerosis. Mult Scler (2013) 19:289-98. doi:10.1177/1352458512454771
    • (2013) Mult Scler , vol.19 , pp. 289-298
    • Quan, C.1    Yu, H.2    Qiao, J.3    Xiao, B.4    Zhao, G.5    Wu, Z.6
  • 98
    • 84876479682 scopus 로고    scopus 로고
    • Diminished Th17 (not Th1) responses underlie multiple sclerosis disease abrogation after hematopoietic stem cell transplantation
    • Darlington PJ, Touil T, Doucet J, Gaucher D, Zeidan J, Gauchat D, et al. Diminished Th17 (not Th1) responses underlie multiple sclerosis disease abrogation after hematopoietic stem cell transplantation. Ann Neurol (2013) 73:341-54. doi:10.1002/ana.23784
    • (2013) Ann Neurol , vol.73 , pp. 341-354
    • Darlington, P.J.1    Touil, T.2    Doucet, J.3    Gaucher, D.4    Zeidan, J.5    Gauchat, D.6
  • 99
    • 77956338425 scopus 로고    scopus 로고
    • Memory CD4+CD127high T cells from patients with multiple sclerosis produce IL-17 in response to myelin antigens
    • Venken K, Hellings N, Hensen K, Rummens J, Stinissen P. Memory CD4+CD127high T cells from patients with multiple sclerosis produce IL-17 in response to myelin antigens. J Neuroimmunol (2010) 226:185-91. doi:10.1016/j.jneuroim.2010.05.025
    • (2010) J Neuroimmunol , vol.226 , pp. 185-191
    • Venken, K.1    Hellings, N.2    Hensen, K.3    Rummens, J.4    Stinissen, P.5
  • 100
    • 84893388714 scopus 로고    scopus 로고
    • Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity
    • 219ra8
    • Schlapbach C, Gehad A, Yang C, Watanabe R, Guenova E, Teague JE, et al. Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity. Sci Transl Med (2014) 6:219ra8. doi:10.1126/scitranslmed.3007828
    • (2014) Sci Transl Med , vol.6
    • Schlapbach, C.1    Gehad, A.2    Yang, C.3    Watanabe, R.4    Guenova, E.5    Teague, J.E.6
  • 101
    • 73349109145 scopus 로고    scopus 로고
    • Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes
    • Jager A, Dardalhon V, Sobel RA, Bettelli E, Kuchroo VK. Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J Immunol (2009) 183:7169-77. doi:10.4049/jimmunol.0901906
    • (2009) J Immunol , vol.183 , pp. 7169-7177
    • Jager, A.1    Dardalhon, V.2    Sobel, R.A.3    Bettelli, E.4    Kuchroo, V.K.5
  • 102
    • 72849131815 scopus 로고    scopus 로고
    • Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
    • Eyerich S, Eyerich K, Pennino D, Carbone T, Nasorri F, Pallotta S, et al. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest (2009) 119:3573-85. doi:10.1172/JCI40202
    • (2009) J Clin Invest , vol.119 , pp. 3573-3585
    • Eyerich, S.1    Eyerich, K.2    Pennino, D.3    Carbone, T.4    Nasorri, F.5    Pallotta, S.6
  • 103
    • 67651154105 scopus 로고    scopus 로고
    • Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
    • Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat Immunol (2009) 10:857-63. doi:10.1038/ni.1767
    • (2009) Nat Immunol , vol.10 , pp. 857-863
    • Duhen, T.1    Geiger, R.2    Jarrossay, D.3    Lanzavecchia, A.4    Sallusto, F.5
  • 104
    • 84914155967 scopus 로고    scopus 로고
    • Th22 cells are expanded in multiple sclerosis and are resistant to IFN-ß
    • Rolla S, Bardina V, De Mercanti S, Quaglino P, De Palma R, Gned D, et al. Th22 cells are expanded in multiple sclerosis and are resistant to IFN-ß. J Leukoc Biol (2014) 96:1155-64. doi:10.1189/jlb.5A0813-463RR
    • (2014) J Leukoc Biol , vol.96 , pp. 1155-1164
    • Rolla, S.1    Bardina, V.2    De Mercanti, S.3    Quaglino, P.4    De Palma, R.5    Gned, D.6
  • 105
    • 83555178479 scopus 로고    scopus 로고
    • Th17 expansion in MS patients is counterbalanced by an expanded CD39+ regulatory T cell population during remission but not during relapse.
    • s10.1016/j.jneuroim.2011.09.013
    • Peelen E, Damoiseaux J, Smolders J, Knippenberg S, Menheere P, Tervaert JW, et al. Th17 expansion in MS patients is counterbalanced by an expanded CD39+ regulatory T cell population during remission but not during relapse. J Neuroimmunol (2011) 240-241:97-103. doi:10.1016/j.jneuroim.2011.09.013
    • (2011) J Neuroimmunol , vol.240-241 , pp. 97-103
    • Peelen, E.1    Damoiseaux, J.2    Smolders, J.3    Knippenberg, S.4    Menheere, P.5    Tervaert, J.W.6
  • 106
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    • Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med (2004) 199:971-9. doi:10.1084/jem.20031579
    • (2004) J Exp Med , vol.199 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 107
    • 27944499757 scopus 로고    scopus 로고
    • Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis
    • Haas J, Hug A, Viehöver A, Fritzsching B, Falk CS, Filser A, et al. Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis. Eur J Immunol (2005) 35:3343-52. doi:10.1002/eji.200526065
    • (2005) Eur J Immunol , vol.35 , pp. 3343-3352
    • Haas, J.1    Hug, A.2    Viehöver, A.3    Fritzsching, B.4    Falk, C.S.5    Filser, A.6
  • 108
    • 33846817153 scopus 로고    scopus 로고
    • Increased frequency of CD4 + CD25 + regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients
    • Feger U, Luther C, Poeschel S, Melms A, Tolosa E, Wiendl H. Increased frequency of CD4 + CD25 + regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients. Clin Exp Immunol (2007) 147:412-8. doi:10.1111/j.1365-2249.2006.03271.x
    • (2007) Clin Exp Immunol , vol.147 , pp. 412-418
    • Feger, U.1    Luther, C.2    Poeschel, S.3    Melms, A.4    Tolosa, E.5    Wiendl, H.6
  • 109
    • 33744904725 scopus 로고    scopus 로고
    • Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4 + CD25 + regulatory T-cell function and FOXP3 expression
    • Venken K, Hellings N, Hensen K, Rummens J, Medaer R, D'hooghe MB, et al. Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4 + CD25 + regulatory T-cell function and FOXP3 expression. J Neurosci Res (2006) 83:1432-46. doi:10.1002/jnr.20852
    • (2006) J Neurosci Res , vol.83 , pp. 1432-1446
    • Venken, K.1    Hellings, N.2    Hensen, K.3    Rummens, J.4    Medaer, R.5    D'hooghe, M.B.6
  • 110
    • 55849126729 scopus 로고    scopus 로고
    • Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor a-chain are excluded from the analysis
    • Michel L, Berthelot L, Pettré S, Wiertlewski S, Lefrère F, Braudeau C, et al. Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor a-chain are excluded from the analysis. J Clin Invest (2008) 118:3411-9. doi:10.1172/JCI35365
    • (2008) J Clin Invest , vol.118 , pp. 3411-3419
    • Michel, L.1    Berthelot, L.2    Pettré, S.3    Wiertlewski, S.4    Lefrère, F.5    Braudeau, C.6
  • 111
    • 66549093255 scopus 로고    scopus 로고
    • Regulatory T cells fail to suppress CD4 + T-bet + T cells in relapsing multiple sclerosis patients
    • Frisullo G, Nociti V, Iorio R, Patanella AK, Caggiula M, Marti A, et al. Regulatory T cells fail to suppress CD4 + T-bet + T cells in relapsing multiple sclerosis patients. Immunology (2009) 127:418-28. doi:10.1111/j.1365-2567.2008.02963.x
    • (2009) Immunology , vol.127 , pp. 418-428
    • Frisullo, G.1    Nociti, V.2    Iorio, R.3    Patanella, A.K.4    Caggiula, M.5    Marti, A.6
  • 112
    • 33751113922 scopus 로고    scopus 로고
    • CD4+CD25+FoxP3+ T lymphocytes fail to suppress myelin basic protein-induced proliferation in patients with multiple sclerosis
    • Kumar M, Putzki N, Limmroth V, Remus R, Lindemann M, Knop D, et al. CD4+CD25+FoxP3+ T lymphocytes fail to suppress myelin basic protein-induced proliferation in patients with multiple sclerosis. J Neuroimmunol (2006) 180:178-84. doi:10.1016/j.jneuroim.2006.08.003
    • (2006) J Neuroimmunol , vol.180 , pp. 178-184
    • Kumar, M.1    Putzki, N.2    Limmroth, V.3    Remus, R.4    Lindemann, M.5    Knop, D.6
  • 113
    • 44449171488 scopus 로고    scopus 로고
    • Natural Naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression
    • Venken K, Hellings N, Broekmans T, Hensen K, Rummens J, Stinissen P. Natural Naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression. J Immunol (2008) 180:6411-20. doi:10.4049/jimmunol.180.9.6411
    • (2008) J Immunol , vol.180 , pp. 6411-6420
    • Venken, K.1    Hellings, N.2    Broekmans, T.3    Hensen, K.4    Rummens, J.5    Stinissen, P.6
  • 114
    • 34548721641 scopus 로고    scopus 로고
    • Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis
    • Haas J, Fritzsching B, Trubswetter P, Korporal M, Milkova L, Fritz B, et al. Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis. J Immunol (2007) 179:1322-30. doi:10.4049/jimmunol.179.2.1322
    • (2007) J Immunol , vol.179 , pp. 1322-1330
    • Haas, J.1    Fritzsching, B.2    Trubswetter, P.3    Korporal, M.4    Milkova, L.5    Fritz, B.6
  • 115
    • 0037530472 scopus 로고    scopus 로고
    • Thymic export function and T cell homeostasis in patients with relapsing remitting multiple sclerosis
    • Hug A, Korporal M, Schroder I, Haas J, Glatz K, Storch-Hagenlocher B, et al. Thymic export function and T cell homeostasis in patients with relapsing remitting multiple sclerosis. J Immunol (2003) 171:432-7. doi:10.4049/jimmunol.171.1.432
    • (2003) J Immunol , vol.171 , pp. 432-437
    • Hug, A.1    Korporal, M.2    Schroder, I.3    Haas, J.4    Glatz, K.5    Storch-Hagenlocher, B.6
  • 116
    • 73349127157 scopus 로고    scopus 로고
    • CD39+Foxp3+ regulatory T cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis
    • Fletcher JM, Lonergan R, Costelloe L, Kinsella K, Moran B, O'Farrelly C, et al. CD39+Foxp3+ regulatory T cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis. J Immunol (2009) 183:7602-10. doi:10.4049/jimmunol.0901881
    • (2009) J Immunol , vol.183 , pp. 7602-7610
    • Fletcher, J.M.1    Lonergan, R.2    Costelloe, L.3    Kinsella, K.4    Moran, B.5    O'Farrelly, C.6
  • 117
    • 34147128572 scopus 로고    scopus 로고
    • Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation
    • Korn T, Reddy J, Gao W, Bettelli E, Awasthi A, Petersen TR, et al. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med (2007) 13:423-31. doi:10.1038/nm1564
    • (2007) Nat Med , vol.13 , pp. 423-431
    • Korn, T.1    Reddy, J.2    Gao, W.3    Bettelli, E.4    Awasthi, A.5    Petersen, T.R.6
  • 118
    • 84867142342 scopus 로고    scopus 로고
    • The switch between relapse and remission in multiple sclerosis: continuous inflammatory response balanced by Th1 suppression and neurotrophic factors
    • Gurevich M, Achiron A. The switch between relapse and remission in multiple sclerosis: continuous inflammatory response balanced by Th1 suppression and neurotrophic factors. J Neuroimmunol (2012) 252:83-8. doi:10.1016/j.jneuroim.2012.07.014
    • (2012) J Neuroimmunol , vol.252 , pp. 83-88
    • Gurevich, M.1    Achiron, A.2
  • 119
    • 23944511180 scopus 로고    scopus 로고
    • Tolerance induction by bone marrow transplantation in a multiple sclerosis model
    • Herrmann MM, Gaertner S, Stadelmann C, van den Brandt J, Böscke R, Budach W, et al. Tolerance induction by bone marrow transplantation in a multiple sclerosis model. Blood (2005) 106:1875-83. doi:10.1182/blood-2004-12-4607
    • (2005) Blood , vol.106 , pp. 1875-1883
    • Herrmann, M.M.1    Gaertner, S.2    Stadelmann, C.3    van den Brandt, J.4    Böscke, R.5    Budach, W.6
  • 120
    • 0034618094 scopus 로고    scopus 로고
    • Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction
    • Babbe H, Roers A, Waisman A, Lassmann H, Goebels N, Hohlfeld R, et al. Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J Exp Med (2000) 192:393-404. doi:10.1084/jem.192.3.393
    • (2000) J Exp Med , vol.192 , pp. 393-404
    • Babbe, H.1    Roers, A.2    Waisman, A.3    Lassmann, H.4    Goebels, N.5    Hohlfeld, R.6
  • 121
    • 1442354894 scopus 로고    scopus 로고
    • Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood
    • Skulina C, Schmidt S, Dornmair K, Babbe H, Roers A, Rajewsky K, et al. Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood. Proc Natl Acad Sci U S A (2004) 101:2428-33. doi:10.1073/pnas.0308689100
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 2428-2433
    • Skulina, C.1    Schmidt, S.2    Dornmair, K.3    Babbe, H.4    Roers, A.5    Rajewsky, K.6
  • 122
    • 84883019402 scopus 로고    scopus 로고
    • Axons are injured by antigen-specific CD8+ T cells through a MHC class I- and granzyme B-dependent mechanism
    • Sauer BM, Schmalstieg WF, Howe CL. Axons are injured by antigen-specific CD8+ T cells through a MHC class I- and granzyme B-dependent mechanism. Neurobiol Dis (2013) 59:194-205. doi:10.1016/j.nbd.2013.07.010
    • (2013) Neurobiol Dis , vol.59 , pp. 194-205
    • Sauer, B.M.1    Schmalstieg, W.F.2    Howe, C.L.3
  • 123
    • 1842423766 scopus 로고    scopus 로고
    • Increased CD8+ cytotoxic T cell responses to myelin basic protein in multiple sclerosis
    • Zang YCQ, Li S, Rivera VM, Hong J, Robinson RR, Breitbach WT, et al. Increased CD8+ cytotoxic T cell responses to myelin basic protein in multiple sclerosis. J Immunol (2004) 172:5120-7. doi:10.4049/jimmunol.172.8.5120
    • (2004) J Immunol , vol.172 , pp. 5120-5127
    • Zang, Y.C.Q.1    Li, S.2    Rivera, V.M.3    Hong, J.4    Robinson, R.R.5    Breitbach, W.T.6
  • 124
    • 34247160776 scopus 로고    scopus 로고
    • Increased CD8+ central memory T cells in patients with multiple sclerosis
    • Liu G, Fang L, Hjelmstrom P, Gao X. Increased CD8+ central memory T cells in patients with multiple sclerosis. Mult Scler (2007) 13:149-55. doi:10.1177/1352458506069246
    • (2007) Mult Scler , vol.13 , pp. 149-155
    • Liu, G.1    Fang, L.2    Hjelmstrom, P.3    Gao, X.4
  • 125
    • 0036191549 scopus 로고    scopus 로고
    • Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patients
    • Jacobsen M, Cepok S, Quak E, Happel M, Gaber R, Ziegler A, et al. Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patients. Brain (2002) 125:538-50. doi:10.1093/brain/awf059
