메뉴 건너뛰기




Volumn 11, Issue 6, 2010, Pages 527-534

The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 9; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR PU 1;

EID: 77952584843     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1867     Document Type: Article
Times cited : (475)

References (44)
  • 1
    • 42649115767 scopus 로고    scopus 로고
    • TH17 cells in development: An updated view of their molecular identity and genetic programming
    • Dong, C. TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat. Rev. Immunol. 8, 337-348 (2008).
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 337-348
    • Dong, C.1
  • 4
    • 33646196946 scopus 로고    scopus 로고
    • Regulation of Th2 differentiation and Il4 locus accessibility
    • Ansel, K.M., Djuretic, I., Tanasa, B. & Rao, A. Regulation of Th2 differentiation and Il4 locus accessibility. Annu. Rev. Immunol. 24, 607-656 (2006).
    • (2006) Annu. Rev. Immunol. , vol.24 , pp. 607-656
    • Ansel, K.M.1    Djuretic, I.2    Tanasa, B.3    Rao, A.4
  • 5
    • 33646012294 scopus 로고    scopus 로고
    • T helper cell differentiation: Regulation by cis elements and epigenetics
    • Lee, G.R., Kim, S.T., Spilianakis, C.G., Fields, P.E. & Flavell, R.A. T helper cell differentiation: regulation by cis elements and epigenetics. Immunity 24, 369-379 (2006).
    • (2006) Immunity , vol.24 , pp. 369-379
    • Lee, G.R.1    Kim, S.T.2    Spilianakis, C.G.3    Fields, P.E.4    Flavell, R.A.5
  • 6
    • 0036885067 scopus 로고    scopus 로고
    • The lineage decisions of helper T cells
    • Murphy, K.M. & Reiner, S.L. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2, 933-944 (2002).
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 933-944
    • Murphy, K.M.1    Reiner, S.L.2
  • 7
    • 77952583601 scopus 로고    scopus 로고
    • PU.1 regulates TCR expression by modulating GATA-3 activity
    • Chang, H.C. et al. PU.1 regulates TCR expression by modulating GATA-3 activity. J. Immunol. 183, 4887-4894 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 4887-4894
    • Chang, H.C.1
  • 8
    • 20444502955 scopus 로고    scopus 로고
    • PU.1 expression delineates heterogeneity in primary Th2 cells
    • Chang, H.C. et al. PU.1 expression delineates heterogeneity in primary Th2 cells. Immunity 22, 693-703 (2005).
    • (2005) Immunity , vol.22 , pp. 693-703
    • Chang, H.C.1
  • 9
    • 68149125188 scopus 로고    scopus 로고
    • IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines
    • Ahyi, A.N., Chang, H.C., Dent, A.L., Nutt, S.L. & Kaplan, M.H. IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines. J. Immunol. 183, 1598-1606 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 1598-1606
    • Ahyi, A.N.1    Chang, H.C.2    Dent, A.L.3    Nutt, S.L.4    Kaplan, M.H.5
  • 11
    • 42249098670 scopus 로고    scopus 로고
    • IL-9-and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity
    • Forbes, E.E. et al. IL-9-and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity. J. Exp. Med. 205, 897-913 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 897-913
    • Forbes, E.E.1
  • 12
    • 0032487434 scopus 로고    scopus 로고
    • Expression of interleukin 9 in the lungs of transgenic mice causes airway infammation, mast cell hyperplasia, and bronchial hyperresponsiveness
    • Temann, U.A., Geba, G.P., Rankin, J.A. & Flavell, R.A. Expression of interleukin 9 in the lungs of transgenic mice causes airway infammation, mast cell hyperplasia, and bronchial hyperresponsiveness. J. Exp. Med. 188, 1307-1320 (1998).
    • (1998) J. Exp. Med. , vol.188 , pp. 1307-1320
    • Temann, U.A.1    Geba, G.P.2    Rankin, J.A.3    Flavell, R.A.4
  • 13
    • 0036141448 scopus 로고    scopus 로고
    • Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology
    • Temann, U.A., Ray, P. & Flavell, R.A. Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology. J. Clin. Invest. 109, 29-39 (2002).
