Determinant spreading associated with demyelination in a nonhuman primate model of multiple sclerosis

Journal of Immunology

Volumn 162, Issue 4, 1999, Pages 2384-2390

  McFarland, Hugh I ^a   Lobito, Adrian A ^a   Johnson, Michele M ^a   Nyswaner, Jeffrey T ^a   Frank, Joseph A ^b   Palardy, Gregory R ^a   Tresser, Nancy ^b   Genain, Claude P ^c   Mueller, John P ^d,e   Matis, Louis A ^d   Lenardo, Michael J ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d ALEXION PHARMACEUTICALS   (United States)

^e PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GLYCOPROTEIN; IMMUNOGLOBULIN; MYELIN BASIC PROTEIN; PROTEIN ANTIBODY; PROTEOLIPID PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DEMYELINATION; HISTOPATHOLOGY; IMMUNIZATION; IMMUNOGLOBULIN DEPOSITION; IMMUNOPATHOGENESIS; MARMOSET; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; RADIODIAGNOSIS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; AUTOANTIBODIES; CALLITHRIX; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; EPITOPES; INJECTIONS, INTRADERMAL; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEINS; MYELIN PROTEOLIPID PROTEIN; MYELIN-ASSOCIATED GLYCOPROTEIN; OLIGODENDROGLIA; RECOMBINANT FUSION PROTEINS;