    • (2002) Brain , vol.125 , pp. 538-550
    • Jacobsen, M.1    Cepok, S.2    Quak, E.3    Happel, M.4    Gaber, R.5    Ziegler, A.6
  • 126
    • 44349181984 scopus 로고    scopus 로고
    • Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF
    • Malmestrom C, Lycke J, Haghighi S, Andersen O, Carlsson L, Wadenvik H, et al. Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF. J Neuroimmunol (2008) 196:159-65. doi:10.1016/j.jneuroim.2008.03.001
    • (2008) J Neuroimmunol , vol.196 , pp. 159-165
    • Malmestrom, C.1    Lycke, J.2    Haghighi, S.3    Andersen, O.4    Carlsson, L.5    Wadenvik, H.6
  • 127
    • 0035801332 scopus 로고    scopus 로고
    • A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis
    • Huseby ES, Liggitt D, Brabb T, Schnabel B, Ohlén C, Goverman J. A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis. J Exp Med (2001) 194:669-76. doi:10.1084/jem.194.5.669
    • (2001) J Exp Med , vol.194 , pp. 669-676
    • Huseby, E.S.1    Liggitt, D.2    Brabb, T.3    Schnabel, B.4    Ohlén, C.5    Goverman, J.6
  • 128
    • 84897931965 scopus 로고    scopus 로고
    • Disease exacerbation of multiple sclerosis is characterized by loss of terminally differentiated autoregulatory CD8+ T cells
    • Cunnusamy K, Baughman EJ, Franco J, Ortega SB, Sinha S, Chaudhary P, et al. Disease exacerbation of multiple sclerosis is characterized by loss of terminally differentiated autoregulatory CD8+ T cells. Clin Immunol (2014) 152:115-26. doi:10.1016/j.clim.2014.03.005
    • (2014) Clin Immunol , vol.152 , pp. 115-126
    • Cunnusamy, K.1    Baughman, E.J.2    Franco, J.3    Ortega, S.B.4    Sinha, S.5    Chaudhary, P.6
  • 129
    • 79951960075 scopus 로고    scopus 로고
    • Neuroantigen-specific CD8+ regulatory T-cell function is deficient during acute exacerbation of multiple sclerosis
    • Baughman EJ, Mendoza JP, Ortega SB, Ayers CL, Greenberg BM, Frohman EM, et al. Neuroantigen-specific CD8+ regulatory T-cell function is deficient during acute exacerbation of multiple sclerosis. J Autoimmun (2011) 36:115-24. doi:10.1016/j.jaut.2010.12.003
    • (2011) J Autoimmun , vol.36 , pp. 115-124
    • Baughman, E.J.1    Mendoza, J.P.2    Ortega, S.B.3    Ayers, C.L.4    Greenberg, B.M.5    Frohman, E.M.6
  • 130
    • 77951712594 scopus 로고    scopus 로고
    • Role of CD8+ CD25+ Foxp3+ regulatory T cells in multiple sclerosis
    • Correale J, Villa A. Role of CD8+ CD25+ Foxp3+ regulatory T cells in multiple sclerosis. Ann Neurol (2009) 67:625-38. doi:10.1002/ana.21944
    • (2009) Ann Neurol , vol.67 , pp. 625-638
    • Correale, J.1    Villa, A.2
  • 131
    • 39049142995 scopus 로고    scopus 로고
    • B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
    • Hauser SL, Waubant E, Arnold DL, Vollmer T, Antel J, Fox RJ, et al. B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. N Engl J Med (2008) 358:676-88. doi:10.1056/NEJMoa0706383
    • (2008) N Engl J Med , vol.358 , pp. 676-688
    • Hauser, S.L.1    Waubant, E.2    Arnold, D.L.3    Vollmer, T.4    Antel, J.5    Fox, R.J.6
  • 132
    • 33750604563 scopus 로고    scopus 로고
    • Oligoclonal bands in multiple sclerosis cerebrospinal fluid: an update on methodology and clinical usefulness
    • Link H, Huang Y. Oligoclonal bands in multiple sclerosis cerebrospinal fluid: an update on methodology and clinical usefulness. J Neuroimmunol (2006) 180:17-28. doi:10.1016/j.jneuroim.2006.07.006
    • (2006) J Neuroimmunol , vol.180 , pp. 17-28
    • Link, H.1    Huang, Y.2
  • 133
    • 0032950794 scopus 로고    scopus 로고
    • Identification of autoantibodies associated with myelin damage in multiple sclerosis
    • Genain CP, Cannella B, Hauser SL, Raine CS. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat Med (1999) 5:170-5. doi:10.1038/5532
    • (1999) Nat Med , vol.5 , pp. 170-175
    • Genain, C.P.1    Cannella, B.2    Hauser, S.L.3    Raine, C.S.4
  • 134
    • 22544453860 scopus 로고    scopus 로고
    • Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein
    • O'Connor KC, Appel H, Bregoli L, Call ME, Catz I, Chan JA, et al. Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. J Immunol (2005) 175:1974-82. doi:10.4049/jimmunol.175.3.1974
    • (2005) J Immunol , vol.175 , pp. 1974-1982
    • O'Connor, K.C.1    Appel, H.2    Bregoli, L.3    Call, M.E.4    Catz, I.5    Chan, J.A.6
  • 135
    • 77951757865 scopus 로고    scopus 로고
    • Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?
    • Bar-Or A, Fawaz L, Fan B, Darlington PJ, Rieger A, Ghorayeb C, et al. Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS? Ann Neurol (2010) 67:452-61. doi:10.1002/ana.21939
    • (2010) Ann Neurol , vol.67 , pp. 452-461
    • Bar-Or, A.1    Fawaz, L.2    Fan, B.3    Darlington, P.J.4    Rieger, A.5    Ghorayeb, C.6
  • 136
    • 0021956416 scopus 로고
    • Antigen-specific interaction between T and B cells
    • Lanzavecchia A. Antigen-specific interaction between T and B cells. Nature (1985) 314:537-9. doi:10.1038/314537a0
    • (1985) Nature , vol.314 , pp. 537-539
    • Lanzavecchia, A.1
  • 137
    • 84890819172 scopus 로고    scopus 로고
    • MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies
    • Molnarfi N, Schulze-Topphoff U, Weber MS, Patarroyo JC, Prod'homme T, Varrin-Doyer M, et al. MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. J Exp Med (2013) 210:2921-37. doi:10.1084/jem.20130699
    • (2013) J Exp Med , vol.210 , pp. 2921-2937
    • Molnarfi, N.1    Schulze-Topphoff, U.2    Weber, M.S.3    Patarroyo, J.C.4    Prod'homme, T.5    Varrin-Doyer, M.6
  • 138
    • 77957126531 scopus 로고    scopus 로고
    • Memory B cells from a subset of treatment-naïve relapsing-remitting multiple sclerosis patients elicit CD4+ T-cell proliferation and IFN-γ production in response to myelin basic protein and myelin oligodendrocyte glycoprotein
    • Harp CT, Ireland S, Davis LS, Remington G, Cassidy B, Cravens PD, et al. Memory B cells from a subset of treatment-naïve relapsing-remitting multiple sclerosis patients elicit CD4+ T-cell proliferation and IFN-γ production in response to myelin basic protein and myelin oligodendrocyte glycoprotein. Eur J Immunol (2010) 40:2942-56. doi:10.1002/eji.201040516
    • (2010) Eur J Immunol , vol.40 , pp. 2942-2956
    • Harp, C.T.1    Ireland, S.2    Davis, L.S.3    Remington, G.4    Cassidy, B.5    Cravens, P.D.6
  • 139
    • 10344224545 scopus 로고    scopus 로고
    • Receptor revision and atypical mutational characteristics in clonally expanded B cells from the cerebrospinal fluid of recently diagnosed multiple sclerosis patients
    • Monson NL, Brezinschek H, Brezinschek RI, Mobley A, Vaughan GK, Frohman EM, et al. Receptor revision and atypical mutational characteristics in clonally expanded B cells from the cerebrospinal fluid of recently diagnosed multiple sclerosis patients. J Neuroimmunol (2005) 158:170-81. doi:10.1016/j.jneuroim.2004.04.022
    • (2005) J Neuroimmunol , vol.158 , pp. 170-181
    • Monson, N.L.1    Brezinschek, H.2    Brezinschek, R.I.3    Mobley, A.4    Vaughan, G.K.5    Frohman, E.M.6
  • 140
    • 0034644009 scopus 로고    scopus 로고
    • The immune system. Second of two parts.
    • Delves PJ, Roitt IM. The immune system. Second of two parts. N Engl J Med (2000) 343:108-17. doi:10.1056/NEJM200007133430207
    • (2000) N Engl J Med , vol.343 , pp. 108-117
    • Delves, P.J.1    Roitt, I.M.2
  • 142
    • 78751469622 scopus 로고    scopus 로고
    • Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells
    • Iwata Y, Matsushita T, Horikawa M, DiLillo DJ, Yanaba K, Venturi GM, et al. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood (2011) 117:530-41. doi:10.1182/blood-2010-07-294249
    • (2011) Blood , vol.117 , pp. 530-541
    • Iwata, Y.1    Matsushita, T.2    Horikawa, M.3    DiLillo, D.J.4    Yanaba, K.5    Venturi, G.M.6
  • 143
    • 84868619716 scopus 로고    scopus 로고
    • Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions
    • Yoshizaki A, Miyagaki T, DiLillo DJ, Matsushita T, Horikawa M, Kountikov EI, et al. Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature (2012) 491:264-8. doi:10.1038/nature11501
    • (2012) Nature , vol.491 , pp. 264-268
    • Yoshizaki, A.1    Miyagaki, T.2    DiLillo, D.J.3    Matsushita, T.4    Horikawa, M.5    Kountikov, E.I.6
  • 144
    • 80054880898 scopus 로고    scopus 로고
    • Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission
    • Knippenberg S, Peelen E, Smolders J, Thewissen M, Menheere P, Cohen Tervaert JW, et al. Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission. J Neuroimmunol (2011) 239:80-6. doi:10.1016/j.jneuroim.2011.08.019
    • (2011) J Neuroimmunol , vol.239 , pp. 80-86
    • Knippenberg, S.1    Peelen, E.2    Smolders, J.3    Thewissen, M.4    Menheere, P.5    Cohen Tervaert, J.W.6
  • 145
    • 84908384767 scopus 로고    scopus 로고
    • Unaltered regulatory B-cell frequency and function in patients with multiple sclerosis
    • Michel L, Chesneau M, Manceau P, Genty A, Garcia A, Salou M, et al. Unaltered regulatory B-cell frequency and function in patients with multiple sclerosis. Clin Immunol (2014) 155:198-208. doi:10.1016/j.clim.2014.09.011
    • (2014) Clin Immunol , vol.155 , pp. 198-208
    • Michel, L.1    Chesneau, M.2    Manceau, P.3    Genty, A.4    Garcia, A.5    Salou, M.6
  • 146
    • 34248230257 scopus 로고    scopus 로고
    • Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis
    • Duddy M, Niino M, Adatia F, Hebert S, Freedman M, Atkins H, et al. Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis. J Immunol (2007) 178:6092-9. doi:10.4049/jimmunol.178.10.6092
    • (2007) J Immunol , vol.178 , pp. 6092-6099
    • Duddy, M.1    Niino, M.2    Adatia, F.3    Hebert, S.4    Freedman, M.5    Atkins, H.6
  • 147
    • 51549118693 scopus 로고    scopus 로고
    • Helminth infections associated with multiple sclerosis induce regulatory B cells
    • Correale J, Farez M, Razzitte G. Helminth infections associated with multiple sclerosis induce regulatory B cells. Ann Neurol (2008) 64:187-99. doi:10.1002/ana.21438
    • (2008) Ann Neurol , vol.64 , pp. 187-199
    • Correale, J.1    Farez, M.2    Razzitte, G.3
  • 148
    • 84905403296 scopus 로고    scopus 로고
    • Dendritic cell-targeted vaccines
    • Cohn L, Delamarre L. Dendritic cell-targeted vaccines. Front Immunol (2014) 5:255. doi:10.3389/fimmu.2014.00255
    • (2014) Front Immunol , vol.5 , pp. 255
    • Cohn, L.1    Delamarre, L.2
  • 149
    • 27144543530 scopus 로고    scopus 로고
    • Differential processing of autoantigens in lysosomes from human monocyte-derived and peripheral blood dendritic cells
    • Burster T, Beck A, Tolosa E, Schnorrer P, Weissert R, Reich M, et al. Differential processing of autoantigens in lysosomes from human monocyte-derived and peripheral blood dendritic cells. J Immunol (2005) 175:5940-9. doi:10.4049/jimmunol.175.9.5940
    • (2005) J Immunol , vol.175 , pp. 5940-5949
    • Burster, T.1    Beck, A.2    Tolosa, E.3    Schnorrer, P.4    Weissert, R.5    Reich, M.6
  • 150
    • 79952438607 scopus 로고    scopus 로고
    • Harnessing dendritic cells for immunotherapy
    • Delamarre L, Mellman I. Harnessing dendritic cells for immunotherapy. Semin Immunol (2011) 23:2-11. doi:10.1016/j.smim.2011.02.001
    • (2011) Semin Immunol , vol.23 , pp. 2-11
    • Delamarre, L.1    Mellman, I.2
  • 151
    • 0035865232 scopus 로고    scopus 로고
    • Microbial lipopeptides stimulate dendritic cell maturation via toll-like receptor 2
    • Hertz CJ, Kiertscher SM, Godowski PJ, Bouis DA, Norgard MV, Roth MD, et al. Microbial lipopeptides stimulate dendritic cell maturation via toll-like receptor 2. J Immunol (2001) 166:2444-50. doi:10.4049/jimmunol.166.4.2444
    • (2001) J Immunol , vol.166 , pp. 2444-2450
    • Hertz, C.J.1    Kiertscher, S.M.2    Godowski, P.J.3    Bouis, D.A.4    Norgard, M.V.5    Roth, M.D.6
  • 152
    • 0029005339 scopus 로고
    • Generation of antigen-specific CD4+ T cell lines from naive precursors
    • Mehta-Damani A, Markowicz S, Engleman EG. Generation of antigen-specific CD4+ T cell lines from naive precursors. Eur J Immunol (1995) 25:1206-11. doi:10.1002/eji.1830250511
    • (1995) Eur J Immunol , vol.25 , pp. 1206-1211
    • Mehta-Damani, A.1    Markowicz, S.2    Engleman, E.G.3
  • 153
    • 56449097442 scopus 로고    scopus 로고
    • Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity
    • Hildner K, Edelson BT, Purtha WE, Diamond M, Matsushita H, Kohyama M, et al. Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science (2008) 322:1097-100. doi:10.1126/science.1164206
    • (2008) Science , vol.322 , pp. 1097-1100
    • Hildner, K.1    Edelson, B.T.2    Purtha, W.E.3    Diamond, M.4    Matsushita, H.5    Kohyama, M.6
  • 154
    • 33748510173 scopus 로고    scopus 로고
    • Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response
    • Karni A, Abraham M, Monsonego A, Cai G, Freeman GJ, Hafler D, et al. Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response. J Immunol (2006) 177:4196-202. doi:10.4049/jimmunol.177.6.4196
    • (2006) J Immunol , vol.177 , pp. 4196-4202
    • Karni, A.1    Abraham, M.2    Monsonego, A.3    Cai, G.4    Freeman, G.J.5    Hafler, D.6
  • 157
    • 22644433445 scopus 로고    scopus 로고
    • CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation
    • Fabriek BO, Van Haastert ES, Galea I, Polfliet MM, Döpp ED, Van Den Heuvel MM, et al. CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation. Glia (2005) 51:297-305. doi:10.1002/glia.20208
    • (2005) Glia , vol.51 , pp. 297-305
    • Fabriek, B.O.1    Van Haastert, E.S.2    Galea, I.3    Polfliet, M.M.4    Döpp, E.D.5    Van Den Heuvel, M.M.6
  • 159
    • 0022644493 scopus 로고
    • Immunocytochemical characterisation of the immune reaction in the central nervous system in multiple sclerosis. Possible role for microglia in lesion growth.
