메뉴 건너뛰기




Volumn 105, Issue 2, 2005, Pages 735-741

Functional defect of regulatory CD4+CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; COMPLEMENTARY DNA; FAS ANTIGEN; INTERLEUKIN 2 RECEPTOR; MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3;

EID: 11244291391     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-11-3900     Document Type: Article
Times cited : (380)

References (45)
  • 1
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 1995;155:1151-1164.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 2
    • 0030442723 scopus 로고    scopus 로고
    • The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients
    • Saoudi A, Seddon B, Fowell D, Mason D. The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients. J Exp Med. 1996;184:2393-2398.
    • (1996) J Exp Med , vol.184 , pp. 2393-2398
    • Saoudi, A.1    Seddon, B.2    Fowell, D.3    Mason, D.4
  • 3
    • 0036597371 scopus 로고    scopus 로고
    • + suppressor T cells: More questions than answers
    • + suppressor T cells: more questions than answers. Nat Rev Immunol. 2002;2:389-400.
    • (2002) Nat Rev Immunol , vol.2 , pp. 389-400
    • Shevach, E.M.1
  • 4
    • 0035054606 scopus 로고    scopus 로고
    • Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro
    • Stephens LA, Mottet C, Mason D, Powrie F. Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur J Immunol. 2001;31:1247-1254.
    • (2001) Eur J Immunol , vol.31 , pp. 1247-1254
    • Stephens, L.A.1    Mottet, C.2    Mason, D.3    Powrie, F.4
  • 5
    • 0037026003 scopus 로고    scopus 로고
    • Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes
    • Annunziato F, Cosmi L, Liotta F, et al. Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes. J Exp Med. 2002;196:379-387.
    • (2002) J Exp Med , vol.196 , pp. 379-387
    • Annunziato, F.1    Cosmi, L.2    Liotta, F.3
  • 6
    • 0035806244 scopus 로고    scopus 로고
    • Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood
    • Dieckmann D, Plottner H, Berchtold S, Berger T, Schuler G. Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J Exp Med. 2001;193:1303-1310.
    • (2001) J Exp Med , vol.193 , pp. 1303-1310
    • Dieckmann, D.1    Plottner, H.2    Berchtold, S.3    Berger, T.4    Schuler, G.5
  • 7
    • 0035806323 scopus 로고    scopus 로고
    • Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
    • Levings MK, Sangregorio R, Roncarolo MG. Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med. 2001;193:1295-1302.
    • (2001) J Exp Med , vol.193 , pp. 1295-1302
    • Levings, M.K.1    Sangregorio, R.2    Roncarolo, M.G.3
  • 8
    • 0035806290 scopus 로고    scopus 로고
    • Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    • Jonuleit H, Schmitt E, Stassen M, Tuettenberg A, Knop J, Enk AH. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med. 2001;193:1285-1294.
    • (2001) J Exp Med , vol.193 , pp. 1285-1294
    • Jonuleit, H.1    Schmitt, E.2    Stassen, M.3    Tuettenberg, A.4    Knop, J.5    Enk, A.H.6
  • 9
    • 0031821875 scopus 로고    scopus 로고
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med. 1998;188:287-296.
    • (1998) J Exp Med , vol.188 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 10
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299:1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 14
    • 0036141438 scopus 로고    scopus 로고
    • Multiple immuno-regulatory defects in type-1 diabetes
    • Kukreja A, Cost G, Marker J, et al. Multiple immuno-regulatory defects in type-1 diabetes. J Clin Invest. 2002;109:131-140.
    • (2002) J Clin Invest , vol.109 , pp. 131-140
    • Kukreja, A.1    Cost, G.2    Marker, J.3
  • 15
    • 0142119367 scopus 로고    scopus 로고
    • Multiple sclerosis: A study of chemokine receptors and regulatory T cells in relation to MRI variables
    • Putheti P, Morris M, Stawiarz L, et al. Multiple sclerosis: a study of chemokine receptors and regulatory T cells in relation to MRI variables. Eur J Neurol. 2003;10:529-535.