    • (2002) J. Clin. Invest. , vol.109 , pp. 29-39
    • Temann, U.A.1    Ray, P.2    Flavell, R.A.3
  • 14
    • 65249123621 scopus 로고    scopus 로고
    • IL-9 promotes IL-13-dependent paneth cell hyperplasia and up-regulation of innate immunity mediators in intestinal mucosa
    • Steenwinckel, V. et al. IL-9 promotes IL-13-dependent paneth cell hyperplasia and up-regulation of innate immunity mediators in intestinal mucosa. J. Immunol. 182, 4737-4743 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 4737-4743
    • Steenwinckel, V.1
  • 15
    • 33847362865 scopus 로고    scopus 로고
    • IL-13 mediates in vivo IL-9 activities on lung epithelial cells but not on hematopoietic cells
    • Steenwinckel, V. et al. IL-13 mediates in vivo IL-9 activities on lung epithelial cells but not on hematopoietic cells. J. Immunol. 178, 3244-3251 (2007).
    • (2007) J. Immunol. , vol.178 , pp. 3244-3251
    • Steenwinckel, V.1
  • 16
    • 33845905754 scopus 로고    scopus 로고
    • IL9 leads to airway infammation by inducing IL13 expression in airway epithelial cells
    • Temann, U.A., Laouar, Y., Eynon, E.E., Homer, R. & Flavell, R.A. IL9 leads to airway infammation by inducing IL13 expression in airway epithelial cells. Int. Immunol. 19, 1-10 (2007).
    • (2007) Int. Immunol. , vol.19 , pp. 1-10
    • Temann, U.A.1    Laouar, Y.2    Eynon, E.E.3    Homer, R.4    Flavell, R.A.5
  • 17
    • 0033696860 scopus 로고    scopus 로고
    • IL-9-defcient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development
    • Townsend, J.M. et al. IL-9-defcient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development. Immunity 13, 573-583 (2000).
    • (2000) Immunity , vol.13 , pp. 573-583
    • Townsend, J.M.1
  • 18
    • 0036683621 scopus 로고    scopus 로고
    • Anti-interleukin-9 antibody treatment inhibits airway infammation and hyperreactivity in mouse asthma model
    • Cheng, G. et al. Anti-interleukin-9 antibody treatment inhibits airway infammation and hyperreactivity in mouse asthma model. Am. J. Respir. Crit. Care Med. 166, 409-416 (2002).
    • (2002) Am. J. Respir. Crit. Care Med. , vol.166 , pp. 409-416
    • Cheng, G.1
  • 19
    • 0037033299 scopus 로고    scopus 로고
    • The absence of interleukin 9 does not affect the development of allergen-induced pulmonary infammation nor airway hyperreactivity
    • McMillan, S.J., Bishop, B., Townsend, M.J., McKenzie, A.N. & Lloyd, C.M. The absence of interleukin 9 does not affect the development of allergen-induced pulmonary infammation nor airway hyperreactivity. J. Exp. Med. 195, 51-57 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 51-57
    • McMillan, S.J.1    Bishop, B.2    Townsend, M.J.3    McKenzie, A.N.4    Lloyd, C.M.5
  • 20
    • 0038518063 scopus 로고    scopus 로고
    • Segmental allergen challenge in patients with atopic asthma leads to increased IL-9 expression in bronchoalveolar lavage fuid lymphocytes
    • Erpenbeck, V.J. et al. Segmental allergen challenge in patients with atopic asthma leads to increased IL-9 expression in bronchoalveolar lavage fuid lymphocytes. J. Allergy Clin. Immunol. 111, 1319-1327 (2003).
    • (2003) J. Allergy Clin. Immunol. , vol.111 , pp. 1319-1327
    • Erpenbeck, V.J.1
  • 21
    • 4444262198 scopus 로고    scopus 로고
    • IL-9 and its receptor in allergic and nonallergic lung disease: Increased expression in asthma
    • Shimbara, A. et al. IL-9 and its receptor in allergic and nonallergic lung disease: increased expression in asthma. J. Allergy Clin. Immunol. 105, 108-115 (2000).
