Clonal expansions of CD8+ T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction

Journal of Experimental Medicine

Volumn 192, Issue 3, 2000, Pages 393-404

  Babbe, Holger ^a   Roers, Axel ^a   Waisman, Ari ^a   Lassmann, Hans ^b   Goebels, Norbert ^c   Hohlfeld, Reinhard ^c   Friese, Michael ^a   Schröder, Roland ^a   Deckert, Martina ^d   Schmidt, Stephan ^d   Ravid, Rivka ^e   Rajewsky, Klaus ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF VIENNA   (Austria)

^c MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^d UNIVERSITY OF BONN   (Germany)

^e NETHERLANDS BRAIN BANK   (Netherlands)

Author keywords

Autoimmunity; Demyelinating disease; Gene rearrangement; Peripheral blood; T cell receptor chain

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

ADULT; AMINO ACID SEQUENCE; ARTICLE; CELL ISOLATION; CLONE; CONTROLLED STUDY; FEMALE; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; LEUKEMIA CELL LINE; LYMPHOCYTIC INFILTRATION; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

ADULT; BRAIN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CLONE CELLS; FEMALE; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA;

EID: 0034618094     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.3.393     Document Type: Article

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