Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 42, 2011, Pages 17372-17377

  Shi, Jing ^a   Knevel, Rachel ^a   Suwannalai, Parawee ^a   Van Der Linden, Michael P ^a   Janssen, George M C ^a   Van Veelen, Peter A ^a   Levarht, Nivine E W ^a   Van Der Helm van Mil, Annette H M ^a   Cerami, Anthony ^a   Huizinga, Tom W J ^a   Toes, Rene E M ^a   Trouw, Leendert A ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CARBAMYLATED PROTEIN ANTIBODY; CITRULLINATED PROTEIN ANTIBODY; CITRULLINE; HOMOCITRULLINE; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY DETECTION; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FOOT RADIOGRAPHY; HAND RADIOGRAPHY; HUMAN; INHIBITION KINETICS; MAJOR CLINICAL STUDY; PREDICTION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; AUTOANTIGENS; BIOLOGICAL MARKERS; BLOOD PROTEINS; CASE-CONTROL STUDIES; CITRULLINE; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; JOINTS;

CYPRINIDAE;

EID: 80054806901     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1114465108     Document Type: Article

References (35)

1. Klareskog L, Rönnelid J, Lundberg K, Padyukov L, Alfredsson L (2008) Immunity to citrullinated proteins in rheumatoid arthritis. Annu Rev Immunol 26:651-675. (Pubitemid 351600388)
2. Kallberg H, et al.; Epidemiological Investigation of Rheumatoid Arthritis study group (2007) Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis. Am J Hum Genet 80:867-875. (Pubitemid 46668455)
3. van der Helm-van Mil AH, Verpoort KN, Breedveld FC, Toes RE, Huizinga TW (2005) Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis. Arthritis Res Ther 7:R949-R958.
4. van der Woude D, et al. (2009) Prevalence of and predictive factors for sustained disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: Results from two large early arthritis cohorts. Arthritis Rheum 60:2262-2271.
5. Visser K, et al. (2008) Pretreatment serum levels of anti-cyclic citrullinated peptide antibodies are associated with the response to methotrexate in recent-onset arthritis. Ann Rheum Dis 67:1194-1195.
6. György B, Tóth E, Tarcsa E, Falus A, Buzás EI (2006) Citrullination: A posttranslational modification in health and disease. Int J Biochem Cell Biol 38:1662-1677.
7. Wang Y, et al. (2004) Human PAD4 regulates histone arginine methylation levels via demethylimination. Science 306:279-283. (Pubitemid 39336873)
8. Li P, et al. (2010) PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. J Exp Med 207:1853-1862.
9. Mydel P, et al. (2010) Carbamylation-dependent activation of T cells: A novel mechanism in the pathogenesis of autoimmune arthritis. J Immunol 184:6882-6890.
10. Sirpal S (2009) Myeloperoxidase-mediated lipoprotein carbamylation as a mechanistic pathway for atherosclerotic vascular disease. Clin Sci (Lond) 116:681-695.
11. Wang Z, et al. (2007) Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nat Med 13:1176-1184. (Pubitemid 47530630)
12. Turunen S, Koivula MK, Risteli L, Risteli J (2010) Anticitrulline antibodies can be caused by homocitrulline-containing proteins in rabbits. Arthritis Rheum 62: 3345-3352.
13. Willemze A, et al. (2011) The interaction between HLA shared epitope alleles and smoking and its contribution to autoimmunity against several citrullinated antigens. Arthritis Rheum 63:1823-1832.
14. van der Linden MP, et al. (2009) Association of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis. Arthritis Rheum 60: 2242-2247.
15. Berlyne GM (1998) Carbamylated proteins and peptides in health and in uremia. Nephron 79:125-130.
16. Masson-Bessière C, et al. (2001) The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin. J Immunol 166:4177-4184. (Pubitemid 32224951)
17. Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ (1998) Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest 101:273-281. (Pubitemid 28058927)
18. Aletaha D, et al. (2010) The 2010 Rheumatoid Arthritis classification critereia: An American College of Rheumatology/European League Against Rheumatism collaberative initiative. Arthritis Rheum 62:2569-2581.
19. Hill JA, et al. (2008) Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice. J Exp Med 205:967-979. (Pubitemid 351549891)
20. Kuhn KA, et al. (2006) Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J Clin Invest 116:961-973.
21. Uysal H, et al. (2009) Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis. J Exp Med 206:449-462.
22. Clavel C, et al. (2008) Induction of macrophage secretion of tumor necrosis factor alpha through Fcgamma receptor IIa engagement by rheumatoid arthritis-specific autoantibodies to citrullinated proteins complexed with fibrinogen. Arthritis Rheum 58:678-688. (Pubitemid 351364865)
23. Lu MC, et al. (2010) Anti-citrullinated protein antibodies bind surface-expressed citrullinated Grp78 on monocyte/macrophages and stimulate tumor necrosis factor alpha production. Arthritis Rheum 62:1213-1223.
24. Schuerwegh AJM, et al. (2010) Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis. Proc Natl Acad Sci USA 107:2586-2591.
25. Trouw LA, et al. (2009) Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways. Arthritis Rheum 60:1923-1931.
26. Linn-Rasker SP, et al. (2006) Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles. Ann Rheum Dis 65:366-371. (Pubitemid 43268227)
27. van Gaalen FA, et al. (2004) Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis. Arthritis Rheum 50:2113-2121.
28. Verpoort KN, et al. (2005) Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis. Arthritis Rheum 52:3058-3062. (Pubitemid 41447086)
29. Verpoort KN, et al. (2007) Fine specificity of the anti-citrullinated protein antibody response is influenced by the shared epitope alleles. Arthritis Rheum 56:3949-3952. (Pubitemid 350262321)
30. van der Helm-van Mil AH, et al. (2007) A prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: How to guide individual treatment decisions. Arthritis Rheum 56:433-440.
31. van Dongen H, et al. (2007) Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: A double-blind, randomized, placebo-controlled trial. Arthritis Rheum 56:1424-1432.
32. de Rooy DPC, van der Linden MP, Knevel R, Huizinga TW, van der Helm-van Mil AH (2011) Predicting arthritis outcomes - What can be learned from the Leiden Early Arthritis Clinic? Rheumatology (Oxford) 50:93-100.
33. Arnett FC, et al. (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315-324. (Pubitemid 18091653)
34. Suwannalai P, et al. (2011) Anti-citrullinated protein antibodies have a low avidity compared with antibodies against recall antigens. Ann Rheum Dis 70:373-379.
35. van der Heijde D (2000) How to read radiographs according to the Sharp/van der Heijde method. J Rheumatol 27:261-263.