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Volumn 226, Issue 1-2, 2010, Pages 185-191

Memory CD4+CD127high T cells from patients with multiple sclerosis produce IL-17 in response to myelin antigens

Author keywords

Multiple sclerosis; Myelin reactive T cells; T helper 17 cells

Indexed keywords

INTERLEUKIN 17; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; TETANUS TOXOID; CYTOKINE; LEUKOCYTE ANTIGEN; MYELIN ASSOCIATED GLYCOPROTEIN; OLIGODENDROCYTE MYELIN GLYCOPROTEIN; OLIGODENDROCYTE-MYELIN GLYCOPROTEIN;

EID: 77956338425     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2010.05.025     Document Type: Article
Times cited : (35)

References (52)
  • 3
    • 1542723658 scopus 로고    scopus 로고
    • Expansion and functional relevance of high-avidity myelin-specific CD4+ T cells in multiple sclerosis
    • Bielekova B., Sung M.H., Kadom N., Simon R., McFarland H., Martin R. Expansion and functional relevance of high-avidity myelin-specific CD4+ T cells in multiple sclerosis. J. Immunol. 2004, 172:3893-3904.
    • (2004) J. Immunol. , vol.172 , pp. 3893-3904
    • Bielekova, B.1    Sung, M.H.2    Kadom, N.3    Simon, R.4    McFarland, H.5    Martin, R.6
  • 4
    • 0034026912 scopus 로고    scopus 로고
    • Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation
    • Bitsch A., Schuchardt J., Bunkowski S., Kuhlmann T., Bruck W. Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation. Brain 2000, 123:1174-1183.
    • (2000) Brain , vol.123 , pp. 1174-1183
    • Bitsch, A.1    Schuchardt, J.2    Bunkowski, S.3    Kuhlmann, T.4    Bruck, W.5
  • 5
    • 34848821989 scopus 로고    scopus 로고
    • Distinct regulation of interleukin-17 in human T helper lymphocytes
    • Chen Z., Tato C.M., Muul L., Laurence A., O'Shea J.J. Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum. 2007, 56:2936-2946.
    • (2007) Arthritis Rheum. , vol.56 , pp. 2936-2946
    • Chen, Z.1    Tato, C.M.2    Muul, L.3    Laurence, A.4    O'Shea, J.J.5
  • 6
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston A., Coles A. Multiple sclerosis. Lancet 2008, 372:1502-1517.
    • (2008) Lancet , vol.372 , pp. 1502-1517
    • Compston, A.1    Coles, A.2
  • 9
    • 0015264390 scopus 로고
    • Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species
    • Deibler G.E., Martenson R.E., Kies M.W. Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species. Prep. Biochem. 1972, 2:139-165.
    • (1972) Prep. Biochem. , vol.2 , pp. 139-165
    • Deibler, G.E.1    Martenson, R.E.2    Kies, M.W.3
  • 10
    • 0032879769 scopus 로고    scopus 로고
    • Autoreactivity to myelin antigens: myelin/oligodendrocyte glycoprotein is a prevalent autoantigen
    • Diaz-Villoslada P., Shih A., Shao L., Genain C.P., Hauser S.L. Autoreactivity to myelin antigens: myelin/oligodendrocyte glycoprotein is a prevalent autoantigen. J. Neuroimmunol. 1999, 99:36-43.
    • (1999) J. Neuroimmunol. , vol.99 , pp. 36-43
    • Diaz-Villoslada, P.1    Shih, A.2    Shao, L.3    Genain, C.P.4    Hauser, S.L.5
  • 18
    • 0030697438 scopus 로고    scopus 로고
    • Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: reactivity to the extracellular domain of MOG is directed against three main regions
    • Kerlero d.R., Hoffman M., Mendel I., Yust I., Kaye J., Bakimer R., Flechter S., Abramsky O., Milo R., Karni A., Ben Nun A. Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: reactivity to the extracellular domain of MOG is directed against three main regions. Eur. J. Immunol. 1997, 27:3059-3069.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 3059-3069
    • Kerlero, D.1    Hoffman, M.2    Mendel, I.3    Yust, I.4    Kaye, J.5    Bakimer, R.6    Flechter, S.7    Abramsky, O.8    Milo, R.9    Karni, A.10    Ben Nun, A.11
  • 23
    • 0032753320 scopus 로고    scopus 로고
    • Multiple sclerosis: B- and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein
    • Lindert R.B., Haase C.G., Brehm U., Linington C., Wekerle H., Hohlfeld R. Multiple sclerosis: B- and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein. Brain 1999, 122:2089-2100.
    • (1999) Brain , vol.122 , pp. 2089-2100
    • Lindert, R.B.1    Haase, C.G.2    Brehm, U.3    Linington, C.4    Wekerle, H.5    Hohlfeld, R.6
  • 25
    • 0032519421 scopus 로고    scopus 로고
    • Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells
    • Lovett-Racke A.E., Trotter J.L., Lauber J., Perrin P.J., June C.H., Racke M.K. Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells. J. Clin. Invest 1998, 101:725-730.
    • (1998) J. Clin. Invest , vol.101 , pp. 725-730
    • Lovett-Racke, A.E.1    Trotter, J.L.2    Lauber, J.3    Perrin, P.J.4    June, C.H.5    Racke, M.K.6
  • 26
    • 0344389016 scopus 로고    scopus 로고
    • Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis
    • Matusevicius D., Kivisakk P., He B., Kostulas N., Ozenci V., Fredrikson S., Link H. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult. Scler. 1999, 5:101-104.
    • (1999) Mult. Scler. , vol.5 , pp. 101-104
    • Matusevicius, D.1    Kivisakk, P.2    He, B.3    Kostulas, N.4    Ozenci, V.5    Fredrikson, S.6    Link, H.7
  • 28
    • 0034658339 scopus 로고    scopus 로고
    • Human autoreactive CD4+ T cells from naive CD45RA+ and memory CD45RO+ subsets differ with respect to epitope specificity and functional antigen avidity
    • Muraro P.A., Pette M., Bielekova B., McFarland H.F., Martin R. Human autoreactive CD4+ T cells from naive CD45RA+ and memory CD45RO+ subsets differ with respect to epitope specificity and functional antigen avidity. J. Immunol. 2000, 164:5474-5481.
    • (2000) J. Immunol. , vol.164 , pp. 5474-5481
    • Muraro, P.A.1    Pette, M.2    Bielekova, B.3    McFarland, H.F.4    Martin, R.5
  • 30
    • 44049108877 scopus 로고    scopus 로고
    • Differentiation of human T(H)-17 cells does require TGF-beta! Nat
    • O'Garra A., Stockinger B., Veldhoen M. Differentiation of human T(H)-17 cells does require TGF-beta! Nat. Immunol. 2008, 9:588-590.
    • (2008) Immunol. , vol.9 , pp. 588-590
    • O'Garra, A.1    Stockinger, B.2    Veldhoen, M.3
  • 32
    • 33644974688 scopus 로고    scopus 로고
    • Secondary progressive multiple sclerosis: current knowledge and future challenges
    • Rovaris M., Confavreux C., Furlan R., Kappos L., Comi G., Filippi M. Secondary progressive multiple sclerosis: current knowledge and future challenges. Lancet Neurol. 2006, 5:343-354.
    • (2006) Lancet Neurol. , vol.5 , pp. 343-354
    • Rovaris, M.1    Confavreux, C.2    Furlan, R.3    Kappos, L.4    Comi, G.5    Filippi, M.6
  • 34
    • 0031892792 scopus 로고    scopus 로고
    • Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation
    • Scholz C., Patton K.T., Anderson D.E., Freeman G.J., Hafler D.A. Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation. J. Immunol. 1998, 160:1532-1538.
    • (1998) J. Immunol. , vol.160 , pp. 1532-1538
    • Scholz, C.1    Patton, K.T.2    Anderson, D.E.3    Freeman, G.J.4    Hafler, D.A.5
  • 36
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra M., Martin R. Immunology of multiple sclerosis. Annu. Rev. Immunol. 2005, 23:683-747.
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 37
    • 40449089827 scopus 로고    scopus 로고
    • Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells
    • Stromnes I.M., Cerretti L.M., Liggitt D., Harris R.A., Goverman J.M. Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells. Nat. Med. 2008, 14:337-342.
    • (2008) Nat. Med. , vol.14 , pp. 337-342
    • Stromnes, I.M.1    Cerretti, L.M.2    Liggitt, D.3    Harris, R.A.4    Goverman, J.M.5
  • 39
    • 66549105934 scopus 로고    scopus 로고
    • Multiple sclerosis - a response-to-damage model
    • 't Hart B.A., Hintzen R.Q., Laman J.D. Multiple sclerosis - a response-to-damage model. Trends Mol. Med. 2009, 15:235-244.
    • (2009) Trends Mol. Med. , vol.15 , pp. 235-244
    • 't Hart, B.A.1    Hintzen, R.Q.2    Laman, J.D.3
  • 42
    • 38749143286 scopus 로고    scopus 로고
    • Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis
    • Tzartos J.S., Friese M.A., Craner M.J., Palace J., Newcombe J., Esiri M.M., Fugger L. Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am. J. Pathol. 2007, 172:146-155.
    • (2007) Am. J. Pathol. , vol.172 , pp. 146-155
    • Tzartos, J.S.1    Friese, M.A.2    Craner, M.J.3    Palace, J.4    Newcombe, J.5    Esiri, M.M.6    Fugger, L.7
  • 43
    • 33744936550 scopus 로고    scopus 로고
    • IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production
    • Vaknin-Dembinsky A., Balashov K., Weiner H.L. IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J. Immunol. 2006, 176:7768-7774.
    • (2006) J. Immunol. , vol.176 , pp. 7768-7774