    • Woodroofe MN, Bellamy AS, Feldmann M, Davison AN, Cuzner ML. Immunocytochemical characterisation of the immune reaction in the central nervous system in multiple sclerosis. Possible role for microglia in lesion growth. J Neurol Sci (1986) 74:135-52. doi:10.1016/0022-510X(86)90100-0
    • (1986) J Neurol Sci , vol.74 , pp. 135-152
    • Woodroofe, M.N.1    Bellamy, A.S.2    Feldmann, M.3    Davison, A.N.4    Cuzner, M.L.5
  • 160
    • 0028231281 scopus 로고
    • Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiple sclerosis lesions
    • Bö L, Mörk S, Kong PA, Nyland H, Pardo CA, Trapp BD. Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiple sclerosis lesions. J Neuroimmunol (1994) 51:135-46. doi:10.1016/0165-5728(94)90075-2
    • (1994) J Neuroimmunol , vol.51 , pp. 135-146
    • Bö, L.1    Mörk, S.2    Kong, P.A.3    Nyland, H.4    Pardo, C.A.5    Trapp, B.D.6
  • 161
    • 33644948466 scopus 로고    scopus 로고
    • Efficient presentation of myelin oligodendrocyte glycoprotein peptides but not protein by astrocytes from HLA-DR2 and HLA-DR4 transgenic mice
    • Kort JJ, Kawamura K, Fugger L, Weissert R, Forsthuber TG. Efficient presentation of myelin oligodendrocyte glycoprotein peptides but not protein by astrocytes from HLA-DR2 and HLA-DR4 transgenic mice. J Neuroimmunol (2006) 173:23-34. doi:10.1016/j.jneuroim.2005.11.014
    • (2006) J Neuroimmunol , vol.173 , pp. 23-34
    • Kort, J.J.1    Kawamura, K.2    Fugger, L.3    Weissert, R.4    Forsthuber, T.G.5
  • 163
    • 79952138032 scopus 로고    scopus 로고
    • Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis
    • Hedstrom AK, Sundqvist E, Baarnhielm M, Nordin N, Hillert J, Kockum I, et al. Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis. Brain (2011) 134:653-64. doi:10.1093/brain/awq371
    • (2011) Brain , vol.134 , pp. 653-664
    • Hedstrom, A.K.1    Sundqvist, E.2    Baarnhielm, M.3    Nordin, N.4    Hillert, J.5    Kockum, I.6
  • 164
    • 84887058596 scopus 로고    scopus 로고
    • Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
    • Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, et al. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 45:1353-60. doi:10.1038/ng.2770
    • (2013) Nat Genet , vol.45 , pp. 1353-1360
    • Beecham, A.H.1    Patsopoulos, N.A.2    Xifara, D.K.3    Davis, M.F.4    Kemppinen, A.5    Cotsapas, C.6
  • 165
    • 67349179231 scopus 로고    scopus 로고
    • From genes to function: the next challenge to understanding multiple sclerosis
    • Fugger L, Friese MA, Bell JI. From genes to function: the next challenge to understanding multiple sclerosis. Nat Rev Immunol (2009) 9:408-17. doi:10.1038/nri2554
    • (2009) Nat Rev Immunol , vol.9 , pp. 408-417
    • Fugger, L.1    Friese, M.A.2    Bell, J.I.3
  • 166
  • 167
    • 55549104692 scopus 로고    scopus 로고
    • Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis
    • Friese MA, Jakobsen KB, Friis L, Etzensperger R, Craner MJ, McMahon RM, et al. Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis. Nat Med (2008) 14:1227-35. doi:10.1038/nm.1881
    • (2008) Nat Med , vol.14 , pp. 1227-1235
    • Friese, M.A.1    Jakobsen, K.B.2    Friis, L.3    Etzensperger, R.4    Craner, M.J.5    McMahon, R.M.6
  • 168
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, et al. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 447:661-78. doi:10.1038/nature05911
    • (2007) Nature , vol.447 , pp. 661-678
    • Burton, P.R.1    Clayton, D.G.2    Cardon, L.R.3    Craddock, N.4    Deloukas, P.5    Duncanson, A.6
  • 169
    • 84871950028 scopus 로고    scopus 로고
    • Risk for myasthenia gravis maps to a 151 Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08
    • Gregersen PK, Kosoy R, Lee AT, Lamb J, Sussman J, McKee D, et al. Risk for myasthenia gravis maps to a 151 Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08. Ann Neurol (2012) 72:927-35. doi:10.1002/ana.23691
    • (2012) Ann Neurol , vol.72 , pp. 927-935
    • Gregersen, P.K.1    Kosoy, R.2    Lee, A.T.3    Lamb, J.4    Sussman, J.5    McKee, D.6
  • 170
    • 0023500817 scopus 로고
    • The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis.
    • Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum (1987) 30:1205-13. doi:10.1002/art.1780301102
    • (1987) Arthritis Rheum , vol.30 , pp. 1205-1213
    • Gregersen, P.K.1    Silver, J.2    Winchester, R.J.3
  • 171
    • 33645290018 scopus 로고    scopus 로고
    • MHC class II proteins and disease: a structural perspective
    • Jones EY, Fugger L, Strominger JL, Siebold C. MHC class II proteins and disease: a structural perspective. Nat Rev Immunol (2006) 6:271-82. doi:10.1038/nri1805
    • (2006) Nat Rev Immunol , vol.6 , pp. 271-282
    • Jones, E.Y.1    Fugger, L.2    Strominger, J.L.3    Siebold, C.4
  • 172
    • 84878841826 scopus 로고    scopus 로고
    • HLA-DR15-derived self-peptides are involved in increased autologous T cell proliferation in multiple sclerosis
    • Mohme M, Hotz C, Stevanovic S, Binder T, Lee J, Okoniewski M, et al. HLA-DR15-derived self-peptides are involved in increased autologous T cell proliferation in multiple sclerosis. Brain (2013) 136:1783-98. doi:10.1093/brain/awt108
    • (2013) Brain , vol.136 , pp. 1783-1798
    • Mohme, M.1    Hotz, C.2    Stevanovic, S.3    Binder, T.4    Lee, J.5    Okoniewski, M.6
  • 173
    • 0028825348 scopus 로고
    • Naturally processed peptides from rheumatoid arthritis associated and non-associated HLA-DR alleles
    • Kirschmann DA, Duffin KL, Smith CE, Welply JK, Howard SC, Schwartz BD, et al. Naturally processed peptides from rheumatoid arthritis associated and non-associated HLA-DR alleles. J Immunol (1995) 155:5655-62.
    • (1995) J Immunol , vol.155 , pp. 5655-5662
    • Kirschmann, D.A.1    Duffin, K.L.2    Smith, C.E.3    Welply, J.K.4    Howard, S.C.5    Schwartz, B.D.6
  • 174
    • 0142043832 scopus 로고    scopus 로고
    • Interferon gamma responses to myelin peptides in multiple sclerosis correlate with a new clinical measure of disease progression
    • Moldovan IR, Rudick RA, Cotleur AC, Born SE, Lee J, Karafa MT, et al. Interferon gamma responses to myelin peptides in multiple sclerosis correlate with a new clinical measure of disease progression. J Neuroimmunol (2003) 141:132-40. doi:10.1016/S0165-5728(03)00221-2
    • (2003) J Neuroimmunol , vol.141 , pp. 132-140
    • Moldovan, I.R.1    Rudick, R.A.2    Cotleur, A.C.3    Born, S.E.4    Lee, J.5    Karafa, M.T.6
  • 175
    • 0026517943 scopus 로고
    • Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis
    • Olsson T, Sun J, Hillert J, Höjeberg B, Ekre HP, Andersson G, et al. Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis. Eur J Immunol (1992) 22:1083-7. doi:10.1002/eji.1830220431
    • (1992) Eur J Immunol , vol.22 , pp. 1083-1087
    • Olsson, T.1    Sun, J.2    Hillert, J.3    Höjeberg, B.4    Ekre, H.P.5    Andersson, G.6
  • 176
    • 51249090471 scopus 로고    scopus 로고
    • T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis
    • Hedegaard CJ, Krakauer M, Bendtzen K, Lund H, Sellebjerg F, Nielsen CH. T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis. Immunology (2008) 125:161-9. doi:10.1111/j.1365-2567.2008.02837.x
    • (2008) Immunology , vol.125 , pp. 161-169
    • Hedegaard, C.J.1    Krakauer, M.2    Bendtzen, K.3    Lund, H.4    Sellebjerg, F.5    Nielsen, C.H.6
  • 177
    • 0027389119 scopus 로고
    • Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients
    • Valli A, Sette A, Kappos L, Oseroff C, Sidney J, Miescher G, et al. Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients. J Clin Invest (1993) 91:616-28. doi:10.1172/JCI116242
    • (1993) J Clin Invest , vol.91 , pp. 616-628
    • Valli, A.1    Sette, A.2    Kappos, L.3    Oseroff, C.4    Sidney, J.5    Miescher, G.6
  • 178
    • 0025966510 scopus 로고
    • A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis
    • Martin R, Howell MD, Jaraquemada D, Flerlage M, Richert J, Brostoff S, et al. A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis. J Exp Med (1991) 173:19-24. doi:10.1084/jem.173.1.19
    • (1991) J Exp Med , vol.173 , pp. 19-24
    • Martin, R.1    Howell, M.D.2    Jaraquemada, D.3    Flerlage, M.4    Richert, J.5    Brostoff, S.6
  • 179
    • 2142696842 scopus 로고    scopus 로고
    • Effect of gender on T-cell proliferative responses to myelin proteolipid protein antigens in patients with multiple sclerosis and controls
    • Greer JM, Csurhes PA, Pender MP, McCombe PA. Effect of gender on T-cell proliferative responses to myelin proteolipid protein antigens in patients with multiple sclerosis and controls. J Autoimmun (2004) 22:345-52. doi:10.1016/j.jaut.2004.03.004
    • (2004) J Autoimmun , vol.22 , pp. 345-352
    • Greer, J.M.1    Csurhes, P.A.2    Pender, M.P.3    McCombe, P.A.4
  • 180
    • 0034326642 scopus 로고    scopus 로고
    • Surges of increased T cell reactivity to an encephalitogenic region of myelin proteolipid protein occur more often in patients with multiple sclerosis than in healthy subjects
    • Pender MP, Csurhes PA, Greer JM, Mowat PD, Henderson RD, Cameron KD, et al. Surges of increased T cell reactivity to an encephalitogenic region of myelin proteolipid protein occur more often in patients with multiple sclerosis than in healthy subjects. J Immunol (2000) 165:5322-31. doi:10.4049/jimmunol.165.9.5322
    • (2000) J Immunol , vol.165 , pp. 5322-5331
    • Pender, M.P.1    Csurhes, P.A.2    Greer, J.M.3    Mowat, P.D.4    Henderson, R.D.5    Cameron, K.D.6
  • 181
    • 0030861738 scopus 로고    scopus 로고
    • Increased immunoreactivity to two overlapping peptides of myelin proteolipid protein in multiple sclerosis
    • Greer JM, Csurhes PA, Cameron KD, McCombe PA, Good MF, Pender MP. Increased immunoreactivity to two overlapping peptides of myelin proteolipid protein in multiple sclerosis. Brain (1997) 120:1447-60. doi:10.1093/brain/120.8.1447
    • (1997) Brain , vol.120 , pp. 1447-1460
    • Greer, J.M.1    Csurhes, P.A.2    Cameron, K.D.3    McCombe, P.A.4    Good, M.F.5    Pender, M.P.6
  • 182
    • 0034678450 scopus 로고    scopus 로고
    • Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85-99 complex
    • Krogsgaard M, Wucherpfennig KW, Cannella B, Hansen BE, Svejgaard A, Pyrdol J, et al. Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85-99 complex. J Exp Med (2000) 191:1395-412. doi:10.1084/jem.191.8.1395
    • (2000) J Exp Med , vol.191 , pp. 1395-1412
    • Krogsgaard, M.1    Wucherpfennig, K.W.2    Cannella, B.3    Hansen, B.E.4    Svejgaard, A.5    Pyrdol, J.6
  • 183
    • 0033791462 scopus 로고    scopus 로고
    • Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The altered peptide ligand in relapsing MS study group
    • Kappos L, Comi G, Panitch H, Oger J, Antel J, Conlon P, et al. Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The altered peptide ligand in relapsing MS study group. Nat Med (2000) 6:1176-82. doi:10.1038/80525
    • (2000) Nat Med , vol.6 , pp. 1176-1182
    • Kappos, L.1    Comi, G.2    Panitch, H.3    Oger, J.4    Antel, J.5    Conlon, P.6
  • 185
    • 18544397838 scopus 로고    scopus 로고
    • T cell response to myelin basic protein in the context of the multiple sclerosis-associated HLA-DR15 haplotype: peptide binding, immunodominance and effector functions of T cells
    • Vergelli M, Kalbus M, Rojo SC, Hemmer B, Kalbacher H, Tranquill L, et al. T cell response to myelin basic protein in the context of the multiple sclerosis-associated HLA-DR15 haplotype: peptide binding, immunodominance and effector functions of T cells. J Neuroimmunol (1997) 77:195-203. doi:10.1016/S0165-5728(97)00075-1
    • (1997) J Neuroimmunol , vol.77 , pp. 195-203
    • Vergelli, M.1    Kalbus, M.2    Rojo, S.C.3    Hemmer, B.4    Kalbacher, H.5    Tranquill, L.6
  • 186
    • 84902486689 scopus 로고    scopus 로고
    • Multiple sclerosis autoantigen myelin basic protein escapes control by ubiquitination during proteasomal degradation
    • Belogurov A, Kudriaeva A, Kuzina E, Smirnov I, Bobik T, Ponomarenko N, et al. Multiple sclerosis autoantigen myelin basic protein escapes control by ubiquitination during proteasomal degradation. J Biol Chem (2014) 289:17758-66. doi:10.1074/jbc.M113.544247
    • (2014) J Biol Chem , vol.289 , pp. 17758-17766
    • Belogurov, A.1    Kudriaeva, A.2    Kuzina, E.3    Smirnov, I.4    Bobik, T.5    Ponomarenko, N.6
  • 187
    • 0027362631 scopus 로고
    • Identification of a novel T cell epitope of human proteolipid protein (residues 40-60) recognized by proliferative and cytolytic CD4+ T cells from multiple sclerosis patients
    • Pelfrey CM, Trotter JL, Tranquill LR, McFarland HF. Identification of a novel T cell epitope of human proteolipid protein (residues 40-60) recognized by proliferative and cytolytic CD4+ T cells from multiple sclerosis patients. J Neuroimmunol (1993) 46:33-42. doi:10.1016/0165-5728(93)90231-M
    • (1993) J Neuroimmunol , vol.46 , pp. 33-42
    • Pelfrey, C.M.1    Trotter, J.L.2    Tranquill, L.R.3    McFarland, H.F.4
  • 188
    • 0030112686 scopus 로고    scopus 로고
    • T cell response to two immunodominant proteolipid protein (PLP) peptides in multiple sclerosis patients and healthy controls
    • Pelfrey CM, Tranquill LR, Vogt AB, McFarland HF. T cell response to two immunodominant proteolipid protein (PLP) peptides in multiple sclerosis patients and healthy controls. Mult Scler (1996) 1:270-8.