    • (2000) J. Allergy Clin. Immunol. , vol.105 , pp. 108-115
    • Shimbara, A.1
  • 22
    • 65549123549 scopus 로고    scopus 로고
    • Two frst-in-human, open-label, phase i dose-escalation safety trials of MEDI-528, a monoclonal antibody against interleukin-9, in healthy adult volunteers
    • White, B., Leon, F., White, W. & Robbie, G. Two frst-in-human, open-label, phase I dose-escalation safety trials of MEDI-528, a monoclonal antibody against interleukin-9, in healthy adult volunteers. Clin. Ther. 31, 728-740 (2009).
    • (2009) Clin. Ther. , vol.31 , pp. 728-740
    • White, B.1    Leon, F.2    White, W.3    Robbie, G.4
  • 23
    • 0031821934 scopus 로고    scopus 로고
    • Interleukin-9 enhances resistance to the intestinal nematode Trichuris muris
    • Faulkner, H., Renauld, J.C., Van Snick, J. & Grencis, R.K. Interleukin-9 enhances resistance to the intestinal nematode Trichuris muris. Infect. Immun. 66, 3832-3840 (1998).
    • (1998) Infect. Immun. , vol.66 , pp. 3832-3840
    • Faulkner, H.1    Renauld, J.C.2    Van Snick, J.3    Grencis, R.K.4
  • 24
    • 56349154943 scopus 로고    scopus 로고
    • Transforming growth factor-β ' reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    • Veldhoen, M. et al. Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat. Immunol. 9, 1341-1346 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 1341-1346
    • Veldhoen, M.1
  • 25
    • 69149107148 scopus 로고    scopus 로고
    • + natural regulatory T cells
    • + natural regulatory T cells. Proc. Natl. Acad. Sci. USA 106, 12885-12890 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 12885-12890
    • Elyaman, W.1
  • 26
    • 68149179251 scopus 로고    scopus 로고
    • IL-9 as a mediator of Th17-driven infammatory disease
    • Nowak, E.C. et al. IL-9 as a mediator of Th17-driven infammatory disease. J. Exp. Med. 206, 1653-1660 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 1653-1660
    • Nowak, E.C.1
  • 27
    • 0028077321 scopus 로고
    • + T cells depends on IL-2, is synergistically enhanced by a combination of TGF-β and IL-4, and is inhibited by IFN-γ
    • + T cells depends on IL-2, is synergistically enhanced by a combination of TGF-β and IL-4, and is inhibited by IFN-γ. J. Immunol. 153, 3989-3996 (1994).
    • (1994) J. Immunol. , vol.153 , pp. 3989-3996
    • Schmitt, E.1
  • 28
    • 33748320914 scopus 로고    scopus 로고
    • Mast cells are essential intermediaries in regulatory T-cell tolerance
    • Lu, L.F. et al. Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature 442, 997-1002 (2006).
    • (2006) Nature , vol.442 , pp. 997-1002
    • Lu, L.F.1
  • 29
    • 56349093347 scopus 로고    scopus 로고
    • - effector T cells
    • - effector T cells. Nat. Immunol. 9, 1347-1355 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 1347-1355
    • Dardalhon, V.1
  • 30
    • 58149214356 scopus 로고    scopus 로고
    • + T cells
    • + T cells. Immunity 30, 155-167 (2009).
    • (2009) Immunity , vol.30 , pp. 155-167
    • Wei, G.1
  • 31
    • 53049100179 scopus 로고    scopus 로고
    • Expired nitric oxide and airway reactivity in infants at risk for asthma
    • Tepper, R.S. et al. Expired nitric oxide and airway reactivity in infants at risk for asthma. J. Allergy Clin. Immunol. 122, 760-765 (2008).