    • (2003) Eur J Neurol , vol.10 , pp. 529-535
    • Putheti, P.1    Morris, M.2    Stawiarz, L.3
  • 16
    • 1842607712 scopus 로고    scopus 로고
    • Circulating CD4(+)CD25(+) T regulatory cells are not altered in multiple sclerosis and unaffected by disease-modulating drugs
    • Putheti P, Pettersson A, Soderstrom M, Link H, Huang YM. Circulating CD4(+)CD25(+) T regulatory cells are not altered in multiple sclerosis and unaffected by disease-modulating drugs. J Clin Immunol. 2004;24:155-161.
    • (2004) J Clin Immunol , vol.24 , pp. 155-161
    • Putheti, P.1    Pettersson, A.2    Soderstrom, M.3    Link, H.4    Huang, Y.M.5
  • 19
    • 1942456867 scopus 로고    scopus 로고
    • + regulatory T cells deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis
    • May 1
    • + regulatory T cells deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis. Blood. 2004 May 1;103(3):3428-30.
    • (2004) Blood , vol.103 , Issue.3 , pp. 3428-3430
    • Boyer, O.1    Saadoun, D.2    Abriol, J.3
  • 21
    • 0025140118 scopus 로고
    • Myasthenia gravis: Effect of thymectomy in 425 patients. A 15-year experience
    • Molnar J, Szobor A. Myasthenia gravis: effect of thymectomy in 425 patients. A 15-year experience. Eur J Cardiothorac Surg. 1990;4:8-14.
    • (1990) Eur J Cardiothorac Surg , vol.4 , pp. 8-14
    • Molnar, J.1    Szobor, A.2
  • 22
    • 0023632437 scopus 로고
    • The role of the thymus in myasthenia gravis: Immunohistological and immunological studies in 115 cases
    • Berrih-Aknin S, Morel E, Raimond F, et al. The role of the thymus in myasthenia gravis: immunohistological and immunological studies in 115 cases. Ann N Y Acad Sci. 1987;505:50-70.
    • (1987) Ann N Y Acad Sci , vol.505 , pp. 50-70
    • Berrih-Aknin, S.1    Morel, E.2    Raimond, F.3
  • 23
    • 0021329452 scopus 로고
    • Anti-AChR antibodies, thymic histology, and T cell subsets in myasthenia gravis
    • Berrih S, Morel E, Gaud C, Raimond F, Le Brigand H, Bach JF. Anti-AChR antibodies, thymic histology, and T cell subsets in myasthenia gravis. Neurology. 1984;34:66-71.
    • (1984) Neurology , vol.34 , pp. 66-71
    • Berrih, S.1    Morel, E.2    Gaud, C.3    Raimond, F.4    Le Brigand, H.5    Bach, J.F.6
  • 24
    • 0026027752 scopus 로고
    • T-cell antigenic sites involved in myasthenia gravis: Correlations with antibody titre and disease severity
    • Berrih-Aknin S, Cohen-Kaminsky S, Lepage V, Neumann D, Bach JF, Fuchs S. T-cell antigenic sites involved in myasthenia gravis: correlations with antibody titre and disease severity. J Autoimmun. 1991;4:137-153.
    • (1991) J Autoimmun , vol.4 , pp. 137-153
    • Berrih-Aknin, S.1    Cohen-Kaminsky, S.2    Lepage, V.3    Neumann, D.4    Bach, J.F.5    Fuchs, S.6
  • 25
    • 0024429407 scopus 로고
    • Evidence of enhanced recombinant interleukin-2 sensitivity in thymic lymphocytes from patients with myasthenia gravis: Possible role in autoimmune pathogenesis
    • Cohen-Kaminsky S, Levasseur P, Binet JP, Berrih-Aknin S. Evidence of enhanced recombinant interleukin-2 sensitivity in thymic lymphocytes from patients with myasthenia gravis: possible role in autoimmune pathogenesis. J Neuroimmunol. 1989;24:75-85.