    • (1996) Mult Scler , vol.1 , pp. 270-278
    • Pelfrey, C.M.1    Tranquill, L.R.2    Vogt, A.B.3    McFarland, H.F.4
  • 189
    • 0032522194 scopus 로고    scopus 로고
    • T cell recognition of myelin proteolipid protein and myelin proteolipid protein peptides in the peripheral blood of multiple sclerosis and control subjects
    • Trotter JL, Pelfrey CM, Trotter AL, Selvidge JA, Gushleff KC, Mohanakumar T, et al. T cell recognition of myelin proteolipid protein and myelin proteolipid protein peptides in the peripheral blood of multiple sclerosis and control subjects. J Neuroimmunol (1998) 84:172-8. doi:10.1016/S0165-5728(97)00260-9
    • (1998) J Neuroimmunol , vol.84 , pp. 172-178
    • Trotter, J.L.1    Pelfrey, C.M.2    Trotter, A.L.3    Selvidge, J.A.4    Gushleff, K.C.5    Mohanakumar, T.6
  • 190
    • 0029019568 scopus 로고
    • T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans
    • Markovic-Plese S, Fukaura H, Zhang J, al-Sabbagh A, Southwood S, Sette A, et al. T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans. J Immunol (1995) 155:982-92.
    • (1995) J Immunol , vol.155 , pp. 982-992
    • Markovic-Plese, S.1    Fukaura, H.2    Zhang, J.3    al-Sabbagh, A.4    Southwood, S.5    Sette, A.6
  • 191
    • 0025782929 scopus 로고
    • Peripheral blood mononuclear cells from multiple sclerosis patients recognize myelin proteolipid protein and selected peptides
    • Trotter JL, Hickey WF, van der Veen RC, Sulze L. Peripheral blood mononuclear cells from multiple sclerosis patients recognize myelin proteolipid protein and selected peptides. J Neuroimmunol (1991) 33:55-62. doi:10.1016/0165-5728(91)90034-5
    • (1991) J Neuroimmunol , vol.33 , pp. 55-62
    • Trotter, J.L.1    Hickey, W.F.2    van der Veen, R.C.3    Sulze, L.4
  • 192
    • 0025979945 scopus 로고
    • T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis
    • Sun J, Link H, Olsson T, Xiao BG, Andersson G, Ekre HP, et al. T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis. J Immunol (1991) 146:1490-5.
    • (1991) J Immunol , vol.146 , pp. 1490-1495
    • Sun, J.1    Link, H.2    Olsson, T.3    Xiao, B.G.4    Andersson, G.5    Ekre, H.P.6
  • 193
    • 0031706506 scopus 로고    scopus 로고
    • Increased reactivity to myelin oligodendrocyte glycoprotein peptides and epitope mapping in HLA DR2(15)+ multiple sclerosis
    • Wallström E, Khademi M, Andersson M, Weissert R, Linington C, Olsson T. Increased reactivity to myelin oligodendrocyte glycoprotein peptides and epitope mapping in HLA DR2(15)+ multiple sclerosis. Eur J Immunol (1998) 28:3329-35. doi:10.1002/(SICI)1521-4141(199810)28:10<3329::AID-IMMU3329>3.0.CO;2-B
    • (1998) Eur J Immunol , vol.28 , pp. 3329-3335
    • Wallström, E.1    Khademi, M.2    Andersson, M.3    Weissert, R.4    Linington, C.5    Olsson, T.6
  • 194
    • 79960536431 scopus 로고    scopus 로고
    • Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis
    • Raddassi K, Kent SC, Yang J, Bourcier K, Bradshaw EM, Seyfert-Margolis V, et al. Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis. J Immunol (2011) 187:1039-46. doi:10.4049/jimmunol.1001543
    • (2011) J Immunol , vol.187 , pp. 1039-1046
    • Raddassi, K.1    Kent, S.C.2    Yang, J.3    Bourcier, K.4    Bradshaw, E.M.5    Seyfert-Margolis, V.6
  • 195
    • 0027144752 scopus 로고
    • Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein.
    • Kerlero de Rosbo N, Milo R, Lees MB, Burger D, Bernard CC, Ben-Nun A. Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein. J Clin Invest (1993) 92:2602-8. doi:10.1172/JCI116875
    • (1993) J Clin Invest , vol.92 , pp. 2602-2608
    • Kerlero de Rosbo, N.1    Milo, R.2    Lees, M.B.3    Burger, D.4    Bernard, C.C.5    Ben-Nun, A.6
  • 198
    • 33646094483 scopus 로고    scopus 로고
    • Epitope specificity of serum antibodies directed against the extracellular domain of myelin oligodendrocyte glycoprotein: influence of relapses and immunomodulatory treatments
    • Khalil M, Reindl M, Lutterotti A, Kuenz B, Ehling R, Gneiss C, et al. Epitope specificity of serum antibodies directed against the extracellular domain of myelin oligodendrocyte glycoprotein: influence of relapses and immunomodulatory treatments. J Neuroimmunol (2006) 174:147-56. doi:10.1016/j.jneuroim.2006.01.012
    • (2006) J Neuroimmunol , vol.174 , pp. 147-156
    • Khalil, M.1    Reindl, M.2    Lutterotti, A.3    Kuenz, B.4    Ehling, R.5    Gneiss, C.6
  • 199
    • 0032753320 scopus 로고    scopus 로고
    • Multiple sclerosis: B- and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein
    • Lindert RB, Haase CG, Brehm U, Linington C, Wekerle H, Hohlfeld R. Multiple sclerosis: B- and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein. Brain (1999) 122:2089-100. doi:10.1093/brain/122.11.2089
    • (1999) Brain , vol.122 , pp. 2089-2100
    • Lindert, R.B.1    Haase, C.G.2    Brehm, U.3    Linington, C.4    Wekerle, H.5    Hohlfeld, R.6
  • 200
    • 33847180757 scopus 로고    scopus 로고
    • Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis
    • Zhou D, Srivastava R, Nessler S, Grummel V, Sommer N, Bruck W, et al. Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis. Proc Natl Acad Sci U S A (2006) 103:19057-62. doi:10.1073/pnas.0607242103
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 19057-19062
    • Zhou, D.1    Srivastava, R.2    Nessler, S.3    Grummel, V.4    Sommer, N.5    Bruck, W.6
  • 201
    • 33144474262 scopus 로고    scopus 로고
    • Antibodies to native myelin oligodendrocyte glycoprotein are serologic markers of early inflammation in multiple sclerosis
    • Lalive PH, Menge T, Delarasse C, Della Gaspera B, Pham-Dinh D, Villoslada P, et al. Antibodies to native myelin oligodendrocyte glycoprotein are serologic markers of early inflammation in multiple sclerosis. Proc Natl Acad Sci U S A (2006) 103:2280-5. doi:10.1073/pnas.0510672103
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 2280-2285
    • Lalive, P.H.1    Menge, T.2    Delarasse, C.3    Della Gaspera, B.4    Pham-Dinh, D.5    Villoslada, P.6
  • 202
    • 80053300042 scopus 로고    scopus 로고
    • Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis
    • Probstel AK, Dornmair K, Bittner R, Sperl P, Jenne D, Magalhaes S, et al. Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis. Neurology (2011) 77:580-8. doi:10.1212/WNL.0b013e318228c0b1
    • (2011) Neurology , vol.77 , pp. 580-588
    • Probstel, A.K.1    Dornmair, K.2    Bittner, R.3    Sperl, P.4    Jenne, D.5    Magalhaes, S.6
  • 203
    • 11144342815 scopus 로고    scopus 로고
    • Antibodies against glycosylated native MOG are elevated in patients with multiple sclerosis
    • Gaertner S, de Graaf KL, Greve B, Weissert R. Antibodies against glycosylated native MOG are elevated in patients with multiple sclerosis. Neurology (2004) 63:2381-3. doi:10.1212/01.WNL.0000147259.34163.33
    • (2004) Neurology , vol.63 , pp. 2381-2383
    • Gaertner, S.1    de Graaf, K.L.2    Greve, B.3    Weissert, R.4
  • 204
    • 77957067791 scopus 로고    scopus 로고
    • Elevated intrathecal myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis
    • Klawiter EC, Piccio L, Lyons J, Mikesell R, O'Connor KC, Cross AH. Elevated intrathecal myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis. Arch Neurol (2010) 67:1102-8. doi:10.1001/archneurol.2010.197
    • (2010) Arch Neurol , vol.67 , pp. 1102-1108
    • Klawiter, E.C.1    Piccio, L.2    Lyons, J.3    Mikesell, R.4    O'Connor, K.C.5    Cross, A.H.6
  • 205
    • 0033059092 scopus 로고    scopus 로고
    • Elevated levels of antibody to myelin oligodendrocyte glycoprotein is not specific for patients with multiple sclerosis
    • Karni A, Bakimer-Kleiner R, Abramsky O, Ben-Nun A. Elevated levels of antibody to myelin oligodendrocyte glycoprotein is not specific for patients with multiple sclerosis. Arch Neurol (1999) 56:311-5. doi:10.1001/archneur.56.3.311
    • (1999) Arch Neurol , vol.56 , pp. 311-315
    • Karni, A.1    Bakimer-Kleiner, R.2    Abramsky, O.3    Ben-Nun, A.4
  • 206
    • 39549088973 scopus 로고    scopus 로고
    • Anti-myelin antibodies predict the clinical outcome after a first episode suggestive of MS
    • Tomassini V, de Giglio L, Reindl M, Russo P, Pestalozza I, Pantano P, et al. Anti-myelin antibodies predict the clinical outcome after a first episode suggestive of MS. Mult Scler (2007) 13:1086-94. doi:10.1177/1352458507077622
    • (2007) Mult Scler , vol.13 , pp. 1086-1094
    • Tomassini, V.1    de Giglio, L.2    Reindl, M.3    Russo, P.4    Pestalozza, I.5    Pantano, P.6
  • 207
  • 208
    • 0038790058 scopus 로고    scopus 로고
    • Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event
    • Berger T, Rubner P, Schautzer F, Egg R, Ulmer H, Mayringer I, et al. Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event. N Engl J Med (2003) 349:139-45. doi:10.1056/NEJMoa022328
    • (2003) N Engl J Med , vol.349 , pp. 139-145
    • Berger, T.1    Rubner, P.2    Schautzer, F.3    Egg, R.4    Ulmer, H.5    Mayringer, I.6
  • 209
    • 33846449107 scopus 로고    scopus 로고
    • Lack of association between antimyelin antibodies and progression to multiple sclerosis
    • Kuhle J, Pohl C, Mehling M, Edan G, Freedman MS, Hartung H, et al. Lack of association between antimyelin antibodies and progression to multiple sclerosis. N Engl J Med (2007) 356:371-8. doi:10.1056/NEJMoa063602
    • (2007) N Engl J Med , vol.356 , pp. 371-378
    • Kuhle, J.1    Pohl, C.2    Mehling, M.3    Edan, G.4    Freedman, M.S.5    Hartung, H.6
  • 210
    • 22144448177 scopus 로고    scopus 로고
    • Anti-myelin antibodies do not allow earlier diagnosis of multiple sclerosis
    • Lim ET, Berger T, Reindl M, Dalton CM, Fernando K, Keir G, et al. Anti-myelin antibodies do not allow earlier diagnosis of multiple sclerosis. Mult Scler (2005) 11:492-4. doi:10.1191/1352458505ms1187sr
    • (2005) Mult Scler , vol.11 , pp. 492-494
    • Lim, E.T.1    Berger, T.2    Reindl, M.3    Dalton, C.M.4    Fernando, K.5    Keir, G.6
  • 211
    • 0035283493 scopus 로고    scopus 로고
    • The fine specificity of the myelin oligodendrocyte glycoprotein autoantibody response in patients with multiple sclerosis and normal healthy controls
    • Haase CG, Guggenmos J, Brehm U, Andersson M, Olsson T, Reindl M, et al. The fine specificity of the myelin oligodendrocyte glycoprotein autoantibody response in patients with multiple sclerosis and normal healthy controls. J Neuroimmunol (2001) 114:220-5. doi:10.1016/S0165-5728(00)00462-8
    • (2001) J Neuroimmunol , vol.114 , pp. 220-225
    • Haase, C.G.1    Guggenmos, J.2    Brehm, U.3    Andersson, M.4    Olsson, T.5    Reindl, M.6
  • 212
    • 0036604101 scopus 로고    scopus 로고
    • The human T cell response to myelin oligodendrocyte glycoprotein: a multiple sclerosis family-based study
    • Koehler NK, Genain CP, Giesser B, Hauser SL. The human T cell response to myelin oligodendrocyte glycoprotein: a multiple sclerosis family-based study. J Immunol (2002) 168:5920-7. doi:10.4049/jimmunol.168.11.5920
    • (2002) J Immunol , vol.168 , pp. 5920-5927
    • Koehler, N.K.1    Genain, C.P.2    Giesser, B.3    Hauser, S.L.4
  • 213
    • 0036644486 scopus 로고    scopus 로고
    • High immunogenicity of intracellular myelin oligodendrocyte glycoprotein epitopes
    • Weissert R, Kuhle J, de Graaf KL, Wienhold W, Herrmann MM, Müller C, et al. High immunogenicity of intracellular myelin oligodendrocyte glycoprotein epitopes. J Immunol (2002) 169:548-56. doi:10.4049/jimmunol.169.1.548
    • (2002) J Immunol , vol.169 , pp. 548-556
    • Weissert, R.1    Kuhle, J.2    de Graaf, K.L.3    Wienhold, W.4    Herrmann, M.M.5    Müller, C.6
  • 214
    • 84903777311 scopus 로고    scopus 로고
    • CNS myelin induces regulatory functions of DC-SIGN-expressing, antigen-presenting cells via cognate interaction with MOG
    • Garcia-Vallejo JJ, Ilarregui JM, Kalay H, Chamorro S, Koning N, Unger WW, et al. CNS myelin induces regulatory functions of DC-SIGN-expressing, antigen-presenting cells via cognate interaction with MOG. J Exp Med (2014) 211:1465-83. doi:10.1084/jem.20122192
    • (2014) J Exp Med , vol.211 , pp. 1465-1483
    • Garcia-Vallejo, J.J.1    Ilarregui, J.M.2    Kalay, H.3    Chamorro, S.4    Koning, N.5    Unger, W.W.6
  • 215
    • 0029060142 scopus 로고
    • The small heat-shock protein alpha B-crystallin as candidate autoantigen in multiple sclerosis
    • Van Noort JM, van Sechel AC, Bajramovic JJ, el Ouagmiri M, Polman CH, Lassmann H, et al. The small heat-shock protein alpha B-crystallin as candidate autoantigen in multiple sclerosis. Nature (1995) 375:798-801. doi:10.1038/375798a0
    • (1995) Nature , vol.375 , pp. 798-801
    • Van Noort, J.M.1    van Sechel, A.C.2    Bajramovic, J.J.3    El Ouagmiri, M.4    Polman, C.H.5    Lassmann, H.6
  • 216
    • 79955035421 scopus 로고    scopus 로고
    • Chaperone activity of a B-crystallin is responsible for its incorrect assignment as an autoantigen in multiple sclerosis
    • Rothbard JB, Zhao X, Sharpe O, Strohman MJ, Kurnellas M, Mellins ED, et al. Chaperone activity of a B-crystallin is responsible for its incorrect assignment as an autoantigen in multiple sclerosis. J Immunol (2011) 186:4263-8. doi:10.4049/jimmunol.1003934
    • (2011) J Immunol , vol.186 , pp. 4263-4268
    • Rothbard, J.B.1    Zhao, X.2    Sharpe, O.3    Strohman, M.J.4    Kurnellas, M.5    Mellins, E.D.6
  • 217
    • 71049147858 scopus 로고    scopus 로고
    • Naturally presented peptides on major histocompatibility complex I and II molecules eluted from central nervous system of multiple sclerosis patients
    • Fissolo N, Haag S, de Graaf KL, Drews O, Stevanovic S, Rammensee HG, et al. Naturally presented peptides on major histocompatibility complex I and II molecules eluted from central nervous system of multiple sclerosis patients. Mol Cell Proteomics (2009) 8:2090-101. doi:10.1074/mcp.M900001-MCP200
    • (2009) Mol Cell Proteomics , vol.8 , pp. 2090-2101
    • Fissolo, N.1    Haag, S.2    de Graaf, K.L.3    Drews, O.4    Stevanovic, S.5    Rammensee, H.G.6
  • 218
    • 0036779688 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of myasthenia gravis
    • Vincent A. Unravelling the pathogenesis of myasthenia gravis. Nat Rev Immunol (2002) 2:797-804. doi:10.1038/nri916
    • (2002) Nat Rev Immunol , vol.2 , pp. 797-804
    • Vincent, A.1
  • 219
    • 0016256287 scopus 로고
    • Serum globulin in myasthenia gravis: inhibition of alpha-bungarotoxin binding to acetylcholine receptors
    • Almon RR, Andrew CG, Appel SH. Serum globulin in myasthenia gravis: inhibition of alpha-bungarotoxin binding to acetylcholine receptors. Science (1974) 186:55-7. doi:10.1126/science.186.4158.55
    • (1974) Science , vol.186 , pp. 55-57
    • Almon, R.R.1    Andrew, C.G.2    Appel, S.H.3
  • 220
    • 0017171683 scopus 로고
    • Antibody to acetylcholine receptor in myasthenia gravis. Prevalence, clinical correlates, and diagnostic value.