    • (2008) J. Allergy Clin. Immunol. , vol.122 , pp. 760-765
    • Tepper, R.S.1
  • 33
    • 33846489173 scopus 로고    scopus 로고
    • Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells
    • Djuretic, I.M. et al. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat. Immunol. 8, 145-153 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 145-153
    • Djuretic, I.M.1
  • 34
    • 0036301997 scopus 로고    scopus 로고
    • H1 gene induction
    • H1 gene induction. Nat. Immunol. 3, 652-658 (2002).
    • (2002) Nat. Immunol. , vol.3 , pp. 652-658
    • Mullen, A.C.1
  • 35
    • 55349117409 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination
    • Thieu, V.T. et al. Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination. Immunity 29, 679-690 (2008).
    • (2008) Immunity , vol.29 , pp. 679-690
    • Thieu, V.T.1
  • 36
    • 34548128307 scopus 로고    scopus 로고
    • H-17 cells requires interferon-regulatory factor 4
    • H-17 cells requires interferon-regulatory factor 4. Nat. Immunol. 8, 958-966 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 958-966
    • Brustle, A.1
  • 37
    • 33751506710 scopus 로고    scopus 로고
    • Interleukin-17 is a negative regulator of established allergic asthma
    • Schnyder-Candrian, S. et al. Interleukin-17 is a negative regulator of established allergic asthma. J. Exp. Med. 203, 2715-2725 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 2715-2725
    • Schnyder-Candrian, S.1
  • 38
    • 0033168593 scopus 로고    scopus 로고
    • Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung infammation
    • Gonzalo, J.A. et al. Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung infammation. J. Immunol. 163, 403-411 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 403-411
    • Gonzalo, J.A.1
  • 39
    • 0035253654 scopus 로고    scopus 로고
    • Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway infammation and hyperresponsiveness in mice
    • Kawasaki, S. et al. Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway infammation and hyperresponsiveness in mice. J. Immunol. 166, 2055-2062 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 2055-2062
    • Kawasaki, S.1
  • 40
    • 58149117501 scopus 로고    scopus 로고
    • Contribution of CCR4 and CCR8 to antigen-specifc T(H)2 cell traf-fcking in allergic pulmonary infammation
    • Mikhak, Z. et al. Contribution of CCR4 and CCR8 to antigen-specifc T(H)2 cell traf-fcking in allergic pulmonary infammation. J. Allergy Clin. Immunol. 123, 67-73 (2009).
    • (2009) J. Allergy Clin. Immunol. , vol.123 , pp. 67-73
    • Mikhak, Z.1
  • 41
    • 9644281044 scopus 로고    scopus 로고
    • Interleukin-13 in asthma pathogenesis
    • DOI 10.1111/j.0105-2896.2004.00215.x
    • Wills-Karp, M. Interleukin-13 in asthma pathogenesis. Immunol. Rev. 202, 175-190 (2004). (Pubitemid 39576912)
    • (2004) Immunological Reviews , vol.202 , pp. 175-190
    • Wills-Karp, M.1
  • 42
    • 18644373047 scopus 로고    scopus 로고
    • PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis
    • Dakic, A. et al. PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J. Exp. Med. 201, 1487-1502 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 1487-1502
    • Dakic, A.1
  • 43
    • 58749105841 scopus 로고    scopus 로고
    • IL-23 mediates stability but not commitment to the Th17 lineage
    • Stritesky, G.L., Yeh, N. & Kaplan, M.H. IL-23 mediates stability but not commitment to the Th17 lineage. J. Immunol. 181, 5948-5955 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 5948-5955
    • Stritesky, G.L.1    Yeh, N.2    Kaplan, M.H.3
  • 44
    • 2942617055 scopus 로고    scopus 로고
    • A rapid fow cytometric method for determining the cellular composition of bronchoalveolar lavage fuid cells in mouse models of asthma
    • van Rijt, L.S. et al. A rapid fow cytometric method for determining the cellular composition of bronchoalveolar lavage fuid cells in mouse models of asthma. J. Immunol. Methods 288, 111-121 (2004).
    • (2004) J. Immunol. Methods , vol.288 , pp. 111-121
    • Van Rijt, L.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.