IRAP identifies an endosomal compartment required for MHC class i cross-presentation

Science

Volumn 325, Issue 5937, 2009, Pages 213-217

  Saveanu, Loredana ^a,b   Carroll, Oliver ^a,b   Weimershaus, Mirjana ^a,b   Guermonprez, Pierre ^a,c   Firat, Elke ^d   Lindo, Vivian ^e   Greer, Fiona ^e   Davoust, Jean ^a,b   Kratzer, Roland ^a,b   Keller, Susanna R ^f   Niedermann, Gabriele ^d   Van Endert, Peter ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c INSTITUT CURIE   (France)

^d UNIVERSITY OF FREIBURG   (Germany)

^e M SCAN Ltd   (United Kingdom)

^f UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE; INSULIN REGULATED AMINOPEPTIDASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEASOME; RAB PROTEIN; RAB14+ PROTEIN; UNCLASSIFIED DRUG;

ANTIGEN; CELL ORGANELLE; ENZYME ACTIVITY; HOMINID; HORMONE; PEPTIDE; PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CROSS PRESENTATION; DENDRITIC CELL; ENDOPLASMIC RETICULUM; ENDOSOME; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SPACE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ADOPTIVE TRANSFER; ANIMALS; ANTIGEN PRESENTATION; CD8-POSITIVE T-LYMPHOCYTES; CROSS-PRIMING; CYSTINYL AMINOPEPTIDASE; DENDRITIC CELLS; ENDOSOMES; EPITOPES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; MICE; MICE, KNOCKOUT; PHAGOCYTOSIS; PHAGOSOMES; PROTEASOME ENDOPEPTIDASE COMPLEX; SUBSTRATE SPECIFICITY;

EID: 67650465638     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1172845     Document Type: Article

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24. We thank Metabolex Inc. for an anti-IRAP serum, N. Shastri for an anti-ERAP serum, B. Rocha for HY mice, O. Lantz for TAP knockout mice, L. Chatenoud for OT-II mice, B. Fouquet and N. Merzougui for technical help, and A. M. Lennon-Dumesnil for critical reading of the manuscript. Supported by grant PR0TARVAC of the European Commission (P.v.E., F.G., G.N.), by INSERM fellowships (O.C., R.K.), and by grants from the Deutsche Forschungsgemeinschaft and from the Medical Faculty of the University of Freiburg (G.N.).