EID: 0033558081     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Martin, R., H. F. McFarland, and D. E. McFarlin. 1992. Immunological aspects of demyelinating disease. Annu. Rev. Immunol. 10:153.
2. Rivers, T. M., D. H. Sprunt, and G. P. Berry. 1993. Observations on attempts to produce acute disseminated encephalomyelitis in monkeys. J. Exp. Med. 58:39.
3. Martenson, R. E. 1984. Myelin basic protein speciation. In Experimental Allergic Encephalomyelitis: A Useful Model for Multiple Sclerosis. E. C. Alvord, Jr., ed. Liss, New York, p. 146.
4. Swanborg, R. H. 1995. Experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease. Clin. Immunol. Immunopathol. 77:4.
5. Massacesi, L., C. P. Genain, D. Lee-Parritz, N. L. Letvin, D. Canfield, and S. L. Hauser. 1995. Active and passively induced experimental autoimmune encephalomyelitis in common marmosets: a new model for multiple sclerosis. Ann. Neurol. 37:519.
6. Waxman, S. G. 1998. Demyelinating diseases: new pathological insights, new therapeutic targets. N. Engl. J. Med. 338:323.
7. Pettinelli, C. B., and D. E. McFarlin. 1981. Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1+2-T lymphocytes. J. Immunol. 127:1420.
8. Swanborg, R. H. 1983. Autoimmune effector cells V: a monoclonal antibody specific for rat helper T lymphocytes inhibits adoptive transfer of autoimmune encephalomyelitis. J. Immunol. 130:1503.
9. Willenborg, D. O. 1979. Experimental allergic encephalomyelitis in the Lewis rat: studies on the mechanism of recovery from disease and acquired resistance to reinduction. J. Immunol. 123:1145.
10. Raine, C. S. 1983. Multiple sclerosis and chronic relapsing EAE: comparative ultrastructural neuropathology. In Multiple Sclerosis. C. W. Hallpike, M. Adams, and W. W. Tourtellotte, eds. Williams and Wilkins, Baltimore, p. 413.
11. Genain, C. P., M. H. Nguyen, N. L. Letvin, R. Pearl, R. L. Davis, M. Adelman, M. B. Lees, C. Linington, and S. L. Hauser. 1995. Antibody facilitation of multiple sclerosis-like lesions in a non human primate. J. Clin. Invest. 96:2966.
12. Johnson, D., D. A. Hafler, R. J. Fallis, M. B. Lees, R. O. Brady, R. H. Quarles, and H. L. Weiner. 1986. Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis. J. Neuroimmunol. 13:99.
13. Kerlero de Rosbo, N., R. Milo, M. B. Lees, D. Burger, C. C. Bernard, and A. Ben-Nun. 1993. Reactivity to myelin antigens in multiple sclerosis: peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein. J. Clin. Invest. 92:2602.
14. Genain, C. P., K. Abel, N. Belmar, F. Villinger, D. P. Rosenberg, C. Linington, C. S. Raine, and S. L. Hauser. 1996. Late complications of immune deviation therapy in a nonhuman primate. Science 274:2054.
15. Pearson, C. I., W. van Ewijk, and H. O. McDevitt. 1997. Induction of apoptosis and T helper 2 (Th2) responses correlates with peptide affinity for the major histocomatibility complex in self-reactive T cell receptor transgenic mice. J. Exp. Med. 185:583.
16. Miller, A., O. Lider, and H. L. Weiner. 1991. Antigen driven bystander suppression following oral administration of antigens. J. Exp. Med. 174:791.
17. Tan, L-J., M. K. Kennedy, M. C. Dal Canto, and S. D. Miller. 1991. Successful treatment of paralytic relapses in adoptive experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance. J. Immunol. 147:1797.
18. Critchfield, J. M., M. K. Racke, J. C. Zuniga-Pflucker, B. Cannella, C. S. Raine, J. Goverman, and M. J. Lenardo. 1994. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science 263:1139.
19. Elliot, E. A., H. I. McFarland, S. H. Nye, R. Cofiell, T. M. Wilson, J. A. Wilkins, S. P. Squinto, L. A. Matis, and J. P. Meuller. 1996. Treatment of experimental encephalomyelitis with a novel chimeric fusion protein of myelin basic protein and proteolipid protein. J. Clin. Invest. 98:1602.
20. Lehmann, P. V., T. Forsthuber, A. Miller, and E. E. Sercarz. 1992. Spreading of T cell autoimmunity to cryptic determinants of an autoantigen. Nature 358:155.
21. Vanderlugt, C. J., and S. D. Miller. 1996. Epitope spreading. Curr. Opin. Immunol. 8:831.
22. McRae, B. L, C. L. Vanderlugt, M. C. Dal Canto, and S. D. Miller. 1995. Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis. J. Exp. Med. 182:75.
23. Yu, M., J. M. Johnson, and V. K. Tuohy. 1996. A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease. J. Exp. Med. 183:1777.
24. Nye, S. H., C. M. Pelfrey, J. J. Burkwit, R. R. Voskuhl, M. J. Lenardo, and J. P. Nueller. 1995. Purification of immunologically active recombinant 21.5 kDa isoform of human myelin basic protein. Mol. Immunol. 32:131.