    • (1989) J Neuroimmunol , vol.24 , pp. 75-85
    • Cohen-Kaminsky, S.1    Levasseur, P.2    Binet, J.P.3    Berrih-Aknin, S.4
  • 26
    • 0025045510 scopus 로고
    • Myasthenic thymus and thymoma are selectively enriched in acetylcholine receptor-reactive T cells
    • Sommer N, Willcox N, Harcourt GC, Newsom-Davis J. Myasthenic thymus and thymoma are selectively enriched in acetylcholine receptor-reactive T cells. Ann Neurol. 1990;28:312-319.
    • (1990) Ann Neurol , vol.28 , pp. 312-319
    • Sommer, N.1    Willcox, N.2    Harcourt, G.C.3    Newsom-Davis, J.4
  • 27
    • 0024600918 scopus 로고
    • Autoimmune T lymphocytes in myasthenia gravis. Determination of target epitopes using T lines and recombinant products of the mouse nicotinic acetylcholine receptor gene
    • Melms A, Chrestel S, Schalke BC, et al. Autoimmune T lymphocytes in myasthenia gravis. Determination of target epitopes using T lines and recombinant products of the mouse nicotinic acetylcholine receptor gene. J Clin Invest. 1989;83:785-790.
    • (1989) J Clin Invest , vol.83 , pp. 785-790
    • Melms, A.1    Chrestel, S.2    Schalke, B.C.3
  • 28
    • 0030911161 scopus 로고    scopus 로고
    • Thymocyte Fas expression is dysregulated in myasthenia gravis patients with anti-acetylcholine receptor antibody
    • Moulian N, Bidault J, Truffault F, Yamamoto AM, Levasseur P, Berrih-Aknin S. Thymocyte Fas expression is dysregulated in myasthenia gravis patients with anti-acetylcholine receptor antibody. Blood. 1997;89:3287-3295.
    • (1997) Blood , vol.89 , pp. 3287-3295
    • Moulian, N.1    Bidault, J.2    Truffault, F.3    Yamamoto, A.M.4    Levasseur, P.5    Berrih-Aknin, S.6
  • 29
    • 0025029359 scopus 로고
    • Thymic B cells from myasthenia gravis patients are activated B cells. Phenotypic and functional analysis
    • Leprince C, Cohen-Kaminsky S, Berrih-Aknin S, et al. Thymic B cells from myasthenia gravis patients are activated B cells. Phenotypic and functional analysis. J Immunol. 1990;145:2115-2122.
    • (1990) J Immunol , vol.145 , pp. 2115-2122
    • Leprince, C.1    Cohen-Kaminsky, S.2    Berrih-Aknin, S.3
  • 31
    • 0032103108 scopus 로고    scopus 로고
    • An acetylcholine receptor alpha subunit promoter confers intrathymic expression in transgenic mice. Implications for tolerance of a transgenic self-antigen and for autoreactivity in myasthenia gravis
    • Salmon AM, Bruand C, Cardona A, Changeux JP, Berrih-Aknin S. An acetylcholine receptor alpha subunit promoter confers intrathymic expression in transgenic mice. Implications for tolerance of a transgenic self-antigen and for autoreactivity in myasthenia gravis. J Clin Invest. 1998;101:2340-2350.
    • (1998) J Clin Invest , vol.101 , pp. 2340-2350
    • Salmon, A.M.1    Bruand, C.2    Cardona, A.3    Changeux, J.P.4    Berrih-Aknin, S.5
  • 32
    • 0030587964 scopus 로고    scopus 로고
    • Expression of acetylcholine receptor genes in human thymic epithelial cells: Implications for myasthenia gravis
    • Wakkach A, Guyon T, Bruand C, Tzartos S, Cohen-Kaminsky S, Berrih-Aknin S. Expression of acetylcholine receptor genes in human thymic epithelial cells: implications for myasthenia gravis. J Immunol. 1996;157:3752-3760.
    • (1996) J Immunol , vol.157 , pp. 3752-3760
    • Wakkach, A.1    Guyon, T.2    Bruand, C.3    Tzartos, S.4    Cohen-Kaminsky, S.5    Berrih-Aknin, S.6
  • 33
    • 0018117040 scopus 로고
    • Thymic hyperplasia and neoplasia: A review of current concepts
    • Levine GD, Rosai J. Thymic hyperplasia and neoplasia: a review of current concepts. Hum Pathol. 1978;9:495-515.
