HLA-DR 15 is associated with female sex and younger age at diagnosis in multiple sclerosis

Journal of Neurology Neurosurgery and Psychiatry

Volumn 72, Issue 2, 2002, Pages 184-187

  Hensiek, A E ^a   Sawcer, S J ^a   Feakes, R ^a   Deans, J ^a   Mander, A ^b   Akesson, E ^a   Roxburgh, R ^a   Coraddu, F ^a   Smith, S ^c   Compston, D A S ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DR ANTIGEN; HLA DR15 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; UNCLASSIFIED DRUG;

AGE; ALLELE; ARTICLE; CEREBROSPINAL FLUID; CLINICAL FEATURE; DISEASE COURSE; DISEASE PREDISPOSITION; FEMALE; HAPLOTYPE; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOMES RESEARCH; PHENOTYPE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGE FACTORS; ALLELES; COHORT STUDIES; DISABILITY EVALUATION; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE DETECTION; HLA-DR ANTIGENS; HUMANS; MALE; MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; PHENOTYPE; PROGNOSIS; SEX FACTORS;

EID: 0036155101     PISSN: 00223050     EISSN: None     Source Type: Journal    
DOI: 10.1136/jnnp.72.2.184     Document Type: Article

References (39)

1. Genes and susceptibility to multiple sclerosis
2. The genetic analysis of multiple sclerosis
3. Histocompatibility determinants in multiple sclerosis, with special reference to clinical course
4. B-cell alloantigen Ag7a in multiple sclerosis
5. B lymphocyte alloantigens associated with multiple sclerosis
6. Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity
7. HLA associations with multiple sclerosis in the Canary Islands
8. DRB1-DQA1-DQB1 loci and multiple sclerosis predisposition in the Sardinian population
9. HLA-DR and -DQ associations with multiple sclerosis in Turkey
10. Familial factors influence disability in MS multiplex families
11. Is multiple sclerosis severity a genetically influenced trait?
12. Distinct patterns of multiple sclerosis pathology indicates heterogeneity in pathogenesis
13. Occurence of multiple sclerosis-like illness in women who have a Leber's hereditary optic neuropathy mitochondrial DNA mutation
14. Primary progressive multiple sclerosis
15. HLA-DPB1 *0501-associated opticospinal multiple sclerosis: Clinical, neuroimaging and immunogenetic studies
16. HLA-DR15 is associated with lower age at onset in multiple sclerosis
17. Sex and age at diagnosis are correlated with the HLA-DR2, DQ6 haplotype in multiple sclerosis
18. New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
19. Rating neurological impairment in multiple sclerosis: An expanded disability scale status
20. Genetic variants in the tumor necrosis factor receptor 1 gene in patients with MS
21. Major histocompatibility complex class II alleles and the course and outcome of MS: A population-based study
22. Nomenclature for factors of the HLA system 1998
23. Primarily chronic progressive and relapsing/remitting multiple sclerosis: Two immunogenetically distinct entities
24. Combined effect of HLA-DRB1 * 1501 and interleukin-1 receptor antagonist gene allele 2 in susceptibility to relapsing/remitting multiple sclerosis
25. An immunogenetic heterogeneity in multiple sclerosis
26. HLA profile in MS suggests two forms of the disease and the existence of protective haplotypes
27. Histocompatibility genes in MS patients participating in a multicentre trial of azathioprine
28. HLA and prognosis in multiple sclerosis
29. Diagnostic criteria for primary progressive multiple sclerosis: A position paper
30. Western versus Asian types of multiple sclerosis: Immunogenetically and clinically distinct disorders
31. HLA and heterogeneity of MSHLA and heterogeneity of MSHLA and heterogeneity of MS
32. Clinical subgroups of MS in relation to HLA: DR alleles as possible markers of disease progression
33. Genetic basis of MS; HLA antigens, disease progression and oligoclonal IgG in CSF
34. A study of the HLA-DR region in clinical subgroups of multiple sclerosis and its influence on prognosis
35. Interaction between HLA-DR2 and abnormal brain MRI in optic neuritis and early MS
36. HLA DRB1 * 1501 and intrathecal inflammation in multiple sclerosis
37. International Panel on the Diagnosis of MS. New diagnostic criteria for multiple sclerosis
38. Genetic control of multiple sclerosis: Increased production of lymphotoxin and tumor necrosis factor alpha by HLA-DR1 + T cells
39. Cytokine profile of myelin basic protein reactive T-cells in multiple sclerosis and healthy individuals