Batf3 deficiency reveals a critical role for CD8α+ dendritic cells in cytotoxic T cell immunity

Science

Volumn 322, Issue 5904, 2008, Pages 1097-1100

  Hildner, Kai ^a   Edelson, Brian T ^a   Purtha, Whitney E ^b   Diamond, Mark ^a   Matsushita, Hirokazu ^a   Kohyama, Masako ^a   Calderon, Boris ^a   Schraml, Barbara U ^a   Unanue, Emil R ^a   Diamond, Michael S ^a,b   Schreiber, Robert D ^a   Murphy, Theresa L ^a   Murphy, Kenneth M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Departments of Medicine Pathology and Molecular Microbiology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8ALPHA ANTIGEN; PROTEIN BATF3; REPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANTIGEN; TUMOR; VIRUS;

ARTICLE; CELL MATURATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN DEFICIENCY; TUMOR REJECTION; WEST NILE FLAVIVIRUS;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, VIRAL; ANTIGENS, CD8; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CD4-POSITIVE T-LYMPHOCYTES; CROSS-PRIMING; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; FEMALE; FIBROSARCOMA; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; REPRESSOR PROTEINS; SPLEEN; T-LYMPHOCYTES, CYTOTOXIC; WEST NILE FEVER; WEST NILE VIRUS;

MUS; WEST NILE VIRUS;

EID: 56449097442     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1164206     Document Type: Article

References (31)

1. M. J. Bevan, J. Exp. Med. 143, 1283 (1976).
2. J. M. den Haan, S. M. Lehar, M. J. Bevan, J. Exp. Med. 192, 1685 (2000).
3. K. Shortman, S. H. Naik, Nat. Rev. Immunol. 7, 19 (2007).
4. R. S. Allan et al., Science 301, 1925 (2003).
5. G. T. Belz et al., J. Immunol. 172, 1996 (2004).
6. G. T. Belz, K. Shortman, M. J. Bevan, W. R. Heath, J. Immunol. 175, 196 (2005).
7. O. Schulz et al., Nature 433, 887 (2005).
8. A. Y. Huang et al., Science 264, 961 (1994).
9. A. F. Ochsenbein et al., Nature 411, 1058 (2001).
10. M. C. Wolkers, G. Stoetter, F. A. Vyth-Dreese, T. N. Schumacher, J. Immunol. 167, 3577 (2001).
11. S. Jung et al., Immunity 17, 211 (2002).
12. H. C. Probst et al., Clin. Exp. Immunol. 141, 398 (2005).
13. M. Zenke, T. Hieronymus, Trends Immunol. 27, 140 (2006).
14. M. Iacobelli, W. Wachsman, K. L. McGuire, J. Immunol. 165, 860 (2000).
15. D. Dudziak et al., Science 315, 107 (2007).
16. S. H. Naik et al., J. Immunol. 174, 6592 (2005).
17. M. J. Barnden, J. Allison, W. R. Heath, F. R. Carbone, Immunol. Cell Biol. 76, 34 (1998).
18. N. S. Wilson et al., Nat. Immunol. 7, 165 (2006).
19. M. S. Diamond, B. Shrestha, A. Marri, D. Mahan, M. Engle, J. Virol. 77, 2578 (2003).
20. E. M. Sitati, M. S. Diamond, J. Virol. 80, 12060 (2006).
21. V. Shankaran et al., Nature 410, 1107 (2001).
22. G. P. Dunn et al., Nat. Immunol. 6, 722 (2005).
23. M. L. Lin, Y. Zhan, J. A. Villadangos, A. M. Lew, Immunol. Cell Biol. 86, 353 (2008).
24. G. T. Belz et al., Proc. Natl. Acad. Sci. U.S.A. 101, 8670 (2004).
25. J. Waithman et al., J. Immunol. 179, 4535 (2007).
26. M. L. del Rio, J. I. Rodriguez-Barbosa, E. Kremmer, R. Forster, J. Immunol. 178, 6861 (2007).
27. S. S. Sung et al., J. Immunol. 176, 2161 (2006).
28. L. S. Bursch et al., J. Exp. Med. 204, 3147 (2007).
29. A. D. Edwards et al., J. Immunol. 171, 47 (2003).
30. Materials and methods are available as supporting material on Science Online.
31. This work was supported by the Howard Hughes Medical Institute (K.M.M.), the Emmy Noether Program of the German Research Foundation (K.H.), and a Burroughs Wellcome Fund Career Award for Medical Scientists (B.T.E.).