CTLA-4 gene and the susceptibility of multiple sclerosis: An updated meta-analysis study including 12,916 cases and 15,455 controls

Journal of Neurogenetics

Volumn 28, Issue 1-2, 2014, Pages 153-163

  Liu, Jie ^a   Zhang, Hong Xin ^b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Shanghai Institute of Hematology   (China)

Author keywords

Association; Comprehensive meta analysis; CTLA 4; Multiple sclerosis

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CARRIER PROTEIN; CHOLINE TRANSPORTER-LIKE PROTEIN 4, HUMAN;

ALLELE; ARTICLE; ASIA; DNA POLYMORPHISM; EUROPE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; META ANALYSIS (TOPIC); MULTIPLE SCLEROSIS; PRIORITY JOURNAL; WESTERN HEMISPHERE; FACTUAL DATABASE; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; MALE; META ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICS AND NUMERICAL DATA;

DATABASES, FACTUAL; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MEMBRANE TRANSPORT PROTEINS; MULTIPLE SCLEROSIS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84901393374     PISSN: 01677063     EISSN: 15635260     Source Type: Journal    
DOI: 10.3109/01677063.2014.880703     Document Type: Article

References (39)

1. Andreevski, T. V., Sudomoina, M. A., Gusev, E. I., Boko, A. N., Alekseenkov, A. D., & Favorova, O. O. (2002). Polymorphism A/G in position-49 of CTLA4 exon 1 in multiple sclerosis in Russians. Mol Biol (Mosk), 36, 643-648.
2. Bagos, P. G., Karnaouri, A. C., Nikolopoulos, G. K., & Hamodrakas, S. J. (2007). No evidence for association of CTLA-4 gene polymorphisms with the risk of developing multiple sclerosis: A meta-analysis. Mult Scler, 13, 156-168. (Pubitemid 46592767)
3. Bilinska, M., Frydecka, I., Noga, L., Dobosz, T., Zoedziewska, M., Suwalska, K., Tutak, A., & Pokryszko-Dragan, A. (2004). Progression of multiple sclerosis is associated with exon 1 CTLA-4 gene polymorphism. Acta Neurol Scand, 110, 67-71. (Pubitemid 38850558)
4. Borhani Haghighi, A., Ghahramani, S., Azarpira, N., Pourjafar, M., & Nikseresht, A. R. (2008). Cytotoxic T lymphocyte associated antigen-4 exon 1 A/G polymorphism in Iranian patients with multiple sclerosis. Eur J Neurol, 15, 862-864.
5. Brunet, J. F., Denizot, F., Luciani, M. F., Roux-Dosseto, M., Suzan, M., Mattei, M. G., & Golstein, P. (1987). A new member of the immunoglobulin superfamily-CTLA-4. Nature, 328, 267-270.
6. Chambers, C. A., Sullivan, T. J., & Allison, J. P. (1997). Lymphoproliferation in CTLA-4-defi cient mice is mediated by costimulation-dependent activation of CD4-T cells. Immunity, 7, 885-895. (Pubitemid 28064901)
7. Cizmarevi ć, N. S., Ga š parovi ć, I., Peterlin, B., Sepcić, J., Rudolf, G., Kapovi ć, M., Lavtar, P., & Risti ć, S. (2011). CTLA-4-49 A/G gene polymorphism in Croatian and Slovenian multiple sclerosis patients. Int J Immunogenet, 38, 419-426.
8. Dinci ć, E., Zivkovi ć, M., Stankovi ć, A., Obradovi ć, D., Alavanti ć, D., Kosti ć, V., & Raicevi ć, R. (2006). Association of polymorphisms in CTLA-4, IL-1ra and IL-1beta genes with multiple sclerosis in Serbian population. J Neuroimmunol, 177, 146-150. (Pubitemid 44108235)
9. Disanto, G., Morahan, J. M., Ramagopalan, S. V. (2012). Multiple sclerosis: Risk factors and their interactions. CNS Neurol Disord Drug Targets, 11, 545-555.
