The switch between relapse and remission in multiple sclerosis: Continuous inflammatory response balanced by Th1 suppression and neurotrophic factors

Journal of Neuroimmunology

Volumn 252, Issue 1-2, 2012, Pages 83-88

  Gurevich, Michael ^a   Achiron, Anat ^a,b  

^a SHEBA MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Acute relapse; Gene expression; Multiple sclerosis; Peripheral blood; Remission

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GELATINASE B; INTERLEUKIN 8; NEUROTROPHIC FACTOR; TRANSCRIPTION FACTOR T BET;

ADULT; ARTICLE; BLOOD; CONTROLLED STUDY; FEMALE; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; MULTIPLE SCLEROSIS; NEUROPROTECTION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RELAPSE; REMISSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TH1 CELL;

ADULT; FEMALE; HUMANS; INFLAMMATION; MALE; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; NERVE GROWTH FACTORS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECURRENCE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TH1 CELLS; TRANSCRIPTOME;

EID: 84867142342     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2012.07.014     Document Type: Article

References (44)

1. Achiron A., Gurevich M., Friedman N., Kaminski N., Mandel M. Blood transcriptional signatures of multiple sclerosis: unique gene expression of disease activity. Ann. Neurol. 2004, 55:410-417.
2. Achiron A., Feldman A., Mandel M., Gurevich M. Impaired expression of peripheral blood apoptotic-related gene transcripts in acute multiple sclerosis relapse. Ann. N. Y. Acad. Sci. 2007, 1107:155-167.
3. Alt C., Laschinger M., Engelhardt B. Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis. Eur. J. Immunol. 2002, 32:2133-2144.
4. Arthur A.T., Armati P.J., Bye C., Heard R.N., Stewart G.J., Pollard J.D., Booth D.R. Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission. BMC Med. Genet. 2008, 9:17.
5. Banisor I., Leist T.P., Kalman B. Involvement of beta-chemokines in the development of inflammatory demyelination. J. Neuroinflammation 2005, 2:7.
6. Bettelli E., Sullivan B., Szabo S.J., Sobel R.A., Glimcher L.H., Kuchroo V.K. Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J. Exp. Med. 2004, 200:79-87.
7. Biernacki K., Prat A., Blain M., Antel J.P. Regulation of cellular and molecular trafficking across human brain endothelial cells by Th1- and Th2-polarized lymphocytes. J. Neuropathol. Exp. Neurol. 2004, 63:223-232.
8. Chen M.C., Hsu T.L., Luh T.Y., Hsieh S.L. Overexpression of bcl-2 enhances LIGHT- and interferon-gamma-mediated apoptosis in Hep3BT2 cells. J. Biol. Chem. 2000, 275:38794-38801.
9. De Santi L., Annunziata P., Sessa E., Bramanti P. Brain-derived neurotrophic factor and TrkB receptor in experimental autoimmune encephalomyelitis and multiple sclerosis. J. Neurol. Sci. 2009, 287:17-26.
10. Engelhardt B. Molecular mechanisms involved in T cell migration across the blood-brain barrier. J. Neural Transm. 2006, 113:477-485.
11. Frisullo G., Nociti V., Iorio R., Katia Patanella A., Bianco A., Caggiula M., Sancricca C., Tonali P.A., Mirabella M., Batocchi A.P. Glucocorticoid treatment reduces T-bet and pSTAT1 expression in mononuclear cells from relapsing remitting multiple sclerosis patients. Clin. Immunol. 2007, 124:284-293.
12. Giunti D., Borsellino G., Benelli R., Marchese M., Capello E., Valle M.T., Pedemonte E., Noonan D., Albini A., Bernardi G., Mancardi G.L., Battistini L., Uccelli A. Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS. J. Leukoc. Biol. 2003, 73:584-590.
13. Hohlfeld R., Kerschensteiner M., Stadelmann C., Lassmann H., Wekerle H. The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis. J. Neuroimmunol. 2000, 107:161-166.
14. Hohlfeld R., Kerschensteiner M., Stadelmann C., Lassmann H., Wekerle H. The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis. Neurol. Sci. 2006, 27(Suppl. 1):S1-S7.
15. Kaizuka Y., Douglass A.D., Vardhana S., Dustin M.L., Vale R.D. The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells. J. Cell Biol. 2009, 185:521-534.
16. Kerschensteiner M., Hohlfeld R. Neurotrophic factors protect myelin from attack. Int. MS J. 2003, 10:2-4.
17. Kerschensteiner M., Gallmeier E., Behrens L., Leal V.V., Misgeld T., Klinkert W.E., Kolbeck R., Hoppe E., Oropeza-Wekerle R.L., Bartke I., Stadelmann C., Lassmann H., Wekerle H., Hohlfeld R. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation?. J. Exp. Med. 1999, 189:865-870.
18. Kunkel E.J., Butcher E.C. Chemokines and the tissue-specific migration of lymphocytes. Immunity 2002, 16:1-4.
19. Li Y.Q. Immune regulation role of A20 and its clinical significance. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2011, 19:851-856.