    • (1978) Hum Pathol , vol.9 , pp. 495-515
    • Levine, G.D.1    Rosai, J.2
  • 34
    • 0025993355 scopus 로고
    • Myasthenia gravis: Measurement of anti-AChR autoantibodies using cell line TE671
    • Voltz R, Hohlfeld R, Fateh-Moghadam A, et al. Myasthenia gravis: measurement of anti-AChR autoantibodies using cell line TE671. Neurology. 1991;41:1836-1838.
    • (1991) Neurology , vol.41 , pp. 1836-1838
    • Voltz, R.1    Hohlfeld, R.2    Fateh-Moghadam, A.3
  • 36
    • 0035525739 scopus 로고    scopus 로고
    • Human CD4(+)CD25(+) cells: A naturally occurring population of regulatory T cells
    • Ng WF, Duggan PJ, Ponchel F, et al. Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood. 2001;98:2736-2744.
    • (2001) Blood , vol.98 , pp. 2736-2744
    • Ng, W.F.1    Duggan, P.J.2    Ponchel, F.3
  • 37
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
    • Nakamura K, Kitani A, Strober W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med. 2001;194:629-644.
    • (2001) J Exp Med , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 38
    • 0028329009 scopus 로고
    • The apoptosis-1/Fas protein in human systemic lupus erythematosus
    • Mysler E, Bini P, Drappa J, et al. The apoptosis-1/Fas protein in human systemic lupus erythematosus. J Clin Invest. 1994;93:1029-1034.
    • (1994) J Clin Invest , vol.93 , pp. 1029-1034
    • Mysler, E.1    Bini, P.2    Drappa, J.3
  • 39
    • 0030561022 scopus 로고    scopus 로고
    • Increased Fas antigen on T cells in multiple sclerosis
    • Ichikawa H, Ota K, Iwata M. Increased Fas antigen on T cells in multiple sclerosis. J Neuroimmunol. 1996;71:125-129.
    • (1996) J Neuroimmunol , vol.71 , pp. 125-129
    • Ichikawa, H.1    Ota, K.2    Iwata, M.3
  • 40
    • 0037436119 scopus 로고    scopus 로고
    • + T cell-mediated suppression by dendritic cells
    • + T cell-mediated suppression by dendritic cells. Science. 2003;299:1033-1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 41
    • 0027163842 scopus 로고
    • Interleukin-6 overproduction by cultured thymic epithelial cells from patients with myasthenia gravis is potentially involved in thymic hyperplasia
    • Cohen-Kaminsky S, Devergne O, Delattre RM, et al. Interleukin-6 overproduction by cultured thymic epithelial cells from patients with myasthenia gravis is potentially involved in thymic hyperplasia. Eur Cytokine Netw. 1993;4:121-132.
    • (1993) Eur Cytokine Netw , vol.4 , pp. 121-132
    • Cohen-Kaminsky, S.1    Devergne, O.2    Delattre, R.M.3
  • 42
    • 0034526617 scopus 로고    scopus 로고
    • JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome
    • Chatila TA, Blaeser F, Ho N, et al. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J Clin Invest. 2000;106:R75-81.
    • (2000) J Clin Invest , vol.106
    • Chatila, T.A.1    Blaeser, F.2    Ho, N.3
  • 43
    • 0035163909 scopus 로고    scopus 로고
    • X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
    • Wildin RS, Ramsdell F, Peake J, et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet. 2001;27:18-20.
    • (2001) Nat Genet , vol.27 , pp. 18-20
    • Wildin, R.S.1    Ramsdell, F.2    Peake, J.3
  • 44
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • Bennett CL, Christie J, Ramsdell F, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet. 2001;27:20-21.
    • (2001) Nat Genet , vol.27 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3
  • 45
    • 0038345163 scopus 로고    scopus 로고
    • A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes
    • Bassuny WM, Ihara K, Sasaki Y, et al. A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes. Immunogenetics. 2003;55:149-156.
    • (2003) Immunogenetics , vol.55 , pp. 149-156
    • Bassuny, W.M.1    Ihara, K.2    Sasaki, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.