10. Ebers, G. (2013). Interactions of environment and genes in multiple sclerosis. J Neurol Sci, 334, 161-163.
11. Fukazawa, T., Kikuchi, S., Miyagishi, R., Niino, M., Yabe, I., Hamada, T., & Sasaki, H. (2005). CTLA-4 gene polymorphism is not associated with conventional multiple sclerosis in Japanese. J Neuroimmunol, 159, 225-229. (Pubitemid 40126196)
12. Fukazawa, T., Yanagawa, T., Kikuchi, S., Yabe, I., Sasaki, H., Hamada, T., Miyasaka, K., Gomi, K., & Tashiro, K. (1999). CTLA-4 gene polymorphism may modulate disease in Japanese multiple sclerosis patients. J Neurol Sci, 171, 49-55. (Pubitemid 29525577)
13. Goodin, D. S. (2009) The causal cascade to multiple sclerosis: A model for MS pathogenesis. PLoS ONE, 4, e4565.
14. Greve, B., Simonenko, R., Illes, Z., Peterfalvi, A., Hamdi, N., Mycko, M. P., Selmaj K. W., Rozsa, C., Rajczy, K., Bauer, P., Berger, K., & Weissert, R. (2008). Multiple sclerosis and the CTLA4 autoimmunity polymorphism CT60: No association in patients from Germany, Hungary and Poland. Mult Scler, 14, 153-158. (Pubitemid 351639622)
15. Hader, W. J., Elliot, M., & Ebers, G. C. (1988). Epidemiology of multiple sclerosis in London and Middlesex County, Ontario, Canada. Neurology, 38, 617-621.
16. Hafl er, D. (2004). Multiple sclerosis. J Clin Invest, 113, 788-794. (Pubitemid 38544133)
17. Harbo, H. F., Celius, E. G., Vartdal, F., & Spurkland, A. (1999). CTLA4 promoter and exon 1 dimorphisms in multiple sclerosis. Tissue Antigens, 53, 106-110. (Pubitemid 29084180)
18. Heggarty, S., Suppiah, V., Silversides, J., O'doherty, C., Droogan, A., McDonnell, G., Hawkins, S., Graham, C, & Vandenbroeck, K. (2007). CTLA4 gene polymorphisms and multiple sclerosis in Northern Ireland. J Neuroimmunol, 187, 187-191. (Pubitemid 47001548)
19. Heidari, A., Noori Daloii, M. R., Keramatipour, M., Rashikinezhad, A., Sahmani, A. A., & Amirzargar, A. A. (2010). CTLA-4 gene polymorphisms (-318C/T,-49A/G,-6230A/G) in Iranian patients with multiple sclerosis. Iran J Allergy Asthma Immunol, 9, 219-223.
20. Kantarci, O. H., Hebrink, D. D., Achenbach, S. J., Atkinson, E. J., Waliszewska, A., Buckle, G., McMurray, C. T., de Andrade, M., Hafl er, D. A., & Weinshenker, B. G. (2003). CTLA4 is associated with susceptibility to multiple sclerosis. J Neuroimmunol, 134, 133-141. (Pubitemid 36050839)
21. Khoury, S. J., Akalin, E., Chandraker, A., Turka, L. A., Linsley, P. S., Sayegh, M. H., & Hancock, W. W. (1995). CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system. J Immunol, 155, 4521-4524.
22. Ligers, A., Xu, C., Saarinen, S., Hillert, J., & Olerup, O. (1999). The CTLA-4 gene is associated with multiple sclerosis. J Neuroimmunol, 97, 182-190. (Pubitemid 29301428)
23. Liu, J., & Zhang, H. (2013).-1722T/C polymorphism (rs733618) of CTLA-4 signifi cantly associated with systemic lupus erythematosus (SLE): A comprehensive meta-analysis. Hum Immunol, 74, 341-347.
24. Lorentzen, A. R., Celius, E. G., Ekstrøm, P. O., Wiencke, K, Lie, B. A., Myhr, K. M., Ling, V., Thorsby, E., Vartdal, F., Spurkland, A., & Harbo, H. F. (2005). Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients. J Neuroimmunol, 166, 197-201. (Pubitemid 41074670)
25. Luomala, M., Lehtim ä ki, T., Huhtala, H., Ukkonen, M., Koivula, T., Hurme, M., & Elovaara, I. (2003). Promoter polymorphism of IL-10 and severity of multiple sclerosis. Acta Neurol Scand, 108, 396-400. (Pubitemid 37464118)
