The immune system. First of two parts

New England Journal of Medicine

Volumn 343, Issue 1, 2000, Pages 37-49

  Delves, Peter J ^a   Roitt, Ivan M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTIGEN; B LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR; T LYMPHOCYTE RECEPTOR;

ANTIGEN RECOGNITION; B LYMPHOCYTE; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNITY; IMMUNOLOGICAL TOLERANCE; INFLAMMATION; LYMPHOCYTE SUBPOPULATION; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; THYMUS;

ANTIGENS; B-LYMPHOCYTES; HUMANS; IMMUNE SYSTEM; IMMUNE TOLERANCE; IMMUNITY; RECEPTORS, ANTIGEN; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0342656166     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200007063430107     Document Type: Review

References (55)

1. Novotny J, Bruccoleri R, Newell J, Murphy D, Haber E, Karplus M. Molecular anatomy of the antibody binding site. J Biol Chem 1983;258:14433-7.
2. Garcia KC, Teyton L, Wilson IA. Structural basis of T cell recognition. Annu Rev Immunol 1999;17:369-97.
3. Mitchison NA. The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation. Eur J Immunol 1971;1:18-27.
4. Stewart-Tull DES, ed. The theory and practical application of adjuvants. Chichester, England: John Wiley, 1995.
5. Fraser IP, Koziel H, Ezckowitz RAB. The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition receptors that link innate and adaptive immunity. Semin Immunol 1998;10:363-72.
6. Aderem A, Underhill DM. Mechanisms of phagocytosis in macrophages. Annu Rev Immunol 1999;17:593-623.
7. Savill J. Recognition and phagocytosis of cells undergoing apoptosis. Br Med Bull 1997;53:491-508.
8. Bell D, Young JW, Banchereau J. Dendritic cells. Adv Immunol 1999;72:255-324.
9. Medzhitov R, Janeway CA Jr. Innate immunity: impact on the adaptive immune response. Curr Opin Immunol 1997;9:4-9.
10. Matzinger P. An innate sense of danger. Semin Immunol 1998;10:399-415.
11. Wardlaw AJ, Moqbel R, Kay AB. Eosinophils: biology and role in disease. Adv Immunol 1995;60:151-266.
12. Abraham SN, Arock M. Mast cells and basophils in innate immunity. Semin Immunol 1998;10:373-81.
13. Siraganian RP. Basophils. In: Delves PJ, Roitt IM, eds. Encyclopedia of immunology. 2nd ed. London: Academic Press, 1998:332-4.
14. Kinet J-P. The high-affinity IgE receptor (Fc epsilon RI): from physioiogy to pathology. Annu Rev Immunol 1999;17:931-72.
15. Biron CA, Nguyen KB, Pien GC, Cousens LP, Salazar-Mather TP. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu Rev Immunol 1999;17:189-220.
16. Moretta A, Biassoni R, Bottino C, et al. Major histocompatibility complex class I-specific receptors on human natural killer and T lymphocytes. Immunol Rev 1997;155:105-17.
17. Lanier LL. NK cell receptors. Annu Rev Immunol 1998;16:359-93.
18. Law SKA, Reid KBM. Complement. 2nd ed. Oxford, England: IRL Press, 1995.
19. Wallis R, Drickamer K. Molecular determinants of oligomer formation and complement fixation in mannose-binding proteins. J Biol Chem 1999;274:3580-9.
20. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999;340:448-54. [Erratum, N Engl J Med 1999;340:1376.]
21. Mire-Sluis AR, Thorpe R, eds. Cytokines. San Diego, Calif: Academic Press, 1998.
22. Heaney ML, Golde DW. Soluble receptors in human disease. J Leukoc Biol 1998;64:135-46.
23. Merlos-Suarez A, Fernandez-Larrea J, Reddy P, Baselga J, Arribas J. Pro-tumor necrosis factor-alpha processing activity is tightly controlled by a component that does not affect notch processing. J Biol Chem 1998;38:24955-62.
24. Keilholz U, Conradt C, Legha SS. Results of interleukin-2 based treatment in advanced melanoma: a case record-based analysis of 631 patients. J Clin Oncol 1998;16:2921-9.
