A pathogenic role for myelin-specific CD8+ T cells in a model for multiple sclerosis

Journal of Experimental Medicine

Volumn 194, Issue 5, 2001, Pages 669-676

  Huseby, E S ^a   Liggitt, D ^a   Brabb, T ^a   Schnabel, B ^a   Ohlen C ^a   Goverman, J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Autoimmunity; Central nervous system; Cytotoxic T cell; Experimental autoimmne encephalomyelitis; Myelin basic protein

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MYELIN; MYELIN BASIC PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CELL INFILTRATION; CENTRAL NERVOUS SYSTEM; CYTOTOXIC T LYMPHOCYTE; DEMYELINATING DISEASE; IMMUNOPATHOGENESIS; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ADOPTIVE TRANSFER; ANIMALS; AUTOIMMUNITY; BRAIN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CLONE CELLS; DISEASE MODELS, ANIMAL; MICE; MICE, INBRED C3H; MICE, INBRED MRL LPR; MICE, SCID; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEINS; SPINAL CORD; T-LYMPHOCYTES; TIME FACTORS;

EID: 0035801332     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.5.669     Document Type: Article

References (44)

1. Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system
2. Clinical features of multiple sclerosis
3. Multiple sclerosis: Distribution of T cell subsets within active chronic lesions
4. Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions
5. The immunocytochemistry of multiple sclerosis plaques
6. Genetic influences in multiple sclerosis
7. Limited heterogeneity of rearranged T-cell receptor Vα transcripts in brains of multiple sclerosis patients
8. + T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction
9. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22
10. A full genome search in multiple sclerosis
11. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex
12. Repeated treatment with chimeric anti-CD4 antibody in multiple sclerosis
13. Treatment of multiple sclerosis with the monoclonal anti-CD4 antibody cM-T412: Results of a randomized, double-blind, placebo -controlled, MR-monitored phase II trial
14. + T-cell responses to human myelin protein-derived peptides
15. Autoantigen recognition by human CD8 T cell clones: Enhanced agonist response induced by altered peptide ligands
16. High-resolution HLA class I typing in the CEPH families: Analysis of linkage disequilibrium among HLA loci
17. + T cells in murine experimental allergic encephalomyelitis
18. -/- mice
19. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor β after antigen- specific triggering
20. Cutting edge: Myelin basic protein-specific cytotoxic T cell tolerance is maintained in vivo by a single dominant epitope in H-2k mice
21. Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein
22. Endogenous myelin basic protein inactivates the high avidity T cell repertoire
23. Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells
24. High frequency of antoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: Mechanisms of selection of the self-reactive repertoire
25. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
26. Regulatory T cells in autoimmmunity
27. The generation of encephalitogenic T cell lines from experimental allergic encephalomyelitis-resistant strains of mice
28. Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein
29. Genetic and epigenetic influence on EAE phenotypes induced with different encephalitogenic peptides
30. Effect of cloned interferon-gamma on expression of H-2 and la antigens on cell lines of hemopoietic, lymphoid, epithelial, fibroblastic and neuronal origin
31. Cell type-specific regulation of major histocompatibility complex (MHC) class I gene expression in astrocytes, oligodendrocytes, and neurons
32. Primary demyelination in transgenic mice expressing interferon-γ
33. Interferon-γ confers resistance to experimental allergic encephalomyelitis
34. Treatment of multiple sclerosis with gamma interferon: Exacerbations associated with activation of the immune system
35. Challenging cytokine redundancy: Inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice
36. TNF neutralization in MS: Results of a randomized, placebo-controlled multicenter study
37. Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2
38. Fas and Fas ligand enhance the pathogenesis of experimental allergic encephalomyelitis, but are not essential for immune privilege in the central nervous system
39. Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis
40. Distinct patterns of multiple sclerosis pathology indicates heterogeneity on pathogenesis
41. Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
42. Multiple sclerosis: Presence of lymphatic capillaries and lymphoid tissue in the brain and spinal cord
43. Lymphocyte targeting of the central nervous system: A review of afferent and efferent CNS-immune pathways
44. Class I-restricted processing and presentation of exogenous cell- associated antigen in vivo