26. Malferrari, G., Stella, A., Monferini, E., Saltini, G., Proverbio, M. C, Grimaldi, L. M., Rossi-Bernardi, L, & Biunno, I. (2005). Ctla4 and multiple sclerosis in the Italian population. Exp Mol Pathol, 78, 55-57. (Pubitemid 41373317)
27. M ä urer, M., Ponath, A., Kruse, N., & Rieckmann, P. (2002). CTLA4 exon 1 dimorphism is associated with primary progressive multiple sclerosis. J Neuroimmunol, 131, 213-215.
28. Mkhikian, H., Grigorian, A., Li, C. F., Chen, H. L., Newton, B., Zhou, R. W., Beeton, C., Torossian, S., Tatarian, G. G., Lee, S. U., Lau, K., Walker, E., Siminovitch, K. A., Chandy, K. G., Yu, Z., Dennis, J. W., & Demetriou, M. (2011). Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis. Nat Commun, 2, 334. doi: 10. 1038/ncomms1333
29. Oksenberg, J. R., & Baranzini, S. E. (2010). Multiple sclerosis genetics - Is the glass half full, or half empty? Nat Rev Neurol, 6, 429-437.
30. Palacios, R., Comas, D., Elorza, J., & Villoslada, P. (2008). Genomic regulation of CTLA4 and multiple sclerosis. J Neuroimmunol, 203, 108-115.
31. Rasmussen, H. B., Kelly, M. A, Francis, D. A., & Clausen J. (2001). CTLA4 in multiple sclerosis. Lack of genetic association in a European Caucasian population but evidence of interaction with HLA-DR2 among Shanghai Chinese. J Neurol Sci, 184, 143-147. (Pubitemid 32181364)
32. Stuart, R, Lovett-Racke, A. E., Frohman, E. M., Hawker, K., & Racke, M. K. (2007). Genetic analysis of the exon 1 position 49 CD152 dimorphism in multiple sclerosis. J Neuroimmunol, 191, 45-50. (Pubitemid 350060998)
33. Suppiah, V., Alloza, I., Heggarty, S., Goris, A., Dubois, B., Carton, H., & Vandenbroeck K. (2005). The CTLA4-49. A/GG-CT60G haplotype is associated with susceptibility to multiple sclerosis in Flanders. J Neuroimmunol, 164, 148-153. (Pubitemid 40826773)
34. Teutsch, S. M., Booth, D. R., Bennetts, B. H., Heard, R. N., & Stewart, G. J. (2004). Association of common T cell activation gene polymorphisms with multiple sclerosis in Australian patients. J Neuroimmunol, 148, 218-230. (Pubitemid 38229574)
35. van Veen, T., Crusius, J. B., van Winsen, L., Xia, B., Barkhof, F., Salvador Pe ñ a, A, Polman, C. H., & Uitdehaag, B. M. (2003). CTLA-4 and CD28 gene polymorphisms in susceptibility, clinical course and progression of multiple sclerosis. J Neuroimmunol, 140, 188-193. (Pubitemid 36836105)
36. Wray, B. N., Stankovich, J., Whittock, L., Dwyer, T., Ponsonby, A. L., van der Mei, I. A., Taylor, B., Dickinson, J., Foote, S., & McMorran, B. J. (2008). CTLA-4 and multiple sclerosis: The A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population. J Neuroimmunol, 196, 139-142.
37. Xuan, C., Zhang, B. B., Li, M., Deng, K. F., Yang, T, & Zhang, X. E. (2011). No association between APOE epsilon 4 allele and multiple sclerosis susceptibility: A metaanalysis from 5472 cases and 4727 controls. J Neurol Sci, 308, 110-116.
38. Yousefi pour, G., Erfani, N., Momtahan, M., Moghaddasi, H., & Ghaderi, A. (2009). CTLA4 exon 1 and promoter polymorphisms in patients with multiple sclerosis. Acta Neurol Scand, 120, 424-429.
39. Zamvil, S., Nelson, P., Trotter, J., Mitchell, D., Knobler, R., Fritz, R., & Steinman, L. (1985). T-cell clones specifi c for myelin basic protein induce chronic relapsing paralysis and demyelination. Nature, 317, 355-358. (Pubitemid 15232523)