20. Li Y., Chu N., Rostami A., Zhang G.X. Dendritic cells transduced with SOCS-3 exhibit a tolerogenic/DC2 phenotype that directs type 2 Th cell differentiation in vitro and in vivo. J. Immunol. 2006, 177:1679-1688.
21. Liao H., Bu W.Y., Wang T.H., Ahmed S., Xiao Z.C. Tenascin-R plays a role in neuroprotection via its distinct domains that coordinate to modulate the microglia function. J. Biol. Chem. 2005, 280:8316-8323.
22. Lovett-Racke A.E., Rocchini A.E., Choy J., Northrop S.C., Hussain R.Z., Ratts R.B., Sikder D., Racke M.K. Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes. Immunity 2004, 21:719-731.
23. Lund B.T., Ashikian N., Ta H.Q., Chakryan Y., Manoukian K., Groshen S., Gilmore W., Cheema G.S., Stohl W., Burnett M.E., Ko D., Kachuck N.J., Weiner L.P. Increased CXCL8 (IL-8) expression in Multiple Sclerosis. J. Neuroimmunol. 2004, 155:161-171.
24. Matsui H., Hikichi Y., Tsuji I., Yamada T., Shintani Y. LIGHT, a member of the tumor necrosis factor ligand superfamily, prevents tumor necrosis factor-alpha-mediated human primary hepatocyte apoptosis, but not Fas-mediated apoptosis. J. Biol. Chem. 2002, 277:50054-50061.
25. Nath N., Prasad R., Giri S., Singh A.K., Singh I. T-bet is essential for the progression of experimental autoimmune encephalomyelitis. Immunology 2006, 118:384-391.
26. Palmer D.C., Restifo N.P. Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function. Trends Immunol. 2009, 30:592-602.
27. Rinta S., Kuusisto H., Raunio M., Paalavuo R., Levula M., Lehtimaki T., Elovaara I. Apoptosis-related molecules in blood in multiple sclerosis. J. Neuroimmunol. 2008, 205:135-141.
28. Satoh J., Misawa T., Tabunoki H., Yamamura T. Molecular network analysis of T-cell transcriptome suggests aberrant regulation of gene expression by NF-kappaB as a biomarker for relapse of multiple sclerosis. Dis. Markers 2008, 25:27-35.
29. Schatz D.G., Ji Y. Recombination centres and the orchestration of V(D)J recombination. Nat. Rev. Immunol. 2011, 11:251-263.
30. Schatz D.G., Swanson P.C. V(D)J recombination: mechanisms of initiation. Annu. Rev. Genet. 2011, 45:167-202.
31. Schenk M., Bouchon A., Seibold F., Mueller C. TREM-1-expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J. Clin. Invest. 2007, 117:3097-3106.
32. Semple B.D., Kossmann T., Morganti-Kossmann M.C. Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networks. J. Cereb. Blood Flow Metab. 2010, 30:459-473.
33. Stadelmann C., Kerschensteiner M., Misgeld T., Bruck W., Hohlfeld R., Lassmann H. BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells?. Brain 2002, 125:75-85.
34. Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., Glimcher L.H. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000, 100:655-669.
35. Takahashi R., Nishimoto S., Muto G., Sekiya T., Tamiya T., Kimura A., Morita R., Asakawa M., Chinen T., Yoshimura A. SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-{gamma} and IL-17A production. J. Exp. Med. 2011, 208:2055-2067.
36. Tessarz A.S., Weiler S., Zanzinger K., Angelisova P., Horejsi V., Cerwenka A. Non-T cell activation linker (NTAL) negatively regulates TREM-1/DAP12-induced inflammatory cytokine production in myeloid cells. J. Immunol. 2007, 178:1991-1999.
37. Tian L., Yoshihara Y., Mizuno T., Mori K., Gahmberg C.G. The neuronal glycoprotein telencephalin is a cellular ligand for the CD11a/CD18 leukocyte integrin. J. Immunol. 1997, 158:928-936.
38. Tian L., Kilgannon P., Yoshihara Y., Mori K., Gallatin W.M., Carpen O., Gahmberg C.G. Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18. Eur. J. Immunol. 2000, 30:810-818.
39. Tuller T., Atar S., Ruppin E., Gurevich M., Achiron A. Global map of physical interactions among differentially expressed genes in multiple sclerosis relapses and remissions. Hum. Mol. Genet. 2011, 20:3606-3619.
40. Verhoeven K., De Jonghe P., Van de putte T., Nelis E., Zwijsen A., Verpoorten N., De Vriendt E., Jacobs A., Van Gerwen V., Francis A., Ceuterick C., Huylebroeck D., Timmerman V. Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10. Am. J. Hum. Genet. 2003, 73:926-932.
41. Waubant E., Goodkin D.E., Gee L., Bacchetti P., Sloan R., Stewart T., Andersson P.B., Stabler G., Miller K. Serum MMP-9 and TIMP-1 levels are related to MRI activity in relapsing multiple sclerosis. Neurology 1999, 53:1397-1401.
42. Wosik K., Biernacki K., Khouzam M.P., Prat A. Death receptor expression and function at the human blood brain barrier. J. Neurol. Sci. 2007, 259:53-60.
43. Zhu D.M., Dustin M.L., Cairo C.W., Thatte H.S., Golan D.E. Mechanisms of Cellular Avidity Regulation in CD2-CD58-Mediated T Cell Adhesion. ACS Chem. Biol. 2006, 1:649-658.
44. Zipp F. Apoptosis in multiple sclerosis. Cell Tissue Res. 2000, 301:163-171.