    • Lindstrom JM, Seybold ME, Lennon VA, Whittingham S, Duane DD. Antibody to acetylcholine receptor in myasthenia gravis. Prevalence, clinical correlates, and diagnostic value. Neurology (1976) 26:1054-9. doi:10.1212/WNL.26.11.1054
    • (1976) Neurology , vol.26 , pp. 1054-1059
    • Lindstrom, J.M.1    Seybold, M.E.2    Lennon, V.A.3    Whittingham, S.4    Duane, D.D.5
  • 221
    • 0016755254 scopus 로고
    • Myasthenia gravis: passive transfer from man to mouse
    • Toyka KV, Brachman DB, Pestronk A, Kao I. Myasthenia gravis: passive transfer from man to mouse. Science (1975) 190:397-9. doi:10.1126/science.1179220
    • (1975) Science , vol.190 , pp. 397-399
    • Toyka, K.V.1    Brachman, D.B.2    Pestronk, A.3    Kao, I.4
  • 222
    • 0035105784 scopus 로고    scopus 로고
    • Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies
    • Hoch W, McConville J, Helms S, Newsom-Davis J, Melms A, Vincent A. Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat Med (2001) 7:365-8. doi:10.1038/85520
    • (2001) Nat Med , vol.7 , pp. 365-368
    • Hoch, W.1    McConville, J.2    Helms, S.3    Newsom-Davis, J.4    Melms, A.5    Vincent, A.6
  • 223
    • 46849112624 scopus 로고    scopus 로고
    • IgG1 antibodies to acetylcholine receptors in 'seronegative' myasthenia gravis
    • Leite MI, Jacob S, Viegas S, Cossins J, Clover L, Morgan BP, et al. IgG1 antibodies to acetylcholine receptors in 'seronegative' myasthenia gravis. Brain (2008) 131:1940-52. doi:10.1093/brain/awn092
    • (2008) Brain , vol.131 , pp. 1940-1952
    • Leite, M.I.1    Jacob, S.2    Viegas, S.3    Cossins, J.4    Clover, L.5    Morgan, B.P.6
  • 224
    • 79952513213 scopus 로고    scopus 로고
    • Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis
    • Higuchi O, Hamuro J, Motomura M, Yamanashi Y. Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis. Ann Neurol (2011) 69:418-22. doi:10.1002/ana.22312
    • (2011) Ann Neurol , vol.69 , pp. 418-422
    • Higuchi, O.1    Hamuro, J.2    Motomura, M.3    Yamanashi, Y.4
  • 225
    • 0021243562 scopus 로고
    • Autoimmune human T lymphocytes specific for acetylcholine receptor
    • Hohlfeld R, Toyka KV, Heininger K, Grosse-Wilde H, Kalies I. Autoimmune human T lymphocytes specific for acetylcholine receptor. Nature (1984) 310:244-6. doi:10.1038/310244a0
    • (1984) Nature , vol.310 , pp. 244-246
    • Hohlfeld, R.1    Toyka, K.V.2    Heininger, K.3    Grosse-Wilde, H.4    Kalies, I.5
  • 226
    • 11244291391 scopus 로고    scopus 로고
    • Functional defect of regulatory CD4+CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis
    • Balandina A, Lécart S, Dartevelle P, Saoudi A, Berrih-Aknin S. Functional defect of regulatory CD4+CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis. Blood (2005) 105:735-41. doi:10.1182/blood-2003-11-3900
    • (2005) Blood , vol.105 , pp. 735-741
    • Balandina, A.1    Lécart, S.2    Dartevelle, P.3    Saoudi, A.4    Berrih-Aknin, S.5
  • 227
    • 0022538508 scopus 로고
    • Epstein-Barr virus-transformed B cells can present acetylcholine receptor to autologous autoreactive T cells
    • Hohlfeld R, Michels M, Tesch H, Fahsbender A, Heininger K, Conti-Tronconi BM, et al. Epstein-Barr virus-transformed B cells can present acetylcholine receptor to autologous autoreactive T cells. Immunol Lett (1986) 12:171-4. doi:10.1016/0165-2478(86)90101-X
    • (1986) Immunol Lett , vol.12 , pp. 171-174
    • Hohlfeld, R.1    Michels, M.2    Tesch, H.3    Fahsbender, A.4    Heininger, K.5    Conti-Tronconi, B.M.6
  • 229
    • 10344250945 scopus 로고    scopus 로고
    • A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis
    • Lennon VA, Wingerchuk DM, Kryzer TJ, Pittock SJ, Lucchinetti CF, Fujihara K, et al. A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet (2004) 364:2106-12. doi:10.1016/S0140-6736(04)17551-X
    • (2004) Lancet , vol.364 , pp. 2106-2112
    • Lennon, V.A.1    Wingerchuk, D.M.2    Kryzer, T.J.3    Pittock, S.J.4    Lucchinetti, C.F.5    Fujihara, K.6
  • 230
    • 23944444890 scopus 로고    scopus 로고
    • IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
    • Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med (2005) 202:473-7. doi:10.1084/jem.20050304
    • (2005) J Exp Med , vol.202 , pp. 473-477
    • Lennon, V.A.1    Kryzer, T.J.2    Pittock, S.J.3    Verkman, A.S.4    Hinson, S.R.5
  • 231
  • 232
    • 34249650146 scopus 로고    scopus 로고
    • Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis
    • Roemer SF, Parisi JE, Lennon VA, Benarroch EE, Lassmann H, Bruck W, et al. Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis. Brain (2007) 130:1194-205. doi:10.1093/brain/awl371
    • (2007) Brain , vol.130 , pp. 1194-1205
    • Roemer, S.F.1    Parisi, J.E.2    Lennon, V.A.3    Benarroch, E.E.4    Lassmann, H.5    Bruck, W.6
  • 233
    • 70349752929 scopus 로고    scopus 로고
    • Cytotoxic effect of neuromyelitis optica antibody (NMO-IgG) to astrocytes: an in vitro study
    • Sabater L, Giralt A, Boronat A, Hankiewicz K, Blanco Y, Llufriu S, et al. Cytotoxic effect of neuromyelitis optica antibody (NMO-IgG) to astrocytes: an in vitro study. J Neuroimmunol (2009) 215:31-5. doi:10.1016/j.jneuroim.2009.07.014
    • (2009) J Neuroimmunol , vol.215 , pp. 31-35
    • Sabater, L.1    Giralt, A.2    Boronat, A.3    Hankiewicz, K.4    Blanco, Y.5    Llufriu, S.6
  • 234
    • 84867034949 scopus 로고    scopus 로고
    • Neuromyelitis optica lesions may inform multiple sclerosis heterogeneity debate
    • Brück W, Popescu B, Lucchinetti CF, Markovic-Plese S, Gold R, Thal DR, et al. Neuromyelitis optica lesions may inform multiple sclerosis heterogeneity debate. Ann Neurol (2012) 72:385-94. doi:10.1002/ana.23621
    • (2012) Ann Neurol , vol.72 , pp. 385-394
    • Brück, W.1    Popescu, B.2    Lucchinetti, C.F.3    Markovic-Plese, S.4    Gold, R.5    Thal, D.R.6
  • 235
    • 53949126186 scopus 로고    scopus 로고
    • Functional consequences of neuromyelitis optica-IgG astrocyte interactions on blood-brain barrier permeability and granulocyte recruitment
    • Vincent T, Saikali P, Cayrol R, Roth AD, Bar-Or A, Prat A, et al. Functional consequences of neuromyelitis optica-IgG astrocyte interactions on blood-brain barrier permeability and granulocyte recruitment. J Immunol (2008) 181:5730-7. doi:10.4049/jimmunol.181.8.5730
    • (2008) J Immunol , vol.181 , pp. 5730-5737
    • Vincent, T.1    Saikali, P.2    Cayrol, R.3    Roth, A.D.4    Bar-Or, A.5    Prat, A.6
  • 236
    • 72949093353 scopus 로고    scopus 로고
    • Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica
    • Bennett JL, Lam C, Kalluri SR, Saikali P, Bautista K, Dupree C, et al. Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica. Ann Neurol (2009) 66:617-29. doi:10.1002/ana.21802
    • (2009) Ann Neurol , vol.66 , pp. 617-629
    • Bennett, J.L.1    Lam, C.2    Kalluri, S.R.3    Saikali, P.4    Bautista, K.5    Dupree, C.6
  • 237
    • 72949114659 scopus 로고    scopus 로고
    • Neuromyelitis optica: pathogenicity of patient immunoglobulin in vivo
    • Bradl M, Misu T, Takahashi T, Watanabe M, Mader S, Reindl M, et al. Neuromyelitis optica: pathogenicity of patient immunoglobulin in vivo. Ann Neurol (2009) 66:630-43. doi:10.1002/ana.21837
    • (2009) Ann Neurol , vol.66 , pp. 630-643
    • Bradl, M.1    Misu, T.2    Takahashi, T.3    Watanabe, M.4    Mader, S.5    Reindl, M.6
  • 238
  • 239
    • 84896740779 scopus 로고    scopus 로고
    • Neuromyelitis optica spectrum disorders with aquaporin-4 and myelin-oligodendrocyte glycoprotein antibodies: a comparative study
    • Kitley J, Waters P, Woodhall M, Leite MI, Murchison A, George J, et al. Neuromyelitis optica spectrum disorders with aquaporin-4 and myelin-oligodendrocyte glycoprotein antibodies: a comparative study. JAMA Neurol (2014) 71:276-83. doi:10.1001/jamaneurol.2013.5857
    • (2014) JAMA Neurol , vol.71 , pp. 276-283
    • Kitley, J.1    Waters, P.2    Woodhall, M.3    Leite, M.I.4    Murchison, A.5    George, J.6
  • 240
    • 77249090731 scopus 로고    scopus 로고
    • Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice
    • Saadoun S, Waters P, Bell BA, Vincent A, Verkman AS, Papadopoulos MC. Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice. Brain (2010) 133:349-61. doi:10.1093/brain/awp309
    • (2010) Brain , vol.133 , pp. 349-361
    • Saadoun, S.1    Waters, P.2    Bell, B.A.3    Vincent, A.4    Verkman, A.S.5    Papadopoulos, M.C.6
  • 241
    • 84921689305 scopus 로고    scopus 로고
    • Neuromyelitis optica pathology in rats following intraperitoneal injection of NMO-IgG and intracerebral needle injury
    • Asavapanumas N, Verkman AS. Neuromyelitis optica pathology in rats following intraperitoneal injection of NMO-IgG and intracerebral needle injury. Acta Neuropathol Commun (2014) 2:48. doi:10.1186/2051-5960-2-48
    • (2014) Acta Neuropathol Commun , vol.2 , pp. 48
    • Asavapanumas, N.1    Verkman, A.S.2
  • 242
    • 84876426161 scopus 로고    scopus 로고
    • The ex vivo production of IL-6 and IL-21 by CD4+ T cells is directly associated with neurological disability in neuromyelitis optica patients
    • Linhares UC, Schiavoni PB, Barros PO, Kasahara TM, Teixeira B, Ferreira TB, et al. The ex vivo production of IL-6 and IL-21 by CD4+ T cells is directly associated with neurological disability in neuromyelitis optica patients. J Clin Immunol (2013) 33:179-89. doi:10.1007/s10875-012-9780-2
    • (2013) J Clin Immunol , vol.33 , pp. 179-189
    • Linhares, U.C.1    Schiavoni, P.B.2    Barros, P.O.3    Kasahara, T.M.4    Teixeira, B.5    Ferreira, T.B.6
  • 243
    • 80051864035 scopus 로고    scopus 로고
    • Increased T-cell immunity against aquaporin-4 and proteolipid protein in neuromyelitis optica
    • Matsuya N, Komori M, Nomura K, Nakane S, Fukudome T, Goto H, et al. Increased T-cell immunity against aquaporin-4 and proteolipid protein in neuromyelitis optica. Int Immunol (2011) 23:565-73. doi:10.1093/intimm/dxr056
    • (2011) Int Immunol , vol.23 , pp. 565-573
    • Matsuya, N.1    Komori, M.2    Nomura, K.3    Nakane, S.4    Fukudome, T.5    Goto, H.6
  • 244
    • 78751662679 scopus 로고    scopus 로고
    • Type 1 diabetes: etiology, immunology, and therapeutic strategies
    • Van Belle TL, Coppieters KT, von Herrath MG. Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol Rev (2011) 91:79-118. doi:10.1152/physrev.00003.2010
    • (2011) Physiol Rev , vol.91 , pp. 79-118
    • Van Belle, T.L.1    Coppieters, K.T.2    von Herrath, M.G.3
  • 245
    • 85047690395 scopus 로고    scopus 로고
    • Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health.