25. Amor, S., N. Groome, C. Linington, M. M. Morris, K. Dommair, M. V. Gardinier, J. M. Matthieu, and D. Baker. 1994. Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice. J. Immunol. 153:4349.
26. Diebler, G. E., R. E. Martenson, and M. W. Kies. 1972. Large scale preparation of myelin basic protein in central nervous tissue of several mammalian species. Prep. Biochem. 2:139.
27. Raine, C. S. 1997. The lesion in multiple sclerosis and chronic relapsing experimental allergic encephalomyelitis: a structural comparison. In Multiple Sclerosis. C. S. Raine, H. F. McFarland, and W. W. Tourtellotte, eds. Chapman and Hall Medical, London, p. 243.
28. Steiner, G. 1931. Krankheitserreger und Gewebsbefund bei Multiple Sklerose. Springer, Berlin.
29. McDonald, W. I., and D. Barnes. 1989. Lessons from magnetic resonance imaging in multiple sclerosis. Trends Neurosci. 12:376.
30. Adams, C. W. M. 1975. The onset and progression of the lesion in multiple sclerosis. J. Neurol. Sci. 25:165.
31. Hulette, C. M., B. T. Downey, and P. C. Burger. 1992. Macrophage markers in diagnostic neuropathology. Am. J. Surgical Pathol. 16:493.
32. Zhou, L-J., and T. F. Tedder. 1995. Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J. Immunol. 154: 3821.
33. Tedder, T. F., M. Streuli, S. F. Schlossman, and H. Saito. 1988. Isolation and structure of a cDNA encoding the B1 (CD20) cell surface antigen of human B lymphocytes. Proc. Natl. Acad. Sci. USA 85:208.
34. Esiri, M. M. 1980. Multiple sclerosis: a quantitative and qualitative study of immunoglobulin-containing cells in the central nervous system. Neuropathol. Appl. Neurobiol. 6:9.
35. Linington, C., M. Bradl, H. Lassman, C. Brunner, and K. Vass. 1988. Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein. Am. J. Pathol. 130:443.
36. Schluesener, H. J., R. A. Sobel, C. Linington, and H. L. Weiner. 1987. A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease. J. Immunol. 139:4016.
37. Hunter, R. L., and B. Bennett. 1986. The adjuvant activity of nonionic block polymer surfactants. III. Characterization of selected biologically active surfaces. Scand. J. Immunol. 23:287.
38. Bennett, B., I. J. Check, M. R. Olsen, and R. L. Hunter. 1992. A comparison of commercially available adjuvants for use in research. J. Immunol. Methods 153: 31.
39. Barrios, C., C. Brandt, M. Berney, P-H. Lambert, and C. A. Siegrist. 1996. Partial correction of the TH2/TH1 imbalance in neonatal murine responses to vaccine antigens through selective adjuvant effects. Eur. J. Immunol. 26:2666.
40. Peters, J. H., R. Geiseler, B. Theile, and F. Steinbach. 1996. Dendritic cells: from ontogenic orphans to myelomonocytic descendants. Immunol. Today 17:273.
41. Olsson, T., S. Baig, B. Hojeberg, and H. Link. 1990. Antimyelin basic protein and antimyelin antibody producing cells in multiple sclerosis. Ann. Neurol. 27:132.
42. Pette, M., K. Fujita, B. Kitze, J. N. Whitaker, E. Albert, L. Kappos, and H. Wekerle. 1990. Myelin basic protein-specific T lymphocyte lines from MS patients and healthy individuals. Neurology 40:1770.
43. Hawkins, C. P., P. M. Munro, F. MacKenzie, J. Kesselring, P. S. Tofts, E. P. Du Boulay, D. N. Landon, and W. I. McDonald. 1990. Duration and selectivity of blood-brain barrier breakdown in chronic relapsing experimental allergic encephalomyelitis studied by gadolinium-DTPA and protein markers. Brain 113:365.
44. Kermode, A. G., A. J. Thompson, P. Tofts, D. G. MacManus, B. E. Kendall, D. P. Kingsley, I. F. Moseley, P. Rudge, and W. I. McDonald. 1990. Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis. Brain 113:1477.
45. Katz, D., J. K. Taubenberger, B. Cannella, D. E. McFarlin, C. S. Raine, and H. F. McFarland. 1993. Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis. Ann. Neurol. 34:661.
46. Davie, C. A., C. P. Hawkins, G. J. Barker, A. Brennan, P. S. Tofts, D. H. Miller, and W. I. McDonald. 1994. Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain 117:49.
47. Bernard, C. C., T. G. Johns, A. Slavin, M. Ichikawa, C. Ewing, J. Liu, and J. Bettadapura. 1997. Myelin oligodendrocyte glycoprotein: a novel candidate autoantigen in multiple sclerosis. J. Mol. Med. 75:77.
48. Bauer, J., T. Sminia, F. G. Wouterlood, and C. D. Dijkstra. 1994. Phagocytic activity of macrophages and microglial cells during the course of acute and chronic relapsing experimental autoimmune encephalomyelitis. J. Neurosci. Res. 38:365.
49. Benveniste, E. N. 1997. Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J. Mol. Med. 75:165.
50. Andre, I., A. Gonzalez, B. Wang, J. Katz, C. Benoist, and D. Mathis. 1996. Checkpoints in the progression of autoimmune disease: Lessons from diabetes models. Proc. Natl. Acad. Sci. USA 93:2260.