25. Feldmann M, Elliott MJ, Woody JN, Maini RN. Anti-tumor necrosis factor-alpha therapy of rheumatoid arthritis. Adv Immunol 1997;64:283-350.
26. Lasky LA. Selectin-carbohydrate interactions and the initiation of the inflammatory response. Annu Rev Biochem 1995;64:113-39.
27. Arnaout MA, Michishita M. Genetic abnormalities in leukocyte adhesion molecule deficiency. In: Gupta S, Griscelli C, eds. New concepts in immunodeficiency diseases. Chichester, England: John Wiley, 1993:191-202.
28. Metcalf D, Nicola N. Colony stimulating factors. Cambridge, England: Cambridge University Press, 1995.
29. Edelman GM. Antibody structure and molecular immunology. Science 1973;180:830-40.
30. Porter RR. Structural studies of immunoglobulins. Science 1973;180:713-6.
31. Davis MM, Boniface JJ, Reich Z, et al. Ligand recognition by alpha beta T cell receptors. Annu Rev Immunol 1998;16:523-44.
32. Born W, Cady C, Jones-Carson J, Mukasa A, Lahn M, O'Brien R. Immunoregulatory functions of gamma delta T cells. Adv Immunol 1999;71:77-144.
33. Tonegawa S. Somatic generation of antibody diversity. Nature 1983;302:575-81.
34. Schatz DG, Oettinger MA, Schlissel MS. V(D)J recombination: molecular biology and regulation. Annu Rev Immunol 1992;10:359-83.
35. Agrawal A, Schatz DG. RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination. Cell 1997;89:43-53.
36. Schwarz K, Gauss GH, Ludwig L, et al. RAG mutations in human B cell-negative SCID. Science 1996;274:97-9.
37. Radic MZ, Zouali M. Receptor editing, immune diversification, and self-tolerance. Immunity 1996;5:505-11.
38. Casellas R, Nussenzweig A, Wuerffel R, et al. Ku80 is required for immunoglobulin isotype switching. EMBO J 1998;17:2404-11.
39. Dutton RW, Bradley LM, Swain SL. T cell memory. Annu Rev Immunol 1998;16:201-23.
40. Hayakawa K, Asano M, Shinton SA, et al. Positive selection of natural autoreactive B cells. Science 1999;285:113-6.
41. Youinou P, Jamin C, Lydyard PM. CD5 expression in human B-cell populations. Immunol Today 1999;20:312-6.
42. Slifka MK, Ahmed R. Long-lived plasma cells: a mechanism for maintaining persistent antibody production. Curr Opin Immunol 1998;10:252-8.
43. Kruisbeek AM. Regulation of T cell development by the thymic microenvironment. Semin Immunol 1999;11:1-70.
44. Jamieson BD, Douek DC, Killian S, et al. Generation of functional thymocytes in the human adult. Immunity 1999;10:569-75.
45. Anderson G, Moore NC, Owen JJT, Jenkinson EJ. Cellular interactions in thymocyte development. Annu Rev Immunol 1996;14:73-99.
46. Fink PJ, Bevan MJ. Positive selection of thymocytes. Adv Immunol 1995;59:99-133.
47. Kruisbeek AM, Amsen D. Mechanisms underlying T-cell tolerance. Curr Opin Immunol 1996;8:233-44.
48. Rathmell JC, Thompson CB. The central effectors of cell death in the immune system. Annu Rev Immunol 1999;17:781-828.
49. Sebzda E, Mariathasan S, Ohteki T, Jones R, Bachmann MF, Ohashi PS. Selection of the T cell repertoire. Annu Rev Immunol 1999;17:829-74.
50. Ellmeier W, Sawada S, Littman DR. The regulation of CD4 and CD8 coreceptor gene expression during T cell development. Annu Rev Immunol 1999;17:523-54.
51. Goodman T, Lefrancois L. Expression of the gamma delta T-cell receptor on intestinal CD8+ intraepithelial lymphocytes. Nature 1988;333:855-8.
52. Miller JF, Basten A. Mechanisms of tolerance to self. Curr Opin Immunol 1996;8:815-21.
53. Miller JFAP, Morahan G. Peripheral T cell tolerance. Annu Rev Immunol 1992;10:51-69.
54. Van Parijs L, Abbas AK. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science 1998;280:243-8.
55. Townsend SE, Weintraub BC, Goodnow CC. Growing up on the streets: why B-cell development differs from T-cell development. Immunol Today 1999;20:217-20.