    • Arif S, Tree TI, Astill TP, Tremble JM, Bishop AJ, Dayan CM, et al. Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Invest (2004) 113(3):451-63. doi:10.1172/JCI19585
    • (2004) J Clin Invest , vol.113 , Issue.3 , pp. 451-463
    • Arif, S.1    Tree, T.I.2    Astill, T.P.3    Tremble, J.M.4    Bishop, A.J.5    Dayan, C.M.6
  • 246
    • 77958136352 scopus 로고    scopus 로고
    • Cutting edge: increased IL-17-secreting T cells in children with new-onset type 1 diabetes
    • Marwaha AK, Crome SQ, Panagiotopoulos C, Berg KB, Qin H, Ouyang Q, et al. Cutting edge: increased IL-17-secreting T cells in children with new-onset type 1 diabetes. J Immunol (2010) 185:3814-8. doi:10.4049/jimmunol.1001860
    • (2010) J Immunol , vol.185 , pp. 3814-3818
    • Marwaha, A.K.1    Crome, S.Q.2    Panagiotopoulos, C.3    Berg, K.B.4    Qin, H.5    Ouyang, Q.6
  • 248
    • 80755148666 scopus 로고    scopus 로고
    • Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes
    • Ferraro A, Socci C, Stabilini A, Valle A, Monti P, Piemonti L, et al. Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes. Diabetes (2011) 60:2903-13. doi:10.2337/db11-0090
    • (2011) Diabetes , vol.60 , pp. 2903-2913
    • Ferraro, A.1    Socci, C.2    Stabilini, A.3    Valle, A.4    Monti, P.5    Piemonti, L.6
  • 250
    • 12144249838 scopus 로고    scopus 로고
    • Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes
    • Lindley S, Dayan CM, Bishop A, Roep BO, Peakman M, Tree TI. Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes (2005) 54:92-9. doi:10.2337/diabetes.54.1.92
    • (2005) Diabetes , vol.54 , pp. 92-99
    • Lindley, S.1    Dayan, C.M.2    Bishop, A.3    Roep, B.O.4    Peakman, M.5    Tree, T.I.6
  • 251
    • 58149188480 scopus 로고    scopus 로고
    • The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells
    • Schneider A, Rieck M, Sanda S, Pihoker C, Greenbaum C, Buckner JH. The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells. J Immunol (2008) 181:7350-5. doi:10.4049/jimmunol.181.10.7350
    • (2008) J Immunol , vol.181 , pp. 7350-7355
    • Schneider, A.1    Rieck, M.2    Sanda, S.3    Pihoker, C.4    Greenbaum, C.5    Buckner, J.H.6
  • 252
    • 0035871763 scopus 로고    scopus 로고
    • Intermolecular antigen spreading occurs during the preclinical period of human type 1 diabetes
    • Brooks-Worrell B, Gersuk VH, Greenbaum C, Palmer JP. Intermolecular antigen spreading occurs during the preclinical period of human type 1 diabetes. J Immunol (2001) 166:5265-70. doi:10.4049/jimmunol.166.8.5265
    • (2001) J Immunol , vol.166 , pp. 5265-5270
    • Brooks-Worrell, B.1    Gersuk, V.H.2    Greenbaum, C.3    Palmer, J.P.4
  • 253
    • 0021019885 scopus 로고
    • Insulin antibodies in insulin-dependent diabetics before insulin treatment
    • Palmer JP, Asplin CM, Clemons P, Lyen K, Tatpati O, Raghu PK, et al. Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science (1983) 222:1337-9. doi:10.1126/science.6362005
    • (1983) Science , vol.222 , pp. 1337-1339
    • Palmer, J.P.1    Asplin, C.M.2    Clemons, P.3    Lyen, K.4    Tatpati, O.5    Raghu, P.K.6
  • 254
    • 23044455740 scopus 로고    scopus 로고
    • Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients
    • Toma A, Haddouk S, Briand J, Camoin L, Gahery H, Connan F, et al. Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients. Proc Natl Acad Sci U S A (2005) 102:10581-6. doi:10.1073/pnas.0504230102
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 10581-10586
    • Toma, A.1    Haddouk, S.2    Briand, J.3    Camoin, L.4    Gahery, H.5    Connan, F.6
  • 255
    • 0025141413 scopus 로고
    • Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes
    • Bonifacio E, Bingley PJ, Shattock M, Dean BM, Dunger D, Gale EA, et al. Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes. Lancet (1990) 335:147-9. doi:10.1016/0140-6736(90)90013-U
    • (1990) Lancet , vol.335 , pp. 147-149
    • Bonifacio, E.1    Bingley, P.J.2    Shattock, M.3    Dean, B.M.4    Dunger, D.5    Gale, E.A.6
  • 256
    • 0025039679 scopus 로고
    • Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
    • Baekkeskov S, Aanstoot HJ, Christgau S, Reetz A, Solimena M, Cascalho M, et al. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature (1990) 347:151-6. doi:10.1038/347151a0
    • (1990) Nature , vol.347 , pp. 151-156
    • Baekkeskov, S.1    Aanstoot, H.J.2    Christgau, S.3    Reetz, A.4    Solimena, M.5    Cascalho, M.6
  • 257
    • 0028801042 scopus 로고
    • Identification of protein tyrosine phosphatase-like IA2 (islet cell antigen 512) as the insulin-dependent diabetes-related 37/40K autoantigen and a target of islet-cell antibodies
    • Bonifacio E, Lampasona V, Genovese S, Ferrari M, Bosi E. Identification of protein tyrosine phosphatase-like IA2 (islet cell antigen 512) as the insulin-dependent diabetes-related 37/40K autoantigen and a target of islet-cell antibodies. J Immunol (1995) 155:5419-26.
    • (1995) J Immunol , vol.155 , pp. 5419-5426
    • Bonifacio, E.1    Lampasona, V.2    Genovese, S.3    Ferrari, M.4    Bosi, E.5
  • 258
    • 36749011882 scopus 로고    scopus 로고
    • The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
    • Wenzlau JM, Juhl K, Yu L, Moua O, Sarkar SA, Gottlieb P, et al. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci U S A (2007) 104:17040-5. doi:10.1073/pnas.0705894104
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 17040-17045
    • Wenzlau, J.M.1    Juhl, K.2    Yu, L.3    Moua, O.4    Sarkar, S.A.5    Gottlieb, P.6
  • 259
    • 0032701129 scopus 로고    scopus 로고
    • Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4
    • Peakman M, Stevens EJ, Lohmann T, Narendran P, Dromey J, Alexander A, et al. Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4. J Clin Invest (1999) 104:1449-57. doi:10.1172/JCI7936
    • (1999) J Clin Invest , vol.104 , pp. 1449-1457
    • Peakman, M.1    Stevens, E.J.2    Lohmann, T.3    Narendran, P.4    Dromey, J.5    Alexander, A.6
  • 260
    • 0035852674 scopus 로고    scopus 로고
    • Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65)
    • Nepom GT, Lippolis JD, White FM, Masewicz S, Marto JA, Herman A, et al. Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65). Proc Natl Acad Sci U S A (2001) 98:1763-8. doi:10.1073/pnas.98.4.1763
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 1763-1768
    • Nepom, G.T.1    Lippolis, J.D.2    White, F.M.3    Masewicz, S.4    Marto, J.A.5    Herman, A.6
  • 261
    • 0027534912 scopus 로고
    • Glutamic acid decarboxylase 67-reactive T cells: a marker of insulin-dependent diabetes
    • Honeyman MC, Cram DS, Harrison LC. Glutamic acid decarboxylase 67-reactive T cells: a marker of insulin-dependent diabetes. J Exp Med (1993) 177:535-40. doi:10.1084/jem.177.2.535
    • (1993) J Exp Med , vol.177 , pp. 535-540
    • Honeyman, M.C.1    Cram, D.S.2    Harrison, L.C.3
  • 262
    • 3242768392 scopus 로고    scopus 로고
    • GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes
    • Reijonen H, Mallone R, Heninger A, Laughlin EM, Kochik SA, Falk B, et al. GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes. Diabetes (2004) 53:1987-94. doi:10.2337/diabetes.53.8.1987
    • (2004) Diabetes , vol.53 , pp. 1987-1994
    • Reijonen, H.1    Mallone, R.2    Heninger, A.3    Laughlin, E.M.4    Kochik, S.A.5    Falk, B.6
  • 263
    • 79956218486 scopus 로고    scopus 로고
    • Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8
    • Dang M, Rockell J, Wagner R, Wenzlau JM, Yu L, Hutton JC, et al. Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8. J Immunol (2011) 186:6056-63. doi:10.4049/jimmunol.1003815
    • (2011) J Immunol , vol.186 , pp. 6056-6063
    • Dang, M.1    Rockell, J.2    Wagner, R.3    Wenzlau, J.M.4    Yu, L.5    Hutton, J.C.6
  • 264
    • 45249117656 scopus 로고    scopus 로고
    • Identification of novel IGRP epitopes targeted in type 1 diabetes patients
    • Jarchum I, Nichol L, Trucco M, Santamaria P, DiLorenzo TP. Identification of novel IGRP epitopes targeted in type 1 diabetes patients. Clin Immunol (2008) 127:359-65. doi:10.1016/j.clim.2008.01.015
    • (2008) Clin Immunol , vol.127 , pp. 359-365
    • Jarchum, I.1    Nichol, L.2    Trucco, M.3    Santamaria, P.4    DiLorenzo, T.P.5
  • 266
    • 36448978896 scopus 로고    scopus 로고
    • Type 1 diabetes as a relapsing-remitting disease?
    • von Herrath M, Sanda S, Herold K. Type 1 diabetes as a relapsing-remitting disease? Nat Rev Immunol (2007) 7:988-94. doi:10.1038/nri2192
    • (2007) Nat Rev Immunol , vol.7 , pp. 988-994
    • von Herrath, M.1    Sanda, S.2    Herold, K.3
  • 267
    • 0035888030 scopus 로고    scopus 로고
    • T cell activation in rheumatoid synovium is B cell dependent
    • Takemura S, Klimiuk PA, Braun A, Goronzy JJ, Weyand CM. T cell activation in rheumatoid synovium is B cell dependent. J Immunol (2001) 167:4710-8. doi:10.4049/jimmunol.167.8.4710
    • (2001) J Immunol , vol.167 , pp. 4710-4718
    • Takemura, S.1    Klimiuk, P.A.2    Braun, A.3    Goronzy, J.J.4    Weyand, C.M.5
  • 268
    • 0037255527 scopus 로고    scopus 로고
    • Clonal analysis of B cells in the synovial membrane of patients with rheumatoid arthritis
    • Shiokawa S, Matsumato N, Nishimura J. Clonal analysis of B cells in the synovial membrane of patients with rheumatoid arthritis. Scand J Rheumatol (2003) 32:12-8. doi:10.1080/03009740310000346
    • (2003) Scand J Rheumatol , vol.32 , pp. 12-18
    • Shiokawa, S.1    Matsumato, N.2    Nishimura, J.3
  • 269
    • 50249164315 scopus 로고    scopus 로고
    • Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis
    • Yamada H, Nakashima Y, Okazaki K, Mawatari T, Fukushi J, Kaibara N, et al. Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis. Ann Rheum Dis (2007) 67:1299-304. doi:10.1136/ard.2007.080341
    • (2007) Ann Rheum Dis , vol.67 , pp. 1299-1304
    • Yamada, H.1    Nakashima, Y.2    Okazaki, K.3    Mawatari, T.4    Fukushi, J.5    Kaibara, N.6
  • 271
    • 0032055597 scopus 로고    scopus 로고
    • IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages
    • Jovanovic DV, Di Battista JA, Martel-Pelletier J, Jolicoeur FC, He Y, Zhang M, et al. IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages. J Immunol (1998) 160:3513-21.
    • (1998) J Immunol , vol.160 , pp. 3513-3521
    • Jovanovic, D.V.1    Di Battista, J.A.2    Martel-Pelletier, J.3    Jolicoeur, F.C.4    He, Y.5    Zhang, M.6
  • 272
    • 78650764391 scopus 로고    scopus 로고
    • Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production
    • Van Hamburg JP, Asmawidjaja PS, Davelaar N, Mus AM, Colin EM, Hazes JM, et al. Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production. Arthritis Rheum (2011) 63:73-83. doi:10.1002/art.30093
    • (2011) Arthritis Rheum , vol.63 , pp. 73-83
    • Van Hamburg, J.P.1    Asmawidjaja, P.S.2    Davelaar, N.3    Mus, A.M.4    Colin, E.M.5    Hazes, J.M.6
  • 273
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy
    • Ehrenstein MR, Evans JG, Singh A, Moore S, Warnes G, Isenberg DA, et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med (2004) 200:277-85. doi:10.1084/jem.20040165
    • (2004) J Exp Med , vol.200 , pp. 277-285
    • Ehrenstein, M.R.1    Evans, J.G.2    Singh, A.3    Moore, S.4    Warnes, G.5    Isenberg, D.A.6
  • 276
    • 0034153473 scopus 로고    scopus 로고
    • Isolation and characteristics of autoreactive T cells specific to aggrecan G1 domain from rheumatoid arthritis patients
    • Li NL, Zhang DQ, Zhou KY, Cartman A, Leroux JY, Poole AR, et al. Isolation and characteristics of autoreactive T cells specific to aggrecan G1 domain from rheumatoid arthritis patients. Cell Res (2000) 10:39-49. doi:10.1038/sj.cr.7290034
    • (2000) Cell Res , vol.10 , pp. 39-49
    • Li, N.L.1    Zhang, D.Q.2    Zhou, K.Y.3    Cartman, A.4    Leroux, J.Y.5    Poole, A.R.6
  • 277
    • 0001248015 scopus 로고
    • An unusual protein component of high molecular weight in the serum of certain patients with rheumatoid arthritis
    • Franklin EC, Holman HR, Muller-Eberhard HJ, Kunkel HG. An unusual protein component of high molecular weight in the serum of certain patients with rheumatoid arthritis. J Exp Med (1957) 105:425-38. doi:10.1084/jem.105.5.425
    • (1957) J Exp Med , vol.105 , pp. 425-438
    • Franklin, E.C.1    Holman, H.R.2    Muller-Eberhard, H.J.3    Kunkel, H.G.4
  • 278
    • 0026730111 scopus 로고
    • Clinical significance of rheumatoid factors in early rheumatoid arthritis: results of a follow up study
    • Van Zeben D, Hazes JM, Zwinderman AH, Cats A, van der Voort EA, Breedveld FC. Clinical significance of rheumatoid factors in early rheumatoid arthritis: results of a follow up study. Ann Rheum Dis (1992) 51:1029-35. doi:10.1136/ard.51.9.1029
    • (1992) Ann Rheum Dis , vol.51 , pp. 1029-1035
    • Van Zeben, D.1    Hazes, J.M.2    Zwinderman, A.H.3    Cats, A.4    van der Voort, E.A.5    Breedveld, F.C.6
  • 279
    • 0028243235 scopus 로고
    • Antibodies to 65Kd heat-shock protein were elevated in rheumatoid arthritis
    • Oda A, Miyata M, Kodama E, Satoh H, Sato Y, Nishimaki T, et al. Antibodies to 65Kd heat-shock protein were elevated in rheumatoid arthritis. Clin Rheumatol (1994) 13:261-4.
    • (1994) Clin Rheumatol , vol.13 , pp. 261-264
    • Oda, A.1    Miyata, M.2    Kodama, E.3    Satoh, H.4    Sato, Y.5    Nishimaki, T.6
  • 280
    • 84876295703 scopus 로고    scopus 로고
    • Autoimmunity in rheumatoid arthritis: different antigens-common principles.
