Axons are injured by antigen-specific CD8+ T cells through a MHC class I- and granzyme B-dependent mechanism

Neurobiology of Disease

Volumn 59, Issue , 2013, Pages 194-205

  Sauer, Brian M ^a,b,c   Schmalstieg, William F ^b   Howe, Charles L ^b,c  

^a Mayo Clinic   (United States)

^b MAYO CLINIC   (United States)

^c MAYO GRADUATE SCHOOL   (United States)

Author keywords

Axon injury; CD8+ T cell; Granzyme B; Interferon gamma (IFN ); Major histocompatibility complex class I (MHC I); Microfluidic neuron culture; Multiple sclerosis; OT I

Indexed keywords

GAMMA INTERFERON; GRANZYME B; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; APOPTOSIS; ARTICLE; AXONAL INJURY; BRAIN CELL; CD8+ T LYMPHOCYTE; CELL ISOLATION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME REGULATION; FETUS; GENE SEQUENCE; GLIA CELL; MOUSE; MULTIPLE SCLEROSIS; NERVE CELL CULTURE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIKARYON; PRIORITY JOURNAL;

AXON INJURY; CD8(+) T CELL; GRANZYME B; INTERFERON GAMMA (IFNΓ); MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I (MHC I); MICROFLUIDIC NEURON CULTURE; MULTIPLE SCLEROSIS; OT-I;

ANIMALS; ANTIGENS, CD8; AXONS; CEREBRAL CORTEX; EMBRYO, MAMMALIAN; GENE EXPRESSION REGULATION; GRANZYMES; HISTOCOMPATIBILITY ANTIGENS CLASS I; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NEUROGLIA; NEURONS; OVALBUMIN; PEPTIDE FRAGMENTS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 84883019402     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2013.07.010     Document Type: Article

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