A humanized model for multiple sclerosis using HLA-DR2 and a human T- cell receptor

Nature Genetics

Volumn 23, Issue 3, 1999, Pages 343-347

  Madsen, Lars S ^a   Andersson, Ellen Christina ^a   Jansson, Liselotte ^e   Krogsgaard, Michelle ^g   Andersen, Claus B ^b   Engberg, Jan ^a   Strominger, Jack L ^c   Svejgaard, Arne ^a   Hjorth, Jens Peter ^d   Holmdahl, Rikard ^e   Wucherpfennig, Kai W ^f   Fugger, Lars ^g  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b University of Copenhagen   (Denmark)

^c HARVARD UNIVERSITY   (United States)

^d AARHUS UNIVERSITY   (Denmark)

^e LUND UNIVERSITY   (Sweden)

^f DANA FARBER CANCER INSTITUTE   (United States)

^g AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DR2 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELIN BASIC PROTEIN; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; GENETIC LINKAGE; GENETIC PREDISPOSITION; HLA SYSTEM; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD4; AUTOANTIGENS; CENTRAL NERVOUS SYSTEM; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; ENCEPHALITIS; FREUND'S ADJUVANT; GENES, IMMUNOGLOBULIN; GENETIC PREDISPOSITION TO DISEASE; HLA-DR2 ANTIGEN; HUMANS; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEINS; NUCLEAR PROTEINS; PEPTIDE FRAGMENTS; PERTUSSIS TOXIN; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; VIRULENCE FACTORS, BORDETELLA;

ANIMALIA; MUS MUSCULUS;

EID: 0032719206     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/15525     Document Type: Article

References (30)

1. Steinman, L. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 85, 299-302 (1996).
2. Noseworthy, J.H. Progress in determining the causes and treatment of multiple sclerosis. Nature 399, A40-47 (1999).
3. Ebers, G.C., Sadovnick, A.D. & Risch, N.J. A genetic basis for familial aggregation in multiple sclerosis. Canadian Collaborative Study Group. Nature 377, 150-151 (1995).
4. Ebers, G.C. & Dyment, D.A. Genetics of multiple sclerosis. Semin. Neurol. 18, 295-299 (1998).
5. Coraddu, F. et al. HLA typing in the United Kingdom multiple sclerosis genome screen. Neurogenetics 2, 24-33 (1998).
6. Olerup, O. & Hillert, J. HLA class II-associated genetic susceptibility in multiple sclerosis: a critical evaluation. Tissue Antigens 38, 1-15 (1991).
7. Haines, J.L. et al. Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. The Multiple Sclerosis Genetics Group. Hum. Mol. Genet. 7, 1229-1234 (1998).
8. Haines, J.L. et al. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. The Multiple Sclerosis Genetics Group. Nature Genet. 13, 469-471 (1996).
9. Sawcer, S. et al. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nature Genet. 13, 464-468 (1996).
10. Ebers, G.C. et al. A full genome search in multiple sclerosis. Nature Genet. 13, 472-476 (1996).
11. Kuokkanen, S. et al. Genomewide scan of multiple sclerosis in Finnish multiplex families. Am. J. Hum. Genet. 61, 1379-1387 (1997).
12. Sawcer, S. & Goodfellow, P.N. Inheritance of susceptibility to multiple sclerosis. Curr. Opin. Immunol. 10, 697-703 (1998).
13. Wucherpfennig, K.W. et al. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J. Immunol. 152, 5581-5592 (1994).
14. Wucherpfennig, K.W. et al. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J. Exp. Med. 179, 279-290 (1994).
15. Kouskoff, V., Fehling, H.J., Lemeur, M., Benoist, C. & Mathis, D. A vector driving the expression of foreign cDNAs in the MHC class II positive cells of transgenic mice. J. Immunol. Methods 166, 287-291 (1993).
16. Fugger, L., Michie, S.A., Rulifson, I., Lock, C.B. & McDevitt, G.S. Expression of HLA-DR4 and human CD4 transgenes in mice determines the Vb T cell repertoire and mediates an HLA-DR restricted immune response. Proc. Natl Acad. Sci. USA 91, 6151-6155 (1994).
17. Kouskoff, V., Signorelli, K., Benoist, C. & Mathis, D. Cassette vectors directing expression of T cell receptor genes in transgenic mice. J. Immunol. Methods 180, 273-280 (1995).
18. + T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis. J. Exp. Med. 188, 1883-1894 (1998).
19. + T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice. J. Exp. Med. 188, 1875-1882 (1998).
20. Goverman, J. et al. Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 72, 551-560 (1993).
21. Fogdell, A., Hillert, J., Sachs, C. & Olerup, O. The multiple sclerosis- and narcolepsy-associated HLA class II haplotype includes the DRB5*0101 allele. Tissue Antigens 46, 333-336 (1995).
22. Spurkland, A. et al. The HLA-DQ(α1*0102, β1*0602) heterodimer may confer susceptibility to multiple sclerosis in the absence of the HLA-DR(α 1*01, β1*1501) heterodimer. Tissue Antigens 50, 15-22 (1997).
23. Pearson, C.I., van Ewijk, W. & McDevitt, H.O. Induction of apoptosis and T helper 2 (Th2) responses correlates with peptide affinity for the major histocompatibility complex in self-reactive T cell receptor transgenic mice. I. Exp. Med. 185, 583-599 (1997).
24. Goverman, J. Tolerance and autoimmunity in TCR transgenic mice specific for myelin basic protein. Immunol. Rev. 169, 147-159 (1999).
25. Katz, J.D., Wang, B., Haskins, K., Benoist, C. & Mathis, D. Following a diabetogenic T cell from genesis through pathogenesis. Cell 74, 1089-1100 (1993).
26. Fugger, L., Rothbard, J. & McDevitt, G.S. Specificity of an HLA-DRB1*0401 restricted T cell response to type II collagen. Eur. J. Immunol. 26, 928-933 (1996).
27. Killeen, N., Sawada, S. & Littman, D.R. Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. EMBO J. 12, 1547-1553 (1993).
28. Jansson, L., Olsson, T., Hojeberg, B. & Holmdahl, R. Chronic experimental autoimmune encephalomyelitis induced by the 89-101 myelin basic protein peptide in B10RIII (H-2r) mice. Eur. J. Immunol. 21, 693-699 (1991).
29. Sundvall, M. et al. Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis. Nature Genet. 10, 313-317 (1995).
30. Smith, K.J., Pyrdol, J., Gauthier, L., Wiley, D.C. & Wucherpfennig, K.W. Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein. J. Exp. Med. 188, 1511-1520 (1998).