    • Trouw LA, Huizinga TW, Toes RE. Autoimmunity in rheumatoid arthritis: different antigens-common principles. Ann Rheum Dis (2013) 72(Suppl 2):ii132. doi:10.1136/annrheumdis-2012-202349
    • (2013) Ann Rheum Dis , vol.72 , pp. ii132
    • Trouw, L.A.1    Huizinga, T.W.2    Toes, R.E.3
  • 281
    • 84875750538 scopus 로고    scopus 로고
    • Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis
    • Brink M, Hansson M, Mathsson L, Jakobsson P, Holmdahl R, Hallmans G, et al. Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis. Arthritis Rheum (2013) 65:899-910. doi:10.1002/art.37835
    • (2013) Arthritis Rheum , vol.65 , pp. 899-910
    • Brink, M.1    Hansson, M.2    Mathsson, L.3    Jakobsson, P.4    Holmdahl, R.5    Hallmans, G.6
  • 282
    • 84877587255 scopus 로고    scopus 로고
    • Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition
    • Amara K, Steen J, Murray F, Morbach H, Fernandez-Rodriguez BM, Joshua V, et al. Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition. J Exp Med (2013) 210:445-55. doi:10.1084/jem.20121486
    • (2013) J Exp Med , vol.210 , pp. 445-455
    • Amara, K.1    Steen, J.2    Murray, F.3    Morbach, H.4    Fernandez-Rodriguez, B.M.5    Joshua, V.6
  • 283
    • 77955464379 scopus 로고    scopus 로고
    • Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis
    • Van der Woude D, Rantapaa-Dahlqvist S, Ioan-Facsinay A, Onnekink C, Schwarte CM, Verpoort KN, et al. Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis. Ann Rheum Dis (2010) 69:1554-61. doi:10.1136/ard.2009.124537
    • (2010) Ann Rheum Dis , vol.69 , pp. 1554-1561
    • Van der Woude, D.1    Rantapaa-Dahlqvist, S.2    Ioan-Facsinay, A.3    Onnekink, C.4    Schwarte, C.M.5    Verpoort, K.N.6
  • 284
    • 33645511657 scopus 로고    scopus 로고
    • Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis
    • Kuhn KA, Kulik L, Tomooka B, Braschler KJ, Arend WP, Robinson WH, et al. Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J Clin Invest (2006) 116:961-73. doi:10.1172/JCI25422
    • (2006) J Clin Invest , vol.116 , pp. 961-973
    • Kuhn, K.A.1    Kulik, L.2    Tomooka, B.3    Braschler, K.J.4    Arend, W.P.5    Robinson, W.H.6
  • 285
    • 67650065027 scopus 로고    scopus 로고
    • Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways
    • Trouw LA, Haisma EM, Levarht EW, van der Woude D, Ioan-Facsinay A, Daha MR, et al. Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways. Arthritis Rheum (2009) 60:1923-31. doi:10.1002/art.24622
    • (2009) Arthritis Rheum , vol.60 , pp. 1923-1931
    • Trouw, L.A.1    Haisma, E.M.2    Levarht, E.W.3    van der Woude, D.4    Ioan-Facsinay, A.5    Daha, M.R.6
  • 286
    • 80054806901 scopus 로고    scopus 로고
    • Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage
    • Shi J, Knevel R, Suwannalai P, van der Linden MP, Janssen GM, van Veelen PA, et al. Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage. Proc Natl Acad Sci U S A (2011) 108:17372-7. doi:10.1073/pnas.1114465108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 17372-17377
    • Shi, J.1    Knevel, R.2    Suwannalai, P.3    van der Linden, M.P.4    Janssen, G.M.5    van Veelen, P.A.6
  • 287
    • 84879848482 scopus 로고    scopus 로고
    • Autoantibodies to posttranslationally modified type II collagen as potential biomarkers for rheumatoid arthritis
    • Strollo R, Ponchel F, Malmström V, Rizzo P, Bombardieri M, Wenham CY, et al. Autoantibodies to posttranslationally modified type II collagen as potential biomarkers for rheumatoid arthritis. Arthritis Rheum (2013) 65:1702-12. doi:10.1002/art.37964
    • (2013) Arthritis Rheum , vol.65 , pp. 1702-1712
    • Strollo, R.1    Ponchel, F.2    Malmström, V.3    Rizzo, P.4    Bombardieri, M.5    Wenham, C.Y.6
  • 288
    • 0022921770 scopus 로고
    • Collagen antibodies in rheumatoid arthritis. Significance of antibodies to denatured collagen and their association with HLA-DR4.
    • Rowley M, Tait B, Mackay IR, Cunningham T, Phillips B. Collagen antibodies in rheumatoid arthritis. Significance of antibodies to denatured collagen and their association with HLA-DR4. Arthritis Rheum (1986) 29:174-84. doi:10.1002/art.1780290204
    • (1986) Arthritis Rheum , vol.29 , pp. 174-184
    • Rowley, M.1    Tait, B.2    Mackay, I.R.3    Cunningham, T.4    Phillips, B.5
  • 289
    • 79960360564 scopus 로고    scopus 로고
    • Autoantibodies associated with diseases of the CNS: new developments and future challenges
    • Vincent A, Bien CG, Irani SR, Waters P. Autoantibodies associated with diseases of the CNS: new developments and future challenges. Lancet Neurol (2011) 10:759-72. doi:10.1016/S1474-4422(11)70096-5
    • (2011) Lancet Neurol , vol.10 , pp. 759-772
    • Vincent, A.1    Bien, C.G.2    Irani, S.R.3    Waters, P.4
  • 290
    • 84904823530 scopus 로고    scopus 로고
    • Acute mechanisms underlying antibody effects in anti-N-methyl-D-aspartate receptor encephalitis
    • Moscato EH, Peng X, Jain A, Parsons TD, Dalmau J, Balice-Gordon RJ. Acute mechanisms underlying antibody effects in anti-N-methyl-D-aspartate receptor encephalitis. Ann Neurol (2014) 76:108-19. doi:10.1002/ana.24195
    • (2014) Ann Neurol , vol.76 , pp. 108-119
    • Moscato, E.H.1    Peng, X.2    Jain, A.3    Parsons, T.D.4    Dalmau, J.5    Balice-Gordon, R.J.6
  • 291
    • 33846809197 scopus 로고    scopus 로고
    • Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma
    • Dalmau J, Tüzün E, Wu H, Masjuan J, Rossi JE, Voloschin A, et al. Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol (2007) 61:25-36. doi:10.1002/ana.21050
    • (2007) Ann Neurol , vol.61 , pp. 25-36
    • Dalmau, J.1    Tüzün, E.2    Wu, H.3    Masjuan, J.4    Rossi, J.E.5    Voloschin, A.6
  • 292
    • 71449110008 scopus 로고    scopus 로고
    • Evidence for antibody-mediated pathogenesis in anti-NMDAR encephalitis associated with ovarian teratoma
    • Tüzün E, Zhou L, Baehring JM, Bannykh S, Rosenfeld MR, Dalmau J. Evidence for antibody-mediated pathogenesis in anti-NMDAR encephalitis associated with ovarian teratoma. Acta Neuropathol (2009) 118:737-43. doi:10.1007/s00401-009-0582-4
    • (2009) Acta Neuropathol , vol.118 , pp. 737-743
    • Tüzün, E.1    Zhou, L.2    Baehring, J.M.3    Bannykh, S.4    Rosenfeld, M.R.5    Dalmau, J.6
  • 293
    • 0031667162 scopus 로고    scopus 로고
    • T-cell receptor analysis in anti-Hu associated paraneoplastic encephalomyelitis
    • Voltz R, Dalmau J, Posner JB, Rosenfeld MR. T-cell receptor analysis in anti-Hu associated paraneoplastic encephalomyelitis. Neurology (1998) 51:1146-50. doi:10.1212/WNL.51.4.1146
    • (1998) Neurology , vol.51 , pp. 1146-1150
    • Voltz, R.1    Dalmau, J.2    Posner, J.B.3    Rosenfeld, M.R.4
  • 294
    • 68449095394 scopus 로고    scopus 로고
    • Patients with lung cancer and paraneoplastic Hu syndrome harbor HuD-specific type 2 CD8+ T cells
    • Roberts WK, Deluca IJ, Thomas A, Fak J, Williams T, Buckley N, et al. Patients with lung cancer and paraneoplastic Hu syndrome harbor HuD-specific type 2 CD8+ T cells. J Clin Invest (2009) 119:2042-51. doi:10.1172/JCI36131
    • (2009) J Clin Invest , vol.119 , pp. 2042-2051
    • Roberts, W.K.1    Deluca, I.J.2    Thomas, A.3    Fak, J.4    Williams, T.5    Buckley, N.6
  • 295
    • 13844276121 scopus 로고    scopus 로고
    • Analysis of eluted peptides from type 1 diabetes-susceptible HLA class II molecules identified novel islet protein, heparin/heparan sulfate-interacting protein
    • Nakanishi K, Komatsu Y, Kogawa N, Matsushita H. Analysis of eluted peptides from type 1 diabetes-susceptible HLA class II molecules identified novel islet protein, heparin/heparan sulfate-interacting protein. Biochem Biophys Res Commun (2005) 329:356-61. doi:10.1016/j.bbrc.2005.01.144
    • (2005) Biochem Biophys Res Commun , vol.329 , pp. 356-361
    • Nakanishi, K.1    Komatsu, Y.2    Kogawa, N.3    Matsushita, H.4
  • 296
    • 84861216903 scopus 로고    scopus 로고
    • Autoantigen conformation influences both B- and T-cell responses and encephalitogenicity
    • De Graaf KL, Albert M, Weissert R. Autoantigen conformation influences both B- and T-cell responses and encephalitogenicity. J Biol Chem (2012) 287:17206-13. doi:10.1074/jbc.M111.304246
    • (2012) J Biol Chem , vol.287 , pp. 17206-17213
    • De Graaf, K.L.1    Albert, M.2    Weissert, R.3
  • 297
    • 0024829522 scopus 로고
    • HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region
    • Wordsworth BP, Lanchbury JS, Sakkas LI, Welsh KI, Panayi GS, Bell JI. HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region. Proc Natl Acad Sci U S A (1989) 86:10049-53. doi:10.1073/pnas.86.24.10049
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 10049-10053
    • Wordsworth, B.P.1    Lanchbury, J.S.2    Sakkas, L.I.3    Welsh, K.I.4    Panayi, G.S.5    Bell, J.I.6
  • 298
    • 0024555080 scopus 로고
    • HLA genes associated with rheumatoid arthritis. Identification of susceptibility alleles using specific oligonucleotide probes.
    • Nepom GT, Byers P, Seyfried C, Healey LA, Wilske KR, Stage D, et al. HLA genes associated with rheumatoid arthritis. Identification of susceptibility alleles using specific oligonucleotide probes. Arthritis Rheum (1989) 32:15-21. doi:10.1002/anr.1780320104
    • (1989) Arthritis Rheum , vol.32 , pp. 15-21
    • Nepom, G.T.1    Byers, P.2    Seyfried, C.3    Healey, L.A.4    Wilske, K.R.5    Stage, D.6
  • 299
    • 0027427790 scopus 로고
    • A shared HLA-DRB1 sequence confers RA susceptibility in Greeks
    • Carthy D, Ollier W, Papasteriades C, Pappas H, Thomson W. A shared HLA-DRB1 sequence confers RA susceptibility in Greeks. Eur J Immunogenet (1993) 20:391-8. doi:10.1111/j.1744-313X.1993.tb00158.x
    • (1993) Eur J Immunogenet , vol.20 , pp. 391-398
    • Carthy, D.1    Ollier, W.2    Papasteriades, C.3    Pappas, H.4    Thomson, W.5
  • 300
    • 3242713277 scopus 로고    scopus 로고
    • A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis
    • Begovich AB, Carlton VE, Honigberg LA, Schrodi SJ, Chokkalingam AP, Alexander HC, et al. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet (2004) 75:330-7. doi:10.1086/422827
    • (2004) Am J Hum Genet , vol.75 , pp. 330-337
    • Begovich, A.B.1    Carlton, V.E.2    Honigberg, L.A.3    Schrodi, S.J.4    Chokkalingam, A.P.5    Alexander, H.C.6
  • 301
    • 0034777837 scopus 로고    scopus 로고
    • A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins
    • Cucca F, Lampis R, Congia M, Angius E, Nutland S, Bain SC, et al. A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins. Hum Mol Genet (2001) 10:2025-37. doi:10.1093/hmg/10.19.2025
    • (2001) Hum Mol Genet , vol.10 , pp. 2025-2037
    • Cucca, F.1    Lampis, R.2    Congia, M.3    Angius, E.4    Nutland, S.5    Bain, S.C.6
  • 302
    • 0023252262 scopus 로고
    • HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus
    • Todd JA, Bell JI, McDevitt HO. HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature (1987) 329:599-604. doi:10.1038/329599a0
    • (1987) Nature , vol.329 , pp. 599-604
    • Todd, J.A.1    Bell, J.I.2    McDevitt, H.O.3
  • 303
    • 12144291502 scopus 로고    scopus 로고
    • A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
    • Bottini N, Musumeci L, Alonso A, Rahmouni S, Nika K, Rostamkhani M, et al. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet (2004) 36:337-8. doi:10.1038/ng1323
    • (2004) Nat Genet , vol.36 , pp. 337-338
    • Bottini, N.1    Musumeci, L.2    Alonso, A.3    Rahmouni, S.4    Nika, K.5    Rostamkhani, M.6
  • 304
    • 20244373351 scopus 로고    scopus 로고
    • Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms
    • Vella A, Cooper JD, Lowe CE, Walker N, Nutland S, Widmer B, et al. Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. Am J Hum Genet (2005) 76:773-9. doi:10.1086/429843
    • (2005) Am J Hum Genet , vol.76 , pp. 773-779
    • Vella, A.1    Cooper, J.D.2    Lowe, C.E.3    Walker, N.4    Nutland, S.5    Widmer, B.6
  • 306
    • 33745240931 scopus 로고    scopus 로고
    • A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region
    • Smyth DJ, Cooper JD, Bailey R, Field S, Burren O, Smink LJ, et al. A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet (2006) 38:617-9. doi:10.1038/ng1800
    • (2006) Nat Genet , vol.38 , pp. 617-619
    • Smyth, D.J.1    Cooper, J.D.2    Bailey, R.3    Field, S.4    Burren, O.5    Smink, L.J.6
  • 307
    • 34347341846 scopus 로고    scopus 로고
    • Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
    • Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet (2007) 39:857-64. doi:10.1038/ng2068
    • (2007) Nat Genet , vol.39 , pp. 857-864
    • Todd, J.A.1    Walker, N.M.2    Cooper, J.D.3    Smyth, D.J.4    Downes, K.5    Plagnol, V.6
  • 308
    • 3042698329 scopus 로고    scopus 로고
    • Remapping the insulin gene/IDDM2 locus in type 1 diabetes
    • Barratt BJ, Payne F, Lowe CE, Hermann R, Healy BC, Harold D, et al. Remapping the insulin gene/IDDM2 locus in type 1 diabetes. Diabetes (2004) 53:1884-9. doi:10.2337/diabetes.53.7.1884
    • (2004) Diabetes , vol.53 , pp. 1884-1889
    • Barratt, B.J.1    Payne, F.2    Lowe, C.E.3    Hermann, R.4    Healy, B.C.5    Harold, D.6
  • 309
    • 58149231390 scopus 로고    scopus 로고
    • Association of the HLA-DPB1*0501 allele with anti-aquaporin-4 antibody positivity in Japanese patients with idiopathic central nervous system demyelinating disorders
    • Matsushita T, Matsuoka T, Isobe N, Kawano Y, Minohara M, Shi N, et al. Association of the HLA-DPB1*0501 allele with anti-aquaporin-4 antibody positivity in Japanese patients with idiopathic central nervous system demyelinating disorders. Tissue Antigens (2009) 73:171-6. doi:10.1111/j.1399-0039.2008.01172.x
    • (2009) Tissue Antigens , vol.73 , pp. 171-176
    • Matsushita, T.1    Matsuoka, T.2    Isobe, N.3    Kawano, Y.4    Minohara, M.5    Shi, N.6
  • 310
    • 65449158482 scopus 로고    scopus 로고
    • Is neuromyelitis optica associated with human leukocyte antigen?