    • Vaknin-Dembinsky, A.1    Balashov, K.2    Weiner, H.L.3
  • 44
    • 0037376324 scopus 로고    scopus 로고
    • Functional properties of myelin oligodendrocyte glycoprotein-reactive T cells in multiple sclerosis patients and controls
    • Van der Aa A., Hellings N., Bernard C.C., Raus J., Stinissen P. Functional properties of myelin oligodendrocyte glycoprotein-reactive T cells in multiple sclerosis patients and controls. J. Neuroimmunol. 2003, 137:164-176.
    • (2003) J. Neuroimmunol. , vol.137 , pp. 164-176
    • Van der Aa, A.1    Hellings, N.2    Bernard, C.C.3    Raus, J.4    Stinissen, P.5
  • 45
    • 33744904725 scopus 로고    scopus 로고
    • Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4+CD25+ regulatory T-cell function and FOXP3 expression
    • Venken K., Hellings N., Hensen K., Rummens J.L., Medaer R., D'hooghe M.B., Dubois B., Raus J., Stinissen P. Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4+CD25+ regulatory T-cell function and FOXP3 expression. J. Neurosci. Res. 2006, 83:1432-1446.
    • (2006) J. Neurosci. Res. , vol.83 , pp. 1432-1446
    • Venken, K.1    Hellings, N.2    Hensen, K.3    Rummens, J.L.4    Medaer, R.5    D'hooghe, M.B.6    Dubois, B.7    Raus, J.8    Stinissen, P.9
  • 46
    • 34147092225 scopus 로고    scopus 로고
    • A CFSE based assay for measuring CD4(+)CD25(+) regulatory T cell mediated suppression of auto-antigen specific and polyclonal T cell responses
    • Venken K., Thewissen M., Hellings N., Somers V., Hensen K., Rummens J.L., Stinissen P. A CFSE based assay for measuring CD4(+)CD25(+) regulatory T cell mediated suppression of auto-antigen specific and polyclonal T cell responses. J. Immunol. Meth. 2007, 322:1-11.
    • (2007) J. Immunol. Meth. , vol.322 , pp. 1-11
    • Venken, K.1    Thewissen, M.2    Hellings, N.3    Somers, V.4    Hensen, K.5    Rummens, J.L.6    Stinissen, P.7
  • 47
    • 44449171488 scopus 로고    scopus 로고
    • Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function is disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression
    • Venken K., Hellings N., Broekmans T., Hensen K., Rummens J.L., Stinissen P. Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function is disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression. J. Immunol. 2008, 180:6411-6420.
    • (2008) J. Immunol. , vol.180 , pp. 6411-6420
    • Venken, K.1    Hellings, N.2    Broekmans, T.3    Hensen, K.4    Rummens, J.L.5    Stinissen, P.6
  • 48
    • 37149003363 scopus 로고    scopus 로고
    • Compromised CD4+ CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level
    • Venken K., Hellings N., Thewissen M., Somers V., Hensen K., Rummens J.L., Medaer R., Hupperts R., Stinissen P. Compromised CD4+ CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level. Immunology 2008, 123:79-89.
    • (2008) Immunology , vol.123 , pp. 79-89
    • Venken, K.1    Hellings, N.2    Thewissen, M.3    Somers, V.4    Hensen, K.5    Rummens, J.L.6    Medaer, R.7    Hupperts, R.8    Stinissen, P.9
  • 49
    • 76249094369 scopus 로고    scopus 로고
    • Disturbed regulatory T cell homeostasis in multiple sclerosis
    • Venken K., Hellings N., Liblau R., Stinissen P. Disturbed regulatory T cell homeostasis in multiple sclerosis. Trends Mol. Med. 2010, 16:58-68.
    • (2010) Trends Mol. Med. , vol.16 , pp. 58-68
    • Venken, K.1    Hellings, N.2    Liblau, R.3    Stinissen, P.4
  • 50
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    • Viglietta V., Baecher-Allan C., Weiner H.L., Hafler D.A. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J. Exp. Med. 2004, 199:971-979.
    • (2004) J. Exp. Med. , vol.199 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 51
    • 0028926223 scopus 로고
    • Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein
    • Wucherpfennig K.W., Strominger J.L. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 1995, 80:695-705.
    • (1995) Cell , vol.80 , pp. 695-705
    • Wucherpfennig, K.W.1    Strominger, J.L.2
  • 52
    • 0025246367 scopus 로고
    • The T lymphocyte in experimental allergic encephalomyelitis
    • Zamvil S.S., Steinman L. The T lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 1990, 8:579-621.
    • (1990) Annu. Rev. Immunol. , vol.8 , pp. 579-621
    • Zamvil, S.S.1    Steinman, L.2


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