    • Zephir H, Fajardy I, Outteryck O, Blanc F, Roger N, Fleury M, et al. Is neuromyelitis optica associated with human leukocyte antigen? Mult Scler (2009) 15:571-9. doi:10.1177/1352458508102085
    • (2009) Mult Scler , vol.15 , pp. 571-579
    • Zephir, H.1    Fajardy, I.2    Outteryck, O.3    Blanc, F.4    Roger, N.5    Fleury, M.6
  • 312
    • 0036042848 scopus 로고    scopus 로고
    • Multiple MAG peptides are recognized by circulating T and B lymphocytes in polyneuropathy and multiple sclerosis
    • Andersson M, Yu M, Söderström M, Weerth S, Baig S, Solders G, et al. Multiple MAG peptides are recognized by circulating T and B lymphocytes in polyneuropathy and multiple sclerosis. Eur J Neurol (2002) 9:243-51. doi:10.1046/j.1468-1331.2002.00391.x
    • (2002) Eur J Neurol , vol.9 , pp. 243-251
    • Andersson, M.1    Yu, M.2    Söderström, M.3    Weerth, S.4    Baig, S.5    Solders, G.6
  • 313
    • 3142781394 scopus 로고    scopus 로고
    • The myelin-associated oligodendrocytic basic protein region MOBP15-36 encompasses the immunodominant major encephalitogenic epitope(s) for SJL/J mice and predicted epitope(s) for multiple sclerosis-associated HLA-DRB1*501
    • Kerlero de Rosbo N, Kaye JF, Eisenstein M, Mendel I, Hoeftberger R, Lassmann H, et al. The myelin-associated oligodendrocytic basic protein region MOBP15-36 encompasses the immunodominant major encephalitogenic epitope(s) for SJL/J mice and predicted epitope(s) for multiple sclerosis-associated HLA-DRB1*1501. J Immunol (2004) 173:1426-35. doi:10.4049/jimmunol.173.2.1426
    • (2004) J Immunol , vol.173 , pp. 1426-1435
    • Kerlero de Rosbo, N.1    Kaye, J.F.2    Eisenstein, M.3    Mendel, I.4    Hoeftberger, R.5    Lassmann, H.6
  • 314
    • 0036709641 scopus 로고    scopus 로고
    • T cell response to 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in multiple sclerosis patients
    • Muraro PA, Kalbus M, Afshar G, McFarland HF, Martin R. T cell response to 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in multiple sclerosis patients. J Neuroimmunol (2002) 130:233-42. doi:10.1016/S0165-5728(02)00229-1
    • (2002) J Neuroimmunol , vol.130 , pp. 233-242
    • Muraro, P.A.1    Kalbus, M.2    Afshar, G.3    McFarland, H.F.4    Martin, R.5
  • 315
    • 0030861145 scopus 로고    scopus 로고
    • Multiple sclerosis: comparison of the human T-cell response to S100 beta and myelin basic protein reveals parallels to rat experimental autoimmune panencephalitis
    • Schmidt S, Linington C, Zipp F, Sotgiu S, de Waal Malefyt R, Wekerle H, et al. Multiple sclerosis: comparison of the human T-cell response to S100 beta and myelin basic protein reveals parallels to rat experimental autoimmune panencephalitis. Brain (1997) 120:1437-45. doi:10.1093/brain/120.8.1437
    • (1997) Brain , vol.120 , pp. 1437-1445
    • Schmidt, S.1    Linington, C.2    Zipp, F.3    Sotgiu, S.4    de Waal Malefyt, R.5    Wekerle, H.6
  • 316
    • 0027988539 scopus 로고
    • Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis
    • Banki K, Colombo E, Sia F, Halladay D, Mattson DH, Tatum AH, et al. Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis. J Exp Med (1994) 180:1649-63. doi:10.1084/jem.180.5.1649
    • (1994) J Exp Med , vol.180 , pp. 1649-1663
    • Banki, K.1    Colombo, E.2    Sia, F.3    Halladay, D.4    Mattson, D.H.5    Tatum, A.H.6
  • 317
    • 84861855230 scopus 로고    scopus 로고
    • Anti-LRP4 autoantibodies in AChR- and MuSK-antibody-negative myasthenia gravis
    • Pevzner A, Schoser B, Peters K, Cosma N, Karakatsani A, Schalke B, et al. Anti-LRP4 autoantibodies in AChR- and MuSK-antibody-negative myasthenia gravis. J Neurol (2012) 259:427-35. doi:10.1007/s00415-011-6194-7
    • (2012) J Neurol , vol.259 , pp. 427-435
    • Pevzner, A.1    Schoser, B.2    Peters, K.3    Cosma, N.4    Karakatsani, A.5    Schalke, B.6
  • 318
    • 84894261654 scopus 로고    scopus 로고
    • Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a case series, characterisation of the antigen, and analysis of the effects of antibodies
    • Petit-Pedrol M, Armangue T, Peng X, Bataller L, Cellucci T, Davis R, et al. Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a case series, characterisation of the antigen, and analysis of the effects of antibodies. Lancet Neurol (2014) 13:276-86. doi:10.1016/S1474-4422(13)70299-0
    • (2014) Lancet Neurol , vol.13 , pp. 276-286
    • Petit-Pedrol, M.1    Armangue, T.2    Peng, X.3    Bataller, L.4    Cellucci, T.5    Davis, R.6
  • 319
    • 84873339590 scopus 로고    scopus 로고
    • Encephalitis and antibodies to dipeptidyl-peptidase-like protein-6, a subunit of Kv4.2 potassium channels
    • Boronat A, Gelfand JM, Gresa-Arribas N, Jeong H, Walsh M, Roberts K, et al. Encephalitis and antibodies to dipeptidyl-peptidase-like protein-6, a subunit of Kv4.2 potassium channels. Ann Neurol (2013) 73:120-8. doi:10.1002/ana.23756
    • (2013) Ann Neurol , vol.73 , pp. 120-128
    • Boronat, A.1    Gelfand, J.M.2    Gresa-Arribas, N.3    Jeong, H.4    Walsh, M.5    Roberts, K.6
  • 321
    • 0026547716 scopus 로고
    • Anti-Hu-associated paraneoplastic encephalomyelitis/sensory neuronopathy. A clinical study of 71 patients
    • Dalmau J, Graus F, Rosenblum MK, Posner JB. Anti-Hu-associated paraneoplastic encephalomyelitis/sensory neuronopathy. A clinical study of 71 patients. Medicine (1992) 71:59-72. doi:10.1097/00005792-199203000-00001
    • (1992) Medicine , vol.71 , pp. 59-72
    • Dalmau, J.1    Graus, F.2    Rosenblum, M.K.3    Posner, J.B.4
  • 322
    • 0037105989 scopus 로고    scopus 로고
    • Cytotoxic T cell activity against peptides of Hu protein in anti-Hu syndrome
    • Tanaka M, Maruyama Y, Sugie M, Motizuki H, Kamakura K, Tanaka K. Cytotoxic T cell activity against peptides of Hu protein in anti-Hu syndrome. J Neurol Sci (2002) 201:9-12. doi:10.1016/S0022-510X(02)00157-0
    • (2002) J Neurol Sci , vol.201 , pp. 9-12
    • Tanaka, M.1    Maruyama, Y.2    Sugie, M.3    Motizuki, H.4    Kamakura, K.5    Tanaka, K.6
  • 323
    • 0021049118 scopus 로고
    • Antibodies to cerebellar Purkinje cells in patients with paraneoplastic cerebellar degeneration and ovarian carcinoma
    • Greenlee JE, Brashear HR. Antibodies to cerebellar Purkinje cells in patients with paraneoplastic cerebellar degeneration and ovarian carcinoma. Ann Neurol (1983) 14:609-13. doi:10.1002/ana.410140603
    • (1983) Ann Neurol , vol.14 , pp. 609-613
    • Greenlee, J.E.1    Brashear, H.R.2
  • 324
    • 0022240863 scopus 로고
    • Autoimmune response of patients with paraneoplastic cerebellar degeneration to a Purkinje cell cytoplasmic protein antigen
    • Jaeckle KA, Graus F, Houghton A, Cardon-Cardo C, Nielsen SL, Posner JB. Autoimmune response of patients with paraneoplastic cerebellar degeneration to a Purkinje cell cytoplasmic protein antigen. Ann Neurol (1985) 18:592-600. doi:10.1002/ana.410180513
    • (1985) Ann Neurol , vol.18 , pp. 592-600
    • Jaeckle, K.A.1    Graus, F.2    Houghton, A.3    Cardon-Cardo, C.4    Nielsen, S.L.5    Posner, J.B.6
  • 325
    • 0026071720 scopus 로고
    • Anti-Ri: an antibody associated with paraneoplastic opsoclonus and breast cancer
    • Luque FA, Furneaux HM, Ferziger R, Rosenblum MK, Wray SH, Schold SC, et al. Anti-Ri: an antibody associated with paraneoplastic opsoclonus and breast cancer. Ann Neurol (1991) 29:241-51. doi:10.1002/ana.410290303
    • (1991) Ann Neurol , vol.29 , pp. 241-251
    • Luque, F.A.1    Furneaux, H.M.2    Ferziger, R.3    Rosenblum, M.K.4    Wray, S.H.5    Schold, S.C.6
  • 326
    • 0032957526 scopus 로고    scopus 로고
    • Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders
    • Dalmau J, Gultekin SH, Voltz R, Hoard R, DesChamps T, Balmaceda C, et al. Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders. Brain (1999) 122:27-39. doi:10.1093/brain/122.1.27
    • (1999) Brain , vol.122 , pp. 27-39
    • Dalmau, J.1    Gultekin, S.H.2    Voltz, R.3    Hoard, R.4    DesChamps, T.5    Balmaceda, C.6
  • 328
    • 1542316169 scopus 로고    scopus 로고
    • Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer
    • Bataller L, Wade DF, Graus F, Stacey HD, Rosenfeld MR, Dalmau J. Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer. Neurology (2004) 62:778-82. doi:10.1212/01.WNL.0000113749.77217.01
    • (2004) Neurology , vol.62 , pp. 778-782
    • Bataller, L.1    Wade, D.F.2    Graus, F.3    Stacey, H.D.4    Rosenfeld, M.R.5    Dalmau, J.6
  • 329
    • 0028232762 scopus 로고
    • Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus
    • Kim J, Namchuk M, Bugawan T, Fu Q, Jaffe M, Shi Y, et al. Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus. J Exp Med (1994) 180:595-606. doi:10.1084/jem.180.2.595
    • (1994) J Exp Med , vol.180 , pp. 595-606
    • Kim, J.1    Namchuk, M.2    Bugawan, T.3    Fu, Q.4    Jaffe, M.5    Shi, Y.6
  • 330
    • 60249088084 scopus 로고    scopus 로고
    • CRMP5 antibodies found in a patient with limbic encephalitis and myasthenia gravis
    • Monstad SE, Nøstbakken JK, Vedeler CA. CRMP5 antibodies found in a patient with limbic encephalitis and myasthenia gravis. J Neurol Neurosurg Psychiatry (2009) 80:241-2. doi:10.1136/jnnp.2008.149336
    • (2009) J Neurol Neurosurg Psychiatry , vol.80 , pp. 241-242
    • Monstad, S.E.1    Nøstbakken, J.K.2    Vedeler, C.A.3
  • 331
    • 0032980492 scopus 로고    scopus 로고
    • Antiamphiphysin antibodies are associated with various paraneoplastic neurological syndromes and tumors
    • Antoine JC, Absi L, Honnorat J, Boulesteix JM, de Brouker T, Vial C, et al. Antiamphiphysin antibodies are associated with various paraneoplastic neurological syndromes and tumors. Arch Neurol (1999) 56:172-7. doi:10.1001/archneur.56.2.172
    • (1999) Arch Neurol , vol.56 , pp. 172-177
    • Antoine, J.C.1    Absi, L.2    Honnorat, J.3    Boulesteix, J.M.4    de Brouker, T.5    Vial, C.6
  • 332
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
    • Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol (1986) 136:2348-57.
    • (1986) J Immunol , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 333
    • 0034716925 scopus 로고    scopus 로고
    • Regulatory T cells: key controllers of immunologic self-tolerance.
    • Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell (2000) 101:455-8. doi:10.1016/S0092-8674(00)80856-9
    • (2000) Cell , vol.101 , pp. 455-458
    • Sakaguchi, S.1
  • 334
    • 0037059462 scopus 로고    scopus 로고
    • Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
    • Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science (2002) 295:338-42. doi:10.1126/science.1065543
    • (2002) Science , vol.295 , pp. 338-342
    • Szabo, S.J.1    Sullivan, B.M.2    Stemmann, C.3    Satoskar, A.R.4    Sleckman, B.P.5    Glimcher, L.H.6
  • 335
    • 0342656166 scopus 로고    scopus 로고
    • The immune system. First of two parts.
    • Delves PJ, Roitt IM. The immune system. First of two parts. N Engl J Med (2000) 343:37-49. doi:10.1056/NEJM200007063430107
    • (2000) N Engl J Med , vol.343 , pp. 37-49
    • Delves, P.J.1    Roitt, I.M.2
  • 336
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • Zheng W, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell (1997) 89:587-96. doi:10.1016/S0092-8674(00)80240-8
    • (1997) Cell , vol.89 , pp. 587-596
    • Zheng, W.1    Flavell, R.A.2
  • 337
    • 45749101727 scopus 로고    scopus 로고
    • Induction and effector functions of T(H)17 cells
    • Bettelli E, Korn T, Oukka M, Kuchroo VK. Induction and effector functions of T(H)17 cells. Nature (2008) 453:1051-7. doi:10.1038/nature07036
    • (2008) Nature , vol.453 , pp. 1051-1057
    • Bettelli, E.1    Korn, T.2    Oukka, M.3    Kuchroo, V.K.4
  • 338
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, et al. The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 126:1121-33. doi:10.1016/j.cell.2006.07.035
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3    Tadokoro, C.E.4    Lepelley, A.5    Lafaille, J.J.6
  • 339
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 299:1057-61. doi:10.1126/science.1079490
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 340
    • 56349093347 scopus 로고    scopus 로고
    • IL-4 inhibits TGF-ß-induced Foxp3+ T cells and, together with TGF-ß, generates IL-9+ IL-10+ Foxp3- effector T cells
    • Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, Sobel RA, et al. IL-4 inhibits TGF-ß-induced Foxp3+ T cells and, together with TGF-ß, generates IL-9+ IL-10+ Foxp3- effector T cells. Nat Immunol (2008) 9:1347-55. doi:10.1038/ni.1677
    • (2008) Nat Immunol , vol.9 , pp. 1347-1355
    • Dardalhon, V.1    Awasthi, A.2    Kwon, H.3    Galileos, G.4    Gao, W.5    Sobel, R.A.6
  • 341
    • 77952584843 scopus 로고    scopus 로고
    • The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation
    • Chang H, Sehra S, Goswami R, Yao W, Yu Q, Stritesky GL, et al. The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat Immunol (2010) 11:527-34. doi:10.1038/ni.1867
    • (2010) Nat Immunol , vol.11 , pp. 527-534
    • Chang, H.1    Sehra, S.2    Goswami, R.3    Yao, W.4    Yu, Q.5    Stritesky, G.L.6
  • 342
    • 56349154943 scopus 로고    scopus 로고
    • Transforming growth factor-ß 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    • Veldhoen M, Uyttenhove C, van Snick J, Helmby H, Westendorf A, Buer J, et al. Transforming growth factor-ß 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol (2008) 9:1341-6. doi:10.1038/ni.1659
    • (2008) Nat Immunol , vol.9 , pp. 1341-1346
    • Veldhoen, M.1    Uyttenhove, C.2    van Snick, J.3    Helmby, H.4    Westendorf, A.5    Buer, J.6
  • 343
    • 84928584195 scopus 로고    scopus 로고
    • The development and in vivo function of T helper 9 cells
    • Kaplan MH, Hufford MM, Olson MR. The development and in vivo function of T helper 9 cells. Nat Rev Immunol (2015) 15:295-307. doi:10.1038/nri3824
    • (2015) Nat Rev Immunol , vol.15 , pp. 295-307
    • Kaplan, M.H.1    Hufford, M.M.2    Olson, M.R.3
  • 344
    • 77956469491 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells
    • Ramirez J, Brembilla NC, Sorg O, Chicheportiche R, Matthes T, Dayer J, et al. Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells. Eur J Immunol (2010) 40:2450-9. doi:10.1002/eji.201040461
    • (2010) Eur J Immunol , vol.40 , pp. 2450-2459
    • Ramirez, J.1    Brembilla, N.C.2    Sorg, O.3    Chicheportiche, R.4    Matthes, T.5    Dayer, J.6


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